Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Eposter Presentations

Diabetes, Obesity, Metabolism and Nutrition

ea0081ep246 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association between interleukin-6 and renal function in patients with diabetes mellitus

Vasilkova Volha , Mokhort Tatsiana , Pchelin Ivan , Borovets Yana

Background and Aims: to assess the relationship between level of interleukin-6 (IL-6) and the renal function in patients with diabetes mellitus (DM).Method: A total of 416 patients with DM, aged 34 to 75 years, were examined. Control group included 60 healthy patients the same age/All patients underwent standard clinical and laboratory examination, with an assessment of the levels of natriuretic peptides (BNP, proBNP) and level of IL-6. Renal function wa...

ea0081ep247 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

COVID-19 triggered inborn errors of metabolism in adults: a case report of mitochondrial fatty acid β-oxidation disorder

Serebrennikov Viacheslav , Serebrennikova Kseniya

Introduction: Autosomal recessively inherited disorders in the metabolism of mitochondrial fatty acid β-oxidation (FAO) constitute a group of rare diseases with different clinical manifestations and prognosis depending on the type of enzyme deficiency. Hypoketotic hypoglycemia is common to all these types of disorders and is associated with increased consumption of glucose and impaired synthesis of ketone bodies from fatty acids during the fasting periods, infection, or p...

ea0081ep248 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation between pulse wave velocity and cardiovascular risk in type 2 diabetes

Besrour Chayma , Imen Rojbi , Habib Ben Ahmed , Sabrine Mekni , Nadia Mchirgui , Ibtissem Ben Nacef , Karima Khiari

Introduction: Diabetes increases the risk of high blood pressure, atherosclerosis, coronary heart disease and stroke. Therefore, People with diabetes have an increased cardiovascular risk. Arterial stiffness is a marker of cardiovascular risk and has been shown to have an independent prognostic effect on cardiovascular disease. The aim of this study was to examine the relationship between cardiovascular risk and arterial stiffness in type 2 diabetes.Meth...

ea0081ep249 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evaluation of pulse wave velocity in type 2 diabetes

Besrour Chayma , Imen Rojbi , Habib Ben Ahmed , Sabrine Mekni , Nadia Mchirgui , Ibtissem Ben Nacef , Karima Khiari

Introduction: Type 2 diabetes is an insidious and progressive disease; accounting for about 90% of all diabetes cases worldwide. Atherosclerosis is a common pathology in diabetes that involves a combination of fatty degeneration (atherosis) and stiffening of the arterial vessels (sclerosis), and the best tool to evaluate the arterial stiffness is the pulse wave velocity. The aim of this study is to evaluate the arterial stiffness in type 2 diabetic patients.<p class="abste...

ea0081ep250 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetes Mellitus and COVID-19: Is there a bidirectional relationship?

Rihab Ajili , Imen Mlouki , Souha Ayed , Arij Naimi , Syrine Karchoud , Nawres Ouerghi , Nouha Sfar , Sana El Mhamdi

Introduction: Diabetes mellitus is a well-known risk factor for worse clinical outcomes in patients with Coronavirus Disease 2019 (COVID-19). However, the relationship between these two entities seems to be bidirectional. The aim of this study was to identify the relationship between diabetes and COVID-19.Methods: We conducted a prospective study including all patients admitted at the COVID-19 departments of The University Hospital Taher Sfar (Tunisia), ...

ea0081ep251 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Canagliflozin and liraglutide effect on myocardial damage in diabetic rats with experimental myocardial infarction

Timkina Natalya , Simanenkova Anna , Shimshilashvili Anzhelika , Timofeeva Valeria , Chernikova Alena , Minasian Sarkis , Galagudza Michael

Background: Cardiovascular events are the major cause of mortality among patients with type 2 diabetes mellitus (DM2). Menopause in women additionally increases cardiovascular risk. Despite myocardial infarction (MI) treatment approach in diabetic patients is not specific, some glucose-lowering drugs could have cardioprotective properties. In general, most glucagon-like peptide-1 receptor agonists (GLP-1Ra) and sodium-glucose co-transporter-2 inhibitors (SGLT-2i) have cardiova...

ea0081ep252 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Comparative analysis of characteristics of pregnant women with pathological oral glucose tolerance test vs negative oral glucose tolerance test in a trimester of 2019

Simon Frapolli Victor Jose , Ignacio Martinez Montoro Jose , Picon Cesar Maria Jose , Gutierrez Repiso Carolina , Suarez Arana Maria , Tinahones Madueno Francisco Jose , Molina Vega Maria

Introduction: Gestational diabetes mellitus (GDM) is the metabolic disorder most frequently associated with pregnancy, presenting important maternal and fetal implications. Strict glycemic control through lifestyle measures and/or pharmacotherapy is essential to achieve adequate obstetric-perinatal results. The objective of this study is to compare baseline characteristics and perinatal results in patients diagnosed with GDM after performing oral glucose tolerance test (OGTT) ...

ea0081ep253 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

PSMA6 and KEAP1 genes methylation in patients with type 1 diabetes and diabetic retinopathy

Kardonaite Deimante , Verkauskiene Rasa , Radzeviciene Lina , Daugintyte-Petrusiene Laura , Balciuniene Vilma Jurate , Sokolovska Jelizaveta , Paramonova Natalia

Background: Diabetic retinopathy (DR) is one of the most common complications resulting from uncontrolled diabetes mellitus (DM). DR is the leading cause of blindness and low vision. DR is usually diagnosed at an advanced stage, so despite the individual treatment, it is only possible to slow down the progression of DR. Therefore, new potential biomarkers are needed for an earlier DR prognosis to prevent the development of DR. According to the latest studies, ubiquitin-proteas...

ea0081ep254 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effects of semaglutide on glycemic control and weight loss in a patient with Prader-Willi Syndrome: a case report

Sani Elena , Prato Giuliana Da , Zenti Maria Grazia , Bordugo Andrea , Trombetta Maddalena , Bonora Enzo

Background: Prader-Willi syndrome (PWS) is the most frequent genetic cause of obesity and is often complicated by glucose metabolism alterations. Conventional therapies prescribed in type 2 diabetes mellitus (T2DM), like oral hypoglycemic agents and insulin, frequently failed to achieve adequate glycemic control in patients with PWS. Beneficial effects of the glucagon like peptide-1 receptor agonists (GLP1RAs) exenatide and liraglutide have been reported for the management of ...

ea0081ep255 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Central nervous system condition in children with diabetes mellitus type I

Nikolaeva Nataliia , Gumeniuk Olga , Chernenkov Yuriy , Bolotova Nina

Diabetes mellitus is a metabolic disease that is accompanied by brain injury manifested as cognitive, emotional and vascular impairment.Purpose: To study prevalence and degree of disorders of central nervous system in children with diabetes mellitus type I (TIDM).Objects and methods: Examination of nervous system in 100 children - age 7-18 yrs [9.0-17.8] with TIDM was provided. The control group consisted of healthy children (n...

ea0081ep256 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association of sarcopenia with peripheral nerve functions in type 2 diabetes mellitus patients in East India: A prospective cross sectional study.

Behera Kishore , Mohapatra Subarna , Priyadarsini Nibedita , Nanda Pranati , Srinivasan Ananda

Background: Diabetic peripheral neuropathy (DPN) is considered to be the risk factor for the development of sarcopenia. Various previous studies showed the correlation between DPN and muscle disorders, but the study regarding the association between sarcopenia and nerve conduction parameters in diabetic peripheral neuropathy is limited.Aim: This study was planned to detect the association between sarcopenia with peripheral nerve functions in type 2 diabe...

ea0081ep257 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Subclinical left ventricular dysfunction in patients with obesity and chronic obstructive pulmonary disease

Klester Elena , Klester Karolina , Stefanovskaya Oksana

The purpose of the work: to compare the changes in the global longitudinal strain of the left ventricle in obese patients with and without COPD.Material and methods of research: group I consisted of obese patients without COPD (n=50; 21 - males, mean age - 48.8±9.1 years). Group II – 40 patients with obesity and COPD, comparable in age, gender. Group III – 37 patients with COPD without obesity, comparable in age, gender and risk g...

ea0081ep258 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effect of mimic-mir-21/au@ nanosystem on browning activation: a possible therapeutic tool against obesity

Lhamyani Said , Gentile Adriana-Mariel , Giraldez Perez Rosa Maria , Grueso Elia , Mengual Mesa Maria , Estepa Enrique , Olveira Gabriel , Tinahones Francisco-Jose , Bekay Rajaa El

Background and aim: Obesity is a chronic disease associated with a positive energy balance leading to lipotoxicity, which contributes to the onset of obesity-associated metabolic disorders such as type 2 diabetes and insulin resistance. It’s well known that thermogenesis in brown adipose tissue (BAT) and “browning” of white AT (WAT) increase energy expenditure, thus promoting weight loss and protect against obesity. Recently, the microRNAs (miRNAs) that regulate...

ea0081ep259 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The intestinal microbiome and the adipomyokine profile of different phenotypes of obesity

Volkova Natalya , Ganenko Lilia , Naboka Yulia , Shestopalov Alexander , Davidenko Ilya , Degtyareva Yuliya

Currently, it has been established that obesity is a heterogeneous disease. There are metabolically healthy (MHO) and metabolically unhealthy obesity (MNHO) depending on the presence of cardiometabolic disorders. Potential factors that differentiate obesity into phenotypes include the gut microbiome and endocrine activity of adipose and muscle tissue. Purpose of the study was to compare intestinal microbiome and adipomyokine profile in patients with different obesity phenotype...

ea0081ep260 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Maternal weight gain during pregnancy and neonatal birth weight among women with gestational diabetes mellitus

Lajili Olfa , Temessek Aroua , Rachdi Rim , Htira Yosra , Ben Mami Feika

Introduction: Body mass index (BMI) and gestational weight gain are increasing globally. However, the association between gestational weight gain consistent with the Institute of Medicine (IOM) guidelines and neonatal birth weight among women with gestationnel diabetes (GDM) remain unclear.Objective: The aim of our study was to assess gestational weight gain among tunisian women with GDM and his effect on neonatal birth weight.Meth...

ea0081ep261 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation between pulse wave velocity and microangiopathy in type 2 diabetes

Besrour Chayma , Imen Rojbi , Habib Ben Ahmed , Sabrine Mekni , Nadia Mchirgui , Ibtissem Ben Nacef , Karima Khiari

Introduction: Microangiopathy is defined as damage to small blood vessels, and more particularly arterioles and arteriolar capillaries that supply organs. It can occur under different conditions and it represents a complication of diabetes. The aim of this study was to examine the relationship between microangiopathic complications and arterial stiffness in type 2 diabetes.Methods: We conducted a prospective study including 249 diabetic patients without ...

ea0081ep262 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evolution of combined impaired fasting glucose and impaired glucose tolerance in 58 β-thalassemia major (β-TM) patients during a mean 7.7 year follow-up

Sanctis Vincenzo De , Daar Shahina , Soliman Ashraf , Tzoulis Ploutarchos , Yassin Mohamed , Kattamis Christos

Background: In patients with β- thalassemia major (β-TM) glucose dysregulation (GD) develops insidiously, aggravating prognosis and quality of life.Objectives: The objectives of this study were to retrospectively review the extent to which β-TM patients, having combined impaired fasting glucose (IFG) and impaired glucose tolerance test (IGT) on oral glucose tolerance test (OGTT), progressed to diabetes (DM) and to analyze ...

ea0081ep263 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hormonal-metabolic and functional predictors of unfavorable cardiovascular prognosis in young patients with type 1 diabetes mellitus.

Oksana Vengrzhinovskay , Bondarenko Irina , Shatskaya Olga , Shestakova Marina , Kalashnikov Victor , Mokrysheva Natalia

Background: Patients with type 1 diabetes have a significantly higher risk of coronary events, as well as diseases of the cardiovascular system.Purpose of the study – to show the relationship between metabolic, structural, and functional parameters of the cardiovascular system in young patients with DM1.Methods: The study included 60 patients without CVD: 40 patients with DM1 and 20 patients without DM1, the groups were comparable in age, sex, AMT, ...

ea0081ep264 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association of adherence to the mediterranean diet and body composition in type 1 diabetes mellitus

Redondo Enrique , Del Carmen Andreo-Lopez Maria , Garcia Javier , Zarco Teresa , Bolivar Victoria Contreras , Luisa Fernandez Soto Maria

Introduction: Body composition is gaining great interest in some pathologies such as Type 1 Diabetes Mellitus (DM1). Adherence to the Mediterranean diet has been shown to be effective in improving the prognosis of cardiovascular disease, which is the main cause of mortality in these patients.Objectives: To assess whether adherence to the Mediterranean diet in DM1 is associated with improvement in disease control parameters, body composition, anthropometr...

ea0081ep265 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Glycemic variability in pregnant women with gestational diabetes mellitus

Ushanova Fatima , Demidova Tatyana , Izmailova Mariyam

Introduction: Glycemic variability (GV) is a more accurate parameter for assessing the risk of developing diabetic complications than traditional parameters for assessing compensation. In most cases, diet therapy is used to treat GDM, while the glycemia in a pregnant woman should correspond to the glucose level in healthy pregnant women. The aim of our work is to compare two-week glycemic profiles and GV in pregnant women with GDM on diet therapy and in healthy pregnant women ...

ea0081ep266 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The common genetic polymorphism of KCNJ11 is associated with features of continuous glycemic profile in individuals with type 2 diabetes mellitus receiving vildagliptin monotherapy

Shorokhova Polina , Baranov Vitaly , Vorokhobina Natalya

Background and aims: The rs5219 variant in the KCNJ11 have been consistently associated with type 2 diabetes (T2D) and therapeutic response to sulfonylureas in type 2 diabetic patients. However, the impact of KCNJ11 genetic polymorphism on the antidiabetic efficacy of vildagliptin has not yet been evaluated. This study was aimed to investigate the association of KCNJ11 rs5219 with vildagliptin glucose lowering ability by monitoring continuous blood glucose profile.<p class...

ea0081ep267 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

GLUCUBE: Usability validation of a non-invasive device for blood glucose measurement.

Mendez Muros Mariola , Naranjo Hernandez David , Tosina Javier Reina , Maria Roa Romero Laura , Barbarov Rostan Gerardo , Asuncion Martinez Brocca Maria

Introduction: The Biomedical Engineering Group of the University of Seville, the Endocrinology and Nutrition Unit of the Virgen Macarena Hospital (ENU-VMH) and the company Igluco Tech are developing the GLUCUBE device, a new non-invasive sensor for blood glucose measurement.Objective: First validation of usability and accessibility of the device by patients in a controlled clinical environment.Material and Methods: General user-cen...

ea0081ep268 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Psychological impact of obesity in adult women

Salah Dhoha Ben , Charfi Hana , Mejdoub Yossra , Maamri Hanen , elleuch mouna , Yaich Sourour , Jdidi Jihen , Kacem Akid Faten Haj , Abid Mohamed

Introduction: Obesity is a global epidemic with a growing prevalence in recent decades. In Tunisia, obesity is a major problem as it is increasing in adults as well as in children and adolescents. It therefore appears important to deepen the knowledge on this pathology and especially on the psychological profile, since studies concerning the mental health of obese subjects remain rare.Purpose: Study the psychological impact of obesity in adult women<...

ea0081ep269 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Should we systematically detect hypothyroidism in obese subjects ?

Salah Dhoha Ben , Eddine Ben Issa Alaa , Elleuch Mouna , Khouloud El Asmar , Mnif Fatma , Charfi Nadia , Mnif Mouna , Majdoub Nabila Rekik , Haj Kacem Akid Faten , Abid Mohamed

Introduction: Hypothyroidism has always been considered one of the most common endocrine etiologies of obesity. That said, would screening for hypothyroidism be justified in the face of obesity? The purpose of our study was to study the thyroid profile of obese people.Patients and methods: We conducted a retrospective study which patients with obesity hospitalized in the diabetology endocrinology department, CHU Hédi Chaker of Sfax, between 01/10/20...

ea0081ep270 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Un unexpected cause of mild hypoglycaemia in an adult

Baleanu Felicia , Georgiana Taujan , Rosu Mihaela , Kosmopoulou Olga , Papadopoulou Blerta , Boros Emese , Laura Iconaru

A 36-year-old Caucasian male was referred in November 2021 to our clinic, for investigations regarding his recent genetic diagnosis of congenital hyperinsulinism, revealed by genetic testing, performed after the birth of couple’s second child presenting with recurrent hypoglycemia.The female newborn diagnosed with fetal macrosomia (birth at 38 weeks, 4.3 kg), required follow-up and further examinations.A massive parallel sequencing on panel of 4867 genes using Roche platf...

ea0081ep271 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of emotional eating in the weight of woman

Viana Victor , Pereira Miguel , Paulo Almeida Jose , Carvalho Davide

Introduction: Obesity is nowadays one of the most important challenges in public health and, therefore, the investigation of their causes is most relevant. Among the various behavioral roots of obesity, the emotional over ingestion determined by emotional factors, i.e. emotional eating (EE), is one of them.Objectives: To study how emotions contribute to obesity in woman.Methods: We gathered a convenience sample 220 woman in the hos...

ea0081ep272 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of bariatric surgery on cognitive function

Barahona Maria-Jose , Simo Andreu , Ibarra Montse , Libran Mireia , Ramos Montse , Perea Veronica , Orois Aida , Quiros Carmen , Casas Laura

Aim: Obesity was shown to be related to global cognitive decline, being especially altered the executive function and the information processing speed. Bariatric surgery (BS) is an effective means of weight reduction in severely obese patients and correlates with improvements in neurocognition. The mechanisms underlying these improvements are not fully elucidated.Material and Methods: Prospective, observational study, including consecutive patients that ...

ea0081ep273 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Serum xanthinoxidase activity (sxo)-glucose homeostasis association in patients with type 2 diabetes mellitus (t2dm)

Khyzhnyak Oksana , Cherniaieva Anna , Mykytyuk Myroslava , Karachentsev Iurii

Introduction: Hyperuricemia is increasingly being considered a potential pathogenic factor for T2DM, metabolic syndrome, and several adverse consequences of vascular disease. It has been suggested that xanthine oxidase may underlie the urine acid-T2DM association. The study aimed to determine the associations between clinical parameters, glucose homeostasis, and SXO activity in patients with T2DM.Methods: 125 patients with T2DM, age (58.9±9.4) years...

ea0081ep274 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Liraglutide improves binge-eating and increases ghrelin levels in obese diabetic 2 patients

Laniush Fedir , Urbanovych Alina

Background and aims: liraglutide belongs to glucagon-like peptide-1 receptor agonists (GLP-1 RA) and is widely used for diabetes type 2 (DT2) management as well as for obesity treatment. GLP-1 RA reduce body weight and suppress eating behavior by delaying gastric emptying and affecting arcuate nucleus in hypothalamus. Binge eating disorder (BED) is the most common eating disorder (ED) in individuals with obesity and DT2. BED is characterized by consuming large amounts of food ...

ea0081ep275 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

A potential complication of diabetes: ischemic colitis

Mauntana Shielah , Gajendran Mahesh

Background: Ischemic colitis (IC) is a disorder characterized by a decrease in blood flow of the large intestine. Many factors can contribute to decreased blood flow in the arteries supplying the large intestine, such as nonocclusive causes like hypertension and atherosclerosis and occlusive causes like embolism from myocardial infarction. With Ischemic colitis’s high mortality rate and its association with many cardiovascular diseases, it’s important to understand t...

ea0081ep276 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Lipoatrophy in type 1 diabetes treated by human insulin: a case report

Azriouil Manale , Guissi Loubna , Kamel Farah , Moussaid Nawal , Rifai Kaoutar , Iraqi Hinde , Elhassan Gharbi Mohamed

Introduction: Lipoatrophy is a rare cutaneous complication in diabetes that presents with localized subcutaneous fat atrophy at the insulin injection site. We report a case of a 62-year-old man type 1 diabetic with lipoatrophy lesions on the thighs.Case report: A 62-year-old male, with clinical history of basedow’s disease, He was diagnosed type 1 diabetes (T1D) when he was 19 years old, treated with premixed human insulin for the last 4 years.His w...

ea0081ep277 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Detection of visceral obesity in children and adolescents based on body composition analysis

Samoilova Iuliia , Matveeva Mariia , Oleynik Oxana , Podchinenova Daria , Mutalimi Venera , Trifonowa Ekaterina , Zaharchuck Poina

Introduction: Visceral obesity is a primary risk factor for metabolic syndrome and is associated with short- and long-term effects on physical and psychosocial health. It is now known that body mass index (BMI), which is used as the main method of diagnosing obesity, does not allow the assessment of body composition and differentiation of visceral adipose tissue.The aim of the study. To investigate the features of body composition that influence metabolic risks in primary scho...

ea0081ep278 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evolution of glucose-insulin homeostasis in children with β - thalassemia major (β -TM): A twenty-year retrospective ICET- A observational analysis from early childhood to young adulthood

Sanctis Vincenzo De , Daar Shahina , Soliman Ashraf , Tzoulis Ploutarchos , Karimi Mehran , Kattamis Christos

We studied retrospectively the changes of glucose-insulin homeostasis from early childhood to young adulthood in β-thalassemia major (β -TM) patients with impaired fasting glucose (IFG) vs those with normal OGTT.Methods: All data entered in the database of β -TM patients’ records from September 1983 to September 2021 were included in the study.Results: The occurrence of dysglycemia (GD)...

ea0081ep279 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Malnutrition risk using morphofunctional evaluation in hematopoietic stem cell transplantation

Munoz Jimenez Concepcion , Teodomiro Carlos Alzas , Garcia-Ramirez Mireia , Romero Laura , Garcia Estefania , Jesus Calanas Continente Alfonso , Jose Molina Maria , Herrera-Martinez Aura D.

Background: Malnutrition affects 30-50% of patients with hematological malignancies; it is due to the disease itself, the treatment-related catabolic process and chemo-or radio-therapy side effects (nausea, vomiting, diarrhea and mucositis). Patients with poor nutritional status have increased morbidity (treatment complications, infections, mucositis) and mortality.AimTo evaluate the nutritional status of all patients that underwent hematopoietic stem ce...

ea0081ep280 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

C-peptide response to standardized test meal in patients with newly diagnosed type 2 diabetes mellitus

Stojanovic Jelena , Andjelic Jelic Marina , Vuksanovic Miljanka , Petkovic Milica Marjanovic , Jojic Biljana , Grujanac Ana Cvetkov , Zivkovic Teodora Beljic

Background: Optimal testing of beta-cell dysfunction is still elusive. Oral based solid-food tests could superiorly approximate real-life stimulation by incorporating incretin activation. Increased body fat was recently associated with better preserved beta-cell secretory response, due to gluco-lipotoxicity induced adaptation.Objective: To assess C-peptide response to standardised test meal (STM) and its dependency on subject characteristics in newly dia...

ea0081ep281 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Flash glucose monitoring system in a regional hospital in the south area of granada

Leon Utrero Sara , Contreras Bolivar Victoria , Torres Enrique Redondo , Sanchez Javier Garcia , Lopez-Ibarra Lozano Pablo Jose

Introduction and Objectives: Poor metabolic control in Type 1 Diabetes Mellitus (DM 1) is associated with micro and macrovascular complications. The implementation of interstitial glucose monitoring systems has contributed to improving glycemic control in recent years. Our objective was to know the metabolic control in people with type 1 DM and the Flash system and to establish if there is an association between its use and glycemic control variables.Mat...

ea0081ep282 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Nurses knowledge in diabetes self-management education in Sfax Tunisia

Elleuch Mouna , Charfi Hana , Salah Dhoha Ben , Salah Ameni , Mnif Fatma , Charfi Nadia , Mnif Mouna , Majdoub Nabila Rekik , Kacem Akid Faten Haj , Abid Mohamed

Introduction: Diabetes mellitus is a major public health problem affecting all ages worldwide. In Tunisia, 18% of the population has diabetes mellitus. In fact, it is one of the first ten causes of death in our country.Therefore, self-management education for diabetic patients play an important role in reducing diabetes complications and mortality rate. The education is conducted not only by doctors, but also by nurses.Purpose: The aim of this study is t...

ea0081ep283 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Pharmacogenomics and efficacy outcome of therapy with glucagon-like peptide-1 receptor agonists in type 2 diabetes

Beniga Camille , Heshmati Hassan

Introduction: Individual variability in drug efficacy and safety due to genetic diversity is a major challenge for clinicians. Pharmacogenetics deals with inherited differences in the efficacy and safety responses to drugs. The incidence of type 2 diabetes (T2D) is increasing worldwide and the disease is reaching pandemic proportions. T2D is treated by oral and/or injectable drugs. The interindividual variability of T2D drug actions may be caused, at least in part, by genetic ...

ea0081ep284 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Factors affecting glycemic outcomes using closed-loop systems in real-world

Fabregas Lara Albert , Andujar David Subias , Gregori Ana Romero , Luchtenberg Maria Florencia , Palomares Albert Cano , Mazarico Isabel , Rigla Mercedes

Aims: To evaluate real-world efficacy of closed-loop systems (CLS) (MinimedTM 780G, DBLG1 -Diabeloop- and Control-IQTM Tandem) as well as to assess those predictive factors related with the achievement of near-normal glycemic control.Methods: A prospective, longitudinal, and observational study was performed. It included T1D adults who initiated CLS between April and December 2021 in our hospital and provided data for &gE;3 months (...

ea0081ep285 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Predicting the effectiveness of metformin in patients with type 2 diabetes mellitus from molecular genetic positions

Sorokina Yulia , Sukhanov Sergey , Zanozina Olga , Mosina Anna

Purpose: to assess the possibility of predicting the effectiveness of pharmacotherapy with metformin in patients with type 2 diabetes mellitus (DM2) depending on the single nucleotide polymorphism of the nitric oxide synthase gene.Materials and methods: 186 patients were examined, referred for planned hospitalization, the duration of DM2 was 6-8 years, the target level of glycated hemoglobin was 7.5%, the actual level was 8.3%. All patients were prescrib...

ea0081ep286 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Age-related changes in proinsulin processing in non-diabetic individuals

Vaňkova Marketa , Vejražkova Daniela , Lukašova Petra , Včelak Josef , Bendlova Běla

Introduction: To understand the pathological changes associated with glucose homeostasis in old age, it is necessary to know the natural changes in the processing of proinsulin into mature insulin. Surprisingly, while there is abundant information about insulin function in diabetics, the situation in healthy adults and old humans was rarely examined.The study aimed: To determine how the proinsulin secretion in individuals with normal glucose tolerance ch...

ea0081ep287 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

New challenge for endocrinologists–heterozygote familial hypercholesterinemia (part 1)

Rasa Ingvars , Jenbajeva Ksenija , Anufrijeva Alīna

Background: Heterozygote familial hypercholesterolemia (HeFH) is a common genetic disorder resulting in high low–density lipoprotein–cholesterol (LDL–C) levels. It has been established that only 3% of patients (pts) among the Latvian population were diagnosed in 2019. The early HeFH diagnosis and treatment can prevent premature cardiovascular complications and save lives. Aim. The study aimed to determine the incidence of HeFH in a single-centre endocrinologist&...

ea0081ep288 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Surrogate measures of insulin secretion and sensitivity (IS) in young children with beta thalassemia major on repeated blood transfusion and iron chelation therapy.

