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Endocrine Abstracts (2022) 81 EP359 | DOI: 10.1530/endoabs.81.EP359

1Hebrew University of Jerusalem, Israel; 2Hebrew University of Jerusalem, Israel; 3Hadassah Medical Center, Israel; 4University of Michigan Medical School, United States; 5University of Colorado, United States

The gastric mucosa is a dynamic and regenerative tissue that functions in extreme conditions of low pH, mechanical insults and bacterial exposure. The mucosa is composed of pit and neck cells which secrete protective mucus, parietal and chief cells that secrete acid and digestive enzymes, enteroendocrine cells that affect motility, secretion and satiety, rare tuft cells, and at two stem-cell compartments. We studied the response of the gastric mucosa to sleeve gastrectomy surgery: a bariatric or weight-loss surgery in which most of the stomach is removed. Histological analysis and single-cell sequencing of gastric mucosa from patients with no history of surgery, and of patients that had surgery years ago revealed that the gastric mucosa adapts to the new anatomy. We observed an increase in proliferation of the stem cells in the isthmus, in the number of cells per crypt, and a change the composition of the enteroendocrine cell population. Moreover, enterochromaffin-like cells that normally secrete histamine change their transcriptional program and express hormones and neurotransmitters that were not expressed prior to surgery. Mathematical modeling pointed to the hormone Gastrin as a main driver for this adaptation. Theoretical predictions from the model were verified using gastrin knockout mice that underwent sleeve gastrectomy. Altogether, our study reveals how the stomach adapts to a new anatomy imposed by a bariatric surgery, and identifies a new set of signals secreted from the endocrine cells of the stomach following surgery.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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