Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Eposter Presentations

Calcium and Bone

ea0081ep132 | Calcium and Bone | ECE2022

Association of preoperative therapy by native form vitamin D and hypocalcemia after parathyroidectomy in primary hyperparathyroidism patients

Elfimova Alina , Eremkina Anna , Rebrova Olga , Kovaleva Elena , Mokrysheva Natalia

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder resulting from oversecretion of parathyroid hormone (PTH) in parathyroid glands. Hypocalcemia can occur in the postoperative period after parathyroidectomy (PTE) and can be challenging to control and requires varying doses of supplementation. Vitamin D deficiency can worsen the severity of PHPT and promote the development of “hungry bone syndrome” due to increased influx of calcium into bon...

ea0081ep133 | Calcium and Bone | ECE2022

Metabolic parameters in patients with primary hyperparathyroidism before and after parathyroidectomy

Bibik Ekaterina , Dobreva Ekaterina , Miliutina Anastasia , Elfimova Alina , Eremkina Anna , Mokrysheva Natalia

Background: Metabolic syndrome may be the nonclassical feature of primary hyperparathyroidism (PHPT) because an increased incidence of various glucose and lipid disorders is often observed in patients with this disease. Earlier we showed PHPT patients had higher serum triglycerides and higher rate of insulin resistance compared to the control group. Dynamics of metabolic parameters after surgery is ambiguous.The aim: of this study was to compare metaboli...

ea0081ep134 | Calcium and Bone | ECE2022

«Hungry bone» syndrome in delay diagnosed primary hyperparathyroidism with fibrocystic osteitis: A case report

Pogosian Karina , Yanevskaya Lubov , Mikhailova Arina , Semenova Alisa , Ryzhkova Daria , Belousova Lidia , Tsoy Uliana , Karonova Tatiana

Background Fibrocystic osteitis is rare PHPT manifestation. Poor management and delay in diagnosis of fibrocystic osteitis may lead to reduced quality of life and also provoke severe postoperative hypocalcemia – «hungry bone» syndrome.Clinical case We present a case of 66-years-old Caucasian woman, with history of urulithiasis/nephrocalcinosis (CKD stage 4), two pathological fractures, and fibrocystic osteitis. In Jan 2021...

ea0081ep135 | Calcium and Bone | ECE2022

Abstract Withdrawn...

ea0081ep136 | Calcium and Bone | ECE2022

Quality of life improvement as a valuable outcome of parathyroidectomy in patients with symptomatic and asymptomatic primary hyperparathyroidism

Nikitina Tatiana , Buzanakov Dmitry , Gladkova Inna , Rusakov Vladimir , Chernikov Roman , Karelina Yulia , Efremov Sergey , Ionova Tatiana

Background Comprehensive evaluation of the effect of surgery in patients with primary hyperparathyroidism (PHPT) and monitoring of patient’s well-being after treatment including assessment of patient-reported outcomes is worthwhile.AIMWe aimed to assess changes in quality of life (QoL) and symptoms in patients with symptomatic and asymptomatic PHPT after surgery (parathyroidectomy, PTX).Materials and methods.Adult patients wit...

ea0081ep137 | Calcium and Bone | ECE2022

Glomerular filtration rate 12 months after parathyroidectomy in patients with primary hyperparathyroidism

Elfimova Alina , Eremkina Anna , Rebrova Olga , Kovaleva Elena , Miliutina Anastasia , Mokrysheva Natalia

Background: In some patients with primary hyperparathyroidism (PHPT), glomerular filtration rate (GFR) demonstrate decrease after parathyroidectomy (PTE). GFR may decrease immediately after surgery due to general anesthesia, but after a month not all patients restore kidney function; a decreased GFR is also observed after 1–2 years after surgery.Aim: To find the pre-surgical factors of GFR decrease after PTE.Methods: Patients ...

ea0081ep138 | Calcium and Bone | ECE2022

A comparison study of sublingual spray versus peroral capsules and oil in vitamin d supplementation

Sausa Sintija , Aleksejeva Marija , Trapina Ilva , Pirags Valdis

Background: Vitamin D is a vital hormone for calcium metabolism, bone and muscle health, and immune responses. Vitamin D deficiency affects entire Latvian population.Aim: To compare the effectiveness of different forms of vitamin D.Materials and methods: In a prospective, open-label, randomized study in the Jaunliepaja Primary Health Care Centre, data from 98 vitamin D deficient volunteers over one month at initiation of substituti...

ea0081ep139 | Calcium and Bone | ECE2022

«Physician to physician» telemedicine consultations in parathyroid pathology: experience of quaternary endocrinological medical center

Gorbacheva Anna , Fadeyeva Maria , Eremkina Anna , Mokrysheva Natalia

Introducton: Telemedicine consultations (TMC) are a useful tool for ensuring communication between medical specialists, especially in a large country and in the era of COVID-19. It is important to study the needs and possibilities of TMC for various diseases, in particular, for the pathology of the parathyroid glands.Materials and methods: TMC between regional health specialists and Endocrinology Research Centre (Moscow, Russian Federation) were conducte...

ea0081ep140 | Calcium and Bone | ECE2022

Practical approach for hypocalcemia in infants: earlier diagnosis, earlier management

Alassaf Abeer

Background: Hypocalcemia is a serious condition that occurs at any age with various etiologies according to various age groups. Hypocalcemia in infant is an emergency condition and the exact etiology should be identified as early as possible to ensure early appropriate management.Methods: We are presenting 3 cases for infants who presented with seizures caused by hypocalcemia.Case 1: A 3-month-old male infant presented with apnea a...

ea0081ep141 | Calcium and Bone | ECE2022

Mediastinal parathyroid lipoadenoma as a cause of primary hyperparathyroidism

Dominguez Jesus Manuel Cornejo , Suarez Alvaro Vidal , Gavira Isabel Maria Mateo , Rodriguez Maria del Mar Roca , Barea Isabel Maria Torres

Introduction: The parathyroid gland is made up of principal cells and oxyphilic cells, surrounded by stroma, whose main component is adipose tissue, which accounts for 25% of the content of the parathyroid in adults. In parathyroid adenomas, prominent parathyroid cellularity can be observed, with a very marked decrease in the stroma. Parathyroid lipoadenoma is a rare variant of parathyroid adenoma, characterized by hyperfunctioning parathyroid cells in an abundant fatty stroma...

ea0081ep142 | Calcium and Bone | ECE2022

Brown Tumors as a first sign of secondary hyperparathyroidism

Boudina Maria , Zouli Chrysanthi , Zisimopoulou Eleana , Fotiadou Aimilia , Stamati Mariana , Christantoniou George , Balodimou Chrysanthi , Chrisoulidou Alexandra

Aim: Brown tumors are a very rare and serious complication of sustained undiagnosed secondary hyperparathyroidism. Diagnosis and differential diagnosis are made by combining clinical, biochemical, radiological and pathological findings. We present the case of a male with chronic renal disease and multiple bone damage.A 58-year-old male was referred to the endocrine clinic because of lower back and pleural pain. He was an obese smoker with a heavy medical...

ea0081ep143 | Calcium and Bone | ECE2022

Bilateral neck exploration is comparable to preoperative visualization methods in searching for parathyroid adenomas on the neck

Buzanakov Dmitrii , Semenov Arseny , Sleptsov Ilya , Chernikov Roman , Novokshonov Konstantin , Karelina Yuliya , Uspenskaya Anna , Gorskaya Nataliya , Alekseyeva Svetlana , Timofeyeva Nataliya , Chinchuk Igor , Fedorov Elisey , Malyugov Yuriy , Rebrova Dina , Shikhmagomedov Shamil , Sablin Ilya , Dzhumatov Timur , Lyubimov Mikhail , Pushkaruk Alexander , Gerasimova Kseniya , Zolotukho Anna , Bubnov Alexander