Sanctis Vincenzo De , Daar Shahina , Soliman Ashraf , Tzoulis Ploutarchos , Karimi Mehran , Kattamis Christos

We assessed glycemia and insulin markers in 18 young children with beta thalassemia major (BTM). Insulin markers measured included: the Homeostatic Model Assessment index of insulin resistance (HOMA-IR), Matsuda index (MI), the insulinogenic index (IGI), and the oral disposition index (oDI). 9 had normal fasting glucose (FG) and 9 had impaired fasting glucose (IFG)Results: HOMA-IR, a marker of IR was significantly higher in children with BTM compared to ...

ea0081ep289 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Obesity in adults with type 1 diabetes mellitus and its relation to their eating habits and physical activity

Pappa Dimitra , Barmpa Eleftheria , Christou Maria , Katsaras Ioannis , Tigas Stylianos , Bargiota Alexandra

Introduction: Obesity is rising worldwide and the number overweight or obese patients with type 1 diabetes mellitus (T1DM) is increased and eating habits (EH) and physical activity (PA) play an important role on glycemic control and weight gain. The aim of the present study was to examine the EH and the exercise level in patients with T1DM and their relation to body weight.Methods: 126 patients with T1DM (55/126 males, 71/126 females) attending our outpa...

ea0081ep290 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Glycemic changes in relation to hepatic iron status in patients with non-transfusion dependent (NTD-SCD) and transfusion dependent sickle cell disease (TD- SCD).

Soliman Ashraf , Yassin Mohamed , De Sanctis Vincenzo

Introduction: We evaluated glycemia and the iron status in patients with NT-SCD and 6 patients with TD- SCD by measuring serum ferritin level (SF), liver iron content (LIC), alanine transferase (ALT) and fasting blood glucose (FBG) over 5 years of follow up.Results: At the initial assessment, 16 adults with (age: 33±14 years), and six of TD-SCD (n=6, age =25±10 years) were studied. 6/16 of NT-SCD had SF > 500 μg/l, and 5/16 ha...

ea0081ep291 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Description of patients with diabetic foot of neuropathic and vascular cause cared for in a multidisciplinary Diabetic Foot Unit

Pinar Gutierrez Ana , Gros-Herguido Noelia , Losada-Vinau Fernando , Farfan-Diaz Fatima , Enriquez-Perez Monica , Ruiz-Trillo Carmen , Ciuro Felipe Pareja , Fuentes Lucas Mengibar , Soto-Moreno Alfonso

Objective: 6% of people with diabetes present with diabetic foot as a complication, which means greater morbidity and mortality compared to those who do not. Its diagnosis and management by multidisciplinary teams including surgeons can improve these patients’ care. The objective was to analyze the main characteristics of patients and health results obtained, as well as to evaluate the impact of PAD (peripheral artery disease) existence in patients cared for in our multid...

ea0081ep292 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Number of gestational diabetes risk factors associates with adverse pregnancy outcomes

Chaves Catarina , Cidade-Rodrigues Catarina , Melo Anabela , Figueiredo Odete , Morgado Ana , Almeida M. Ceu , Martinho Mariana , Almeida Margarida , Cunha Filipe M

Introduction: There are several known risk factors for gestational diabetes mellitus (GDM), a condition associated with worse pregnancy outcomes. Once GDM is established, the association between the presence of GDM risk factors and pregnancy outcomes is less well-known. We studied the association between the number of GDM risk factors and pregnancy outcomes in a population of women with GDM.Methods: Retrospective study of the Portuguese multicentre GDM r...

ea0081ep293 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

HbA1c response after initiation of flash glucose monitoring in adults with diabetes

Tirado Antonio Moreno , Mendez Cristina Montalban , Montero Benitez Maria Zhao , Torrecilla Pedro Jimenez , Gonzalez Lazaro Paloma , Del Val Zaballos Florentino , Meneses Amparo Lomas , Gomez Alfonso Francisco Javier , Iglesias Maria Lopez , Gomez Garcia Ines

Introduction and Objective: Flash glucose monitoring is a form of interstitial glucose monitoring and it is indicated in patients with diabetes mellitus.The objetive of the study was to assess the effect of introducing flash glucose monitoring in adults with diabetes with respect to change in hemoglobin A1c (HbA1c).Material and methods: Prospective observational study of adults with diabetes in our center, in whom a prescription for a flash glucose monit...

ea0081ep294 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The melatonin receptor gene polymorphism rs10830963 is not associated with significant differences in sleep patterns and biorhythms.

Vejrazkova Daniela , Chocholova Denisa , Vankova Marketa , Lukasova Petra , Vcelak Josef , Sladek Martin , Sumova Alena , Bendlova Bela

Introduction: Melatonin is a crucial hormone for controlling sleep rhythms and disruption of its natural secretory rhythmicity is considered to be one of the causes of type 2 diabetes mellitus. The MTNR1B gene encodes the melatonin receptor. Polymorphism rs10830963 in this gene shows an association with fasting blood glucose and impaired glucose tolerance. Current studies suggest that carriers of the minor allele G have a slightly shifted cycle of melatonin secretion toward a ...

ea0081ep295 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

“ Features of the angiography of the eye bottom in patients with diabetic retinopathy” “

Urmanova Firuza , Bakhritdinova Fazilyat , Kengilbaeva Guzal

The purpose of the study is to study the F=features of the angiography of the eye bottom in patients with diabetic retinopathy in patients with type 2 diabetes mellitus (DM2), with different stages of diabetic retinopathy (DR).Material and research methods: 252 people were examined (n=504), of which 168 patients with type 2 type and 84 practically healthy persons. The main group (I; n=174) with DM2, divided into subgroups, depending on ...

ea0081ep296 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of glucoregulation and duration of diabetes on the incidence of diabetes chronic complications in Republic of Srpska/Bosnia and Herzegovina

Popovic Pejicic Snjezana , Pejicic Nina , Stanivuk Ljiljana

Background/Aim.: Importance of glucoreglation qality in diabetes complication prevention was proven in numerous clinical studies. Aim of this study is to determine impact of glucoregulation and duration of diabetes on the incidence of chronic complications of diabetes in Republic of Srpska (RS).Method: Study model included subjects with T1D and T2D who participated in the two-year project in the RS. It was a cross-sectional study with 10...

ea0081ep297 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Cochleo-vestibular disorders in diabetic patients

Fatma Mnif , Zargni Asma , Jemaa Hanene Ben , Hammami Boutheina , Arbi Kawthar El , Salah Dhoha Ben , Elleuch Mouna , Charfi Nadia , Kacem Akid Faten Haj , Charfeddine Ilhem , Abid Mohamed

Introduction: Cochleovestibular disorders in patients with diabetes is not well known as compared to other complications. The aim of this study was to evaluate the epidemiological, clinical and paraclinical characteristics of cochleovestibular dysfunction in diabetes.Materials and Methods: This is a retrospective study of 100 diabetic patients. The patients had a clinical otological and vestibular examination as well as a tonal audiometry and a video nys...

ea0081ep298 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Precipitating factors of diabetic ketoacidosis

Matas Nino , Barač Nekić Anja , Čović Antonela , Vrandečić Fran , Bačun Tatjana , Feldi Ivan , Kaštelan Darko , Dušek Tina , Zibar Tomšić Karin , Novak Anela

Introduction: Diabetic ketoacidosis (DKA) is one of the most serious acute complications of diabetes mellitus (DM). In some studies, infections have been shown to be a precipitating factor in half of the subjects. On the other hand, several recent studies emphasise that poor treatment adherence is also a common cause of DKA.Objective: To identify the most common precipitating factors for DKA in the Republic of Croatia.Patients and ...

ea0081ep299 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Is the 2009 CKD-EPI more accurate with or without the race coefficient for black adults from outside the United States?

Zingano Carolina , Escott Gustavo Monteiro , Rocha Bruna Martins , Porgere Indianara Franciele , Moro Candice Cristine , Delanaye Pierre , Silveiro Sandra Pinho

Introduction: Diabetes is the leading worldwide cause of chronic kidney disease, which is diagnosed by measuring albuminuria and estimating glomerular filtration rate (GFR) with creatinine-based formulas, such as the 2009 CKD-EPI developed in the United States of America (USA). Nonetheless, the race coefficient (RC), present in the 2009 CKD-EPI, may overestimate GFR in other countries.Aim: The goal of this systematic review and meta-analysis was to asses...

ea0081ep300 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

A patient with aniridia and Type 1 diabetes mellitus

Pappa Dimitra , Barmpa Eleftheria , Linaras Maistros , Tsakos Panagiotis , Zikos Nikolaos , Bargiota Alexandra

Introduction: Aniridia is a rare congenital condition which is characterized by a complete or partial absence of the iris and fovea and malformations of the lens and anterior chamber. It is usually related to mutations in PAX6, a member of a multigene family of transcription factors, which is important for the development of the nervous system, the eyes and also the endocrine pancreas and it is found to be associated with mild glucose intolerance. Complete loss of insulin secr...

ea0081ep301 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Endogenous hyperinsulinism and diabetes remission : A report of 2 cases

Ben Rebai Senda , Ben Nacef Ibtissem , Mekni Sabrine , Besrour Chayma , Lakhoua Youssef , Mchirgui Nadia , Rojbi Imen , Khiari Karima

Introduction: Diabetes is a chronic, progressive disease characterized by elevated levels of blood glucose. In type 1 diabetes, some patients experience a “honeymoon period” shortly after diagnosis, wherein insulin needs decrease significantly and a few studies have demonstrated that drug-free glycemic control can be achieved in type 2 diabetes. We describe 2 unusual cases of endogenous hyperinsulinism and diabetes remission.Case presentation 1...

ea0081ep302 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effects of glucagon-like peptide 1 analogue on eating behavior in patients with obesity

Logvinova Oksana , Troshina Ekaterina

Introduction: One of the objectives of weight loss in obesity is to prevent metabolic disorders. An important component in the maintenance of the achieved results is a change of eating behavior.Goal: To study the effect of liraglutide 3.0 mg on the dynamics of metabolic parameters and eating behavior in patients with obesity.Materials and methods: The study enrolled 42 obese patients in whom anthropometric parameters, metabolic par...

ea0081ep303 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of sarcopenia with different DXA indices in a population with high-risk obesity

Gonzalez Arnaiz Elena , Gonzalez Roza Lucia , Ramos Bachiller Beatriz , Pintor de la Maza Begona , Barajas-Galindo David , Cano Rodriguez Isidoro , Ballesteros-Pomar Maria

Background: Sarcopenic obesity(SO) is an entity characterized by excess fat mass(FM) and low muscle mass (LMM) and function. Excess FM itself can lead to loss of muscle mass and function at any age. The combination of obesity and sarcopenia is a proven risk factor for frailty, comorbidities and mortality. New diagnostic criteria have been developed for this entity.Aims: To assess the prevalence and severity of SO with different indices by DXA, in a group...

ea0081ep304 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Empagliflozin and arterial stiffness in type 2 diabetic patients: a real clinical practice case-control study

Tassone Francesco , Ferreri Cinzia , Rossi Arianna , Baffoni Claudia , Borretta Giorgio , Feola Mauro

Background: Sodium-glucose cotransporter-2 (SGLT2) inhibitors demonstrated beneficial effects on cardiovascular and renal events in patients with type 2 diabetes mellitus. The mechanisms underlying these effects are not fully elucidated. Aim of this study was to investigate whether empagliflozin is able to affect arterial stiffness/pulse wave velocity in type 2 diabetic patients.Methods: Pulse wave velocity and other parameters of arterial stiffness were...

ea0081ep305 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association of single nucleotide polymorphisms (SNPs) of the intestinal fatty acid-binding protein (FABP2) gene with peripheral atherosclerosis in patients with type 2 diabetes mellitus.

Sukhanov Sergey , Sorokina Yulia , Zanozina Olga , Lagonskaya Veronika

Relevance: There is a search for candidate genes that contribute to the progression of atherosclerosis in patients with diabetes mellitus. It has been suggested that the FABP2 Ala54Thr polymorphism may be associated with the risk of atherosclerosis.Objective: To evaluate the relationship between polymorphism of the intestinal fatty acid-binding protein (FABP2) gene Ala54Thr with peripheral atherosclerosis in patients with type 2 diabetes mellitus.<p ...

ea0081ep306 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Retrospective analysis of association between coronary artery disease and Glycemic Control in South Indian T2DM population

V Mahadevan

Background: Type 2 diabetes mellitus (T2DM) is independently associated with an increased risk for cardiovascular disease caused mainly by early development of vascular changes leading to atherosclerosis. Coronary artery disease (CAD) is one of the common complications However, the exact correlation between glycemic control and the risk of developing CAD remains unclear. This study sought to assess the correlation of glycemic control and risk of developing CAD in South Indian ...

ea0081ep307 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Predictive factors for distal and symmetric polyneuropathy in diabetic patients

Elleuch Mouna , Souhir Maalej , Houda Hsine , Ben Salah Dhoha , Frikha Hamdi , Haj Kacem Akid Faten , Abid Mohamed

Introduction: Diabetic neuropathy is the most common cause of neuropathy worldwide and is known to affect approximately half of all diabetic patients. It significantly impairs the quality of life of patients.Aim of the study: To establish the predictive factors of distal symmetric polyneuropathy (DSPN) in diabetic patients.Methods: This is a descriptive cross-sectional study including 116 patients. The diagnosis of PNDS was establi...

ea0081ep308 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Depression associated factors among Tunisian diabetic patients

Belkhiri Malak , Fadia Boubaker , Khemiri Ashraf , Bouali Walid , Mrabet Houcem , Wafa Alaya , Baha Zantour , Mohamed Habib Sfar , Zarrouk Lazhar

Introduction: Diabetes mellitus and depression are two major public health problems which can coexist and influence each other. Identification of the predictive and associated factors with depression among diabetics can facilitate the task of clinicians.Objective: Evaluate the socio-demographic and clinical factors associated with depression among patients having diabetes mellitus (DM).Materials and methods: A cross sectional study...

ea0081ep309 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence and risk factors of diabetic painful distal symmetrical polyneuropathy

Ben Salah Dhoha , Abdelmoula Mariem , Mejdoub Yosra , Ketata Nouha , Elleuch Mouna , Mnif Fatma , Charfi Nadia , Mnif Mouna , Rekik Majdoub Nabila , Haj Kacem Akid Faten , Abid Mohamed

Introduction: Distal and symmetrical peripheral polyneuropathy is the most frequent type of diabetic neuropathy. Its painful form (PDN) is the most common cause of non-traumatic neuropathic pain and can place a heavy burden on patients’ lives. Despite the major impact that it can have on the quality of life, PDN is generally underdiagnosed because of a large interindividual variability of symptoms and in the absence of well-established diagnostic criteria.<p class="ab...

ea0081ep310 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Obesity and abdominal adiposity are associated with lower urinary tract symptoms in Tunisian patients with type 2 diabetes : a cross-sectional study

Haj Kacem Akid Faten , Missaoui Abdelmouhaymen , Belhoul Mariem , Belabed Wafa , Ben Salah Dhoha , Fatma Mnif , Rekik Majdoub Nabila , Elleuch Mouna , Abid Mohamed

Background and Aims: Lower urinary tract (LUT) dysfunctions are highly prevalent, especially in women. Diabetes is a well-established risk factor for developing LUT symptoms. Several studies suggest that a high body mass index (BMI) may worsen the urinary discomfort in patients with type 2 diabetes (T2DM). The current survey aims to investigate the relationship between obesity and LUT dysfunctions in patients with T2DM.Patients and Method: We conducted a...

ea0081ep311 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Difference of serum glucose, sodium and potassium levels in diabetic ketoacidosis

Bačun Tatjana , Dragila Željka , Čosić Klara , Rudić Dora , Lekić Ivan , Šolić Krešimir , Čalošević Srđan

Background and aims: Diabetic ketoacidosis is acute complication of diabetes mellitus. Hyperglycemia is one of the diagnostic features of diabetic ketoacidosis. Electrolyte disturbances are common as well. Aim of this study is to examine whether there is a difference in serum glucose, sodium and potassium concentrations with respect to age, gender and severity of diabetic ketoacidosis.Materials and Methods: Medical records from 1 January 2017 to 31 Decem...

ea0081ep312 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Clinical characteristics and glycemic control in Tunisian patients with type 2 diabetes suffering from lower urinary tract dysfunctions: a comparative population-based survey

Haj Kacem Akid Faten , Missaoui Abdelmouhaymen , Behoul Mariem , Mohamed Ahmed Mohamed Abdellahi , Belabed Wafa , Ben Salah Dhoha , Fatma Mnif , Rekik Majdoub Nabila , Elleuch Mouna , Abid Mohamed

Background and Aims: Several studies have pointed a significant relationship between diabetic complications, glycemic imbalance, and the onset of lower urinary tract dysfunction (LUTD) in this population. The current survey aims to assess the clinical and biochemical characteristics related to glycemic control in patients with type 2 diabetes presenting with symptoms of LUTD.Patients and Method: We conducted a comparative cross-sectional study that inclu...

ea0081ep313 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Comparison of admissions for diabetic ketoacidosis in patients older and younger than 25 years of age at San Cecilio Clinical University Hospital in Granada

Garcia Javier , Redondo Enrique , Andreo-Lopez Maria Del Carmen , Leon Utrero Sara , Lopez-Ibarra Lozano Pablo J

Introduction and objectives: Diabetic ketoacidosis (DKA) is a severe acute complication of Diabetes Mellitus (DM) and as such, on a large number of occasions will require hospital admission. As we know, it happens when there is an absolute or relative insulin deficit, although it is true that the characteristics described in the literature of these episodes are very different. Our aim was to compare the characteristics of DKA occurring in patients under 25 years of age with th...

ea0081ep314 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Gestational diabetes mellitus : Association between maternal insulin resistance with pregnacy outcomes and maternal characteristics

Lajili Olfa , Temessek Aroua , Rachdi Rim , Htira Yosra , Ben Mami Feika

Introduction: Gestational diabetes mellitus (GDM) is the most common metabolic disturbance during pregnancy. The prevalence of GDM is rising and correlates with the increase in maternal obesity over recent decades. The aim of our study was to assess the association between maternal insulin resistance with pregnacy outcomes and maternal characteristics among tunisians women with GDM.Methods: A prospective longitudinal study carried out during the year 202...

ea0081ep315 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Analysis of glycemic control in type 1 diabetes patients using flash glucose monitoring

Damas-Fuentes Miguel , Martinez Montoro Jose Ignacio , Simon Frapolli Victor , Fernadez Valero Andrea , Tinahones Madueno Francisco Jose

Introduction: Flash glucose monitoring expansion to an increasing number of patients with type 1 diabetes, coupled with its increased accuracy and ease of use, has increased available data on glycemic control in this population and allows detection of improvement areas in diabetes education and treatment.Objective: To analyze main parameters standardized by ATTD consensus (2019) in our population of patients with type 1 diabetes using flash glucose monit...

ea0081ep316 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Did the COVID-19 pandemic affect the management of gestational diabetes?

Ilias Ioannis , Togias Stefanos , Papadopoulou Vassiliki , Kougioumtzi Ekaterini , Mastrodimou Vassiliki , Michou Ekaterini , Milionis Charalampos , Venaki Evangelia , Koukkou Eftychia

Introduction: Researchers argue that increased morbidity is noted in pregnant women during the current COVID-19 pandemic. Reports indicate that the pandemic has led to disruptions in care of persons with diabetes. Glycated hemoglobin A1c (A1c) is not sufficient in screening for gestational diabetes mellitus (GDM) but may be of use in monitoring glycemia in GDM. To the best of our knowledge no studies honed on late pregnancy glycemia (via A1c), as a surrogate of the access/qual...

ea0081ep317 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of metformin on weight loss and blood pressure in obese hypertensive patients

Obertynska Oksana

Obesity is independently associated with poor control of blood pressure (BP) and weight reduction is generally recommended as the first line of treatment. However, the challenge remains to find the appropriate approach for weight reduction to influence BP status. The aim was to investigate the effect of non-pharmacologically and pharmacologically (metformin) induced weight loss on BP in obese hypertensive patients (HP). Methods: 100 HP (mean body mass in...

ea0081ep318 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Role of incretins, gut microbiota and permeability in the remission of type 2 diabetes mellitus after bariatric surgery

Hernandez-Montoliu Laura , Puig Rocio , Pellitero Silvia , Vendrell Joan , Fernandez-Veledo Sonia , Guerrero Fernando , Vidal Anna , Rodriguez M. Mar , Montseny Rosa , Vilarrasa Nuria

Introduction: Bariatric surgery is an effective therapy for patients with type 2 diabetes mellitus (T2D). Many mechanisms have been proposed for its metabolic benefits, such as caloric restriction, weight loss, increased secretion of gut hormones like glucagon-like peptide 1 (GLP-1) and 2 (GLP-2), bile acid diversion, decrease of pancreatic and hepatic fat deposits and changes in gut microbiome.Aims: Evaluate changes after surgery in gut microbiome profi...

ea0081ep319 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

What is the impact of being overweight on the progressive genius of Crohn’s disease?

