Endocrine Abstracts

Introduction: Metabolic disorders are a relevant cause of morbidity and disability in patients with Cushing’s syndrome (CS) even after a successful treatment. The aim of our study was to assess the prevalence of metabolic syndrome in our CS patients, as central obesity, dyslipidemia, diabetes, and hypertension, and to discuss the main adverse effects of CS on metabolism and emphasize the importance of long-term monitoring and treatment of these complications.Patients and MethodsIt’s a retrospective and descriptive review of thirty-four patients records presenting Cushing’s syndrome. They were divided according to waist circumference, lipid, glucose and tension profiles, before and after treatment.

Results: 45% of our patients had dysglycemia,30% had dyslipidemia, and 23% had arterial hypertension with a pathological waist circumference, a mean age of 29.3 years old, and a female predominance. A decrease of this disorders after surgery or medical treatment were also noted.

Conclusion: Glucocorticoid excess leads to increased dysglycemia, dyslipidemia, visceral adiposity, and hypertension, which together delineate the metabolic syndrome, and increase cardiovascular morbidity and mortality. Treatment modalities and rapidity of controlling hypercortisolism is of paramount importance and have varied impacts on metabolic disorders.

Keywords: Cushing’s syndrome; Metabolic syndrome; Dysglycemia; Dyslipidemia; Hypertension; Obesity.