Background Undetected multiglandular disease (MGD) is a leading cause of persistent primary hyperparathyroidism after surgical treatment. There is still a number of clinically significant parathyroid adenomas that remain unseen preoperatively.Materials and methods A retrospective cohort study was conducted in order to reveal factors associated with risk of MGD. 810 cases of pHPT patients who had received primary surgical treatment at SPBU Hospital in 201...

ea0081ep144 | Calcium and Bone | ECE2022

Serum calcium, magnesium and phosphorus levels in patients with coronavirus disease 2019: an analysis of their relationship with poor outcome and mortality

Diez Juan Jose , Iglesias Pedro , Garcia Agustin , Casasempere Ignacio Martin , Bernabeu-Andreu Francisco A

Purpose: To assess the impact of serum corrected calcium (CorrCa), magnesium (Mg) and phosphorus (P) levels at hospital admission on SARS-CoV-2 infection outcome.Methods: In this retrospective study, all adult patients with laboratory-confirmed COVID-19 hospitalized in Hospital Universitario Puerta de Hierro Madadahonda during 2020 were included. Demographic, clinical and laboratory data were registered and related to the prognosis of the disease. Poor o...

ea0081ep145 | Calcium and Bone | ECE2022

Autosomal dominant hypocalcaemia type 1 with intact PTH and relative hypocalciuria.

Rashid Razan Ali , Quinton Richard , Joshi Ashwin

Autosomal Dominant Hypocalcaemia (ADH) type 1 is caused by activating mutations of the calcium-sensing receptor (CaSR) gene. Although a rare condition, the exact prevalence is uncertain as patients are asymptomatic and, historically, were sometimes diagnosed with hypoparathyroidism (HPT) due insensitivity of earlier PTH assays and failure to check urinary calcium. The consequences of an erroneous diagnosis of HPT in patients with ADH can be profound, as treatment with calcium ...

ea0081ep146 | Calcium and Bone | ECE2022

Quality of life in chronic hypoparathyroidism on conventional treatment

Gins Nikolay , Elfimova Alina , Kovaleva Elena , Eremkina Anna , Mokrysheva Natalia

Introduction: Reduced health-related quality of life (HRQoL) is common in patients with hypoparathyroidism (HypoPT) treated conventionally with calcium and active vitamin D supplements.Aim: we studied the HRQoL in patients with chronic HypoPT estimated with the 36-Item Short-Form Health Survey (SF-36) and multidimensional fatigue inventory (MFI-20).Methods: 64 patients with chronic HypoPT (women/men – 57/7, median age 47[36;59...

ea0081ep147 | Calcium and Bone | ECE2022

25-hydroxyvitamin D, parathyroid hormone and bone turnover markers in patients with addison disease

Salah Dhoha Ben , Boujelben Khouloud , Missaoui Abdelmouhaymen , Elleuch Mouna , Fatma Mnif , Mnif Mouna , Charfi Nadia , Majdoub Nabila Rekik , Akid Faten Haj Kacem , Abid Mohamed

Introduction: Patients with Addison disease require lifelong glucocorticoid replacement treatment and it is recommended that glucocortiocoid therapy should be monitored in these patients to avoid over replacement and minimize long-term consequences of bone loss. The present study was carried out with the aim of evaluating bone turnover markers in patients with Addison disease.Patients and methods: A cross sectional study including 50 patients who are fol...

ea0081ep148 | Calcium and Bone | ECE2022

Pregnancy and lactation induced osteoporosis – a social media based survey

Peltz-sinvani Naama , Ish-Shalom Sophia , Vered Iris , Tripto-Shkolnik Liana

Background: Pregnancy and lactation induced osteoporosis (PLO) presenting as spinal fractures in late pregnancy or early postpartum period is a rare condition. The risk factors and pathophysiology are still incompletely understood. The impact of the disorder on the young mother’s quality of life can be profound, further aggravated by a delay in diagnosis and treatment that often occurs.Aim: To delineate clinical parameters related to fractures in a ...

ea0081ep149 | Calcium and Bone | ECE2022

Bone mineral density in patients with addison disease versus congenital adrenal hyperplasia

Lavrador Mariana , Araujo Barbara Filipa , Carreira Ana , Paiva Sandra , Barros Luisa , Paiva Isabel

Introduction: The treatment of Primary Adrenal Insufficiency involves the chronic use of glucocorticoids. The balance between the dose needed to supply the cortisol deficit and the possible consequences of overtreatment is a challenge. In patients with Addison disease (AD), androgens deficiency is an additional factor for osteoporosis.Objective: To evaluate if there are differences in bone mineral density (BMD) in patients with Addison’s disease ver...

ea0081ep150 | Calcium and Bone | ECE2022

SuperJump training in eumenorrheic women and gut peptides: a randomized controlled study about the mechanism of action on bone and glucose homeostasis

Amato Alessandra , Vasto Sonya , Proia Patrizia , Baldassano Sara

The role played by physical activity in promoting bone health is now widely recognized. Physical activity limits and slows down the physiological demineralization that occurs over the years and plays an important role in the prevention of osteoporosis. SuperJump, a high-impact training activity performed on a mini-trampoline characterized by alternating between aerobic and anaerobic exercises, has been shown to be able to generate a substantial osteogenic response and increase...

ea0081ep151 | Calcium and Bone | ECE2022

Sex differences of the reaction of undercarboxylated osteocalcin to hypoglycaemia

Pospisilova Hana , Duškova Michaela , Kolatorova Lucie , Jandikova Hana , Starka Luboslav

In recent years, there has been increasing evidence for the hypothesis of bones as endocrine organs. Osteocalcin, long considered just a marker of new bone formation, is now seen as the first hormone produced by bones, and seems to be associated with regulating glucose metabolism and reproduction. The aim of this work was to monitor changes of osteocalcin in reaction to hypoglycaemia, and determine if there are differences in such reactions between the sexes. The study include...

ea0081ep152 | Calcium and Bone | ECE2022

Teriparatide for hypoparathyroidism after bariatric surgery

Maggio Ettore , Morgante Cesare , Ramunno Vittoria , Corsello Andrea , Cera Gianluca , Pontecorvi Alfredo , Corsello Salvatore Maria

Background: Hypoparathyroidism is an endocrine disorder characterized by hypocalcemia due to low levels of parathyroid hormone (PTH). Activated vitamin D (calcitriol) and calcium supplementation may be difficult in patients with malabsorption, as calcium requires an acid environment to dissolve. In this setting, subcutaneous administration of PTH analogues may be effective in reducing the dosage of oral calcium and vitamin D supplementation.Case report: ...

ea0081ep153 | Calcium and Bone | ECE2022

The parathyroid carcinoma manifesting during pregnancy

Sazonova Daria , Bibik Ekaterina , Gorbacheva Anna , Eremkina Anna , Mokrysheva Natalia

Background: Parathyroid carcinoma (PC) is a rare cause of primary hyperparathyroidism (PHPT) and extremely rare endocrine malignancy during pregnancy. Different maternal and fetal/neonatal complications of PHPT occur in 67 and 80% of untreated cases respectively, probably more due to severe hypercalcemia.The diagnostic and therapeutic approaches are limited in pregnant women and require individual risk-benefit assessment.Aim: We present a case of PC mani...

ea0081ep154 | Calcium and Bone | ECE2022

Clinical outcomes of COVID-19 infection in rare bone and mineral disorders

Zurita Ana Luisa Priego , Bryce Jillian , Brandi Maria-Luisa , Glasberg Simona , Pereira Alberto M , Sangiorgi Luca , Schalin-Jantti Camilla , van den Akker Erica , Ahmed Faisal , Appelman-Dijkstra Natasha