Akkari Imen , Ameni Hassine , Soumaya Mrabet , Elhem Ben Jazia

Background: Overweight is becoming increasingly more common among patients with inflammatory bowel disease and plays a role in the development and course of the disease especially in Crohn’s disease (CD). However, there is currently little data on his impact on the evolutionary genius of CD. The aim of this study was to assess the impact of overweight on the epidemiological, clinical, therapeutic and progressive characteristics of CD.Patients and Me...

ea0081ep320 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Incidence of hypoglycemia among patients with type 2 diabetes who fasted during Ramadan

Qasim Bayar , Ahmed Mazyar , Mohammed Ayad

Background and Objectives: Fasting causes a major change in the dietary habits including the frequency, the timing, and the patterns which will result in a major change in the metabolic response of the body. Physicians should advise the patients about the complications of diabetes mellitus during fasting especially hypoglycemia, the aim of this study is to determine the relation between type 2 diabetes mellitus and hypoglycemia and to evaluate whether this correlation is signi...

ea0081ep321 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effect of insulin resistance syndrome in obese children on the development of hypertension

Nurgaliyeva Zhanar , Akhatay Dana , Abdrimova Shakhniza

Objective: To investigate the state of blood pressure in children with obesity and insulin resistance.Materials and Methods: 127 obese children, age from 6 to 15 years, average age 11.5 years. Anthropometry, calculation of body mass index (BMI), waist/hip volume ratio, measurement of blood pressure (SBP, DBP), study of the level of immunoreactive insulin, glucose were carried out. Insulin resistance was determined with hyperinsulinemia above 22.0 microns...

ea0081ep322 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Lipid abnormalities in hospitalized patients with diabetes

Sdiri Chaima , Htira Yosra , Msolly Skander , Cheikhrouhou Maryam , Hadj Ali Zohra , Imene Hedfi , Jemai Chaima , Ben Mami Feika

Introduction: Lipid abnormalities are frequent in type 2 diabetes. They increase the risk of cardiovascular events, morbidity and mortality in these patients. The aim of this study was to determine the lipid profile in patients with diabetes during hospitalization.Method: We conducted a prospective study in the department of diabetology in the National Institute of Nutrition in Tunis from October 2021 to January 2022. This work was carried out on the med...

ea0081ep323 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Ketogenic diet and Glucagon-like peptide 1 (GLP1) receptor agonists for obesity: our experience

Pisocri Elisa , Cimorelli Manuela , Cerutti Nadia

Background & aims: it is now known that the benefits due to weight loss are therefore attenuated by the recovery of body weight. Two therapeutic options facilitate the maintenance of weight loss at a distance: very low caloric ketogenic diet (VLCKD) and medications; the recent literature also shows how much the recovery of weight loss is significantly lower in subjects treated with medications for obesity than in them who have taken a VLCKD or low calorie diet. The aim of ...

ea0081ep324 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Features of the course and outcome of pregnancy in gestational diabetes mellitus in real clinical practice

Ushanova Fatima , Demidova Tatyana

Background and aims: Published data on the prevalence of GDM and its complications in real clinical practice in Russia are insufficient. To assess the prevalence of GDM among pregnant women in one of the districts of Moscow, the structure of risk factors, the course and outcomes of pregnancy in women with GDM.Materials and Methods: A retrospective analysis of data from the primary documentation of 510 pregnant women who were diagnosed with GDM during 201...

ea0081ep325 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Mitochondrial Diabetes: a case report

Ouakrim Hind , Ijdda Sara , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Mitochondrial diabetes represents about 1% of diabetes but still very often misunderstood. The most frequent mutation is 3243A >G of the mtDNA, which is responsible for the maternally inherited diabetes and deafness syndrome (MIDD). We report an observation of a patient with strong suspicion of mitochondrial diabetes.Case presentation: 43-year-old female patient, with diabetes for 5 years on an Insulin Therapy.Anamnesis:&hypen;&...

ea0081ep326 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association of fasting heart rate with fasting and post prandial blood glucose levels in Indians

Inamdar Aniket

Background: Diabetes mellitus is associated with abnormal autonomic function. Diabetes and impaired fasting glucose are associated with increased mortality, particularly from cardiovascular causes. Several factors, including fast heart rate, have been identified to be associated with an increased likelihood of having diabetes. Heart rate is a crude index of the autonomic nervous system tone, reflecting a balance of sympathetic and parasympathetic inputs, and correlates wi...

ea0081ep327 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Growth Assessment and Metabolic Syndrome (MetS) Criteria in children with steroid-sensitive Nephrotic syndrome (SSNS) and frequent relapses treated with long-term prednisone therapy (LTPT): Comparison between children who developed obesity versus those who did not develop obesity

Elbaba Mostafa , Soliman Ashraf , Hamed Noor , Alyafei Fawzia , Itani Maya , Al-Naimi Fatima , Al Yousef Doaa , Shaat Dalees Mona

Introduction: Long term prednisone therapy (LTPT) can be associated with overweight, obesity, and short stature. Both LTPT and obesity are considered risk factor for the occurrence of the different components of the metabolic syndrome (MetS).Aim: We studied steroid-associated metabolic and clinical adverse events in children with NS and frequent relapses treated with LTPT (obese vs non-obese). Methods: Data of 30 children with SSNS...

ea0081ep328 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Treatment adherence in patients with type 2 diabetes and its associated factors

Achwak Mehrez , Khalaf Rahma , Sebai Imen , Boukhayatia Fatma , Abdesslam Haifa , Ounaissa Kamilia , Amrouche Chiraz

Introduction: Treatment adherence is fundamental in diabetes control. The aim of our study is to evaluate treatment adherence in patients with type 2 diabetes and to determine its associated factors.Methods: Cross-sectional study enrolling 80 type 2 diabetes patients followed up in the outpatient department of the national institute of nutrition. The Morisky questionnaire was used to evaluate treatment adherence. Age, gender, body mass index (BMI), diabe...

ea0081ep329 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metreleptin treatment in woman with familial partial lipodystrophy and severe hypertriglyceridemia

Barmpa Eleftheria , Pappa Dimitra , Bargiota Alexandra

Introduction: Metreleptin, a recombinant analogue of leptin, is the only drug available for the treatment of generalized or partial lipodystrophy. Familial partial lipodystrophy (FPL) is a rare genetic disorder characterized by selective loss of subcutaneous adipose tissue, ectopic fat deposition, decreased leptin levels, and varying metabolic disorders, which in some patients can be quite severe and life-threatening. We present here such a woman with FPL who is treated with m...

ea0081ep330 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Study of the effects of long-term therapy DPP4i on the morphofunctional state of pancreatic endocrinocytes in the older age group in the clinic and experiment in conditions of type 2 diabetes.

Tuchina Taisiia , Babenko Alina

Introduction: DDP4i improves the function of β-cells and α-cells. However, there have been short-term follow-up and young subjects in many experimental and clinical studies. The imbalance of pancreatic endocrinocytes increases in adulthood and changes become less reversible. We decided that it would be useful to study the morphofunctional features of pancreatic endocrinocytes while taking iDPP4 in the older age group in the clinic and experimentally.<p class="abs...

ea0081ep331 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Development of complex of biomarkers for screening program for early diagnosis of familial diabetes mellitus

Saatov Talat , Karimov Kha , Ibragimov Zafar , Alimov Timur , Alimova Nasiba , Abduvaliev Anvar , Boboev Kodirjon , Ibragimova Elvira , Ishankhodjaev Tokhir , Shamansurova Zulaykho , Tashtemirov Abdunabi

Diabetes mellitus (DM) is a most significant medical-social worldwide problem. Absence of reliable screening program for identification of persons with the higher risk of DM dictates a necessity of sensitive tests of early DM diagnosis. Following genealogical analysis, two experimental groups were formed; patients with type 1 DM with the familial burden (probands) and those at risk (siblings) were included into the 1st and 2nd groups, respectively. Apparently healthy subjects ...

ea0081ep332 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The impact of the interventions based on mobile apps in physical activity among people with Type 2 diabetes mellitus

Lykoudi Elissavet , Vlachou Eugenia , Evangelou Eleni , Ntikoudi Anastasia , Dokoutsidou Eleni , Margari Nikoletta

Introduction: The mobile health (mHealth) technologies use mobiles and also wireless network and devices to offer services for improving health, promoting behavior changes and supporting self-management. The increasing global use of mobile application (app) is widely accepted in managing chronic diseases and especially among people with type 2 diabetes mellitus (T2DM).Aim: The purpose of this study was to identify the impact of the interventions based on...

ea0081ep333 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Contraception in diabetic women: A review of 100 cases

Atfi Fadwa , Abbassi Imane El

Introduction: Contraception in women with diabetes is difficult. It is the subject of an individualised prescription, which takes into account the metabolic and vascular state as well as the gynaecological tolerance of the patient.Materials and Methods: This is a prospective survey having concerned 100 diabetic women surveyed in the Maternity ward of the CHU Ibn Rochd of Casablanca, during a five-month period, between April and September 2021.<p clas...

ea0081ep334 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

A Rare Case: Non Ketotic Hyperglycemic Chorea

Mercan Sarıdaş Filiz , Akif Otegeceli Mehmet , Aydemir Ensar , Ates Coskun , Hocaoğlu Erhan , Cander Soner , Oz Gul Ozen , Ersoy Canan , Erturk Erdinc

Introduction: Hemichorea-hemiballismus, secondary to hyperglycemia, is a rare but easily treatable condition that is usually associated with poorly controlled type II diabetes mellitus. Diagnosis is based on clinical assessment and imaging. Etiology includes primarily cerebrovascular diseases, metabolic, degenerative, infectious diseases, space-occupying lesions, basal ganglia damage due to drugs and toxic substances.Case: Here we report a rare case of a...

ea0081ep335 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Poor glycemic control is associated with major depression among diabetic patients

Belkhiri Malak , Fadia Boubaker , Khemiri Ashraf , Mrabet Houcem , Bouali Walid , Zarrouk Lazhar , Sfar Habib

Introduction: Diabetes mellitus (DM) and depression are two frequent health conditions. Their coexistence may represent a medical challenge for clinicians. In addition, early detection of depression can help in better management of diabetes and preventing its complications.Aim of the study: To assess depression and glycemic control among a group of patients having diabetes.Methods: A cross sectional study was conducted among diabet...

ea0081ep336 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Flash glucose monitoring and glycemic control in type 1 diabetes: Real world data

Martin-Portugues Antonio Ballesteros , Iturregui Marta , Garcia-Garcia-Doncel Lourdes , Cruzado-Begines Concepcion , Ponce-Delgado Silvia , Baena-Nieto Maria Gloria

The use of Flash Glucose Monitoring system (FGM) for the management of type 1 diabetes mellitus (T1D) is rapidly increasing. FGM enables people with diabetes to regularly track their glucose levels without needing to perform capillary finger-stick measurements (SMBG). Clinical studies have shown improvement of glycemic control and hypoglycemia reduction, as well as better comfort and quality of life in people with type 1 diabetes (T1D) using this technology. Objectives: to ass...

ea0081ep337 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The possible biomarkers of the "postСovid-19 syndrome" in patients with type 2 diabetes

Sukhanov Sergey , Sorokina Yulia , Zanozina Olga , Lagonskaya Veronika

COVID-19 has a significant effect on the patient’s well-being even after the norm of laboratory parameters.The patients had cognitive blunting breathlessness, headache, fatigue, myalgia, weakness etc. The symptoms could last 3–12 months, from mild to severe, can lead to death.Purpose: To determine the significance of some biomarkers characterizing the condition of a patient with diabetes mellitus after undergoing covid.Ma...

ea0081ep338 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Features of some metabolic and instrumental indices in patients with type 2 diabetes mellitus and COVID-19 in oxygen deficiency developed for the first time depending on the initial compensation

Darashkevich Ina , Mokhort Tatjana V , Kulaha Alena , Bahamazava Nataliya

Patients with type 2 diabetes mellitus (DM) are one of the most vulnerable categories of patients in terms of adverse outcomes of COVID-19 infection.Aim: To assess the features of laboratory and instrumental data in patients with COVID-19 and type 2 DM (unvaccinated) depending on the value of glycated hemoglobin (HbA1c) at the time of the onset of oxygen deficiency.Materials and methods: The study involved 78 patients with type 2 D...

ea0081ep339 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of COVID-19 pandemic on diabetic patients

Abadlia Salma , Chadia Zouaoui , Najla Bchir , Raddadi Sarra , Benchhida Annam , Souibgui Chaima , Ouertani Haroun

Introduction: The COVID-19 pandemic had a significant emotional and psychological impact on populations worldwide, especially vulnerable people with chronic diseases such as diabetics. The objective of our study was to assess the quality of life and psychological distress of diabetic patients and to study patients’ attitudes towards managing their diabetes.Methods: We conducted a cross sectional descriptive study involving 60 diabetic patients follo...

ea0081ep340 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

COVID-19 pandemic: Impact on follow up care of insulin-requiring diabetic patients

Kardi Asma , Gharbi Radhouen , Salem Maram Ben , Jemel Manel , Kandara Hajer , Chiboub Marwa , Kammoun Ines

Introduction: COVID-19 is a novel pandemic affecting globally. It has led to an unprecedented global health crisis assessing health system’s preparedness to deal with health disasters. The aim of our study was to evaluate the impact of COVID-19 on the follow up care of diabetic patients.Methods: We conducted a retrospective study in 100 insulin-requiring diabetic patients. Data regarding treatment availability, weigh, glycemic control and follow up ...

ea0081ep341 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetes distress and its clinical determinants in Type 2 diabetes patients

Lassoued Najoua , Majdoub Marwa , Achwak Mehrez , Chadly Khalil , Baha Zantour , Wafa Alaya , Mohamed Habib Sfar

Introduction: Diabetes distress (DD) refers to the emotional burdens and worries, often hidden, that are part of the spectrum of the patient experience when managing a chronic and demanding disease like diabetes. The objective of this work was to determine the prevalence of DD and its clinical determinants in type 2 diabetic patients.Patients and methods: Cross-sectional study conducted on 92 type 2 diabetic patients who consulted on an outpatient basis ...

ea0081ep342 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

A diabetic foot case with bilateral charcot arthropathy

Aydemir Ensar , Hocaoglu Erhan , Ates Coskun , Mercan Saridas Filiz , Cander Soner , Oz Gul Ozen , Ersoy Canan , Erturk Erdinc

Background: Diabetic foot infections are an important cause of morbidity and mortality associated with poor glycemic control, polyneuropathy and micro/macrovascular diseases. The clinical, laboratory, radiological, pharmacological and/or surgical evaluation is required. We report a case of diabetic foot infection with bilaterally charcot joint.Case: A 52-year-old female patient with type 2 diabetes mellitus (DM), hypertension (HT), coronary artery diseas...

ea0081ep343 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Foot risk assessment in diabetic patients

Zemni Zeineb , Raja Daii , Lajili Olfa , Bornaz Emna , Salem Amal , Abadlia Salma , Yosra Htira , Imene Hedfi , Hadj Ali Zohra , Ben Mami Faika

Background: The management of diabetic foot starts with prevention, mainly based on the early detection of peripheral neuropathy and peripheral arterial disease, called podiatric risk assessment. This risk must be evaluated in all type 2 diabetics since the discovery. The aim of this study was the assessment of diabetic foot ulcer risk according to International Working Group on the Diabetic Foot (IWGDF) and the identification of risk factors for developing foot lesions.<p...

ea0081ep344 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Relationship between kidney function and the level of amylinemia in patients with diabetes mellitus

Pashkovska Nataliia , Tsaryk Iryna

Background: Chronic kidney disease (CKD) is one of the leading causes of disability and mortality in patients with different types of diabetes mellitus (DM). However, relationships between kidney function and serum amylin levels are still controversial, especially in patients with heterogeneous types of diabetes. The objective of the study was to determine the features of the glomerular filtration rate (GFR) in patients with DM depending on the level of amylinemia.<p class...

ea0081ep345 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Acute pancreatitis revealing major hypertriglyceridemia at 94 g/l!

Rifai Kaoutar , Guissi Loubna , Ahallat Salma , Iraqi Hind , Elhassan Gharbi Mohamed

Introduction: Hypertriglyceridemia (HTG) is a rare but well-known cause of acute pancreatitis, which can be fatal with an overall mortality rate of 36-50% in the most severe forms.Case presentation: A 29-year-old patient was admitted to the emergency department with abdominal pain, bilious vomiting and alteration of general condition. Physical examination showed hemodynamic shock with diffuse abdominal tenderness. The Laboratory results showed a serum li...

ea0081ep346 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

A new case of hypoglycemia of unrelated etiology.

Medina Rivero Daniel , Mateo Gavira Isabel , Sanchez Toscano Esteban

Male, 29 years old. Go to consultations in our center for a second opinion for assessment of hypoglycemia. The patient has reported, for 3 years, symptoms consisting of episodes of dizziness and headache predominantly during the day, which subside after eating food, and which increase in frequency in relation to exercise. He provides capillary glycaemia objectified in family glucometer between 40-70 mg/dl coinciding with the episodes. The patient was initially treated at anoth...

ea0081ep347 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The efficacy of liraglutide for weight loss in a patient with relapse in obesity after bariatric surgery – case report

Dabrowska Anna , Dudka Jaroslaw

Introduction: Obesity is a chronic disease which has become a global epidemic. Approximately 7% of deaths per year is associated with obesity, especially because of its complications such as cardiovascular diseases, type 2 diabetes or cancer. Lifestyle interventions are the first line of management but additional pharmacotherapy or bariatric surgery should be considered in more severe cases.Case report: A 40-year-old woman was referred to Endocrinology O...

ea0081ep348 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Assessment of the Podiatric Risk on Diabetics: Cross-Sectional Study in Regard to 200 Patients

Abir El Amri , Ben Amor Nadia , Yamoun Rihab , Mahjoub Faten , Nsir Sirine , Amorri Amany , Mizouri Ramla , Ben Othman Rym , Berriche Olfa , Henda Jamoussi

Introduction: The diabetic foot is a frequent, serious and costly complication of diabetes. The prevention of diabetic foot involves a systematic podiatric evaluation of diabetic patients to identify the foot at risk. The aim of our study was to determine the podiatric risk in a Tunisian diabetic population according to the classification of the International Working Group on the Diabetic Foot (IWGDF) and the factors associated with podiatric risk.Method...

ea0081ep349 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Cutaneous manifestations of diabetes mellitus

Abir El Amri , Ben Amor Nadia , Yamoun Rihab , Mahjoub Faten , Amorri Amany , Nsir Sirine , Ben Othman Rym , Mizouri Ramla , Berriche Olfa , Henda Jamoussi

Introduction: Diabetes mellitus (DM) is the most common endocrine disorder. The skin manifestations of diabetes can vary depending on the duration of the disease and the control of blood glucose levels. Almost all patients with DM eventually develop skin changes due to the long-term effects of hyperglycemia on microcirculation and skin collagen. This study was conducted to find the hospital based prevalence of mucocutaneous manifestations in patients with diabetes mellitus, th...

ea0081ep350 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Dapagliflozin can Induce and Maintain Type 2 Diabetes Remission

Younis Mahmoud

Introduction: Type 2 diabetes mellitus, has gained a lot of attention in recent years as one of the most important chronic progressive diseases in the world, which slowly crawls towards longevity and which involves many chronic complications, which are dangerous to health and the economy. Sodium-glucose cotransporter-2 (SGLT2) inhibitors represent a category of newly discovered drugs that work by preventing glucose reabsorption in the proximal renal tubules. (SGLT2) Inhibitors...

ea0081ep351 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Double Trouble. Metformin and empagliflozin induced lactic acidosis - A case report

Sharma Bhavna , Mantega Michele , Deore Mahesh , Seetho Ian , Seechurn Shivashankar , Hui Elaine , Rahman Mushtaqur , Qureshi Asjid

63 years old with sarcoidosis since 2018 and type 2 diabetes was referred by GP for hypercalcemia related to likely dehydration and sarcoidosis. She was started on a weaning dose of prednisolone and empagliflozin. She had already been on metformin for several years. She was discharged after calcium improved from 2.97 mmol/l to 2.83 mmol/l. She was advised to follow up in Ambulatory care in 1 week for repeat calcium levels. On follow up, noted to have calcium levels of 2.67 mmo...

ea0081ep352 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Long-term impact of digitally administered Breathe Well-being Diabetes Reversal Program (BDRP) in individuals with type 2 diabetes mellitus

Kumar Goyal Pawan , Kumar Patra Surajeet , Kaicker Aditya , Verma Rohan , Goel Seema , Jangid Rupali , Rehman Saleha , Madhusudhana Venugopal

Introduction: Breathe Well-being Diabetes Reversal Program (BDRP) delivers personalized lifestyle management (LSM) curriculum including education, lifestyle, and health-related content, based on patient’s health profile and preferences. The program assists the physicians in making clinical decisions by providing comprehensive lifestyle data, which facilitates patient adherence and aids in achieving positive health outcomes.Objective: To estimate the...

ea0081ep353 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Sodium-glucose cotransporter-2 (SGLT-2) inhibitor-induced diabetic ketoacidosis and Fournier’s gangrene

Abouzaid Mona , Nee Gan Chien , Pye So

Introduction: The Food and Drug Administration (FDA) had issued warnings on the increased risk of diabetic ketoacidosis and Fournier’s gangrene with patients using Sodium-glucose cotransporter-2 (SGLT-2) inhibitors. Herein, we report a case of simultaneous Fournier’s gangrene and diabetic ketoacidosis after initiation of treatment with Empagliflozin.Case Presentation: We report a case of a 54-year-old woman with type 2 diabetes on empagliflozin...

ea0081ep354 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of depression in type 2 diabetics with Covid 19: 38 cases

Boulbaba Kolsi , Ben Abdallah Kolsi Rihab , Mohamed Elmoctar Sidina , Dammak Mohamed , Boujilbene Khouloud , Elarbi Kawthar , Zargni Asma , Hadj Kacem Faten , Abid Mohamed

Introduction: Diabetes, like any chronic disease, generates in addition to the somatic consequences, serious psychological repercussions, depression and diabetes emerging respectively in the 4th and 9th rank of the most important causes of disturbances in number of years of life corrected for the disability factor. (DALYS).Patients and methods: Descriptive retrospective study of 38 post-Covid diabetics collected from the endocrinology – diabetology ...

ea0081ep355 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Distinct inflammatory signatures of upper- and lower-body adipose tissue in postmenopausal women with normal weight and obesity

Lempesis Ioannis , Hoebers Nicole , Essers Yvonne , Jocken Johan WE , Blaak Ellen E , Manolopoulos Konstantinos N , Goossens Gijs H

Background: Abdominal obesity is associated with insulin resistance and increased cardiometabolic disease risk, whereas lower-body fat accumulation seems protective against metabolic derangements. Differences in upper-body and lower-body adipose tissue (AT) function seem to underlie these opposing associations. Here, we investigated the inflammatory signature of upper- and lower-body AT in women with normal weight and obesity, as well as in human primary abdominal (ABD) and fe...

ea0081ep356 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

A unique family with early-onset, severe obesity and hypopituitarism harboring different POMC pathogenic mutations.

Le Collen Lauriane , Delemer Brigitte , Poitou-Bernert Christine , Martine Vaxillaire , Michel Petit Jean , Alexandru Saveanu , Karine Clement , Philippe Froguel , Amelie Bonnefond

Objective: We describe two first cousins presenting with neonatal corticotropic deficiency and severe, early-onset obesity. This study aims to identify the molecular etiology of these disorders in both cases and highlights the limits of genetic investigations.Methods: We collected the clinical-biological data of the family and, more particularly, of the two first cousins (A and B). We performed several constitutive Next-generation Sequencing (NGS) protoc...

ea0081ep357 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

An evidence-based framework to evaluate melanocortin-4 receptor (MC4R) pathway relevance for obesity-associated genes

Vogel Megan E , Moeller Ida H , Garfield Alastair S , Shah Bhavik P

Introduction: The MC4R pathway is the principal regulator of mammalian energy balance through its modulation of energy intake and energy expenditure. Variants in genes associated with the MC4R pathway can result in rare genetic diseases of obesity. Clinical data in patients with certain genetic defects in the MC4R pathway indicate that setmelanotide, an MC4R agonist, may effectively reduce weight and hunger in scientifically rationalized obese subpopulations in which MC4R-path...

ea0081ep358 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Reduction in Oxytocin levels predict body weight loss in patients with obesity after a very low carbohydrate ketogenic diet (VLCKD).