Background The European Registries for Rare Endocrine Conditions and the European Registries for Rare Bone and Mineral Conditions were created in collaboration with the European Reference Networks for Rare Endocrine and Bone Disorders (Endo-ERN and ERN BOND). Following the onset of the COVID-19 pandemic in 2020, the registries, together with the ESE RD Committee, have collected the occurrence of confirmed and suspected cases of COVID-19 in patients with rare endocrine and bone...

ea0081ep155 | Calcium and Bone | ECE2022

Prevalence of anemia in patients with primary hyperparathyroidism: a single-center observational study

Gorbacheva Anna , Miliutina Anastasia , Elfimova Alina , Eremkina Anna , Mokrysheva Natalia

Background The combination of primary hyperparathyroidism (PHPT) with anemia was first described in 1931. It remains unclear whether PHPT is the direct cause of anemia, or it develops as a PHPT’s complication. The etiology of anemia in PHPT could be multifactorial, including iron deficiency, renal failure as well as bone marrow fibrosis.Aim To assess the prevalence of anemia in patients with PHPT admitted to the Department of Parathyroid Glands Path...

ea0081ep156 | Calcium and Bone | ECE2022

Late diagnosis of life-threatening hypocalcemia in a patient with hypoparathyroidism after hemithyroidectomy: A case report

Maghakyan Sona , Vardanyan Anna , Ghazaryan Ara , Aghajanova Elena

Introduction: Hypocalcemia is defined as a decreased level of calcium in the blood. The presentation of hypocalcemia varies widely, from asymptomatic to life-threatening. The most common cause of chronic hypocalcemia is postsurgical hypoparathyroidism. This may occur after removal of all parathyroid tissue during thyroidectomy and radical neck dissection for malignancies or after inadvertent interruption of the blood supply to the parathyroid glands during head and neck surger...

ea0081ep157 | Calcium and Bone | ECE2022

Vitamin D and bone metabolism in Graves’ disease. A prospective study

Khamisi Selwan , Lundquist Martin , Rasmusson Annica , Engstrom Britt Eden , Karlsson F Anders , Ljunggren Osten

Objective: Vitamin D and osteoporosis in Graves’ disease (GD) have previously been examined in cross-sectional studies with partly divergent results. Here, we prospectively studied vitamin D metabolism and bone health in patients with newly diagnosed GD.Methods: Thirty consecutive patients with de novo overt thyrotoxicosis diagnosed with GD were included. None of the patients at diagnosis were treated with vitamin D supplementation or anti ...

ea0081ep158 | Calcium and Bone | ECE2022

Milk-alkali syndrome in a patient with chronic hypoparathyroidism

Cidade-Rodrigues Catarina , Chaves Catarina , Cunha Filipe , Martinho Mariana , Almeida Margarida

Introduction: Milk-alkali syndrome is defined by the triad hypercalcemia, metabolic alkalosis and renal impairment, due to intake of calcium salts and absorbable alkali. It is the 3rd leading cause of hypercalcemia but often underdiagnosed. Patients with chronic hypoparathyroidism after total thyroidectomy have increased risk for this potentially life-threatening complication and its epidemiology is unclear. We present a case of milk-alkali syndrome in a patient with chronic h...

ea0081ep159 | Calcium and Bone | ECE2022

Long term treatment with teriparatide in hypoparathyroidism

Spada Antonio , Bosco Daniela , Santonati Assunta

Hypoparathyroidism is, in Italy, an orphan disease because the hormonal replacement therapy is possible only with teriparatide (fragment 1–34 of of human parathyroid hormone). Otherwise the patients use oral calcium and calcitriol. This scheme of therapy obtained correct plasmatic calcium and phosphate levels, correct urinary excretion of calcium and phosphate, adequate quality of life – QoL only in a little percentage of patients. Especially kidney stones, intra-ren...

ea0081ep160 | Calcium and Bone | ECE2022

Clinical evidence for the benefits of burosumab therapy in two adult cases of X-Linked Hypophosphatemia

Dinoi Elisa , Pierotti Laura , Mazoni Laura , Borsari Simona , Pardi Elena , Cetani Filomena , Marcocci Claudio

X-linked hypophosphatemia (XLH), representing about 80% of hypophosphatemic rickets, is an X-linked dominant disease due to inactivating mutations in the PHEX gene (located at Xp22.1) resulting in an excessive secretion of the phosphaturic hormone fibroblast growth factor 23 (FGF23). The effects are renal phosphate wasting and reduced active vitamin D synthesis leading to rickets, osteomalacia, bone deformities, odontomalacia, frequent dental abscesses and disproporti...

ea0081ep161 | Calcium and Bone | ECE2022

Abstract Withdrawn...

ea0081ep162 | Calcium and Bone | ECE2022

Hypophosphatemia in patients with primary hyperparathyroidism

Amodeo Alessandro , Dito Giorgia , Guabello Gregorio , Longhi Matteo , Corbetta Sabrina

Osteoporosis management increased determination of serum calcium (Ca) levels, and detection of hypercalcemia in the set of out patients. Serum phosphate (P) levels are less frequently measured in osteometabolic patients. Primary hyperparathyroidism (PHPT) is the most common cause of hypophosphatemia. However, hypophosphatemia receives poor attention during the PHPT diagnostic work up, and also data in literature are scanty. We retrospectively reviewed the clinical records from...

ea0081ep163 | Calcium and Bone | ECE2022

Primary hyperparathyroidism: what is the impact on bone ?

Zarraa Lamiae , Berrabeh Soumiya , Laalaoua Yousra , ROUF Siham , Latrech Hanane

Key words: Primary hyperparathyroidism-PTH level –osteoporosis-osteolytic bone lesions-brown tumorIntroduction: Primary hyperparathyroidism is a frequent pathology responsible for an alteration of the phosphocalcic metabolism at the origin of numerous complications, in particular osseous. The objective of this work is to evaluate the bone impact of primary hyperparathyroidism in our series.Matériel et m&#...

ea0081ep164 | Calcium and Bone | ECE2022

The clinical presentation of primary hyperparathyroidism during the Covid-19 pandemic

Castellano Elena , Borretta Giorgio , Pellegrino Micaela , Tassone Francesco , Craparo Andrea , Baffoni Claudia , Gianotti Laura

Background: In the last decades, the clinical profile of PHPT in Western Countries has changed from a highly symptomatic to a largely asymptomatic disease. However, a substantial stability in its clinical features has been reported in the last two decades. The usual management, including time to diagnosis and treatment, of PHPT during the Covid-19 pandemic has been changed and likely slowed down. Whether further changes in the clinical presentation of PHPT have occurred during...

ea0081ep165 | Calcium and Bone | ECE2022

Reduced bone mineral density in primary adrenal insufficiency: consequences of long-term treatment

Araujo Barbara Filipa , Lavrador Mariana , Araujo Catia , Ferreira Mafalda , Barros Luisa , Paiva Sandra , Paiva Isabel

Introduction: The effects of long-term replacement therapy of primary adrenal insufficiency (PAI) are still a matter of debate. Glucocorticoid (GC) replacement regimens do not completely mimic the endogenous hormonal production and their monitoring is sometimes difficult. Therefore, some patients are exposed to mild GC excess with potential complications, such as hypertension, diabetes, and skeletal fragility. Data on bone mineral density (BMD) in PAI is still scarce and contr...

ea0081ep166 | Calcium and Bone | ECE2022

Endocrinopaties in thalassemia patients

Ozer Ozge , Yorulmaz Goknur , Ozgeyik Mufide Okay , Teke Hava Uskudar , Gunduz Eren

Objectives: Disorders concerning the endocrine system may be seen in patients with transfusion-dependent thalassemia major. It is thought that iron accumulated in the organs, especially with transfusion, causes this. In our study, we tried to reveal a relationship by comparing the iron parameters of these patients with various endocrine parameters.Methods: Our study is a retrospective study.The data of 18 thalassemia major patients who applied to Osmanga...

ea0081ep167 | Calcium and Bone | ECE2022

Classical complications of primary hyperparathyroidism

Zarraa Lamiae , Laalaoua Yousra , Berrabeh Soumiya , ROUF Siham , Latrech Hanane

Key words: Primary hyperparathyroidsm-Bone complications-Renal complications and digestive complications.IntroductionPrimary hyperparathyroidism is a frequent endocrinopathy whose diagnosis is biological and linked to an inappropriate secretion of parathyroid hormone (PTH), wich leads to an altered phosphocalcic metabolism that can be responsible for numerous complications. The aim of this work is to evaluate the classical complica...

ea0081ep168 | Calcium and Bone | ECE2022

Hypercalcemia in sarcoidosis unmasked by treatment with Vitamin D

Kejem Helmine , Williams Scott , George Emmanuel , Chiu Yee Ho , Shankar Upendram Srinivas

We present the case history of a 62 year old male, who was recently diagnosed with sarcoidosis which was confirmed on biopsy of a calf nodule. CT scan revealed pulmonary involvement. Our patient had low vitamin D 12 nmol/l (nr 50–100) and initial adjusted calcium was 2.48 mmol/l (2.13–2.63). DEXA bone density scan revealed osteopenia. He was commenced on loading dose of colecalciferol 40,000 units weekly and received 3 doses. He presented 1 month later with polydipsi...

ea0081ep169 | Calcium and Bone | ECE2022

Expanding the phenotype of Familial hypocalciuric hypercalcemia type 3

Baraf Lior , Averbuch Noa , Carmon Lior , Szalat Auryan , Sukenik-Halevy Rivka , Fraenkel Merav

Introduction: Familial hypocalciuric hypercalcemia (FHH) is a rare mostly asymptomatic genetic disorder affecting the calcium sensing receptor (CaSR) and its associated proteins with autosomal dominant inheritance. Mutation in AP2S1 gene is responsible for FHH3.Aim: Expand the phenotype of FHH type 3.Methods: Clinical and biochemical characterization of a patient with de-novo FHH3 mutation.Results: S...

ea0081ep170 | Calcium and Bone | ECE2022

Vitamin D levels in relationship to thrombotic markers in severe Sars-CoV-2 infection

Kostoglou-Athanassiou Ifigenia , Athanassiou Lambros , Nikolakopoulou Sofia , Konstantinou Alexandra , Mascha Olga , Samaras Charilaos , Athanassiou Panagiotis

Introduction Severe infection from the SARS-CoV-2 virus is associated with various manifestations, including hematological manifestations. Thrombotic events or a tendency to develop thrombotic events also characterize severe COVID-19 disease and may be related to fatalities. Vitamin D is known to have immunomodulating properties and to enhance the body defense system against invading pathogens and to have immunostimulatory properties as far as the innate immune response is con...

ea0081ep171 | Calcium and Bone | ECE2022

A sporadic case of pseudohypoparathyroidism type Ib and fahr’s syndrome

Araujo Catia , Ferreira Mafalda Martins , Araujo Barbara Filipa , Lavrador Mariana , Baptista Carla , Bastos Margarida , Paiva Isabel

Introduction: Pseudohypoparathyroidism is a heterogeneous disease characterized by hypocalcemia, hyperphosphatemia and parathyroid hormone resistance. The distinct pseudohypoparathyroidism types are distinguished by physical features, the coexistence of other hormone resistances and genetic defects. Pseudohypoparathyroidism type Ib is more often associated with sporadic cases, unlike others types.Clinical Case: Male, born in France, diagnosed with pseudo...

ea0081ep172 | Calcium and Bone | ECE2022

Acute hypercalcemic crisis in an elderly with granulomatous disease

Tiu Jr Leo , Capellan Maria Leonora

Background: Tuberculosis rarely leads to clinically significant hypercalcemia. However, elderly patients remain predisposed due to advanced age, multiple comorbidities and polypharmacy.Clinical Case: An 81-year-old female presented with 1 month history of bilateral weak hand grip and sluggish mastication. She was initially managed as progressive Parkinson’s Disease. After 3 weeks, she was now reported to have episodes of fall from imbalance. After f...

ea0081ep173 | Calcium and Bone | ECE2022

Palovarotene for the treatment of fibrodysplasia ossificans progressiva: methodology of the phase III open-label PIVOINE rollover trial

Artyomenko Alexander , Houchard Aude , Zemam Azzeddine

Objectives: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by heterotopic ossification (HO) and progressive restriction of mobility. To date, no approved disease-modifying treatments for FOP exist, but interim phase III trial (NCT03312634) results suggest marked efficacy for palovarotene (PVO).1 Here, we describe methodology of the PIVOINE trial (NCT05027802) designed to allow treatment continuity and further evaluation o...

ea0081ep174 | Calcium and Bone | ECE2022

McCune Albright syndrome – a clinician’s challenge and a multidisciplinary approach: case report

Iftimie Mădălina Elena , Burcea Iulia Florentina , Moise Mihnea-Nicolae , Deculescu Rareş-Ştefan , Budulucă Larisa , Poiana Catalina

Introduction: McCune-Albright syndrome is a rare, heterogenous disorder, consisting of at least two of the following three features: polyostotic fibrous dysplasia, café-au-lait skin pigmentation and autonomous endocrine hyperfunction. We present the case of a patient with an atypical presentation of McCune Albright syndrome (MAS) and severe fibrous dysplasia lesions.Case report: An 18-year-old girl diagnosed with MAS (at the age of four) was referre...

ea0081ep175 | Calcium and Bone | ECE2022

Differences between atypical parathyroid adenomas and parathyroid adenomas in patients with primary hyperparathyroidism

Aydemir Ensar , Ates Coskun , Unsal Yasemin Aydoğan , Hocaoglu Erhan , Saridas Filiz Mercan , Cander Soner , Gul Ozen Oz , Ersoy Canan , Erturk Erdinc

Background: Atypical parathyroid adenoma (APA) is a rare disease that can be challenging to distinguish from benign parathyroid adenoma. APA shows some laboratory and histopathological features with parathyroid cancer. This study attempts to compare clinical, laboratory, radiologic and histopathological characteristics in APA and parathyroid adenoma (PA).Methods: This was a retrospective study was based on the database of eighty-two subjects who underwen...

ea0081ep176 | Calcium and Bone | ECE2022

PTH 1–34 delivery via insulin pump in a patient with severe post-operative hypoparathyroidism

Dinoi Elisa , Mazoni Laura , Pierotti Laura , Apicella Matteo , Marcocci Claudio , Cetani Filomena

Hypoparathyroidism (HypoPT) is the only hormone deficiency syndrome whose standard treatment is not based on the replacement of the missing hormone. Although most cases of postsurgical HypoPT can be effectively managed with the conventional use of oral calcium and active vitamin D (SOC therapy), some patients require very high doses and develop complications such as hypercalciuria, renal stones, nephrocalcinosis and ectopic calcifications. In the last few years, recombinant hu...

ea0081ep177 | Calcium and Bone | ECE2022

Identification of GATA3 pathogenic variants in two patients with hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome

Dinoi Elisa , Pierotti Laura , Mazoni Laura , Borsari Simona , Apicella Matteo , Baldinotti Fulvia , Caligo Maria Adelaide , Marcocci Claudio , Cetani Filomena

Hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome, also known as Barakat syndrome, is a rare autosomal dominant disease characterized by the triad of hypoparathyroidism (H), deafness (D) and renal abnormalities (R). Its genetic cause is known to be the haploinsufficiency of the zinc finger transcription factor GATA3. This disorder exhibits a great clinical variability and an age-dependent penetrance of each feature. The most frequent manifestation is sen...