Tozzi Rossella , Basciani Sabrina , Rossetti Rebecca , Balena Angela , Masi Davide , Risi Renata , Veroi Gabriele , Colonnello Elena , Chiara Massari Maria , Curreli Mariaignazia , Gangitano Elena , Watanabe Mikiko , Mariani Stefania , Gnessi Lucio , Lubrabno Carla

Background: Oxytocin (OXT) enhances glucose uptake and lipid utilization in adipose tissue and skeletal muscle.Dysfunction of the OXT system could underlie the pathogenesis of weight gain. Men and women with obesity were reported to have higher OXT blood levels compared to normal weight subjects. In contrast, metabolic syndrome has been associated with reduced fasting serum oxytocin in larger scale mixed gender studies.Aim: Data regarding the oxytocin sy...

ea0081ep359 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Response of the human gastric epithelium to sleeve gastrectomy surgery

Ben-Haroush Schyr Rachel , Moalem Botros , Sender Dana , Elad Amit , Bardugo Aya , Etzyoni Ayelet , Arad Yhara , Ishai Yuval , Suk Kim Ki , Benson Ariel , Grinbaum Ronit , Samuelson Linda , Grinstein Nechemi , Sandoval Darleen , Ben-Zvi Danny

The gastric mucosa is a dynamic and regenerative tissue that functions in extreme conditions of low pH, mechanical insults and bacterial exposure. The mucosa is composed of pit and neck cells which secrete protective mucus, parietal and chief cells that secrete acid and digestive enzymes, enteroendocrine cells that affect motility, secretion and satiety, rare tuft cells, and at two stem-cell compartments. We studied the response of the gastric mucosa to sleeve gastrectomy surg...

ea0081ep360 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Long-term safety of diazoxide choline extended-release (DCCR) tablets in patients with prader-willi syndrome

Gevers Evelien , Miller Jennifer , Butler Merlin , Bridges Nicola , Goldstone Tony , Obrynba Kathryn , Salehi Parisa , Felner Eric , Bird Lynne , Shoemaker Ashley , Konczal Laura , Lah Melissa , Yanovski Jack , Angulo Moris , Mejia-Corletto Jorge , Stevenson David , Wilding John , Abuzzahab Jennifer , Shaikh Guftar , Viskochil David , Mathew Verghese , Yen Kristen , Woloschak Michael , Bhatnagar Anish

Background: Prader-Willi syndrome (PWS), a rare genetic neurobehavioral-metabolic condition, is characterized by hyperphagia, accumulation of excess fat, hypotonia, and behavioral/psychological complications. There are no currently approved medications to treat hyperphagia in patients with PWS; DCCR is under development as a treatment for PWS.Objectives and Methods: The objective was to evaluate long-term safety of DCCR in individuals with PWS. 125 parti...

ea0081ep361 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Menstrual cycle characteristics in women with type 1 diabetes mellitus

Ilieva-Gerova Maria , Nyagolova Presiyana , Koleva-Tiutiundjieva Daniela , Orbetzova Maria , Raycheva Ralitsa

Background: Women with diabetes mellitus type 1 (DMt1) are known to have a higher prevalence of reproductive disorders, including delayed menarche, menstrual cycle abnormalities and &rcy;olycystic ovary syndrome (PCOS)-like phenotype.Objective: To evaluate the menstrual cycle characteristics of women with type 1 diabetes mellitus as well as to compare them with healthy women of reproductive age.Methods and patients: The study inclu...

ea0081ep362 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Imidazole-osmium reduces elution of lipids from cryofixed rat hepatic tissue for ultrastructural analysis

Durr Sabine , Reipert Siegfried , Krššak Martin , Philippe Cecile , Ehret Viktoria , Luft Matthias , Schintlmeister Arno , Scherer Thomas , Furnsinn Clemens

Introduction: Transmission electron microscopy (TEM) is the main tool for studying the ultrastructural properties of metabolically diseased tissue. For impactful micrographs as well as for interpretation of TEM specimens, the integrity of cellular components is crucial. Elution of substances is a major problem in TEM preparation with no universal solution found so far. Investigating fatty liver disease in a rat model, an important factor is the depiction of undamaged lipid dro...

ea0081ep363 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Homocysteine level in diabetic subjects with venous thrombosis

Fendri Sana , Mariem Boudaya , Salah Raida Ben , Kamel Jamoussi , Zouheir Bahloul

Introduction: Homocysteine is an intermediate sulfur amino acid in the metabolic pathways of cysteine production from methionine, which is increasingly involved in various pathological processes (arterial thrombosis, depression, schizophrenia, dementia). We are interested in the course of our work to study the variation of homocysteine levels in diabetic subjects with venous thrombosis.Materials and methods: This is an observational case-control study, c...

ea0081ep364 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Development of an electrochemical immunosensor based on competition assay for the detection of biomarkers in human urine samples

Reintar Sharmaine , Haudum Christoph , Lluis Acero Josep , OSullivan Ciara , Obermayer-Pietsch Barbara

Introduction: Diabetes mellitus (DM) is a disease characterized by increased glucose levels, mostly either due to insulin deficiency (type 1 DM) or a decreasing ability of insulin receptor binding (type 2 DM) or both. Biomarker measurements such as fasting glucose and haemoglobin A1c are vital to detect and monitor DM. In addition to these parameters and antibody testing, insulin determination has been used for classifying different types of DM. However, the disadvantage of in...

ea0081ep365 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Epidemiology, clinical and complications profile of diabetes mellitus patients hospitalized in libya: a retrospective audit

Abdulrazik Sarah , Misherghi Ahmed , Alktounei Aida , Elhadi Muhammed

Introduction: It was estimated that about one-sixth of the Libyan population have diabetes mellitus. However, there were no previous studies about the hospitalized patients and clinical presentation and outcomes. In this study.Aim: We aimed to determine the clinical profile and complications of diabetic patients admitted to the largest diabetic center in Libya and evaluate the mortality and admission pattern.Methods: Patients with ...

ea0081ep366 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Characterization of a cohort of patients with type 1 diabetes during their unstructured transition to adult care

Braca Fernando , Novoa Yeray , Betancor Acosta Juan Carmelo , Fernandez-Trujillo Paula , Alvarado Martel Dacil , Gonzalez Martin Josu , Maria Wagner Ana

Background and aims: Transition of patients with type 1 diabetes (DM1) from pediatric to adult care is challenging and international guidelines recommend effective transition programs. The aim of this study is to describe our baseline situation, without a structured transition program, and to identify factors associated with worse glycemic outcome.Materials and Methods: This is an observational, retrospective study of patients with DM1, aged 14 or more o...

ea0081ep367 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Levels of IL-10 in CD4+ and CD8+ in patients with Type 2 diabetes mellitus and their correlation with mediterranean diet and anthropometric variables

Knott Torcal Carolina , Jimenez Blanco Sara , Sanchez de la Blanca Carrero Nuria , Serrano-Somavilla Ana , Martinez-Hernandez Rebeca , Jimenez Diaz Jessica , Justel Enriquez Alicia , Sampedro-Nunez Miguel , Marazuela Monica , Garcimartin Alba

Introduction: Type 2 Diabetes Mellitus (T2DM) is a multifactorial and complex chronic disease characterized by insulin resistance and a dysfunctional adipose tissue. T2DM patients usually present a state of low-grade inflammation due to a dysregulation of the cytokine production. Consequently, this seems to contribute to insulin resistance and beta cell failure associated with the progression of this disease.Objective: To examine expression of Interleuki...

ea0081ep368 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Is MGP an inflammatory marker?

Schweighofer Natascha , Colantonio Caterina , Haudum Christoph W , Hutz Barbara , Kolesnik Ewald , Schmidt Albrecht , Zirlik Andreas , Pieber Thomas R , Verheyen Nicolas , Obermayer-Pietsch Barbara

Matrix-GLA-protein (MGP) was repeatedly associated with inflammation markers during the last decade. It is expressed in leucocytes and is a regulator of immune response. Due to posttranslational modification, there are 4 forms. The form responsible for immunomodulation is still unknown. Since the predicted active form - carboxylated, phosphorylated MGP - is not directly associated with immunomodulation, we aimed to investigate the association of dp-ucMGP (dephosphorylated, unc...

ea0081ep369 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Development of THE allele-specific PCR method for studying insulin gene rs689 polymorphism

Saatov Talat , Ibragimov Zafar , Alimov Timur , Ibragimova Elvira , Ishankhodjaev Tokhir , Shamansurova Zulaykho , Karimov Kha , Azimova Shakhnoza , Boboev Kodirjon , Makhnyov Anton

Background: Insulin gene (INS) is known to be responsible for production of insulin by the pancreatic β-cells. It includes variable number of tandem repeats (VNTR) of oligonucleotide consequence (ACAGGGGT (G/C) (T/C) GGGG) in the promoter region (Bell et al, 1981,1982); being the gene involved in the susceptibility to various pathologies. The allele-specific PCR allows direct diagnosis of some genetically determined disorders is rather simple and precise. However, by toda...

ea0081ep370 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Compliance and quality of life in people with type 2 diabetes

Shehu Elona , Ntikoudi Anastasia , Dokoutsidou Eleni , Fasoi Georgia , Mangoulia Polyxeni , Evangelou Eleni , Tsartsalis Athanasios , Vryonidou- Bompota Andromachi , Komninos John , Vlachou Eugenia

Introduction: Type 2 diabetes mellitus (DM2) is the most common disease in the spectrum of metabolic disorders, with its prevalence increasing significantly in recent years. It is estimated that by 2035, 592 million people will have type 2 diabetes. People with type DM2 have high rates of depression and a quality of life that is poorer than that of the general population. Another important factor in the quality of life of people with DM2 is the compliance of patients with the ...

ea0081ep371 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Virulence of SARS-COV-2 in diabetic patients

Trimeche Oumeyma , Zemni Imen , Hadj Mabrouk Amine , Amel Gara , Salem Jdira , Frigui Wassim , Barbana Iyed , Bouazizi Anas , Mansour Rahma , Bouzid Yosra , Bennasrallah Cyrine , Kacem Maryem , Abroug Hela , Ben Fredj Manel , Bouanene Ines , Belguith Asma

Introduction: Diabetes is a serious disease that can lead to a depression of the immune system and thereby it is incriminated in serious complications of many infectious diseases among which is Covid 19. The aim of our study is to determine the virulence of SARS-COV-2 in diabetic patients.Methods: This is a transversal study conducted in the department of epidemiology at Fattouma Bourguiba Hospital in Monastir, in October 2020. The data was collected fro...

ea0081ep372 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Follow-up gestational diabetes in a telemedicine system in pandemic COVID19

Delgado Garcia Esther , Perez Lopez Paloma , Sanchez Ibanez Marta , Nieto Maria , De Marcos White Lourdes , Santader Cartagena Amelia , de Luis Roman Daniel

Background: Gestational diabetes mellitus (GDM) is common complication in pregnancy. During pandemic COVID-19, endocrine service iniciate telemedicine in medical care and monitoring blood glucose.Purpose: The purpose of this study was to asses metabolic control and pregnancy outcome during pregnancy in telematic consult.Materials and Methods: Descriptive study of 20 patients were assesed in telematic review in the first wave of the...

ea0081ep373 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The benefits of breastfeeding on weight loss and glycemic control

Elkhomri Amal , Salma Bensbaa , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Breastfeeding has benefits for infant health, but also for maternal health, lactation has a positive impact on glucose homeostasis and weight loss. This can be explained by the needs of milk production. The mammary gland needs glucose to make lactose. The objective of this study is to evaluate the impact of breastfeeding on glycemic control and weight lossMaterials and Methods: Prospective study conducted in the department of endocrinology ...

ea0081ep374 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Modulation of antimony mediated therapy for an optimal insulin secretion during visceral leishmaniasis

Sinha Sukrat

Objective: Visceral Leishmaniasis is a macrophage associated disorder for the treatment of which antimony based drug like Sodium Antimony Gluconate has been the first choice in the recent past. About 5 percent of the patients may develop insulin dependent diabetes mellitus. It appears to have a direct action on pancreatic beta cells, resulting in initial insulin release followed by impaired insulin secretion. Within this context we looked into alternate therapies of treatment ...

ea0081ep375 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Phenotypical variability in hepatocyte nuclear transcription factor 1 beta (HNF1β) gene mutation – A five case report

V de Assuncao Guilherme , Fonseca Liliana , Mendes Catarina , Teixeira Sofia , Joao Oliveira Maria , Dores Jorge , Borges Teresa , Cardoso Helena

Introduction: MODY 5 is a rare form of autosomal dominant monogenic diabetes with a broad phenotypical spectrum that occurs with pancreatic and extra-pancreatic clinical manifestations, such as: malformation and dysfunction of the pancreas, nephrourologic anomalies, impaired renal function, hepatopathy and neurocognitive defects. It is caused by a mutation of the gene encoding hepatocyte nuclear transcription factor 1 beta (HNF1β).Case 1: M...

ea0081ep376 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The growth effects of long-term (five years) prednisone therapy in frequently relapsing nephrotic syndrome of childhood: impact on statural growth and weight gain

Soliman Ashraf , Hamed Noor , Elbaba Mostafa , Alyafei Fawzia , Itani Maya , Al-Naimi Fatima , Al Yousef Doaa , Shaat Dalees Mona

Nephrotic syndrome (NS) in children usually has an onset between 2-8 years of age and steroids form the mainstay of management. Therapy may affect growth in children with relapsing NS.Aim: This study was carried out to investigate linear growth and weigh gain in children with NS and multiple relapses who receiving long-term prednisone therapy (LTPT) for 5 years.Methods: Data of 30 children with SSNS was analysed retrospectively. Th...

ea0081ep377 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Degenerative complications after insulin therapy: are there benefits to prescribing analogue insulin compared to human insulin?

Rachdi Rim , Lajili Olfa , Moalla Hajer , Souissi Nessrine , Ounaissa Kamilia , Abdesselem Haifa , Amrouche Chiraz

Introduction: Over the past two decades, the development of genetic engineering techniques has led to the emergence of insulin analogue that have the advantage of improving diabetics quality of life compared to human insulin. The aim of our study was to compare the frequency of occurrence of degenerative complications in two groups of patients with type 2 diabetes (T2D) on human insulin (NPH) and analogue insulin, and thus determine whether or not there are benefits to prescri...

ea0081ep378 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetes in the elderly: adherence and particularities of treatment

Mizouri Ramla , Mahjoub Faten , Ben Othman Rym , Ben Amor Nadia , Olfa Berriche , Henda Jamoussi

Introduction: Elderly diabetics are often fragile patients at high cardiovascular risk. The medical, human and socio-economic impact of diabetes is heavy in the elderly. Symptoms in this particular population are often insidious and atypical, which can delay diagnosis and the establishment of effective treatment. Indeed, management is not always easy because it must take into account multiple parameters. The objective of our study was to study the observance and particularitie...

ea0081ep379 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of iSGLT-2 on renal function and lipid spectrum in patients with type 2 diabetes mellitus

Muminova Sitora

Diabetes mellitus (DM) is a global medical and social problem of our time, which is faced by medical science and healthcare in almost all countries of the world. The situation in Uzbekistan follows the global trend. According to 2019 data, 230 610 patients with diabetes are registered in the country: 18 349 patients with type 1 diabetes and 212 261 - with type 2 diabetes. According to screening studies, the prevalence of type 2 diabetes in Uzbekistan over the past 14 years has...

ea0081ep380 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Patient experience and outcome of teleconsultation in management of T2DM during COVID-19 Pandemic in Semi urban and village population in Kerala

B Jayakrishnan

Background: Coronavirus pandemic had pushed both doctors and patients to adapt to teleconsultation for routine consultations in management of type 2 diabetes (T2DM). Telemedicine is believed to be an effective resource in health access but its experience to the patient and its outcome of management are not well understood in semi urban and village population of India. Thus, this study aims to assess the experiences and outcomes of T2DM management by tele-consultation in these ...

ea0081ep381 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Mistakes revealed during continuous glucose monitoring in patients with poorly controlled Type 1 diabetes

Shyshko Volha , Mokhort Tatjana V , Paryavi Parsa , Rasekhjahromi Vahid , Yurenia Alena

Introduction: There is no doubt that continuous monitoring systems can improve diabetes control. The aim of the study was to determine typical deviations of glucose and mistakes in insulin treatment, self-control, predisposing to the poor blood control.Materials and methods: 30 patients with type 1 diabetes were included, mean age 21±7.8, mean age of diabetes manifestation 19.2±13.9 years, mean duration o&acy; diabetes – 15.3±7.5. Inc...

ea0081ep382 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Medication Adherence in Patients with Type 2 Diabetes

Rihab Ajili , Amani Salah , Najoua Lassoued , Fadia Boubaker , Baha Zantour , Wafa Alaya , Habib Sfar

Introduction: Medication Adherence (MA) is the extent to which patients follow medical instructions. Poor MA is frequently encountered in the majority of chronic diseases, including diabetes. The aim of our study was to evaluate MA in patients with poorly controlled type 2 diabetes mellitus (T2DM).Patients and methods: We conducted a cross-sectional study over a period of 2 months, including patients with poorly controlled T2DM, followed at the endocrino...

ea0081ep383 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Does the insulin pump improve glycaemic control in patients with type 1 diabetes?

Najoua Messaoudi , Assarrar Imane , Bouichrat Nisrine , Abir Tahri , Rouf Siham , Latrech Hanane

Introduction: Insulin pump therapy is recommended more and more in type 1 diabetic patients in order to achieve and maintain optimal glycaemic control. The objective of our study was to determine the effectiveness of insulin pump therapy in improving metabolic control in type 1 diabetic patients.Patients-Methods: This is a retrospective, descriptive and analytical study including 20 patients with type 1 diabetes treated by insulin pump, between 2017 and ...

ea0081ep384 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Regulation of glycemia in patients with type 2 diabetes with oral antidiabetics, insulin and combination therapy

Bačun Tatjana , Damjanović Ana , Lekić Ivan , Šojat Dunja , Pirić Marko

Aim of the study: The objectives of this study were to determine the regulation of glycemia (measured by fasting glucose levels and HbA1c) in patients with type 2 diabetes and to examine whether there is a difference in therapy (oral antidiabetics, insulin, combination), age, sex and BMI.Study design: Cross-sectional research with historical data.Patients: The study included 102 patients of both sexes (56% women and 44% men) with a...

ea0081ep385 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Adult-onset loss of the hepatocyte growth hormone receptor (GHR) is associated with increased autophagy in livers of male mice in the context of natural daytime fasting

Sarmento-Cabral Andre , Gutierrez-Casado Elena , del Rio-Moreno Mercedes , Vazquez-Borrego Mari C , Kineman Rhonda D

Liver autophagy, as assessed by accumulation of LC3-II and p62 proteins, is positively correlated with the severity of nonalcoholic steatohepatitis (NASH) in humans. Since growth hormone (GH) is negatively associated with liver steatosis and NASH development, and our laboratory has reported that steatosis and NASH develops in a mouse model of adult-onset, hepatocyte-specific GH-Receptor knockdown (aHepGHRkd), we sought to determine if GH directly regulates the hepatocyte autop...

ea0081ep386 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Predictive factors of postoperative septic complications after flexible ureteroscopy for urinary stones

Jasser Maatougui , Mehdi Raboudi , Besrour Chayma , Haroun Ouertani , Samir Ghozzi

Introduction: The recent advent of flexible ureteroscopy made endoscopic approach to kidney and proximal ureteral calculi evolve to a real effective procedure. However, this technique is not free of postoperative complications. The aim this study was to assess the predictive factors of septic postoperative complications following flexible ureteroscopy for upper urinary tract stones.Methods: This is a descriptive retrospective study concerning 92 patients...

ea0081ep387 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Screening for distal and symmetric polyneuropathy in the diabetic patient: 116 cases

Elleuch Mouna , Souhir Maalej , Houda Hsine , Ben Salah Dhoha , Mohamed Ahmed Mohamed Abdellahi , Haj Kacem Akid Faten , Abid Mohamed

Introduction: The prevalence of diabetes in the world population is increasing day by day so that its frequency reaches epidemic proportions. As a result, the complications of diabetes are becoming more and more frequent. Diabetic neuropathy, the most common complication which affect up to half of the patients.Purpose of the study: To establish the prevalence of distal symmetrical polyneuropathy (DSPN) in diabetic patients and demonstrate the importance ...

ea0081ep388 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetic muscle infarction : a case study

Maaoui Ons , Mekni Sabrine , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Ben Nacef Ibtissem , Khiari Karima

Introduction: Diabetic muscle infarction (DMI) is a rare complication of long-standing, poorly controlled diabetes, and it’s more common in patients with micro-vascular complications. Herein, we present a case of DMI occurring in patient on hemodialysis.Case presentation: A 44-year-old man on maintenance hemodialysis presented with an acutely painful and swelling in his left calf. He had a 21-year history of poorly controlled type one diabetes, with...

ea0081ep389 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Gestational diabetes: a review of 64 cases

Atfi Fadwa , El Abbassi Imane

Introduction: Gestational diabetes (GD) is the consequence of an exaggerated insulin resistance associated with a defect insulin secretion. It is a high-risk pregnancy due to its maternal and foetal complications, the pathogenesis of which involves maternal hyperglycaemia.Materials and methods: This is a retrospective study of 64 parturients, carried out from January 1, 2019 to January 1, 2020 in the gynaecology obstetrics of the Lalla Meryem maternity h...

ea0081ep390 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Uricemia in hypertensive type 2 diabetics: the forgotten metabolic parameter

Haj Kacem Akid Faten , Frikha Hamdi , Chehaider Cyrine , Salah Ameni , Ben Salah Dhoha , Mnif Mouna , Charfi Nadia , Mnif Fatma , Rekik Majdoub Nabila , Elleuch Mouna , Abid Mohamed

Introduction: Hyperuricemia is a common metabolic feature in patients with metabolic syndrome.Aim: The aim of our work is to study the correlation between uric acid level and the metabolic profile in hypertensive type 2 diabetic patients.Methods: This is a retrospective descriptive study of hypertensive type 2 diabetic patients followed in the endocrinology department of Hedi Chaker University Hospital of Sfax, Tunisia between 2019...

ea0081ep391 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Cardiovascular risk in diabetic patients with chronic kidney disease: One more turn of the screw

Missaoui Abdelmouhaymen , Fatma Mnif , Zargni Asma , El Arbi Kawthar , Ben Salah Dhoha , Elleuch Mouna , Haj Kacem Akid Faten , Charfi Nadia , Mnif Mouna , Rekik Majdoub Nabila , Abid Mohamed

Background: Poor glycemic control in patients with diabetes mellitus(DM) is a well-documented responsible factor for microvascular complications, especially eye and kidney damage. The onset of chronic kidney disease(CKD) marks a serious turning point in the clinical history of DM in terms of cardiovascular prognosis. Our study aims to assess the cardiovascular risk(CVR) in diabetic patients with CKD.Method: We conducted a retrospective descriptive study ...

ea0081ep392 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetic foot: a tunisian experience

Elleuch Mouna , Frikha Hamdi , Ben Salah Dhoha , Mnif Fatma , Mnif Mouna , Charfi Nadia , Rekik Majdoub Nabila , Haj Kacem Akid Faten , Abid Mohamed

Introduction and aim: Diabetic foot (DF) is associated with increased morbimortality and cost of diabetes management. The aim of this study is to describe the epidemiological, clinical and paraclinical characteristics and follow-up outcomes of patients with diabetic foot in a Tunisian center.Methods: It is a monocentric retrospective study of 210 patients with diabetic foot followed at the endocrinology department of the Hedi Chaker Sfax University Hospi...

ea0081ep393 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetic nephropathy and hypertension

Dalhoum Meriam , Hadj Ali Zohra , Bani Ines , Htira Yosra , Ben Mami Faika

Introduction: Diabetic nephropathy is a a dreadfull complication of diabetes and it is the leading cause of chronic kidney disease worldwide. Hypertension is a major cause of progression of this complication.Objective: To determine the prevalence of diabetic nephropathy, to search a correlation between the presence and duration of arterial hypertension and the occurrence of diabetic nephropathy.Patients and methods: This is a retro...

ea0081ep394 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The association of hypertension and type 2 diabetes

Dalhoum Meriam , Hadj Ali Zohra , Bani Ines , Htira Yosra , Ben Mami Faika

Introduction: The association of hypertension and type 2 diabetes is frequent. These two pathologies constitute each a cardiovascular risk factor with a cumulative effect which increases the cardiovascular morbi-mortality of hypertensive diabetics.Objective: To measure and compare the frequency of degenerative complications of diabetes in hypertensive and non-hypertensive diabetics.Patients and method: The study was descriptive, re...

ea0081ep395 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The blood lead level is the meaningful indicator to metabolic syndrome in healthy populations

Rae Lee Kyu , Cheol Hwang In , Kon Kim Kyung , Sun Suh Heuy , Dong Ko Ki

Background: Lead is known as an environmental toxic pollutant and hormonal regulatory confounder associated with obesity. Recent China scientific report shows that blood lead level (BLL) is closely related with body mass index. Therefore, we investigated the association between the prevalence of metabolic syndrome and blood lead levels in healthy general population without hypertension, dyslipidemia, and diabetes.Methods: We assessed the socio-demographi...

ea0081ep396 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of bariatric surgery on body composition and cognition: a pilot study

Simo-Servat Andreu , Ibarra Montserrat , Libran Mireia , Alonso Nuria , Rodriguez Silvia , Ramos Montse , Perea Veronica , Garcia-Pascual Luis , Orois Aida , Quiros Carmen , Barahona Constanzo Maria Jose

Aim: Bariatric surgery (BS) modifies body composition. The aim of the study was to establish the first step toward the introduction of the ultrasound (US) and bioelectrical impedance analysis (BIA) in the evaluation of body composition before and after BS. In addition, as obesity was shown to be related to global cognitive decline, we aim to determine possible changes in cognitive test before and after BS.Material and Methods: a prospective pilot study o...

ea0081ep397 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation of obesity with diminished neutralizing antibody count

Nutsubidze Teona , Uchava Lasha , Giorgadze Elen

The obesity epidemic, which has persisted for more than 45 years, is now being faced concurrently with the coronavirus pandemic, with deadly effects. The complex changes caused by obesity, such as chronic inflammation, are known to be detrimental in patients with COVID-19. 33.2% of the Georgian population is obese (1). Therefore, we aimed to explore the synergistic effects between obesity and SARS-CoV-2. The objective of our study is to compare the presence of neutralizing ant...

ea0081ep398 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Berberis vulgaris: perspectives in the treatment of non alcoholic fatty liver disease

Fatma Mnif , Zargni Asma , El Arbi Kawthar , Ben Salah Dhoha , Bousetta Salma , Elleuch Mouna , Charfi Nadia , Mnif Mouna , Rekik Majdoub Nabila , Haj Kacem Akid Faten , Abid Mohamed

Introduction: Berberis vulgaris is a plant, of the family Berberidaceae. Berberine is the main active compound of the barberry. It is an iso quinoline alkaloid of intense yellow color. Berberis vulgaris is used in several medical purposes, including liver protection, anti-oxidant, antimicrobial agent. It also seems to reduce the level of cholesterol in the blood and triglycerides. Our study aims to investigate the effect of the dietary supplement "Berberis Vulgaris" ma...