ea0081ep178 | Calcium and Bone | ECE2022

Sickle cell disease and hyperparathyroidism: case report

Jridi Maysam , Mekni Sabrine , Meriem Adel , Rojbi Imen , Nacef Ibtissem Ben , Mchirgui Nadia , Khiari Karima

Introduction: Primary hyperparathyroidism (pHPT) is a common endocrine disorder usually diagnosed by the presence of elevated serum calcium levels with inappropriate normal or increased parathyroid hormone (PTH) serum levels. This condition has been reported in few cases of patients with sickle cell disease (SCD), a multisystem disorder with acute and chronic complications.Observation: We report a case of a 63-year-old Tunisian woman with a history of ho...

ea0081ep179 | Calcium and Bone | ECE2022

Primary hyperparathyroidism revealed by a brown tumor: a case report

Khaoula Gorgi , Farah Kamel , Lamya Echchad , Kaoutar Rifai , Hinde Iraqi , El Hassan Gharbi Mohamed

Introduction: Brown tumors are osteolytic lesions rarely revealing hyperparathyroidism. They result from abnormalities of bone metabolism. They usually occur in the terminal stage of hyperparathyroidism. We report the case of a patient with hyperparathyroidism revealed by a brown tumor.Case: A 39-year-old female patient with no notable medical history who presented for 1 year a mandibular swelling progressively increasing in size after a dental extractio...

ea0081ep180 | Calcium and Bone | ECE2022

Primary hyperparathyroidism revealed by acute pancreatitis: a case report

Khaoula Gorgi , Farah Kamel , Ghita Khamel , Lamya Echchad , Kaoutar Rifai , Hinde Iraqi , El Hassan Gharbi Mohamed

Introduction: Primary hyperparathyroidism (PPH) can be complicated by pancreatitis. The frequency of association of primary hyperparathyroidism with pancreatitis is rare, varying between 1.5% and 7%. We report the case of a patient with hyperparathyroidism revealed by acute pancreatitis.Case: A 78-year-old patient, without any particular history, who consulted the emergency room for an acute digestive picture with abdominal pain and bilious vomiting, an ...

ea0081ep181 | Calcium and Bone | ECE2022

Small and foudroyant parathyroid carcinoma with lung metastasis and no local invasion at diagnosis

Grigorie Daniel , Ghemigian Mircea , Ioachim Dumitru , Florescu Cristina , Sucaliuc Alina

Parathyroid carcinoma (PC) rarely presents with metastasis at diagnosis and usually in patients also having gross local invasion.Case presentation: We report the case of a 51-year-old postmenopausal woman presenting at our institution in June 2019 with symptomatic hypercalcemia (fatigue, polyuria, constipation and bone pain), but with a surprisingly good general condition. She had been treated with bisphosphonates for osteoporosis (DXA: LS T score &#8722...

ea0081ep182 | Calcium and Bone | ECE2022

Aberrant promoter methylation, expression and function of RASSF1A gene in a series of Italian parathyroid tumors

Verdelli Chiara , Pio Fabrizio Federico , Tavanti Giulia Stefania , Maroni Paola , Morotti Annamaria , Guarnieri Vito , Pardi Elena , Cetani Filomena , Scillitani Alfredo , Maggiore Riccardo , Vaira Valentina , Muscarella Lucia Anna , Corbetta Sabrina

Aberrant epigenetic features occurring in parathyroid tumors involve DNA methylation, histone methylation, and non-coding RNAs. RASSF1A and APC were frequently downregulated in human cancers. Here, we investigated RASSF1A and APC methylation status in a series of parathyroid tumors from Italian patients with primary hyperparathyroidism (PAds, n=80), confirming RASSF1A and APC promoter methylation as a hallmark of sporadic parathyroi...

ea0081ep183 | Calcium and Bone | ECE2022

Prediction of 25-hydroxy vitamin D status by serum alkaline phosphatase (ALP) value.

Ranathunga Ishara , Naveenkumar J P , Sumanatilleke Manilka , Somasundaram Noel

Background and Objectives: The low vitamin D status in an individual leads to a compensatory increase in serum parathyroid hormone (PTH) level giving rise to secondary hyperparathyroidism. The elevated PTH will conserve calcium excretion from the kidneys in the expense of excreting phosphate. Thus, serum calcium levels tend to remain normal until the latter stages of vitamin D deficiency. PTH action on the bone to reabsorb more calcium from the bone lead to elevation of bone a...

ea0081ep184 | Calcium and Bone | ECE2022

The short test with active metabolites of vitamin D in differential diagnosis between primary normocalcemic and secondary hyperparathyroidism for inpatient treatment

Karaseva Elena , Eremkina Anna , Elfimova Alina , Gorbacheva Anna , Bibik Ekaterina , Kovaleva Elena , Mokrysheva Natalia

Objective: Normocalcemic primary hyperparathyroidism (PHPT) is a phenotype of PHPT characterized by normal serum calcium and persistently increased parathyroid hormone (PTH) after exclusion of secondary causes of PTH elevation.The aim: of this study was to investigate the capability of the short test with active metabolites of vitamin D for differential diagnosis between normocalcemic PHPT and secondary hyperparathyroidism (SHPT) for inpatient treatment....

ea0081ep185 | Calcium and Bone | ECE2022

Evaluation of response to alendronate treatment on osteoporosis using cathepsin K and other biomarkers

Novac Roxana , Costin-Ioan Popescu , Valentin-Adrian Cotirlet

Background: Osteoporosis has been an excruciating disease for many years now. Although various treatments are available, there is an unmet need for disease prognosis, early disease diagnosis and prediction of treatment efficacy. New biomarkers are crucial for the diagnosis or prognosis of a disease as well as for monitoring treatment efficacy and improve decision making. Cathepsin K is a cysteine protease that cleaves collagen type I, the major type of collagen found in bone, ...

ea0081ep186 | Calcium and Bone | ECE2022

Bone tissue metabolism in children with dystrophic form of congenital epidermolysis bullosa before and during therapy with cholecalciferol.

Pronina Irina , Makarova Svetlana , Murashkin Nikolay , Semikina Elena , Chumbadze Tamara

Introduction: Malnutrition, deficiency of micro- and macronutrients, including calcium and vitamin D are typical for children with dystrophic form of congenital epidermolysis bullosa (DEB). Thereby, there is a slowdown in osteogenesis and in stimulation of osteoclast activity, bone tissue resorption, which leads to increased bone fragility and low-traumatic fractures.Aim of the study: To evaluate markers of bone tissue metabolism and phosphorus-calcium m...

ea0081ep187 | Calcium and Bone | ECE2022

A special case of type Ib pseudohypoparathyroidism

Chaimae Kadiri , Samah Amhager

Introduction: Pseudohypoparathyroidism type Ib are genetic diseases with transmission maternal, defined by a resistance to the action of the parathormone without resistance to the TSH. Clinical manifestations are variable and depend on the severity of hypocalcaemia. We report the case of a patient presenting with type Ib pseudohypoparathyoidia.Observation: This is a 9-year-old child admitted for care and exploration of a severe hypocalcaemia. The patient...

ea0081ep188 | Calcium and Bone | ECE2022

Chronic bone pain revealing a parathyroid adenoma

Chaimae Kadiri , Hassan Lachkar

Introduction: Primary hyperparathyroidism is an endocrinopathy characterized by the excessive secretion of parathyroid hormone, most commonly associated with parathyroid adenoma. The osteoarticular manifestations of hyperparathyroidism are currently exceptional. The diagnosis is most often established at the asymptomatic stage by measuring calcium levels and parathyroid hormone.Observation: We report the case of a 67-year-old patient with a history of pa...

ea0081ep189 | Calcium and Bone | ECE2022

Bilateral pathologic fracture of the femur in brown tumor İnduced parathyroid carcinoma

Sarıdaş Filiz Mercan , Aydemir Ensar , Ates Coskun , Hocaoğlu Erhan , Cander Soner , Gul Ozen Oz , Ersoy Canan , Erturk Erdinc

Introduction: Brown tumor refers to the skeletal change that develops as one of the complications of hyperparathyroidism, in which cystic and fibrous changes occur in the bone. It occurs in approximately 10−20% of patients with primary hyperparathyroidism. Parathyroid cancer is a rare cause of primary hyperparathyroidism and accounts for approximately 1% of cases. In some cases, hyperparathyroidism may be asymptomatic until it becomes a pathological fracture and may be t...

ea0081ep190 | Calcium and Bone | ECE2022

Giant cells and a hungry bone: a diagnostic and therapeutic challenge.