ea0081ep399 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of obesity severity on the metabolic profile of obese patients

Rachdi Rim , Olfa Berriche , Ali Khaoula Ben , Safi Eya , Ben Amor Nadia , Ben Othman Rym , Mizouri Ramla , Mahjoub Faten , Henda Jamoussi

Introduction: Obesity is one of the major public health issues worldwide and is known to be associated with an increased risk of severe metabolic and cardiovascular complication. The aim of our study was to assess the impact of obesity severity on the metabolic profile of obese patients.Materials and methods: Cross-sectional descriptive study involving 68 obese patients carried within the National Institute of Nutrition in Tunis. The patients were divide...

ea0081ep400 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association of chemerin and serum advanced glycation end products in patients with autoimmune thyroiditis

Bak-Csiha Sara , Halmi Sandor , Hutkai David , Molnar Istvan , Katko Monika , Lőrincz Hajnalka , Harangi Mariann , Paragh Gyorgy , Nagy Endre , Bodor Miklos , Eszter Berta

Background: Hypothyroidism due to autoimmune thyroiditis leads to atherogenic lipid profile and metabolic changes. The formation of advanced glycation end products (AGEs) increases with hyperglycemia, hyperlipidemia and oxidative stress. Degradation of AGEs after AGEs-receptor 1-mediated intracellular uptake and renal clearance of soluble AGEs generated by certain cells like macrophages play a crucial role in the decrement of circulating AGEs level. Chemerin is an adipokine pr...

ea0081ep401 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Efficacy of a groupal lifestyle intervention programme for weight loss in obesity

Cayon-Blanco Manuel , Cepero Dolores , Lopez-Perez M Jose , Garcia-Garcia-Doncel Lourdes , Baena-Nieto Maria Gloria

Introduction: Obesity is one of the most important problems worldwide in recent times. Groupal lifestyle intervention programmes are efficacious in the management of obesity. While exercise and healthy dietary habits have consistently been shown to improve various metabolic markers, adherence to these behaviors is low and methods that increase adherence to health behaviors are needed.Objective: The primary objective of this study is to evaluate the effec...

ea0081ep402 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Bariatric Surgery in Type 1 Diabetes patients: a single centre study

Chopra Tanya , Wills Alice , Kavvoura Foteini

Background: Bariatric surgery significantly aids weight loss, improves glycaemic control and/or induces remission in Type 2 Diabetes patients. However, the impact of bariatric surgery in Type 1 diabetes (T1D) patients is less well-understood. With an increasing prevalence of obesity within the T1D population, it is important to identify whether bariatric surgery improves glycaemic control and prevents future complications.Aim: To evaluate the effect on B...

ea0081ep403 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Covid-19 infection in an individual with Down Syndrome, obesity, and hypothyroidism: a case from the UAE

Grace Fojas Esphie , Al Shamsi Shamma , Salah Noshi Mohamed , Ali Tomader , Lessan Nader

Covid-19 infection severity has been associated with pre-existing conditions including obesity. Individuals with Down Syndrome (DS) are potentially at high risk. Reports on the outcomes of Covid-19 infection in individuals with DS are scant. Here we present such a case. MA is a 27-year old Emirati male with DS, obesity and hypothyroidism. He was brought to the ER with a history of hemoptysis (2 days), fever and cough (1 week). He tested positive for Covid-19. Initial investiga...

ea0081ep404 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diagnosis of sarcopenia using biomipedance analysis

Samoilova Iulia , Matveeva Mariia , Podchinenova Daria , Oleynik Oxana , Mutalimi Venera , Choroshunova Ekaterina

Objective: To study the peculiarities of the composition in patients over 50 years old.Materials and Methods: The study involved 136 adults aged 50 to 82 years. All subjects underwent complex examination, which included anthropometry (height, weight, body mass index (BMI)) and body composition analysis using Inbody 770 (Inbody Co.Ltd., Korea). Statistical processing of the results was performed using MedCalc Statistic software.Results: women’s age w...

ea0081ep405 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of obesity on the development of respiratory abnormalities

Mizouri Ramla , Ben Othman Rym , Ben Amor Nadia , Mahjoub Faten , Yamoun Rihab , Abadlia Salma , Olfa Berriche , Henda Jamoussi

Introduction: Obesity exposes to multiple complications, including cardiovascular and metabolic ones. It can also cause respiratory problems, which are still insufficiently researched. The objective of this study was to detect respiratory abnormalities in a group of obese people followed in an obesity unit.Methods: This was a descriptive and analytical cross-sectional study of 100 obese patients consulting at the human obesity research unit of the Nation...

ea0081ep406 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Pregnancy in women with diabetes: A review of 100 cases

El Abbassi Imane , Atfi Fadwa

Introduction: Pregnancy in diabetics is one of the most frequent forms of high-risk pregnancy. It requires diabetic-obstetric-neonatalogical collaboration. Its risks affect the fetomaternal prognosis in the short and long term. Materials and methods: The aim of our work is to establish the main difficulties in the management of diabetic pregnancy. This is a retrospective study of 100 pregnant diabetic patients followed at the maternity hospital of CHU IBN ROCHD of CASABLANCA, ...

ea0081ep407 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetes and pancreatic cancer: what link?

Haj Kacem Akid Faten , Zargni Asma , El Arbi Kawthar , Ben Salah Dhoha , Fatma Mnif , Charfi Nadia , Mnif Mouna , Rekik Majdoub Nabila , Elleuch Mouna , Abid Mohamed

Introduction: Pancreatic cancer is one of the digestive system cancers whose prognosis has not been improved, both in terms of early diagnosis and prognosis, despite the progress in clinical, radiological and biological investigation. A significant number of patients present at the time of diagnosis of this cancer, or just before, a relatively recent onset diabetes. The link between diabetes and pancreatic cancer is established, but it is sometimes difficult to distinguish whe...

ea0081ep408 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hypothroidism and cardiovascular risk in type 2 diabetic’s patients

Bani Ines , Hadj Ali Zohra , Dalhoum Meriam , Htira Yosra , Ben Mami Feika

Introduction: Hypothyroidism is a frequent endocrinopathy in type 2 diabetes (T2D) which can influence the cardiovascular profile in these patients. Our aim was to study the relationship between hypothyroidism and the occurrence of cardiovascular events in patients with T2D.Method: It is a retrospective study, including 184 T2D patients, conducted in the department C of the National Institute of Nutrition of Tunis during the year 2021.<p class="abste...

ea0081ep410 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

To study the Diabetic Foot at risk using an A 60 second Foot Screening Tool and Risk classification based on the comprehensive foot examination in patients of diabetes - At a Tertiary care Center East India

Behera Kishore , Soren Uttam , Behera Binod Kumar

Introduction: The aetiology of a diabetic foot ulcer is multifactorial. The three principal components that ascertain the likelihood of ulceration in a diabetic foot are peripheral neuropathy, repeated minor trauma and deformity. Aims:To find the prevalence of diabetes patients having the foot at risk using the Simplified 60-Second Diabetic Foot Screen tool (SSDFST).Objectives: To find out the diabetic foot at risk.1. To ascertain the dispersal of variou...

ea0081ep411 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Cognitive decline and diabetes: what is the relationship?

Hentati Nour , Hadj Ali Zohra , Naifar Maryam , Htira Yosra , Ben Mami Feika

Introduction: The number of elderly with cognitive decline has been increasing. Several studies have shown that diabetes is a risk factor for cognitive impairment. Chronic hyperglycemia is implicated, probably by promoting the development of cerebral microvascular disease but physiopathology is complicated.Methods: The study involved thirty-seven diabetic patients hospitalized in the department C of National Institute of Nutrition and Food Technology of ...

ea0081ep412 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Retinal vein occlusion: let’s stay classic and don’t forget diabetes!

Massanou Selma , Kefi Asma , Ben Abdelghani Khaoula , El Euch Mounira , Sassi Syrine , Turki Sami , Abderrahim Ezzedine

Introduction: Retinal vein occlusions (RVO) are a heterogeneous group of disorders characterized by impaired venous return from retinal circulation. RVO can be classified into branch retinal vein occlusion (BRVO), hemiretinal vein occlusion (HRVO), and central retinal vein occlusion (CRVO) depending on the site of the obstruction. Major risk factors for BRVO include systemic arterial hypertension, arteriosclerosis, and diabetes, although many associations have been reported in...

ea0081ep413 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The association of serum magnesium and risk of morbidity and mortality in patients admitted to the intensive care unit: A stratified analysis based on COVID-19 infection classification

Kazemijahromi Mitra , Samimagham HamidReza , Moradkhani Azadeh

Background: Magnesium deficiency is a common clinical electrolyte abnormality in critically ill patients, related to the higher mortality risk, which is easily ignored. We aimed to investigate the association between magnesium levels and mortality and morbidity in patients admitted to the (ICU) based on COVID-19 infection classification.Method: A total of 69 patients admitted to the ICU of Shahid Mohammadi Hospital were included in the study. The serum m...

ea0081ep414 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of pre-diabetes and diabetes mellitus in polycystic ovarian syndrome (PCOS)

Ullah Habib , Noor Kalsoom , Aziz Abdul

Objective: To determine prevalence of pre-diabetes and diabetes mellitus in polycystic ovarian syndrome (PCOS).Study Design: Cross sectional study. Non probability consecutive sampling was done.Sample Size: The estimated sample size was 84 women with 95% confidence level and confidence limit of ±5%.Setting: Outpatient departments of Medicine and Gynaecology & Obstetrics at a tertiary care hospital of...

ea0081ep415 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Flash glucose monitoring in patients with type 1 diabetes

Garcia-Ramirez Mireia , Moyano-Sanchez Ana Maria , Moreno-Moreno Paloma , Rebollo-Roman Angel , Galvez Moreno Maria Angeles

Objective: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Our objective was to describe the characteristics of these patients and their glycemic control expressed as HbA1c and times in range. Methods and patientsObservational longitudinal clinical study between January 2021 and December 2021 in patients with DM1 between 14 and 18 years. Results 95 patients included. Mean age: 16.64 ± 1.25 years, with a mean DM evolution time of 6.46 ± 3....

ea0081ep416 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Lipid profile and deep vein thrombosis

Mariem Boudaya , Fendri Sana , Raida Ben Salah , Kamel Jamoussi , Zouheir Bahloul

Introduction: Homocysteine is an intermediate sulfur amino acid in the metabolic pathways of cysteine production from methionine, which is increasingly involved in various pathological processes (arterial thrombosis, depression, schizophrenia, dementia). We are interested in the course of our work to study its implication on the lipid balance in patients with venous thrombosis.Materials and methods: This is an observational case-control study, comparing ...

ea0081ep417 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of metabolic syndrome and its correlates in young PCOS women in South India

Gopal Jayashree , Dixit Madhulika Dixit

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting approximately 5% to 8% of premenopausal women. Insulin resistance is believed to be a key pathophysiologic factor and increases the risk of associated metabolic syndrome (MetSyn) and diabetes. We looked at the presence of insulin resistance in young women with PCOS from South India. The data is derived from a larger study of polycystic amenorrheic women looking at endothelial pro...

ea0081ep418 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

New-onset diabetes after transplantation (NODAT). A case report

Contreras Pascual Cristina , Gonzalez Lazaro Paloma , Moreno Tirado Antonio , Montero Benitez Maria Zhao , Alvarez Lopez Susana

New-onset diabetes after transplantation (NODAT) is a serious complication after a solid organ transplantation. It has been reported to occur in 4% to 25% of renal transplant recipients, 2.5% to 25% of liver transplant recipients, 40% to 60% of hepatitis C virus (HCV) infection and 2% to 53% of all solid organ transplantations. The diagnosis is performed using unmodified criteria for diagnosing diabetes in the general population and risk factors are the commonly recognized fac...

ea0081ep419 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Latent autoimmune diabetes in adults revealed by graves’ disease

Mohamed Ali Boutheina , Hamid Abdillahi Mohamed , Ahmed Aicha

Introduction: LADA (Latent Autoimmune Diabetes in Adults), is defined by the association of diabetes after 30 years, the presence of antibodies against pancreatic beta cells and the non-use of insulin therapy within 6 months of diagnosis. Graves’ disease is the first cause of hyperthyroidism associating thyrotoxicosis, goiterand exophthalmos with a prevalence 5 times higher in women.Case report: 37-year-old female patient with no notable history, la...

ea0081ep420 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Flash glucose monitoring in DM1: Our experience in a secondary referral hospital

Serrano Laguna Ma del Carmen , Barrera-Martin Ana , Rebollo-Roman Angel , Silva-Fernandez Julia , Galvez Moreno Maria Angeles

Objective: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Our objective was to describe the characteristics of patients in a secondary referral hospital and their glycemic control expressed as FGM targets.Methods and patientsObservational longitudinal clinical study between January 2021 and December 2021 in patients with DM1 referred to a secondary care center in Montilla (Córdoba).Results: 101 patients included. Mean a...

ea0081ep421 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effects of Semaglutide on glycaemic control and weight, in type two diabetic patients, in our diabetic day center

Al-Shaibany Azhar , Mc Cabe Olivia , Shabaht Shah

Introduction: Type two diabetes is characterized by a chronic metabolic state (obesity, high blood pressure, and dyslipidemia) and insulin resistance. There is insufficient pancreatic insulin production and ineffective use of the produced insulin resulting in abnormally high blood glucose levels (hyperglycaemia). Metabolic syndrome and diabetes are associated with increased cardiovascular risk, reduced life expectancy and a reduction in quality of life. Glucagon-like peptide 1...

ea0081ep422 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Chronic diabetes imbalance in hospitalized patients: what are the causes?

Msolly Skander , Htira Yosra , Sdiri Chaima , Cheikhrouhou Maryam , Hadj Ali Zohra , Imene Hedfi , Jemai Chaima , Ben Mami Feika

Introduction: Diabetes balance is associated with a reduction in mortality and in cardiovascular risk in patients with diabetes 1,2. The aim of this study was to determine the causes of chronic diabetes imbalance in hospitalized patients with diabetes.Methods: A cross-sectional study was conducted in a department of diabetology at the Institute of Nutrition of Tunis during 3 months (from September 2021 until December 2021). Patients hospitaliz...

ea0081ep423 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Dietary rules in type 2 diabetic patients: degree of compliance and determining factors

Achwak Mehrez , Alaya Wafa , Mohsen Selma , Lassoued Najoua , Boubaker Fadia , Zantour` Baha

Introduction: Nutrition is a cornerstone of the adequate management of Type 2 diabetes mellitus (T2DM). The aims of our work are to evaluate the degree of observance of dietary rules in T2DM patients, and the factors that influence this observance.Methods: Cross-sectional study including 84 type 2 diabetic patients followed up in the outpatient endocrinology department of Taher Sfar university hospital from September to November 2021. The data was collec...

ea0081ep424 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Particularities of diabetes discovered after the age of 65

Mizouri Ramla , Mahjoub Faten , Ben Amor Nadia , Ben Othman Rym , Olfa Berriche , Henda Jamoussi

Introduction: Diabetes mellitus is a disease that is progressing at an alarming rate in the world. In the elderly, the symptoms are often insidious and atypical, which can delay the diagnosis and the establishment of effective treatment. Indeed, management is not always easy because it must take into account multiple parameters. The objective of our study was to study the clinico-biological and etiological profile of diabetes discovered after the age of 65 years.<p class="...

ea0081ep425 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation of body mass index with random blood sugar levels in rural indians – a hospital based study

Inamdar Aniket , Saboo Bharat , Shrivastav Abhisekh

Background: Obesity is the most important modifiable risk factor in the pathogenesis of type 2 diabetes. Prevalence of diabetes is increasing in India, possibly due to a rise in obesity and changing lifestyles with nutrition transition. Body mass index (BMI) is positively and independently associated with morbidity and mortality from type II diabetes mellitus, hypertension, cardiovascular disease and other chronic diseases. In Caucasian and Asian populations, a strong associat...

ea0081ep426 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association of fasting plasma glucose levels with wake-up timings in diabetic patients in India

Inamdar Aniket , Saboo Bharat

Background: The median sleep time per night has been declining in the world consistently over last 5 decades. The timing of sleep is distinct characteristic of sleep patterns that may impact metabolic disease risk independent of sleep duration, possibly through the effects of circadian rhythms on metabolism. The sleep and wake up timings are driven by both endogenous circadian rhythms that regulate sleep propensity, energy homeostasis and metabolism as well as by sociocultural...

ea0081ep427 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The role of deferoxamine (DFO) in insulin resistance and diabetes

Ahn So-Yeon , Woo Song Min , Yeop Jeong Jae , Ho Kim Tae , Choi Sung-E , Kang Yup , Jin Kim Hae , Young Jeon Ja , JIN Han Seung , Lee Nami , Lee Kwan-Woo

Iron also plays an important role in many physiological processes, including redox balance, inflammation, and metabolism. It is reported perturbation of iron (Fe) homeostasis has also been associated with metabolic diseases. Iron reduction, with iron chelator, has preventive effects in cardiovascular remodeling and obesity. On the other hand, deferoxamine (DFO) increases hypoxia and collagen production in the kidney. Thus, the effects of DFO on metabolic disease remains contro...

ea0081ep428 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Assessment of hypoglycemic properties of extracts from some medicinal plants in the experimental diabetes model

Saatov Talat , Ibragimova Elvira , Irgasheva Sanobar , Mustafakulov Mokhammad , Salakhutdinova Malika , Ishankhodjaev Tokhir , Samarkhodjaeva Nigora , Zainutdinov Bakhodyr

Phytotherapy is the integral part of the combined treatment for diabetes mellitus. A large number of plants possessing hypoglycemic activity are described in the literature, but only small part of them is in use. Hypoglycemic effect of medicinal plants is preconditioned by the wide spectrum of compounds with biological activity in their composition. Flowers of carthamus (Carthamus tinctorius) and leaves of celery (Apium graveolens) are known to possess a numb...

ea0081ep429 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Patient with pancreatic diabetes and insulin pump

Pappa Dimitra , Barmpa Eleftheria , Linaras Maistros , Tsakos Panagiotis , Zikos Nikolaos , Bargiota Alexandra

Introduction: Pancreatic diabetes is a special category of diabetes due to diseases of the exocrine pancreas, characterized by both insulin and glucagon deficiency and clinically could be very challenging to control. We present a case of a woman with pancreatic diabetes treated with sensor augmented pump therapy after undergoing total pancreatectomy for a nonfunctional pancreatic neuroendocrine tumor (NET).Presentation: A sixty-one years old woman underw...

ea0081ep430 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Low serum epidermal growth factor level is associated with lack of diabetic control in type 2 diabetes mellitus in diabetic patients in Jordan

Al-Dwairi Ahmed , Alfaqih Mahmoud

Background: The worldwide type 2 diabetes mellitus (T2DM) prevalence is increasing dramatically. Inflammation is involved in the pathogenesis of T2DM and development of insulin resistance. Lack of diabetic control is associated with alteration in the endocrine milieu and various health sequalae’s. The aim of this research was to assess if uncontrolled T2DM is associated with increased serum levels of inflammatory cytokines and growth factors when compared with controlled ...

ea0081ep431 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Body composition and insulin resistance in type 1 Diabetes Mellitus

Andreo-Lopez Maria Del Carmen , Zarco-Martin Maria Teresa , Garcia-Sanchez Javier , Contreras-Bolivar Victoria , Lopez-Ibarra-Lozano Pablo , Fernandez-Soto Maria Luisa

Introduction: DM 1 is proposed as a condition of accelerated muscle aging and mitochondrial dysfunction as a common link regulating muscle deterioration in aging and DM 1. Loss of muscle mass is associated with insulin resistance, metabolic syndrome and cardiovascular complications.Objectives: To analyze body composition and metabolic variables related to insulin resistance in overweight/obese patients with DM1.Material and MethodsObservational, cross-se...

ea0081ep432 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metabolic impact of flash glucose monitoring system in patients with type 1 diabetes mellitus

Ariza Jimenez Jose Antonio , Cuellar Lloclla Eyvee Arturo , Hernando Jimenez Virginia , Romero Porcel Jose Alvaro

Introduction: Adequate glycemic control is essential in the diabetes prognosis. It has been described that the use of glucose monitor systems leads to an improvement in different metabolic parameters as well as facilitating decision making.Material and methodsRetrospective observational study to evaluate the metabolic impact of flash sensor implantation in a cohort of patients with DM1 of Virgen de Valme University Hospital of Seville. All patients with implantation of the glu...

ea0081ep433 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Why do diabetic patients fail to break the fast in hypoglycemia? About 58 cases

Raki Nezha , Haraj Nassim Essabah , El Aziz Siham , Chadli Asma

Introduction: Ramadan fasting is associated with an increased risk of hypoglycemia in diabetics.Purpose of the study: To assess the prevalence of diabetic patients who are unable to break the fast in the event of hypoglycemia.Method: Descriptive prospective study, including diabetic patients followed in the Endocrinology department of the CHU Ibn Rochd in Casablanca from April to June 2021.Results: Our study ...

ea0081ep434 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Management of diabetic patients during the Ramadan fast: application of international recommendations in clinical practice About 91 cases

Raki Nezha , Haraj Nassim Essabah , El Aziz Siham , Chadli Asma

Introduction: Fasting during the month of Ramadan is a religious rite. Fasting is not without risks in diabetic patients. Several recommendations and consensus of experts have recently made it possible to establish proposals to optimize the management of diabetes during Ramadan, and to specify the authorized population for this sacred practice.Purpose of the study: To assess the prevalence of type 2 diabetics authorized to fast according to the DAR 2021 ...

ea0081ep435 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Dietary survey in diabetic patients during Ramadan

Ragbi Sara , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Ramadan is considered a sacred period during which Muslims practice fasting from sunset until dawn changing the rhythm of life and eating habits. The objective of this study is to evaluate diabetics diet during and after the holy month. Patients and methodsDescriptive cross-sectional study, including diabetic patients, seen during the month of Ramadan, conducted at the Department of Diabetology and Endocrinology of the CHU Ibn Rochd of Casablanca. Data collection...

ea0081ep436 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Insulinoma with Poland Syndrome

Ahmed Suhail , Qureshi Saba , Raza Qureshi Shahzeel , Ajay Joshua , Ahmed Khan Shahid , Botoros George , Kumar Satis , Dashora Umesh Kumar

23-year-old scaffolder, fit and well, presented several times to A&E with episodes of fitting which comprised of an energy surge followed by typical neuroglycopenic and autonomic signs of hypoglycaemia. He was only found to be hypoglycaemic after a severe episode where paramedics were called to his home and discovered his blood sugars to be 1.8 mmol/l with a serum insulin was measurable. His symptoms were moderately relieved by eating a combination of sugary food like hone...

ea0081ep437 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Post COVID-19 complication in patient with diabetes insipidus: what we know nowadays?