Nanjundaswamy Rashmi , Navalgund Sunil , Mallarajapatna Govindarajan , Bindiganavile Srimant Srinivas , Venkataraman Hema

Introduction: Brown tumours (BT) are a recognised complication of severe prolonged untreated hyperparathyroidism (HPT). BT can mimic bone metastases and giant cell tumors (GCT). Hungry bone syndrome (HBS) is a severe and prolonged, postoperative hypocalcemia following parathyroidectomy. BT are a risk factor for HBS. We report the case of a young lady with BT masquerading as a GCT, from a tertiary centre in India.Case study: A 25 year lady presented with ...

ea0081ep191 | Calcium and Bone | ECE2022

Primary hyperparathyroidism in the setting of previous roux-en-Y gastric bypass: a case report

Monte Lavinia , Tuccinardi Dario , Strollo Rocky , Briganti Silvia , Rausa Donatella , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Introduction: Primary hyperparathyroidism (PHPT) after roux-en-Y gastric bypass (RYGB) is poorly described. The diagnosis can be difficult as secondary hyperparathyroidism(SHPT) commonly occurs in patients after RYGB due to calcium hypoabsorption and vitamin D deficiency.Observation: We present the case of a 50-year-old female with a history of normocalcemic hyperparathyroidism and nephrolithiasis. In 2005 the patient had undergone RYGB. During the first...

ea0081ep192 | Calcium and Bone | ECE2022

Fahr Syndrome secondary to pseudohypoparathyroidism.

Shehu Tea , Hoxha Violeta , Ylli Dorina , Ylli Agron

Background: Fahr’s Syndrome, also known as striopallidodentate calcinosis is a rare form of neurological disorder characterized by abnormal calcified deposits in basal ganglia, cerebellar and cerebral cortex. Its prevalence goes from 2 to 12.5%. Etiology of this disorder is very wide and involves endocrinopathy, mitochondrial myopathies dermatological abnormalities, infectious disease or may be idiopathic. We present a case of a patient with diffuse brain calcifications d...

ea0081ep193 | Calcium and Bone | ECE2022

Late hypocalcaemia complicating the management of papillary thyroid carcinoma

Abidi Ihssane , Rifai Kaoutar , Hinde Iraqi , Gharbi Mohamedelhassan

Introduction: COVID-19 is a pandemic related to SARS-COV-2 virus infection. It is most often manifested by an influenza-like syndrome with other symptoms that are more specific such as loss of smell and taste.Its severity is highly variable, ranging from asymptomatic to severe or prolonged forms.We report the case of a 47-year-old female patient, who is being followed for hypoparathyroidism, who developed severe and persistent cram...

ea0081ep194 | Calcium and Bone | ECE2022

Vitamin D deficiency in the type 2 diabetic population of Northern Gran Canaria Island: Still highly prevalent but supplementation is on the rise

Hernandez-Lazaro Alba , de Leon-Durango Ricardo , Kuzior Agnieszka , Acosta-Calero Carmen , Arnas-Leon Claudia , del Sol Sanchez-Bacaicoa Maria , Garcia-Alamo Debora , Martin-Perez Marta , Gonzalez-Diaz Paula , Martin Francisco Javier Martinez

Introduction: Vitamin D deficiency is associated with higher risk of severe COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (around 80.0% with plasma calcifediol <30 ng/ml) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown and the following winter in Northern Gran Canaria. There is an increasing awareness of this problem, both in family physicians and the general population, and t...

ea0081ep195 | Calcium and Bone | ECE2022

Management of denosumab discontinuation in a patient with osteonecrosis of the jaw and coexisting primary hyperparathyroidism

Malagrino Matteo , Belardinelli Elisabetta , Altieri Paola , Pagotto Uberto , Zavatta Guido

Context: Patients with primary hyperparathyroidism (PHPT) may be treated with denosumab due to coexisting osteoporosis. Few studies have been conducted in this population.Case presentation: An 84-year-old woman was seen in the outpatient clinic in March 2018 due to calcium levels at the upper limit of reference range (10,2 mg/dl) associated with elevated levels of PTH (112 pg/ml) and sufficient 25(OH)Vit D (24 ng/ml) levels, findings consistent with mild...

ea0081ep196 | Calcium and Bone | ECE2022

Impact of COVID-19 pandemic on waiting time from referral to definitive surgery in primary hyperparathyroidism: a large tertiary centre experience

Rashid Razan Ali , Ramsingh Jason , Bliss Richard , Truran Peter , Mamoojee Yaasir

Background: The COVID-19 pandemic has resulted in widespread disruption to delivery of emergency and elective care in the last 2 years. Nevertheless, healthcare systems have quickly readapted to accelerate use of novel pathways for delivering clinical services. We reviewed the impact of COVID-19 pandemic on our time from community referral to definitive surgery in patients with Primary Hyperparathyroidism (PHPT).Methods: We retrospectively reviewed the w...

ea0081ep197 | Calcium and Bone | ECE2022

Correlation between vitamin D levels and severity of COVID 19 disease. Argentine Experience

Garcia Maria Laura , Lisdero Ana Paula , Giacoia Evangelina , Lopez Franco , Cruceno Mauro , Pollini Valeria , Esposito Marcia , Scarabino Mariana , Bacigaluppi Susana , Mumbach Aizhar Giselle

Objective Vitamin D (VD) plays a role in immune response. Recent data shows that low levels of VD could worsen COVID-19 outcomes. This study aimed to establish an association between VD levels among COVID-19 patients with clinical outcomes and inflammatory markers.Methods Prospective multicentric cohort study. Consecutively recruitment. Patients were grouped according admission status and level of VD [sufficient >30 ng/ml (VDS), insufficient 20–...

ea0081ep198 | Calcium and Bone | ECE2022

From chronic hypomagnesemia with secondary hypoparathyroidism to basal ganglia calcification

Lomtadze Irine , Mania Maka , Khutsishvili Tamari , Eloshvili Nino

As it is known, hypomagnesemia leads to decreased synthesis of Parathyroid hormone (PTH) and can cause PTH resistance. Chronic hypoparathyroidism itself may lead to basal ganglia calcification. We report a 58 years old male, who has suffered from convulsions for over 10 years, with a history of alcohol abuse (more than 25 units of alcohol/week). During this period there have been frequent aware convulsions, resembling to tetany, typical for hypocalcemia. Hypocalcemia and hypom...

ea0081ep199 | Calcium and Bone | ECE2022

When to expect a positive parathyroid hormone washout in primary hyperparathyroidism – a single center experience

Mustapic Mirna , Andric Jelena , Majic Ana , Jaksic Ozana , Derek Lovorka , Veić Tajana Stoos , Jaksic Vlatka Pandzic

Parathyroid localization by fine needle aspiration and parathyroid hormone (PTH) washout measurement is not a widely accepted method because of possible alterations in parathyroid histology. However, when performed with technical competence this easily available method has been praised to be an immediate confirmation of enlarged parathyroid glands found on ultrasound. We retrospectively reviewed primary hyperparathyroidism (PHPT) patients with previously performed PTH washout ...