Kostitska Iryna , Zherdova Nadiia , Piddubna Antonina , Zhurakivska Oksana , Zhurakivska Olga

A major cause of morbidity is post COVID-19 complications. The symptoms of carbohydrate dysfunction can be due to has relationship with coronavirus disease. In patients with chronic disorders after SARS-CoV-2 infection, aggravation of pre-existing symptoms has also been noticed. Diabetes insipidus (DI) may be at risk of dysnatraemia when developing respiratory complications of COVID-19. Particularly, the combination of two or more concurrent disorder is a major problem in pati...

ea0081ep438 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Protective effect of a marine plant on hepatic toxicity induced by a hyperlipidemic diet

Ben Abdallah Kolsi Rihab , Boulbaba Kolsi , Allouche Noureddine

Introduction: In recent decades, metabolic diseases have continued to increase. Several investigations concerning the origin of these diseases such as dyslipidemia, hypercholesterolemia, diabetes, etc., have been elucidated. These pathologies have been attributed to lifestyles and mainly to diet. Obesity is a serious metabolic and energy disorder, which has become a real major public health problem. Materials and methodsWe were interested in studying the effect of a high-fat d...

ea0081ep439 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Time restricted feeding 16/8 improves metabolic parameters and fatty liver in obese mice

Astudillo Camila , Acevedo Paula , Ceballo Karina , Julio Marcela , Dorfman Mauricio , Cruz Gonzalo

Obesity is a major health problem that is crucial in the pathogenesis of diabetes mellitus, cardiovascular diseases, and some types of cancer. Intermittent fasting is an eating pattern in which periods of fasting, lasting from 12 up to 36h, are alternated with periods of eating. Time restricted feeding (TRF) 16/8 is a type of intermittent fasting that is being used to lose weight and for treating metabolic disorders. Several studies in humans have shown a slight effect of TRF ...

ea0081ep440 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metabolic syndrome in mediterranean patients with mental illness

Jdira Salem , Missaoui AbdelMouhaymen , Trimeche Oumeyma , Hsine Houda , Abbes Wafa , Khochtali Ines

Introduction: Metabolic Syndrome (MetS) represents a cluster of vascular risk factors related to insulin resistance such as abdominal obesity, hypertension, and glucose and lipid dysregulations. Multiple studies suggest an increasing metabolic risk in psychiatric patients. ObjectivesWe aim to assess epidemiological and clinical features of MetS in a Mediterranean psychiatric population. MethodsWe conducted a descriptive cross-sectional study involving 126 patients attending th...

ea0081ep441 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Low hdl cholestero and cardiovascular risk in type 2 diabetes

Bani Ines , Hadj Ali Zohra , Dalhoum Meriam , Htira Yosra , Ben Mami Feika

Introduction: Low high-density lipoprotein (HDL) is a frequent metabolic abnormality, associated with diabetes, may increase the cardiovascular risk of patients with type 2 diabetes. We aimed in this study, determine the prevelence of hypo HDL cholesterol and assess the associated cardiovascular risk.Method: It is a retrospective study, including 184 type 2 diabetic patients, conducted in the department C of the National Institute of Nutrition of Tunis d...

ea0081ep442 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Regulation of glycemic variability in endothelial model: cross-talk between miRNAs and microfilaments in the activation of early fibrotic pathways

La Sala Lucia , Senesi Pamela , Capoitanio Daniele , Tagliabue Elena , Ferrulli Anna , Terruzzi Ileana , Luzi Livio

Glycemic variability (GV), a complex phenomenon affecting subjects with diabetes, is one of the main contributors to the risk to develop both acute and long-term complications in type 1 (T1D) and type 2 (T2D) subjects. DNA double-strand breaks, apoptosis, overgeneration of reactive oxygen species (ROS) and the induction of some regulatory micro-RNAs, sustain the ominous mechanisms mainly attributable to GV. The characteristic cellular phenotype induced by GV is scarcely define...

ea0081ep443 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Mediterranean diet rich in olive oil and vascular diabetes complications

Mizouri Ramla , Abir El Amri , Yamoun Rihab , Mahjoub Faten , Nsir Sirine , Amorri Amany , Ben Othman Rym , Berriche Olfa , Ben Amor Nadia , Henda Jamoussi

Introduction: Olive oil is the most representative food of the traditional Mediterranean Diet (MedDiet) that, besides having high-monounsaturated fatty acids content, contains other minor components with biological properties. Olive oil as a food, and the MedDiet as a food pattern are associated with a decreased risk of cardiovascular disease, obesity and diabetes mellitus. The aim of this study was to determine the relationship between adherence to the Mediterranean Diet and ...

ea0081ep444 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence and Risk Factors for Diabetic Lower Limb Amputation

Abir El Amri , Ben Othman Rym , Yamoun Rihab , Mizouri Ramla , Amorri Amany , Nsir Sirine , Mahjoub Faten , Ben Amor Nadia , Berriche Olfa , Henda Jamoussi

Introduction: The progressive increase in diabetes is likely to increase the incidence of amputations. Despite a wealth of research highlighting the importance of early detection and management, prevention practices remain poor, with inconsistent patient follow-up and compliance. The aim of our study was to assess the prevalence and risk factors for lower limb amputation in a third-line hospital among diabetics.Methods: It was a retrospective study inclu...

ea0081ep445 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

GLIM criteria and nutritional assesment in patients with heart failure

Moyano Sanchez Ana Maria , Alzas Teomiro Carlos Manuel , Munoz Jimenez Concepcion , Garcia Ramirez Mireia Isabel , Lopez Aguilera Jose , Crespin Manuel , Molina Puerta Maria Jose , Galvez Moreno Maria Angeles , Herrera Martinez Aura

Background: Heart failure (HF) is a chronic inflammatory syndrome, with increased morbidity, mortality, and decreased quality of life. The publication of GLIM criteria has standardized the diagnosis of malnutrition. With these criteria, the nutritional status of patients with heart failure, who usually have normal weight, overweight or obesity, has acquired a new perspective, since malnutrition may affect the clinical evolution and prognosis of these patients.<p class="abs...

ea0081ep446 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of early postpartum glucose intolerance in Spanish women with gestational diabetes mellitus

Eguilaz Esparza Nerea , Ollero M Dolores , Mayayo Remirez Yolanda , Irigaray Ana , Ernaga Lorea Ander , Toni Garcia Marta , Martinez De Esteban Juan Pablo

Introduction: Women with gestational diabetes mellitus (GDM) have an increased risk for developing glucose intolerance in postpartum. The aim of our study was to describe the general characteristics of pregnant women with GDM and to assess the prevalence of glucose intolerance in early postpartum by postpartum oral glucose tolerance test (ppOGTT).Methods: Retrospective study from January 2017 to December 2020 including patients with GDM followed at endoc...

ea0081ep447 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effect of lockdown during covid 19 pandemic on HbA1c control among diabetes patients in georgia ajara

Jashi Liana , Dundua Ketevan , Kvanchakhadze Rusudan , Peshkova Tamar

Background: The COVID-19 pandemic changed to the daily life of individuals. These included lockdown and social distancing During COVID-19 pandemic. Healthcare providers from different institutions had to adapt to the way of supporting and managing patients with different chronic conditions including diabetes. The implementation of lockdown affected diabetes care. COVID-19 pandemic enabled healthcare professionals to apply innovation including social networks/telemedicine/telep...

ea0081ep448 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Sudden deafness revealing type 2 diabetes: a case report

Dalhoum Meriam , Hadj Ali Zohra , Bani Ines , Htira Yosra , Ben Mami Faika

Introduction: Sudden idiopathic deafness is often a diagnosis of elimination. It is defined by an isolated sensorineural hearing loss (sensorineural deafness) unilateral and without obvious etiology but a vascular hypothesis is plausible. We report in this context a case of unilateral sudden hearing loss revealing type 2 diabetes (T2DM).Observation: This is a 40-year-old man, sedentary, with no particular pathological history, a 20-pack/year smoker and o...

ea0081ep449 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

How to position Sodium Glucose cotransporter-2 inhibitors in the management of Diabetes in acromegalic patients- Another point of view

Zaina Adnan , Abid Ali , Golden Elena , Arad Eldad

Context: Diabetes mellitus represents one of the most frequent metabolic comorbidities and occurs in 30% to 40% of patients with acromegaly. Patients with acromegaly develop insulin resistance due to GH excess, and in those with longstanding disease, insulin deficiency may occur. Moreover, the use of second-generation somatostatin receptor ligands (SRLs) pasireotide might contribute to the increased development in new-onset diabetes and the worsening of hyperglycemia. Manageme...

ea0081ep450 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Case report of a patient with type 2 diabetes and severe hypomagnesemia

Jambrović Martina , Mikolaj Kiric Maja , Maric Andreja

Introduction: GLP-1 agonists and metformin are widely used antidiabetic drugs with excellent blood glucose-lowering effects, but patients very often develop side effects. The most common side effect of these two groups of drugs is gastrointestinal intolerance in the form of vomiting, diarrhoea, general weakness and dizziness.Case ReportA 58-year-old male patient was hospitalised for the second time in one month due to a recurrence of dizziness, vomiting, ataxia and epileptic s...

ea0081ep451 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metabolic syndrome in Cushing’s syndrome

El Jaafari Fatima Zahra , Bifoume Ndong Charlene-Ludwine , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Metabolic disorders are a relevant cause of morbidity and disability in patients with Cushing’s syndrome (CS) even after a successful treatment. The aim of our study was to assess the prevalence of metabolic syndrome in our CS patients, as central obesity, dyslipidemia, diabetes, and hypertension, and to discuss the main adverse effects of CS on metabolism and emphasize the importance of long-term monitoring and treatment of these complications.Patients and ...

ea0081ep452 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

"Characteristics of cerebral hemodynamics in patients with type 2 diabetes on program hemodialysis"

Yulduz Urmanova , Kholikov Alisher , Khalimova Mekhinbonu

The goal is to study the changes in the parameters of cerebral hemodynamics in patients with diabetes mellitus of type 2 receiving program hemodialysis.Material and methods of research: We have been viewed and surveyed in just a period from January 1, 2019 to June 1, 2021 g - 117 patients suffering from type 2 diabetes mellitus, with chronic kidney insufficiency V stage on program hemodialysis. Of these, women were 58, men -62. The average age of men amo...

ea0081ep453 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

"The prognostic efficiency of the N-terminal fragment of the Brain natriuretic peptide in the diagnosis of chronic heart failure in patients with type 2 diabetes”

Khalimova Zamira , Yusupova Shakhnoza

The purpose of the study is to study the prognostic role of NT¬proBNP in patients with diabetes mellitus type 2 associated chronic heart failure (CHF).Material and research methods: For the period 2015-2021, 185 patients were identified as an object of study, and 185 patients based on the materials of their preparations into therapeutic and prophylactic institutions of Andijan from 30 years and older. Patients were distributed to 3 groups: 1 Group a...

ea0081ep454 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

"Hormonal characteristic of patients with diabetes mellitus 2 types of associated chronic heart failure"

Yusupova Shakhnoza , Khalimova Zamira

The purpose of the study is to study the clinical and hormonal features of diabetes mellitus 2 (DM) associated chronic heart failure (CHF).Material and research methods: For the period 2015-2021, 185 patients were identified as an object of study, and 185 patients based on the materials of their preparations into therapeutic and prophylactic institutions of Andijan from 30 years and older. Patients were distributed to 3 groups: 1 gr. are patients with DM...

ea0081ep455 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

“The Level of awareness of the risk of developing coronary heart disease of patients with type 2 diabetes mellitus complicated by cardio-renal syndrome”

Alimova Kamola

The purpose of the study is to study the Level of awareness of the risk of developing coronary heart disease (CHD) of patients with type 2 diabetes mellitus complicated by 4 type cardio-renal syndrome.Material and methods: We examined in total for the period from October 1, 2021 to December 1, 2021 - 25 patients suffering from type 2 diabetes mellitus with chronic renal disease (CRD) and chronic cardial insufficiency (CCR). The average age of 33.3% of pa...

ea0081ep456 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Plasmalogen levels are associated with the severity of diabetic neuropathy

Akhrarova Nilufar , Saatov Talat , Salimova Munojat , Khamraeva Mehriniso , Zaynutdinov Bakhodir , Shamansurova Zulaykho

Backgrounds: Diabetes mellitus is a complex disease accompanied by the development of complications. In addition to the classic hyperglycemia and dyslipidemia, a number of other factors are involved in the pathogenesis of complications. Plasmalogens disturbances participates in nerve tissue degeneration.Materials and methods: In 76 people with DM2 plasma and erythrocytes membranes plasmalogenes measured and compared according to diabetic neuropathy.<...

ea0081ep457 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Lipid metabolism in patients with type 1 diabetes mellitus accompanied by ischemic heart disease

Artykbaeva Gulnora , Saatov Talat

Cardio-vascular disorders (CVD), ischemic heart disease (IHD) and myocardial infarction (MI) heading the line are the main cause of death among patients with diabetes mellitus (DM). DM has been proved to be an essential risk factor for IHD and MI to be instrumental in regarding all patients as belonging to the CVD high risk group. Dysfunction of adipocytes, insulin resistance, hyperinsulinemia, hyperglycemia and dyslipidemia seen in DM are the triggers for the cascade of hemod...

ea0081ep458 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Are diabetes mellitus and parkinson’s disease linked?: a case report

Khaoula Gorgi , Lamya Echchad , Kaoutar Rifai , Hinde Iraqi , El Hassan Gharbi Mohamed

Introduction: Parkinson’s disease is considered the most common chronic neurodegenerative disease that often affects the elderly, rarely the young. Meanwhile, Diabetes mellitus is the most common chronic metabolic disease. Because of the increase in the prevalence of diabetes and neuro-vegetative diseases, we can wonder about the relationship between the two diseases. We report the case of a patient with type 2 diabetes mellitus associated with young onset Parkinson’...

ea0081ep459 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

An inaugural diabetic ketoacidosis revealed by Fournier’s gangrene

Khaoula Gorgi , Lamya Echchad , Kaoutar Rifai , Hinde Iraqi , El Hassan Gharbi Mohamed

Introduction: Fournier’s gangrene (FG) is a rare but life-threatening disease. Although originally thought to be an idiopathic process, FG has been shown to have a predilection for patients with diabetes, HIV, alcoholism and other immunocompromised states. We report the case of a patient who presented an inaugural diabetic ketoacidosis revealed by Fournier’s gangreneObservation: A 38-year-old male patient with a smoking history, presented to th...

ea0081ep460 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Long-term diabetes complications

Sdiri Chaima , Htira Yosra , Msolly Skander , Cheikhrouhou Maryam , Hadj Ali Zohra , Imene Hedfi , Jemai Chaima , Ben Mami Feika

Introduction: The chronic hyperglycemia related to inadequately controlled diabetes is involved in the onset of degenerative complications, responsible for disabilities. The objective of the present study was to determine the long-term complications observed in hospitalized patients with diabetes.Methods: We used a prospective study conducted in the department of diabetology in the National Institute of Nutrition (Tunisia). This work was carried out on t...

ea0081ep461 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation between pulse wave velocity and retinopathy in type 2 diabetes

Besrour Chayma , Imen Rojbi , Habib Ben Ahmed , Sabrine Mekni , Nadia Mchirgui , Ibtissem Ben Nacef , Karima Khiari

Introduction: Diabetic retinopathy (DR) is a serious complication of diabetes that affects 50% of patients with type 2 diabetes. It represents the first cause of blindness. The aim of this study was to examine the relationship between diabetic retinopathy and arterial stiffness.Methods: We conducted a prospective study including 249 diabetic patients without macroangipathic complications, between July 2020 and May 2021. Using a SphygmoCor®XCEL devic...

ea0081ep462 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation between pulse wave velocity and neuropathy in type 2 diabetes

Besrour Chayma , Imen Rojbi , Habib Ben Ahmed , Sabrine Mekni , Nadia Mchirgui , Ibtissem Ben Nacef , Karima Khiari

Introduction: Diabetic neuropathy (DN) is the most common complication of diabetes affecting up to 50% of patients with type 2 diabetes. Carotid to femoral pulse wave velocity (cfPWV) is an independent cardiovascular marker of morbidity and mortality and is considered the gold standard in the assessment of arterial stiffness. The aim of this study is to examine the relationship between diabetic neuropathy and arterial stiffness.Methods: We conducted a pr...

ea0081ep463 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation between pulse wave velocity and hypertension in type 2 diabetes

Besrour Chayma , Imen Rojbi , Ahmed Habib Ben , Sabrine Mekni , Nadia Mchirgui , Ibtissem Ben Nacef , Karima Khiari

Introduction: People with high blood pressure have a greater risk of developing diabetes, and people with diabetes also have an increased risk of high blood pressure. These two associated pathologies can increase cardiovascular risks and cause other repercussion such as arterial stiffness. The aim of this study is to examine the relationship between pulse wave velocity and hypertension in type 2 diabetes.Methods: We conducted a prospective study includin...

ea0081ep464 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Predicting factors of insulin requirement in gestational diabetes mellitus

Zemni Zeineb , Raja Daii , Abdesselem Haifa , Bornaz Emna , Sdiri Chaima , Alaya Nadia , Ounaissa Kamilia , Boukhayatia Fatma , Sebaii Imen , Yahyaoui Ryme , Ben Brahim Asma , Ammrouche Chiraze

Background: The management of gestational diabetes mellitus (GDM) is based on nutrition therapy associated to insulin therapy in second intention if glycemic targets are not achieved. The aim of this study was to assess predictive factors of insulin requirement in a group of pregnant women with GDM.Methods: We conducted a retrospective study at the Outpatient Department and functional explorations, in the National Institute of Nutrition of Tunis, between...

ea0081ep465 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Are type 2 diabetic insulin-requiring elderly satisfied?

Zaouali Fatma , Lassoued Najoua , Sondos Arfa , Wafa Alaya , Mohamed Habib Sfar

Introduction: Glycemic control in elderly diabetics is a challenge. Treatment Satisfaction reflects this control.Objectives: To assess insulin treatment satisfaction and to determine the factors associated with insulin treatment satisfaction among type 2 diabetic elderly.Methods: A cross-sectional study on 86 type 2 diabetic insulin dependent elderly recruited from the outpatient endocrinology consultation during June and July 2021...

ea0081ep466 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Insulin analogs: do patients know their treatment advantages and modalities?

Bornaz Emna , Gharbi Radhouen , Ghram Lina , Chiboub Marwa , Kandara Hajer , Jemel Manel , Kammoun Ines

Introduction: In Tunisia, the prescription of insulin analogs is increasingly « automatic » by practicians, convinced by this treatment superiority over human insulin in diabetes management. The aim of our study is to determine whether the analogs prescription modalities and advantages are known by the patients, and to assess the factors associated with this knowledge.Patient and Methods: We conducted a retrospective study including 65 diabetic...

ea0081ep467 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metformin adherence and its impact on diabetes control

Kamoun Elyes , Yazidi Meriem , Abidi Sahar , Khessairi Nadia , Mouelhi Yasmine , Oueslati Ibtissem , Chihaoui Melika

Introduction: Metformin is the first-line treatment of type 2 diabetes mellitus. Poor adherence can be lead to poor glycemic control. The aim of our study was to determine the level of metformin adherence and its link with glycemic control in type 2 diabetic patients.Methods: We performed a cross-sectional study including 273 patients with type 2 diabetes taking metformin for at least three years. We assessed metformin adherence using the Girerd question...

ea0081ep468 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Painful fat necrosis as a consequence of insulin application - an unsolvable problem?

Borozan Sanja , Muzurovic Emir , Vujosevic Snezana

We report a case of 39–year-old female presented with painful, scaling skin lesions on insulin application sites. She was diagnosed with type 1 diabetes mellitus (T1DM) at the age of 21 years and treated with intensified conventional insulin therapy. Three months before hospital admission, she suddenly started to feel pain at insulin injection sites, followed by oval subcutaneous deposits and skin ulcer in the further course. Identical local changes repeated after subcuta...

ea0081ep469 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impact of COVID-19 lockdown on glycemic control in diabetic patients hospitalized in emergency months

Rachdi Rim , Ben Amor Nadia , Lajili Olfa , Mahjoub Faten , Mizouri Ramla , Ben Othman Rym , Olfa Berriche , Henda Jamoussi

Introduction: The global pandemic spread of SARScov2 has led to a heavy medical and socio-economic toll since December 2019. Patients suffering from chronic diseases were particularly affected during the lockdown period due to difficulties in accessing care. The aim of our study was to evaluate the impact of the 2-month lockdown introduced in Tunisia in March 2020 on diabetic patients’ glycemic control.Materials and methodsRetrospective study involving 54 diabetic patient...

ea0081ep470 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Mitochondrial diabetes: from diabetes to syndrome

Gallego Diaz Celia , Romero Porcel Jose Alvaro , Cuellar Lloclla E Arturo , Cozar Leon Maria Victoria

Anamnesis: We report the case of a 54-year-old man who consulted for weight loss. He had been diagnosed with diabetes more than 20 years ago with good glycemic control (currently HbA1c 6.9%), no obesity, hypertension, or dyslipidaemia. A history of chronic pancreatitis and retinitis pigmentosa with eyelid ptosis. He maintains regular treatment with metformin, sitagliptin, repaglinide, ASA, Kreon and Pregabalin.Complementary testIn reference to the chief complaint, there had no...

ea0081ep471 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation of knowledge and self-care with glycemic control in people with diabetes

Boulazeri Smaragdi , Ntikoudi Anastasia , Kavga Anna , Kelesi Martha , Mangoulia Polyxeni , Evangelou Eleni , Tsartsalis Athanasios , Komninos John , Vryonidou- Bompota Andromachi , Vlachou Eugenia

Introduction: Diabetes mellitus (DM) is a disease that shows a rapid increase over the recent years and is a major cause of morbidity and mortality. Thus new ways of prevention and treatment are needed and constantly being developed. As a lifelong challenge, DM is likely to affect one’s life in a variety of ways. It requires daily planning and decision making. Self-care is a vital component of the disease. Knowledge consists of information about the disease and its manage...

ea0081ep473 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Oral health related behavior and knowledge in adult patients with diabetes: a questionnaire study

Dalhoum Meriam , Hadj Ali Zohra , Ines Bani , Yosra Htira , Faika Ben Mami

Diabetes is a common disease with concomitant oral manifestations that impact dental care.Purpose: To investigate oral health awareness, oral hygiene and behavior in adults with diabetes.Subjects and methods: This study involved interviews with a sample of 30 patients with diabetes type 2 followed in the C department of the National Institute of Nutrition in Tunis using a questionnaire study on oral health behavior and awareness.</...

ea0081ep474 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Daytime sleepiness in patients with diabetes

Dalhoum Meriam , Hadj Ali Zohra , Ines Bani , Yosra Htira , Faika Ben Mami

Excessive daytime sleepiness (EDS) is commonly considered a cardinal sign of sleep apnea; however, the mechanism underlying the association is unclear.Purpose: The purpose of this study is to investigate the daytime sleepiness in patients with diabetes.Methods: Participants were 30 adults with type 2 diabetes (T2DM) followed in the C department of the National Institute of Nutrition in Tunis. Subjective sleepiness was assessed usin...

ea0081ep475 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prophylactic gonadectomy in A young phenotypic female with turner syndrome 45,XO/46,XY mosaicism: a case report

Ouhessaine Sofia , Haraj Nassim Essabah , El Aziz Siham , Chadli Asma

Introduction: Turner syndrome is a chromosomal disorder that affects an estimated 1/2500 female live births. An estimated subset of 6-12% of all Turner Syndrome patients will be a mosaic with Y-chromosomal elements. It is recognized that a Turner female possessing Y chromosome material has an increased risk of developing gonadoblastoma, a precursor to dysgerminoma. Consequently guidelines recommend prophylactic gonadectomy in Turner females.Obsevation: W...

ea0081ep476 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Can Alopecia Areata predict the appearance of autoimmune diabetes in a patient with autoimmune polyglandular syndrome type 2?

Corlan Ana Silvia , Vlad Mihaela

Autoimmune polyglandular syndrome type 2 can be associated with alopecia areata. We present herein a case of a female patient, 42 years old, who suffered from autoimmune thyroid disease with hypothyroidism and autoimmune adrenalitis and who was recently diagnosed with alopecia areata. She accused sudden, asymptomatic hair loss, which she noticed 3 months ago, accompanied by a burning sensation in her scalp. Her menstrual cycles were normal. The clinical examination identified ...

ea0081ep477 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Globoid cell leukodystrophy: case report and literature review

Outtaleb Fatima Zahra , Tazzite Amal , Gazzaz Bouchaib , Dehbi Hind

Krabbe disease, also known as globoid cell leukodystrophy, is an autonomic recessive genetic disorder caused by GALC mutations. GALC gene codes for galactosylceramidase, which is a lysosomal enzyme. This disorder can occur during early childhood, between the ages of 1 and 8 years old (later onset form) or during adulthood; its prevalence is estimated at 1/100 000. Nevertheless, in most cases, this disorder occurs during childhood. With this case report, our a...

ea0081ep478 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metabolic and hemodynamic disorders in obese patients with true and pseudo-resistant hypertension

Shalimova Anna , Isayeva Ganna , Burakoska Olena , Komir Iryna , Vovchenko Maryna , Prosolenko Kostyantyn

Objective: to conduct a comparative assessment between metabolic and hemodynamic parameters in obese patients with true and pseudo-resistant (due to different causes) hypertension.Materials and methods: The study included 302 patients with uncontrolled hypertension and obesity. Initial treatment efficacy was assessed 3 months after dual therapy was administered. Those patients who did not reach target blood pressure (BP) in dual therapy were transferred ...

ea0081ep479 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

A new rehabilitation complex for muscle strength deficit correction and movement disorders in case of obesity

Vasileva Valeriia , Marchenkova Larisa

Aim: The Aim of the study was evaluation of effectiveness a new complex included aerobic and physical training, kinesiohydrotherapy, balance therapy on changes in muscle strength and movement disorders in patients with obesity.Materials and methods: The study group included 40 patients aged 58 [53;66] y.o. with a BMI≥30 kg/m2. The control group included of 40 people aged 57 [54;63] y.o. with BMI≥30 kg/m2. Study methods i...

ea0081ep480 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Age aspects and body mass index in patients with toxic hepatitis

Prokopchuk Oksana , Hospodarskyy Ihor , Gavryliuk Nadiia , Danchak Svitlana , Kozak Olha

Background: Over the last year the social consequences of obesity has become significant, with weight-based stigmatization and prejudiced common outcomes. Toxic hepatitis is one of those diseases that has obese as comorbidity in different age groups. The pervasiveness of prejudice toward obese in patients with toxic hepatitis makes it imperative that scientists have access to valid and reliable measures to assess weight bias.Objectives: Age groups struct...

ea0081ep481 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of non alcoholic fatty liver disease and fibrosis in morbidly obese patients undergoing bariatric surgery

Khalaf Rahma , Mahjoub Faten , Ben Amor Nadia , Berriche Olfa , Jamoussi Henda

Background: Patients undergoing bariatric surgery have a higher prevalence of non alcoholic liver fatty disease (NAFLD) than the general population; however, its assessment and the accurate staging of fibrosis are often complicated because noninvasive tests are not very accurate in patients with morbid obesity, and liver biopsy cannot be performed as a routine exam. Aim: The aim of this study was to determine the prevalence of non alcoholic fatty liver d...

ea0081ep482 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effect of laparoscopic mini-gastric bypass on the compensation of carbohydrate metabolism in patients with morbid obesity and type 2 diabetes

Mazurina Natalya , Ershova Ekaterina , Komshilova Kseniya , Kim Ekaterina

Objective: Sustained weight loss is a highly effective strategy to treat and prevent the development of type 2 diabetes (T2D). Bariatric surgery leads to significant weight loss, which ensures the achievement of remission of diabetes mellitus and other obesity-related comorbidities. AimThe aim of this study was to estimate glycemic profile of patients with morbid obesity and T2D after laparoscopic mini-gastric bypass (LMGB). MethodsWe conducted a retrospective study of ob...

ea0081ep483 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hypoglycemia after gastric bypass

Ates Coskun , Hocaoglu Erhan , Aydemir Ensar , Mercan Saridas Filiz , Oz Gul Ozen , Cander Soner , Ersoy Canan , Erturk Erdinc

Introduction: Today, approximately 33% of the world population is either overweight or obese. National Health and Nutrition Examination Survey (NHANES) results show that, when 20 years and older American adults are examined, it is seen that 33% of them are overweight, 35.7% of them are obese, and 6.3% of them are morbidly obese (1). Roux-en-Y gastric bypass is a restrictive and malabsorptive combined method and is a complicated operation. Cases of endogenous hyperinsulinemic h...

ea0081ep484 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Quality of life, anxiety-depressive disorders and their assessment in patients with metabolic syndrome

Moskalenko Olga , Kasparov Eduard

This article discusses the assessment of quality of life, psychological state and anxiety-depressive disorders in patients with metabolic syndrome. It is known that the prevalence of metabolic syndrome in different countries is about 30% and varies from included criteria. The problem of the quality of life of obese and overweight patients is relevant and socially significant. Research Methods The authors present the results of a study of 70 patients with MS and 36 apparently h...

ea0081ep485 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation between Type-1 diabetes and obesity

Kumar Subhash , Shankar Anand , Guha Shaibal , Das Amit Kr

Introduction: Increase in global childhood obesity is considered to be one of the detrimental problems all across the world. It is well known that about every 1 in every 300-500 infants suffers from Type-1 Diabetes Mellitus. Obesity has been directly associated with elevation of blood sugar and HbA1c.Objective: This study investigates the prevalence of obesity in Type-1 DM and the distribution of sex, age and its correlation with HbA1.<p class="abste...

ea0081ep486 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Manifistation of psoriasis in patients with type 2 diabetes

Brutskaya-Stempkovskaya Elena , Shepelkevich Alla , Dydyshka Yuliya

Background: It is known that the prevalence of skin diseases in patients with type 2 diabetes (T2D) is increased including psoriasis. Patients with T2D and psoriasis have an increased risk of psoriasis exacerbations. The study of the psoriasis manifestation features in patients with T2D can help to reduce the number of exacerbations, their severity and duration.Aims: To study the influence of T2D on the psoriasis manifestation and exacerbation. Materials...

ea0081ep487 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Neurodegeneration type and severity have linkage with plasma insulin in DM patients

Saatov Talat , Alimov Timur , Ibragimova Elvira , Ishankhodjaev Takhir , Ibragimov Zafar , Artikbaeva Gulnora , Mustafakulov Mukhammadjon , Saidova Dilnoza , Shamansurova Zulaykho

Background: In Pathogenesis of Neurodegeneration in Diabetes Mellitus (DM) addition to insulin resistance, glycemic control and blood plasma lipid levels existing other mechanisms were proposed. We investigated plasma insulin level in patients according to severity of diabetic neuropathy.Materials and methods: In 32 people with DM2 glycemia, HbA1c, blood plasma insulin, blood total cholesterol, triglycerides, Low Density Lipoproteins (LDLP) levels were m...

ea0081ep488 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Salvage nephrectomy for a severe acute emphysematous pyelonephritis with septic shock: a case report

Jasser Maatougui , Mehdi Raboudi , Besrour Chayma , Haroun Ouertani , Samir Ghozzi

Introduction: Emphysematous pyelonephritis is associated with high mortality rate. It is seen in patients with a long-standing diabetes. We report a case of a women presenting a septic shock following a severe acute right emphysematous pyelonephritis and requiring salvage nephrectomy.Case report: A 52-year-old female presented fever with right flank pain. She had a long history of uncontrolled diabetes. Physical examination revealed a with high fever (39...

ea0081ep489 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Ptosis and type 1 diabetes: fortuitous association?

Mizouri Ramla , Ben Othman Rym , Ben Amor Nadia , Mahjoub Faten , Mohsen Selma , Yamoun Rihab , Olfa Berriche , Henda Jamoussi

Introduction: Diabetes is the cause of ophthalmological complications that are all the more severe when the balance of diabetes is precarious. Among the non-retinal ocular targets of diabetes is damage to the optic nerve. The diagnosis of diabetic mononeuritis should only be made after excluding other causes of neuropathy.Observation: We report the case of a patient referred to our service for equilibration of diabetes. This is a 59-year-old patient, typ...

ea0081ep490 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association between severe COVID-19 pneumonia and characteristics of type 2 diabetes patients

Lajili Olfa , Chadia Zouaoui , Rachdi Rim , Najla Bchir , Ouertani Haroun

Introduction: COVID-19 caused by SARS-COV-2 infection can lead to multi-organ injuries and significant mortality in severe and critical patients, especially among those individuals with type 2 diabetes. The aim of our study was to assess associations between severe COVID-19 pneumonia and clinical and biological characteristics of patients with type 2 diabetes.Methods: This was a retrospective and descriptive study including 40 Tunisians patients hospital...

ea0081ep491 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Sulphonylureas induced hypoglycemia: a negleted cause of focal encephalopathy

Lopes Leonor , Bello Carlos , Limbert Maria Clotilde , Sequeira Duarte Joao

Introduction: Sulphonylureas (SU) are an effective therapy for type 2 diabetes (T2DM). As insulin secretagogues, hypoglycemia is a potencial adverse effect. Hypoglycemia may cause neuroglycopenic brain injury, which can mimetize stroke and infections of the central nervous system. Case ReportThe authors report the case of an autonomous 71 year-old woman, with medical history of hypertension and T2DM, treated with enalapril and gliclazide, that was admitted in the Emergency Roo...

ea0081ep492 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetic muscle infarction: a case study

Maaoui Ons , Mekni Sabrine , Ben Rebai Senda , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , agerbi sahar , Chargui Soumaya , Sallemi Nada , Ben Nacef Ibtissem , Khiari Karima

Introduction: Diabetic muscle infarction (DMI) is a rare complication of long-standing, poorly controlled diabetes, and it’s more common in patients with micro-vascular complications. Herein, we present a case of DMI occurring in patient on hemodialysis.Case presentation A 44-year-old man on maintenance hemodialysis presented with an acutely painful and swelling in his left calf. He had a 21-year history of poorly controlled type one diabetes, with micro-vascular complica...

ea0081ep493 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Quality improvement project; Recognition and management of Hyperosmolar Hyperglycemic State (HHS)

Adnan Adnan , Omer Tahir , Rehman Abaid-Ur

Introduction: Hyperosmolar Hyperglycemic State (HHS) is an uncommon and potentially fatal complication of diabetes. HHS is a medical emergency with high mortality. Therefore, it needs to be managed promptly and carefully utilising nationally agreed guidance. Delays in recognition and challenges in management may lead to poor outcome.Aim and Targets: The primary objective is to improve the recognition and management of HHS. The project was set to the stan...

ea0081ep494 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Clinical cardiovascular autonomic neuropathy (CAN) and amputations - a sinister combination for the quality of life in diabetes

Cosma Daniel , Silaghi Cristina Alina , Silaghi Horatiu

Introduction: Diabetic autonomic neuropathy (DAN) and CAN as one of its most common manifestations are serious complication of type 1 and type 2 diabetes mellitus leading to a significant increase in morbidity and mortality. Case presentationA 51-year old male, diagnosed with T2DM for 25 years, complicated by stage III diabetic polyneuropathy, proliferative retinopathy and several amputations on both feet, treated with Metformin (2g/day), Glargine (26 IU/day) and Aspart (21 IU...

ea0081ep495 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The prevalence of diabetic peripheral neuropathy among the futsal players participating in the DiaEuro 2017 Championship

Cosma Daniel , Silaghi Cristina Alina , Silaghi Horatiu

Objectives: To assess the prevalence of diabetic peripheral neuropathy (DPN) among futsal players participating in the 2017 edition of the European Futsal Championship for people with diabetes (DiaEuro).Methods: In this cross-sectional study were included 94 amateur/professional futsal player, from 9 European countries. The evaluation was made based on the data extracted from the standard medical certificate completed by each player’s diabetologist....

ea0081ep496 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metabolic complications of obese Tunisian adults

Zemni Zeineb , Lajili Olfa , Ben Amor Nadia , Bornaz Emna , Khaoula Ben Ali , Safi Eya , Mizouri Ramla , Ben Othmen Ryme , Mahjoub Faten , Berriche Olfa , Jamoussi Henda

Introduction: Obesity is a major health problem through its numerous complications especially metabolic complications associated with cardiovascular risk. The aim of our work was to describe the clinico-metabolic profile of obese Tunisian adults.Methods: This was a descriptive cross-sectional study involved 174 obese patients who consulted between July and December 2020 at the Obesity Unit of the National Institute of Nutrition in Tunis. ResultsThe avera...

ea0081ep497 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metabolic profile of morbid obesity compared to moderate and severe obesity: What particularities?

Berrabeh Soumiya , Zarraa Lamiae , Alla Achwak , Derbel Salma , Elmehraoui Ouafae , Abir Tahri , Zerrouki Dounia , Rouf Siham , Latrech Hanane

Introduction: The prevalence of obesity is increasing in the world. It constitutes a major risk factor associated with diabetes, hypertension, dyslipidemia and cardiovascular diseases. The aim of our work is to compare the metabolic profile of morbid obesity with that of moderate to severe obesity.Patients and methodsIt is a Retrospective, descriptive and analytical study, including 63 obese patients, followed at the endocrinology, diabetology and nutrition department of the C...

ea0081ep498 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

How to treat severe obesity due to binge eating in children?

Arhire Amalia Ioana

Introduction: As the incidence of pediatric obesity is gaining pandemic levels, with children and teenagers developing obesity complications similar to the adult population, a rapid evaluation and treatment is necessary. We present such a case.Case reportA 12-year-old male with a medical history of binge eating, treated by Topiramate, since the age of 11 and 3rd degree obesity, complicated with JNC stage II hypertension, NASH and dyslipidemia was referred to our clinic for nut...

ea0081ep499 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Lipid profile of the obese: about 100 cases

Ben Othman Rym , Mizouri Ramla , Amorri Amany , Ben Amor Nadia , Abir El Amri , Olfa Berriche , Mahjoub Faten , Henda Jamoussi

Obesity is a major public health problem. It is a privileged provider of a constellation of metabolic abnormalities, particularly lipids, increasing the risk of morbidity and mortality and hampering the quality of life of the obese.Material and methods: We conducted a prospective study on 100 obese patients recruited at the Human Obesity Research Unit at the National Institute of Nutrition in Tunis. Our patients benefited from an assay of fasting insulin...

ea0081ep500 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Comparative study of epidemiological, clinical and paraclinical characteristics between a group of complicated obese versus uncomplicated obese: about 400 cases

Mnif Fatma , Souissi Mariem , Ben Salah Dhoha , Boujelben Khouloud , El Arbi Kawthar , Mnif Mouna , Rekik Majdoub Nabila , Elleuch Mouna , Charfi Nadia , Abid Mohamed

Introduction: Obesity, through its complications, influences the functional and vital prognosis. The search for these complications constitutes a major axis of the management of the obese patient, independently of the weight loss. The objective of this work is to focus on the different complications of obesity and to identify, through a comparative study between two groups of obese patients, complicated versus uncomplicated, the different predictive factors of the occurrence o...

ea0081ep501 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Assessment of depression in diabetics with erectile dysfunction (ED): 37 cases

Boulbaba Kolsi , Kolsi Rihab Ben Abdallah , Dammak Mohamed , Boujilbene Khouloud , Elarbi Kawthar , Zargni Asma , Kacem Faten Hadj , Abid Mohamed

Introduction: Diabetes is a disease that can slowly be. Among its complications, erectile dysfunction can appear. Be careful, these problems can be warning signs. These problems can be warning signs, especially cardiovascular, but they also have significant psychological retention.Materials and methods: Prospective study on 37 diabetic patients collegiate in the department of Endocrinology CHU Hedi Chaker Sfax Tunisia. All patients are assessed for erect...

ea0081ep502 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Obesity and lifestyles related to diabetes during COVID-19 pandemic

Regufe Virginia

Diabetes is mainly a consequence of the lifestyle of the current population, characterized by an increase in obesity, sedentarism and a highly caloric diet, added to which is an ageing population. Prevention and its treatment consist in following an adequate diet, practising physical exercise regularly and maintaining normal weight, factors which are achieved through the adoption of healthy lifestyles. However, weight loss remains a problematic issue among diabetics, mainly du...

ea0081ep503 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Inadequate iodine intake in lactating women in the inland area of norway

Aarsland Tonje Eiane , Kaldenbach Siri , Solvik Beate Stokke , Bakken Kjersti S. , Strand Tor Arne

Background: Many studies in Norway have found inadequate iodine status in pregnant and lactating women, but no studies have been undertaken in a random, population-based sample. Globally, the main strategy to eliminate iodine deficiency is iodization of salt. However, this is not compulsory in Norway, where the current legislation only permits iodization up to 5 μg per gram of salt. To reach the Nordic Nutrition Recommendation (NNR) of 200 μg/day iodine, supplements ...

ea0081ep504 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Metabolic burden in mediterranean patients with schizophrenia and psychotic disorders

Missaoui AbdelMouhaymen , Jdira Salem , Trimeche Oumeyma , Hsine Houda , Abbes Wafa , Khochtali Ines

Introduction: Mortality among patients with schizophrenia and psychotic disorders(SAPD) is two to threefold higher than in the general population and is widely attributed to cardiovascular and metabolic morbidity.Objectives: We aim to highlight the metabolic profile of Mediterranean patients diagnosed with SAPD.Methods: We conducted a descriptive and analytical cross-sectional study involving 55 patients who attended the psychiatry...

ea0081ep505 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hepatic steatosis and cardiovascular risk in type 2 diabetes

Bani Ines , Ali Zohra Hadj , Dalhoum Meriam , Htira Yosra , Mami Feika Ben

Introduction: Non-alcoholic fatty liver disease (NAFLD), is a frequent cause of chronic liver disease and is widely associated with metabolic syndrome. When associated with diabetes, it can increase the risk of cardiovascular events. The aim of this study is to evaluate the relationship between hepatic steatosis and the occurrence of cardiovascular events in patients with type 2 diabetes.Method: It is a retrospective study, including 184 type 2 diabetic ...

ea0081ep506 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Clinical and biochemical outcomes of sodium-glucose co-transporter-2 (SGLT2) inhibitors in type 2 diabetes mellitus patients as a fourth oral anti diabetic medicine

Saleem Muhammad , Ram Nanik , Khan Sajjad Ali

Objectives: to evaluate the clinical and biochemical effects of (SGLT2) inhibitors as a fourth oral anti-diabetic drug in patients with type 2 diabetes mellitus (T2DM).Patients (Materials) and Methods: In a tertiary hospital in Karachi, Pakistan, a retrospective assessment of patient medical records was conducted from January 1, 2017 to December 31, 2020.A total of 100 patients (mean age [Standard Deviation]: 53.8 [9.63] years) with poorly controlled T2D...

ea0081ep507 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Verapamil can be used as a type 2 diabetes mellitus saviour and stopping the need for insulin in uncontrolled type 2 diabetes mellitus

Younis Mahmoud

Introduction: Diabetes mellitus is not just a disease as it is already known, the matter is more complicated, and it is considered as an assembly of metabolic defects with end result of hyperglycemia. verapamil can decrease the expression of thioredoxin-interacting protein (TXNIP), which is recognized as an important factor in pancreatic beta cells. verapamil could enhance beta cell mass and function.Materials and methods: 160 type 2 diabetes mellitus an...

ea0081ep508 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Therapeutic optimization of type 2 diabetes: what role of the pharmacist?

Memou Asmaa , Matmour Derouicha , Fetati Habiba , Mekaouche Nadjet Fatima Zohra , Boudia Fatma , Toumi Houari

Introduction: Type 2 diabetes is a chronic disease whose management is characterized by the complexity of its therapeutic axes (methods of taking, storage of drugs, adverse effects, compliance with treatment, etc.), which requires the patient to be well informed to avoid the onset of complications. Faced with this issue, the pharmacist could make a real contribution.Goal: The objective of this work was to assess what role the pharmacist could play in the...

ea0081ep509 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Is Semaglutide superior than Liraglutide in patients with type 2 diabetes on insulin therapy? - case presentation

Mickovski Ivana , Buklioska-Ilievska Daniela , Milosheska Radmila , Hasan Taner

Type 2 diabetes (T2DM) is a chronic and progressive disease associated with microvascular and macrovascular complications leading to increased morbidity and mortality. Insulin remains the cornerstone therapy for longer-duration T2DM and b-cell failure. Glucagon-like peptide-1 receptor agonists are a class of multifactorial T2DM medications that have been shown to improve numerous risk factors for diabetes-related complications, including glycemic control, reduction in body wei...

ea0081ep510 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

A weight loss of 20 kg on liraglutide

Abdillahi Mohamed Hamid , Boutheina Mohamed Ali , Mohamed Aicha Ahmed , Rifai Kaoutar , Gharbi Mh

Introduction: Liraglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist, approved for the treatment of adult patients with type 2 diabetes mellitus of a particular interest in the significant improvement of glycaemic, systolic blood pressure and lipid control with their impact on weight, making it possible to avoid this infernal spiral of weight gain-increased insulin resistance.Observation: 55-year-old female patient, known diabetic for 10 years...

ea0081ep511 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association between cortisol/DHEA-S ratio and inflammatory indicators in patients with non-functioning adrenal incidentalomas

Kowalska Joanna , Zielen-Zynek Iwona , Nowak Justyna , Włodarczyk Aleksander , Hudzik Bartosz , Zubelewicz-Szkodzińska Barbara

Introduction: It is well known that DHEA and DHEA-S has and impact on lipid metabolism, cardiovascular system and others. De Castro et al. showed that cortisol/DHEA-S ratio was an independent predictor of long-term mortality in patients with sepsis. Chronic inflammation is an important factor in cardiovascular diseases development that reduce quality and life expectancy. CVDs are more common in patients with adrenal incidentaloma than in general population. Literature data on ...

ea0081ep512 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Omega 6 and 3 intake in depressive patients

Othman Rym Ben , Gamoudi Amel , Mizouri Ramla , Amor Nadia Ben , Loukil Insaf , Souissi Cyrin , Berriche Olfa , Mahjoub Feten , Jamoussi Henda

Background: several studies show a ralation between the lack of omega 6 and 3 and the developpement of depression. in other hand, there is a modification in the food behaviors in case of depression which can lead to the persistance of symptoms so the intake of omega 6 and 3 should be assessed for every depressive patientMethods: 50 patients whith depression were involved in our study. They were recruited from outpatient department in a psychiatric hospit...

ea0081ep513 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Nutritional status in patients with heart failure and its relation with cardiac function

Alzas Teomiro Carlos Manuel , maria moyano sanchez Ana , Munoz Jimenez Concepcion , Idougourram Soraya Leo n , Aguilera Jose Lo pez , Crespin Manuel , Puerta Maria Jose Molina , Moreno Maria Angeles Ga lvez , Martinez Aura Herrera

Background: Heart failure (HF) has a rising incidence and is one of the most prevalent diseases worldwide. Serum NT-proBNP and systolic ejection fraction correlate with the severity and prognosis of this condition. The nutritional evaluation of patients with HF, who usually have normal weight, overweight or obesity, has acquired a novel approach due to the incorporation of novel techniques (bioelectrical impedance, nutritional ultrasonography), and functional tests.<p clas...

ea0081ep514 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

25(OH)D vitamin D status and anthropometric parameters among patients hospitalized in geriatric department

Nowak Justyna , Jabczyk Marzena , Hudzik Bartosz , Zubelewicz-Szkodzińska Barbara

Introduction: Vitamin D deficiency is observed across all age groups and both sexes. Moreover vitamin D deficiency is common in elderly especially along elderly patients. Elderly people are prone to develop of vitamin D deficiency caused by various factors such as deceased dietary intake, impaired intestinal absorption, reduced sunlight exposure, impaired skin synthesis as well as impaired hydroxylation in the liver and kidneys. Vitamin D deficiency may leads to rickets, osteo...

ea0081ep515 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diplopia, a sign of diabetes: A case report

Mizouri Ramla , Othman Rym Ben , Amor Nadia Ben , Mahjoub Faten , Amri Abir El , Amorri Amany , Olfa Berriche , Henda Jamoussi

Introduction: Diabetes mellitus is the leading cause of neuropathy worldwide. Non-retinal diabetic complications including oculomotor damage represent 1 to 3% of ocular manifestations of diabetes. The affected oculomotor nerves are essentially the external oculomotor nerve (VI), the common oculomotor nerve (III), and more rarely, the pathetic nerve (IV).Observation: We report the case of a patient referred to our department for additional management of r...

ea0081ep516 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Treatment Induced Neuropathy in Diabetes: Case Report

Tong Chin Voon , Wong Poh Shean

Introduction: Treatment-induced neuropathy of diabetes (TIND) is a small fibre neuropathy precipitated by rapid correction of chronic hyperglycemia. Methods: We report two patients who developed TIND after rapid improvement of glycaemic control. Results: 21-year-old gentleman, underlying type 2 DM diagnosed since 2017. He was not compliant to insulin therapy and defaulted follow up. His Hba1c ranged from 16.6%-19%. In July 2020, he...

ea0081ep517 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Trigger finger complicating diabetes: a case report

Farah Kamel , Gorgi Khaoula , Azriouil Manal , Rifai Kaoutar , Iraqi Hind , El Gharbi Mohamed Hassan

Introduction: Trigger finger is a stenosing tenosynovitis in which constriction of the tendon sheath is associated with the presence of a nodule on the flexor tendon of the finger. This is an often unrecognised complication in the diabetic patient. We report the case of a diabetic patient with a complication of trigger finger.Observation: A 55 year old female patient, known to be diabetic for 10 years and treated with a basal-bolus insulin therapy regime...

ea0081ep518 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation between pulse wave velocity and nephropathy in type 2 diabetes

Besrour Chayma , Imen Rojbi , Habib Ben Ahmed , Sabrine Mekni , Nadia Mchirgui , Ibtissem Ben Nacef , Karima Khiari

Introduction: Nephropathy is a kidney complication that affects up to 50% of people with diabetes during their lifetime. Diabetes is the first cause of kidney failure. The aim of this study was to examine the relationship between diabetic nephropathy (DN) and arterial stiffness.Methods: We conducted a prospective study including 249 diabetic patients without macroangipathic complications, between July 2020 and May 2021. Using a SphygmoCor®XCEL devic...

ea0081ep519 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

‘Relationship between of the quality of life indicators and neuromarker S100 in patients with type 2 diabetes mellitus on program hemodialysis’

Kholikov Alisher , Yulduz Urmanova

The purpose of the study: is to assess the quality of life of patients with type 2 diabetes before treatment with hemodialysis using the WHO Brief Questionnaire for the Assessment of Quality of Life (WHOQOL-BREF) and the Hamilton Depression Scale, taking into account the degree of neuromarker S100.Material and methods: We examined in total for the period from January 1, 2018 to January 1, 2021 - 90 patients suffering from type 2 diabetes mellitus with ch...

ea0081ep520 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Obesity and diabetes mellitus as predictors of adverse course of COVID-19 infection

Dydyshka Yuliya , Shepelkevich Alla , Efremava Mariya , Lobashova Veranika , Brutskaya-Stempkovskaya Elena

According to WHO epidemiological data, there are more than 650 million obese people in the world, the medical and social significance of which is determined by the development and aggravation of insulin resistance. Accumulation of experience in the treatment of patients with COVID-19 infection has demonstrated that obesity and diabetes mellitus are important risk factors affecting the clinical severity of inflammatory disease - for impaired function of β-cells along with ...

ea0081ep521 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

India epidemiological mapping study- attempt at early screening - early intervention

Saboo Bharat , Shrivastav Abhishek , Inamdar Aniket , Sai J Jayaprakash , Tewari Ajoy , Hasnani Dhruvi , Chavda Vipul , Dariya Dr S S , Choudhary Rupam

Background: Hypertension is the most important chronic condition leading to cardiovascular complications in India. Lack of awareness and epidemiological data is the reason for inertia for primordial, primary and secondary prevention. Education, region epidemiological mapping and early screening and intervention can help benefit the population in terms of cardiovascular morbidity and mortality.Aims & Objectives: To gather, analyze and intervene a larg...

ea0081ep522 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Gut microbiota genera regarding carbohydrate metabolism status and GLP-1 treatment

Caudet-Esteban Jana , Trelis-Villanueva Maria , Rubio-Almanza Matilde , Camara-Gomez Rosa , Francisco Merino-Torres Juan

Introduction and Objetive: The composition of human gut microbiota is an emerging field of research and is currently regarded as pathophysiologically linked to obesity. However, we still lack a thorough understanding of what constitutes health and disease in this subject. We present herein a descriptive study of the gut microbiota composition among Spanish morbidly obese subjects, clustered regarding the carbohydrate metabolism status (CHMS) displayed.Me...

ea0081ep523 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

HbA1c evaluation predicting hyperglycaemia and avoiding morbidity in steroid initiation

Maher Philip , Durkan Maeve

Introduction: Steroids can precipitate significant hyperglycemia and Diabetes Mellitus in vulnerable populations including DM, pre-DM and the elderly. Steroid risks include deterioration in DM, glucose toxicity, HONK and HHS. This may be avoided by a simple screening HbA1c, which could prompt a ‘safeguard algorithm’ for the patients including instruction in glucose monitoring. The ‘at risk’ cohort is identified, and a surveillance regime is implemented. </p...

ea0081ep524 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Insulin resistance: in type 1 diabetes

Camara M'ballou , Ettalibi Fatiha , Rafi Sana , MGHARI Ghizlane EL , Ansari Nawal EL

Introduction: Insulin resistance is one of the characteristic abnormalities of type 2 diabetes. Recently it has been recognized that type 1 diabetes may also present with insulin resistance of varying intensity. We report a case of insulin resistance in a patient with type 1 diabetes.Observation: The patient was 23 years old, with a history of type 1 diabetes since the age of 20, with positive antibodies against GAD (glutamate acid decarboxylase), reveal...

ea0081ep525 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Neurognic osteoarthropathy: place of Biphosphonates (one case report)

Kamgain Simeu Lionel Steve , Amal Mjabber , Haraj Nassim Essabah , Aziz Siham El , Chadli Asma

Introduction: Charcot’s foot is a rare and extremely serious complication of diabetic neuropathy resulting in foot deformities through the non-infectious destruction of bones and joints. Its diagnosis is very difficult, it is often evoked in front of the persistence of inflammatory signs in spite of a well conducted antibiotic therapy.Case report: 59-year-old patient, T2DM for 3 years on Metformin, active smoker for 20 years. Reports for 1 week the ...

ea0081ep526 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Does the initial daily insuline dose vary with the amount of glycated hemoglobin

Zemni Zeineb , Ghamgui Wissal , Raja Daii , Yamoun Rihab , Salem Amal , Abadlia Salma , Hedfi Imen , Jemaii Chaima , Htira Yosra , Mami Faika Ben

Introduction: Insulin therapy remains a treatment of last resort for type 2 diabetic patients with uncontrolled diabetes with oral antidiabetic. The aim of this study was to find a correlation between the initial dose of insulin and the glycated hemoglobin (A1c) level.Methods: We conducted a cross sectional study. We included 63 patients with type 2 diabetes hospitalized for a switching to insulin in the C department of diabetology and nutrition at the N...

ea0081ep527 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effective treatment of allergy to the insulin excipient meta-cresol with desensitization therapy in type 1 diabetes mellitus: a case report.