ea0081ep200 | Calcium and Bone | ECE2022

Management of hypocalcemia after thyroidectomy

Tayssir Ben Arfi , Wed El Abed , Ines Akrout , Khalil Gnaba

Introduction: Hypocalcemia is a well-known complication of total thyroidectomy. Usually, it’s a reversible and a transitory complication. However, it requires a regular check-up.Objective: The aim of this study is to determine the epidemiological and the therapeutic characteristics of hypocalcemia after total thyroidectomy.Methods: This is a retrospective study about 106 cases of total thyroidectomy that operated between the y...

ea0081ep201 | Calcium and Bone | ECE2022

Chronic asymptomatic hypocalcemia following thyroid surgery

Gharbi Mohamed , Mekni Sabrine , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Nacef Ibtissem Ben , Khiari Karima

Introduction: Postoperative hypoparathyroidism is a frequent complication of total thyroidectomy that must be detected and treated. The resulting hypocalcemia is quite severe and usually occurs in the first few days or weeks after surgery.Herein, we describe a case of chronic asymptomatic hypocalcemia related to postoperative hypoparathyroidism diagnosed years after total thyroidectomy.Observation: We report the case of a 61 year old woman, who had a tot...

ea0081ep202 | Calcium and Bone | ECE2022

Artificial intelligence technology for the early diagnosis of osteoporosis in cushing syndrome

McBride Margaret

In Cushing syndrome (CS), glucocorticoid-induced osteoporosis is suggested to be the main reason for drug-induced osteoporosis. This health condition creates weaknesses in bones which are then easily fractured.Studies estimate that osteoporosis is under diagnosed in the UK by around 50%, and according to the International Osteoporosis Foundation 2021, osteoporosis is a major healthcare burden in Europe with 4.3 million fragility fractures and healthcare costs more tha...

ea0081ep203 | Calcium and Bone | ECE2022

A comparison of bone densitometry and mineral disorders in hemodialysis patients due to diabetics and non diabetics patients

Tekaya Ramy Ben , Hachfi Haifa , Brahem Mouna , Sfar Zahra , Jomaa Olfa , Atii Zohra , Younes Mouhamed

Introduction: The chronic kidney disease (CKD) is associated to various bone and mineral disorders.Many studies showed that diabetics influence the bone and mineral metabolismAim: To investigate the bone disorder in CKD and the effect of diabetes on bone mineral density.Methods: This is a cross sectional study conducted in rheumatology department of Taher Sfar university hospital in mahdia, Tunisia. The study involved 61 patients w...

ea0081ep204 | Calcium and Bone | ECE2022

Abstract Withdrawn...

ea0081ep205 | Calcium and Bone | ECE2022

Regional Migratory Osteoporosis- An under-diagnosed entity

Kapoor Ashutosh , Rao Balmuri Laxmi Manohar

Introduction: Regional Migratory Osteoporosis (RMO) is a rare condition, characterised by a self-limiting migratory arthralgia, which generally tends to involve the lower limbs. The arthralgia is usually, not associated with any history of trauma. Radiologically, Magnetic Resonance Imaging (MRI) is the investigation of choice. Bone Marrow Oedema (BMO) with subchondral sparing are the usual findings in patients with RMO. This condition is usually under diagnosed due to the comp...

ea0081ep206 | Calcium and Bone | ECE2022

Osteoporosis in patients with Addison’s disease: Incidence and predictive factors

Salah Dhoha Ben , Boujelben Khouloud , Zargni Asma , Kacem Akid Faten Haj , Salah Ameni , Fatma Mnif , Mnif Mouna , Charfi Nadia , Majdoub Nabila Rekik , Elleuch Mouna , Abid Mohamed

Introduction: Because of a long-term glucocorticoid replacement over many years, patients with Addison disease may have an increased occurrence of osteoporosis. Furthermore, the prevalence of osteoporosis in patients with Addison disease may also be increased because of premature menopause associated autoimmune endocrinopathies and hypovitaminosis D.The objective of this study is to assess the incidence and risk factors for osteoporosis among patients with Addison disease....

ea0081ep207 | Calcium and Bone | ECE2022

rhPTH(1-84) treatment-induced increased bone turnover in a young woman with postsurgical hypoparathyroidism

Adamidou Foteini , Komzia Paraskevi , Mintziori Gesthimani , Kita Marina

Introduction: rhPTH(1-84) replacement is the treatment of choice in adults with hypoparathyroidism not adequately controlled on standard therapy. Although increased bone turnover markers have consistently been reported in trials of safety and efficacy, marked elevations coupled with significant symptoms have been rare. We describe a case of increased treatment-induced bone turnover, necessitating significant therapeutic adjustments and monitoring.Case re...

ea0081ep208 | Calcium and Bone | ECE2022

Patient with mediastinal mass and hypercalcemia

Mlekus Kozamernik Katarina , Salobir Barbara , Hočevar Marko , Kocjan Tomaž

Introduction: Hypercalcemia is mostly caused by primary hyperparathyroidism and malignancy. Parathyromatosis is a rare condition characterized by multiple nodules of hyperfunctioning parathyroid tissue scattered throughout the neck and superior mediastinum, which can present a diagnostic and therapeutic challenge.Case report: A 56-year-old woman visited the ER due to chest pain, left-sided neck edema, and hematoma. The day before, she experienced left-si...

ea0081ep209 | Calcium and Bone | ECE2022

Complications of a rare condition, untreated due to difficult living conditions

Slahor Lea , Christoph Henzen

Introduction: Pseudohypoparathyroidism is a rare disorder characterized by end-organ resistance to parathyroid hormone, caused by molecular defects of the PTH receptor. Resulting chronic hypocalcemia and hyperphosphatemia require lifelong treatment with active vitamin D metabolites and monitoring, representing a challenge especially in difficult living conditions.Case report: A 19-year-old woman presented to our clinic with carpopedal spasms and tetany. ...

ea0081ep210 | Calcium and Bone | ECE2022

Hypercalcaemia induced acute pancreatitis

Abouzaid Mona , Anthony Sony

Introduction: Milk-alkali syndrome (MAS) consists of hypercalcemia, renal failure, and metabolic alkalosis as a result of ingestion of large amounts of calcium and absorbable alkali. Daily elemental calcium intake of no more than 2 g is considered safe. However, even doses lower than 2 g daily may result in hypercalcemia if additional predisposing factors are present. Vulnerable patients because of vomiting, diuretic use, and deviant eating habits. In these susceptible patient...

ea0081ep211 | Calcium and Bone | ECE2022

Acute confusional state as presenting feature in severe para-neoplastic hypercalcemia

Ali Uzair Akbar , Rana Ghazanfar Iqbal , Jannat Summan

Background: Hypercalcemia is a common clinical problem. Severe hypercalcemia or hypercalcemic crisis is an endocrine emergency and can be life threatening if left untreated. The condition has high mortality and requires immediate therapeutic interventions and diagnostics. A rapid rise to the calcium levels can result in the impaired function of organ systems including central nervous system. Hypercalcemia is mainly (more than 90%) caused by primary hyperparathyroidism or malig...

ea0081ep212 | Calcium and Bone | ECE2022

A rare case of Pseudohypoparathyroidism

Shonia Natia , Zavrashvili Nino

Background: Pseudohypoparathyroidism includes a genotypically diverse group of syndromes of primary resistance to hormones whose actions are mediated by cyclic adenosine 3’: 5’-monophosphate, in most cases caused by mutations and/or epigenetic changes at the complex GNAS locus on chromosome 20q13.3.Renal resistance to PTH leads to impaired formation of 1,25(OH)2D, the fully active form of vitamin D, and reduces expression of sodium-dependent phosphate transporters in...