Terzi Ameni , Yazidi Meriem , Grassa Anis , Khessairi Nadia , Grira Wafa , Oueslati Ibtissem , Chihaoui Melika

Introduction: Insulin allergy is a clinical challenge in the management of type 1 diabetes mellitus since there is no other therapeutic alternative. The specific cause of insulin allergy can be related to insulin itself or to additives including zinc, protamine and meta-cresol. The manifestations range from localized reactions to systemic severe anaphylaxis. We here present the case of a generalized allergy to insulin excipient meta-cresol, in a type 1 diabetic patient success...

ea0081ep528 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Should the Fracture Risk Assessment tool be used without Bone Mineral Density in elderly patients having type 2 diabetes mellitus ?

Belkhiri Malak , Fadia Boubaker , Salem Houda Ben , Brahem Mouna , Mrabet Houcem , Wafa Alaya , Baha Zantour , Younes Mohamed , Habib Sfar Mohamed

Introduction: Osteoporosis and diabetes are two chronic diseases with increasing prevalences, particularly among elderly. Their coexistence results in socio-economic burdens. Clinical and paraclinical assessment for fracture risk among diabetic eldery patients are necessary to implement in clinical practice. Appropriate tools shoud to be determined and tested.Objective: To assess comorbidities and fracture risk in elderly patients having type 2 diabetes ...

ea0081ep529 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Risk factors associated with symptomatic hypoglycemia in type 2 diabetes mellitus patients

Inamdar Aniket

Background: Diabetes mellitus is an emerging global epidemic and is the main illness threatening human health in 21st century. The target clinical outcomes in patients with type 2 diabetes mellitus (T2DM) is good control of HbA1C less than 7 %. However, aggressive treatment is needed to achieve this target in some patients. But this aggressive treatment predisposes patients to a higher risk of hypoglycemia that become a major hurdle in achieving glycemic goal in these patients...

ea0081ep530 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Degenerative complications of diabetes during the switch to insulin

Mehrzi Amal , Abir El Amri , Amani Amorri , Olfa Berriche , Faten Mahjoub , Nadia Ben Amor , Rim Ben Othmen , Ramla Mizouri , Henda Jamoussi

Introduction: Type 2 diabetes is a chronic, silent disease. Patients with diabetes could experience complications during the evolution of their disease. We studied the presence of degenerative complications during the initiation of insulin.Methods: Cross-sectional study including a group of patients with type 2 diabetes requiring a switch to insulin, hospitalized at the A department of Diabetology and Nutrition in the National Institute of Nutrition of T...

ea0081ep531 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Type 1 diabetes, metabolic syndrome and cardiovascular risk

Mohamed Ahmed Mohamed Abdellahi , Salah Dhoha Ben , Soomauroo Siddiqa , Elleuch Mouna , Mnif Mouna , Mejdoub Nabila , Akid Faten Haj Kacem , Abid Mohamed

Introduction: Metabolic syndrome (MS) is responsible for the increased cardiovascular risk in type 2 diabetics, but few studies have looked at the metabolic syndrome in type 1 diabetics. The aim of This study is to evaluate the prevalence of microvascular and macrovascular complications and evaluate the cardiovascular risk among patients with T1DM associated with metabolic syndrome.Materials and Methods: Retrospective study which included 36 type 1 diabe...

ea0081ep532 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

A case of idiopathic postprandial syndrome in a middle-aged nigerian woman

Jesuyajolu Damilola , Mohammed Abdulhafeez , Okeke Charles , Nicholas Armstrong

Introduction: Not much has been reported about Idiopathic Postprandial syndrome, especially in Africa. Many cases are often wrongly diagnosed as reactive hypoglycemia. Idiopathic postprandial syndrome refers to signs and symptoms of hypoglycemia in the absence of low blood sugar occurring after meals and is of unknown cause. Clinical case: We report a case of Idiopathic Postprandial Syndrome in a 44-year old woman living in Nigeria. We present a 44-year-...

ea0081ep533 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of a high calorie diet on the ileum histology of Psammomys Obesus

Guezil Asma , Bellahreche Zineb , Ouahiba Benmessaoud- Mesbah , El hadj Ahmed Koceir

Obesity is associated with low-grade systemic inflammation, indeed the production of pro-inflammatory cytokines by mesenteric adipose tissue has been implicated in the pathogenesis of inflammatory diseases of the small intestine: duodenum, jejunum and ileum. This is the main site of intestinal inflammation. The objective of this work is to study the effect of a high calorie diet on the histology of the ileum in Psammomys obesus. The animals were captured in the area o...

ea0081ep534 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Esophagogastroduodenoscopy Findings in a group of morbidly obese patients undergoing bariatric surgery

Khalaf Rahma , Mahjoub Faten , Amor Nadia Ben , Berriche Olfa , Jamoussi Henda

Background: Studies of morbid obese patients undergoing bariatric surgery (BS) have revealed that obesity is related with an increased prevalence of endoscopic and histologic gastritis. Performing esophagogastroduodenoscopy (EGD) prior to BS allows the detection and treatment of Helicobacter pylori (H.pylori) infection which is considered to be limiting access to bariatric surgery.Aim: The aim of this study was to determine the prevalence of gastric lesi...

ea0081ep535 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of metabolic syndrome in obese children and adolescents

Safi Eya , Olfa Berriche , Khaoula Ben Ali , Rachdi Rim , Lajili Olfa , Ouderni Imen , Amor Nadia Ben , Mahjoub Faten , Henda Jamoussi

Introduction: The metabolic syndrome is a major public health problem. Its prevalence is constantly increasing, especially in children and adolescents. Our objective was to determine the prevalence of metabolic syndrome in a population of obese children and adolescents.Method: This is a descriptive cross-sectional study including 47 children and adolescents recruited at the obesity unit of the National Institute of Nutrition in Tunis. Each patient underw...

ea0081ep536 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The role of hypothalamus mediators in energy imbalance.

Khaydarova Feruza , Latipova Maftunakhon

Obesity is considered a chronic metabolic disease that occurs at any age. Regulation of body weight in the body is carried out through complex interaction of a complex of interrelated systems that control the body’s energy system. Energy imbalance is the cause of obesity and overweight, in which the supply of energy from food exceeds the energy needs of the body. Obesity is closely related to impaired appetite regulation, and hypothalamus is a key place of neural regulati...

ea0081ep537 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Biochemical parameters in laboratory diagnostics of metabolic syndrome

Moskalenko Olga , Kasparov Edward

MS, is defined by a combination of abnormalities, such as obesity, arterial hypertension, elevated blood sugar and cholesterol levels, type 2 diabetes mellitus and is not a disease, but represents a group of risk factors that often occur together, increasing the likelihood of severe disease. It is well known that the main reasons for the increase in the incidence of MS is a decrease in physical activity with a high-calorie diet. The aim of the study: Ass...

ea0081ep538 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Vologdàs Regional Diabetes Center - equal care for everyone

Kholmskaia Nina , Kalugina Valentina Victorovna

Vologda is situated in the North-Western region of Russian Federation. It is mostly rural – about 30% of population lives in remoted villages. One can compare Vologdàs region with Greece – same amount of land area (approximately 140000 m2), but the population density is 10 times less (8 per km2 and 85 per km2 respectively). The Vologdàs region population is approximately 1151000, the amount of Diabetes patients is 42 000 (3,7% of overall population). The te...

ea0081ep539 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

High prevalence of pre-diabetes and diabetes in asymptomatic patients attending an endocrine clinic in a tertiary care institute in Colombo.

Ranathunga Ishara , Naveenkumar J P , Athukorala T G , Sumanatilleke Manilka , Somasundaram Noel

Background and Objectives: The prevalence of pre-diabetes and diabetes has risen exponentially in the recent past. Though the symptomatic patients frequently undergo testing for the diagnosis of the disease, asymptomatic individuals are not routinely subjected to diagnostic testing. Thus, data on asymptomatic people are still lacking. We have studied the prevalence of pre-diabetes and diabetes in asymptomatic subjects attending the Endocrinology clinic in a tertiary care insti...

ea0081ep540 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The Evaluation of the quality of life questionnaire of patients with autoimmune polyglandular type 2 syndrome

Khalimova Zamira , Negmatova Gulzoda

The purpose of the study is to assess the quality of life of patients with autoimmune polyglandular type 2 syndrome using the questionnaire.Material and research methods: Under our observation there were the following 2 groups of patients: 1 gr. - patients with PAI with AIT (primary adrenal insufficiency and autoimmune thyroid) - 25 patients, 2 gr. - PAI with DM 1 (type 1 diabetes mellitus type 1 - 30 patients, as well as 20 healthy pers...

ea0081ep541 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Rickettsiosis in diabetics: a Case Report

Chaimae Kadiri , Hassan Lachkar

Introduction: Rickettsia diseases are infectious, re-emerging, polymorphic, potentially fatal diseases that are widespread worldwide. These are diseases caused by strict intracellular bacteria with a Gram-negative stain associated with arthropods, mainly ticks, but also lice, fleas and other mites. In diabetics, adequate and early management is essential given the risk of developing malignant Mediterranean spotted fever.Observation: We report the case of...

ea0081ep542 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Leo-Bueger’s disease: a rare cause of gangrene in diabetics

Chaimae Kadiri , Hassan Lachkar

Introduction: Leo Burger’s thromboangiitis obliterans ‘TALB’ is a rare inflammatory, segmental and occlusive disease affecting small and medium-sized arteries and the veins of the extremities of the limbs. It is more common in males and its major aggravating factor is smoking.Observation: We present the case of a 66-year-old patient with a history of chronic smoking at a rate of 25 packs per year, known type 2 diabetic for 10 years, well b...

ea0081ep543 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Type 1 diabetes in autoimmune polyendocrinopathy

Bammou Sanaa , N'Koua Severin , Rafi Sana , Mghari Ghizlane El , Ansari Nawal El

Introduction: Type 1 diabetes is accompanied by a high frequency of autoimmune diseases.The aim: of this study is to determine the different epidemiological, clinical, immunological and therapeutic aspects of Type 1 Diabetes in Autoimmune Polyendocrinopathy and to analyze the results obtained.Patients and methods: This is a retrospective study of 44 patients with type 1 diabetes, suffering from Autoimmune Polyendocrinopathy and fol...

ea0081ep544 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hospitalization in a diabetes unit

Sdiri Chaima , Htira Yosra , Msolly Skander , Cheikhrouhou Maryam , Ali Zohra Hadj , Jemai Chaima , Imene Hedfi , Mami Feika Ben

Introduction: Diabetes is a chronic disease. Its management may require frequent hospitalization. The aim of our study was to determine hospitalization reasons in the diabetic department of The National Institute of Nutrition of Tunis.Method: It was a prospective study conducted in the department of diabetology in the National Institute of Nutrition in Tunis for three months. The study was carried out on the medical records of hospitalized patients.<...

ea0081ep545 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Pegylated Interferon induced Latent Autoimmune Diabetes Mellitus of Adults(LADA) in acute setting is not uncommon

Mlawa Gideon , Smith Chrisopher , Bell Janessa , Rehmani Hassan , Bashir Mahamud , Patel Shrini , Elsayed Haythum , Saleem Muhammad , Hussain Musarat

Background: Pegylated interferon-alpha (IFN-α) is licensed as an antiviral, immunomodulatory and anti-proliferative therapy, but may induce autoimmune conditions including Type 1 diabetes Mellitus/latent Autoimmune Diabetes of Adults (LADA). Case Report: A 50-year-old male presented with a 3-week history of polyuria, polydipsia and weight loss. Following review by his General Practitioner he was found to have an elevated serum glucose (55.4 mmol/l)....

ea0081ep546 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Case report: The HAIR-AN syndrome

Bammou Sanaa , Rafi Sana , Mghari Ghizlane EL , Ansari Nawal EL

Introduction: The HAIR-AN syndrome, which consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN), is an underdiagnosed endocrinopathy.Observation: We report the case of Miss A.M., 24 years old, admitted for exploration of hyperandrogenism. Anamnesis: the patient reported polyuropolydipsic syndrome and the notion of weight gain without eating disorders, making a total of 28 kg in 6 months. This period is also marked by th...

ea0081ep547 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Familial hypercholesterolemia: a case report

Khaoula Gorgi , Farah Kamel , Echchad Lamya , Kaoutar Rifai , Hinde Iraqi , Mohamed El Hassan Gharbi

Introduction: Familial hypercholesterolemia is an autosomal dominant genetic disease linked to a mutation in 3 genes involved in the catabolism of LDL particles. It is characterized by an exclusive increase in low-density lipoproteins (LDL). It is associated with a high risk of premature cardiovascular complications. We report the case of a patient with familial hypercholesterolemia.Case: 44-year-old patient, From a first-degree consanguineous marriage, ...

ea0081ep548 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Methods to measure the mitochondrial toxicity in mouse kidney stem cell by toxicant

Lee Minsu , Kim KangMin , Lee Jimin , Kim YongIn , Jeung Eui-Bae

Mitochondria play an important role in generating energy, and they are essential to cell survival. Mitochondria have varieties of functions, such as regulating intracellular calcium concentration and signal transduction, controlling hormone synthesis, inflammatory responses, and free radicals. In particular, this research is interested in the mitochondria in kidney tubular cell. Since mitochondria in tubular cells play an important role in supplying energy, removal of waste an...

ea0081ep550 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Correlation between the markers of peripheral arterial disease, albuminuria, dyslipidemia with the change in HbA1c in patients with T2DM

Rohatgi Ragini , Kudkar Pooja , Alfred Daisy

Introduction: We explored utility of ankle-brachial index (ABI), toe brachial index (TBI), Albumin Creatinine Ratio (ACR), Low Density Lipoprotein Cholesterol (LDL-C) in context with change in HbA1c Methods: We conducted an observational study in 25 T2DM on standard care in real world settingResults: The mean follow up (months) was 19.2 (&pm;6, range 12). The mean age (years) was 57 (&pm;12, 95% CI 52 to 63). Initially 36% (9/25) h...

ea0081ep551 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Dopplerography and neuromarker BDNF indicators correlation in patients with diabetic neuropathy at the later complications stage’

Kamalov Telman , Alimkhanov Olimkhon

The purpose of the study is to study the correlation bond indicators of ultrasonic doppler and neuromarker BDNF in blood in patients with diabetes mellitus type 2 (DM 2) with diabetic neuropathy at the later complications stageMaterial and research methods: A study was conducted 215 patients with DM 2, of which 160 persons suffering from diabetic neuropathy (DNP) in the late complications stage. The following groups of patients were formed: 1 gr. - patie...

ea0081ep552 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

‘The Echocardiography data of patients with type 2 diabetes mellitus complicated by cardio-renal syndrome’

Alimova Kamola

The purpose of the study is to study the Echocardiography dataof patients with type 2 diabetes mellitus complicated by 4 type cardio-renal syndrome Material and methods: We examined in total for the period from October 1, 2021 to December 1, 2021 - 25 patients suffering from type 2 diabetes mellitus with chronic renal disease (CRD) and chronic cardial insufficiency (CCR). The research methods included: 1) general clinical (study of endocrine, neurologica...

ea0081ep553 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

‘The results of the Echo-cardiographic investigations in patients with diabetic foot syndrome and chronic heart failure’

Kamalov Telman , Khaydarov Muzaffar

The purpose of the study is to study the echo-cardiographic disorders in patients with diabetic foot syndrome (DFS) and chronic heart failure (CHF)Material and methods: The study was conducted in 62 patients with SDS treated in the department of surgical diseases and civil defense of the Andijan State Medical Institute in 2019 - 2021. The following groups of patients were formed: 1 gr - patients with DM 2Type and the neuroichemic form of DFS and HSN-31 p...

ea0081ep554 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

‘The Hemodynamic indicators in patients with diabetic foot syndrome and chronic heart failure’

Kamalov Telman , Khaydarov Muzaffar

The purpose of the study is to study the Hemodynamic indicators in patients with diabetic foot syndrome (DFS) and chronic heart failure (CHF) Material and methods: The study was conducted in 62 patients with SDS treated in the department of surgical diseases and civil defense of the Andijan State Medical Institute in 2019 - 2021. The following groups of patients were formed: 1 gr - patients with DM 2 Type and the neuroichemic form of DFS and HSN-31 patie...

ea0081ep555 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

‘Biochemical indicators in patients with type 2 diabetes mellitus in hemodialysis’

Teshabekova Mokhira

The purpose of the study is to study biochemical indicators in patients with type 2 diabetes in hemodialysisMaterial and methods: The study was carried out in 30 patients with type 2 diabetes mellitus (DM 2) treated in the Diabetic Nephropathy Department 2019 - 2021. Healthy volunteers (n= 20) amounted to a control group. The paper included general-clinical, clinical and biochemical, hormonal, immunological methods of blood testing, as well as i...

ea0081ep556 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

‘The renal dysfunction indicators of the patients with severe complications of diabetic foot syndrome(ulcer, gangrene, amputation) and chronic kidney disease’

Shokirov Khamidulla , Kamalov Telman

The purpose of the study is to study the results of the biochemical investigation of the patients with diabetic foot syndrome and chronic kidney disease (CKD). Material and research methods: A study was conducted 60 patients with diabetes mellitus type 2 (DM 2) with diabetic foot syndrome (DFS) in the late complications stage accociated with chronic kidney disease. All observed patients will be divided into 3 groups:1 gr. - 20 pati...

ea0081ep557 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

‘Anamnestic indicators in patients with severe complications of diabetic foot syndrome (ulcer, gangrene, amputation) with chronic kidney disease of various stages’

Shokirov Khamidulla , Kamalov Telman

The purpose of the study is to study the anamnestic indicators in patients with severe complications of diabetic foot syndrome with chronic kidney disease of various stages Material and research methods: A study was included 85 patients with DM 2 with diabetic foot syndrome (DFS) in the late complications stage accociated with chronic kidney disease (CKD). All observed patients will be divided into 4 groups:1 gr. - 22 patients with...

ea0081ep558 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Characteristics of dyslipidemia in a group of patients with diabetes

Mehrzi Amal , Wiem Saadi , Haifa Abdesslem , Abir El Amri , Imen Sebai , Kamilia Ouneissa , Rim Yahyaoui , Asma Ben Brahim , Chiraz Amrouche

Objective: Dyslipidemia represents an added factor of cardiovascular risk for patients with diabetes. The objective of this work was to study the characteristics of dyslipidemia in a group of patients with diabetes.Methods Cross-sectional study including a group of patients with diabetes associated with dyslipidemia, during a period of 6 months, admitted in the day hospital unit of the National Institute of Nutrition of Tunis. The data was collected by c...

ea0081ep559 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Treatment adherence in Type 2 Diabetes: Experimental study research project

Regufe Virginia

Summaries: Treatment adherence in Type 2 Diabetes: Experimental study research project Diabetes is a metabolic disease brought about by high levels of glicose in the blood over a long period of time. It’s a disease which shows an increasing incidence, mainly in developed countries. When untreated, diabetes can cause several acute complications, such as ketoacidosis, hyperglycemic hyperosmolar state or even death. Prevention and treatment consist in ...

ea0081ep560 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Long-term-high-fat/high-carbohydrate-diet-induced subcutaneous adipose tissue inflammation in gerbil model (Gerbillus tarabuli)

Bellahreche Zineb , Guezil Asma , Dahmani Yasmina

Obesity results from an imbalance between energy intake and expenditure. The WHO has considered it as a chronic disease which is associated with many complications, such as insulin resistance, metabolic syndrome, etc. It is defined as an abnormal or excessive accumulation of body fat that can harm health. The distribution of this fat (visceral and subcutaneous), the size of the adipocytes and the inflammatory state of the adipose tissue are of great importance in the progressi...

ea0081ep561 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Source of folic acid in obesity patients in the Odessa region (Ukraine)

Zhygalina-Hritsenyuk Maria , Gozhenko Anatoly

Introduction: Obesity is known to be a disease of civilization. Both genetic and environmental factors play a role in the development of obesity. In the vast majority of cases, the main factor is eating disorders and hypodynamy. The modern human exceeds daily food demand mainly due to saturated fats and refined carbohydrates, with lack of fibre and vitamin. We decided to test the source of folic acid, because this vitamin is part of the folate cycle as a coenzyme to reduce hom...

ea0081ep562 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Cardio-metabolic profile of morbid obesity compared to moderate and severe obesity

Zemni Zeineb , Bornaz Emna , Alaya Nadia , Lajili Olfa , Yamoun Rihab , Safi Eya , Khaoula Ben Ali , Amor Nadia Ben , Mizouri Ramla , Othman Ryme Ben , Berriche olfa , Mahjoub Faten , Jamoussi Henda

Introduction: Obesity is the disease of modern society whose prevalence continues to increase.The aim of this study was to compare the cardio-metabolic profile of morbid obesity with that of moderate to severe obesity.Methods: It was a retrospective study conducted at the obesity unit of the national institute of nutrition in Tunis including 174 obese patients We divided the population into two groups. Group 1 (G1) with morbid obes...

ea0081ep563 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetic ketoacidosis in pregnant women with type 1 DM and Covid 19

Cornejo Dominguez Jesus Manuel , Barea Almudena Lara , Gavira Isabel Maria Mateo , Tinoco Cristina Lopez

Introduction: Diabetes is a recognized risk factor for the development of complications in COVID-19 infection, with an increased incidence of ketoacidosis observed in patients admitted to hospital.Case Reports: We present the case of a patient with type 1 DM complicated by diabetic retinopathy and unplanned pregnancy (pregestational Hba1c 9.1%). In follow-up during pregnancy: progression of retinopathy and fetal renal pyeloectasia in morphological ultras...