ea0081ep213 | Calcium and Bone | ECE2022

Primary hyperparathyroidism – experience of a single center

Elvas Ana Rita , Couto Joana , Martins Raquel G. , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: Primary hyperparathyroidism (pHPT) is the most common cause of hypercalcemia in the outpatient setting and is a frequent endocrine disorder. Large cohort studies of pHPT patients in the Portuguese population are scarce. Aim: To characterize patients with pHPT followed at a tertiary center.Material and Methods: Retrospective analysis of clinical records of patients with pHPT followed in our hospital from 2003 to 2021. ...

ea0081ep214 | Calcium and Bone | ECE2022

Risk factors associated with bone loss in patients with Addison disease

Salah Dhoha Ben , Boujelben Khouloud , Missaoui AbdelMouhaymen , Elleuch Mouna , Fatma Mnif , Mmnif Mouna , Charfi Nadia , Rekik Majdoub Nabila , Kacem Akid Faten Haj , Abid Mohamed

Introduction: Even at physiological doses, glucocorticoid replacement therapy may lead to deleterious outcomes on bone mineral density (BMD).The aim of our study was to investigate the BMD in Tunisian patients with Addison disease and to identify the risk factors associated with its decline.Patients and methods: The study included 50 patients diagnosed with primary adrenal disease (Addison disease). BMD was assessed by the dual -energy -X-ray absopitomet...

ea0081ep215 | Calcium and Bone | ECE2022

Pregnancy and lactation-associated osteoporosis

Jemuovic Zvezdana , Djurovic Marina Nikolic , Djurdjevic Sandra Pekic , Miljic Dragana , Stojanovic Marko , Doknic Mirjana , Petakov Ana , Petakov Milan

Introduction: Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition in which women have fragile fractures associated with significant reduction of BMD during pregnancy or postpartum period.Case report: A 37-year-old female patient was admitted at our Clinic for further investigation of aetiology of osteoporosis in July 2019. Soon after delivery in February 2019 patient had felt left hip and foot pain as well as sharp intensive pain (i...

ea0081ep216 | Calcium and Bone | ECE2022

Association of primary hyperparathyroidism and papillary thyroid Cancer: a case report

Khaoula Gorgi , Zineb Mhamdi , Echchad Lamya , Kaoutar Rifai , Hinde Iraqi , Mohamed El Hassan Gharbi

Introduction: Primary hyperparathyroidism is a common pathology. The association of papillary thyroid carcinoma and primary hyperparathyroidism has been reported in 2.3–4.3% of patients operated on for primary hyperparathyroidism.We report the case of a patient with papillary thyroid carcinoma revealed by primary hyperparathyroidismObservation: 53-year-old patient admitted for management of primary hyperparathyroidism. A cervical ultrasound revealed...

ea0081ep217 | Calcium and Bone | ECE2022

Abstract Withdrawn...

ea0081ep218 | Calcium and Bone | ECE2022

Results of denosumab used in postmenopausal women

Navmenova Yana , Makhlina Elena , Moskvicheva Tamara , Chernova Nelli , Savasteeva Irina

The aim of the study was to assess the effectiveness of postmenopausal osteoporosis (PMOP) therapy with denosumab.Patients and methods 32 postmenopausal women with established PMOP for a period of 24 months or more received denosumab 60 mg subcutaneously once every 6 months combined with calcium and vitamin D. A quantitative assessment of bone mineral density (BMD) was carried out before treatment, after 12 and 24 months of observation, using dual-energy X-ray absorptiometry o...

ea0081ep219 | Calcium and Bone | ECE2022

Is obesity detrimental to postmenopausal bone health?

Dimitrova Radina , Boyadzhieva Mila , Hristozov Kiril , Bocheva Yana

Introduction: Despite available evidence for a relationship between bone health and obesity, the results of clinical trials remain conflicting. Thus, we conducted a cross-sectional study to analyze possible associations between waist circumference (WC), body mass index (BMI) and body weight (BW) with bone health in postmenopausal women.Materials and Methods: The study included 84 women from Northeastern Bulgaria. Their mean age was 60.54±7.07 years,...

ea0081ep220 | Calcium and Bone | ECE2022

Endocrine disorders and osteoporosis: case series

Adel Meriem , Mekni Sabrine , Jridi Maysam , Rojbi Imen , Lakhoua Youssef , Mchirgui Nadia , Nacef Ibtissem Ben , Khiari Karima

Introduction: Homeostasis of calcium and phosphor influence bone metabolism. They depend on several hormones, including parathyroid hormone, thyroid and sexual hormones. Low bone mass seems a common issue in endocrine disorders. The aim of this study is to identify the different endocrine disorders in patients with low bone mass.Methods: Retrospective study collecting the medical files of patients followed in the endocrinology department of Charles Nicol...

ea0081ep221 | Calcium and Bone | ECE2022

IPN60130 for the treatment of fibrodysplasia ossificans progressiva: methodology of the randomized, double-blind, placebo-controlled phase II FALKON trial

Karimian Negar , Powell Christine , Shih Fei

Objectives: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder caused by activin receptor-like kinase-2/activin A receptor type 1 (ALK2/ACVR1) mutation and characterized by heterotopic ossification (HO) inducing progressive restriction of mobility. IPN60130 is a selective ALK2/ACVR1 inhibitor being investigated for the treatment of FOP.1 Here, we describe methodology of the FALKON trial (NCT05039515) designed to compare efficacy a...

ea0081ep222 | Calcium and Bone | ECE2022

Brown tumour of the mandible as the first manifestation of primary hyperparathyroidism: a case report

Majic Ana , Berkovic Maja Cigrovski , Zajc Ivan , Salaric Ivan

Introduction: Brown tumour is a rare, benign, tumour-like lesion of bones.The presence of brown tumour is a rare complication of uncontrolled primary, secondary or tertiary hyperparathyroidism.Brown tumours can be solitary or multifocal and are most commonly located in ribs, clavicles, pelvic girdle, extremities and facial bones (maxilla, mandible, and hard palate).A diagnosis of brown tumour in hyperparathyroidism is established by evaluation of serum calcium, phosphorus and ...

ea0081ep223 | Calcium and Bone | ECE2022

Malignant hypercalcemia showing parathyroid adenoma in a patient with renal impairment

Mohamed Tizgha

Introduction: hyperparathyroidism is usually diagnosed at a pauci or asymptomatic stage. However, in rare cases, the diagnosis is made at the stage of major threatening hypercalcemia. This diagnostic delay may be responsible for complications such as chronic end stage renal disease (CRRD).Observation: we report the case of a 64-year-old patient referred to the endocrinology department for primary hyperparathyroidism, with no particular family history and...

ea0081ep224 | Calcium and Bone | ECE2022

A pathological fracture of the femur and multiple pelvic osteolytic lesions mimicking bone metastases as the first presentation of Primary Hyperparathyroidism

Khan Haris , Nawaz Maimoona , Dang Cuong , Malik Isha

Introduction: Pathological fractures are uncommon in young patients and raise concern about malignancy. Brown tumour (osteitis fibrosa cystica) is a rare benign resorptive bone lesion reported in approximately 3% of patients with primary hyperparathyroidism (PHPT). These have become uncommon in contemporary practice and have the potential to be misdiagnosed because of radiological similarities to other bone diseases especially malignancy.We present a case where the first prese...

ea0081ep225 | Calcium and Bone | ECE2022

Intrathyroidal parathyroid adenoma: a rare localization

Laamouri Rihab , Niculina Raccolta , Ninon Stahl , Felix Lerintiu , Rita Caro Lopez , Agnes Smagala

Primary hyperparathyroidism is a frequent endocrine disorder but intrathyroidal parathyroid adenoma is extremely rare. Combining cervical ultrasound and MIBI scintigraphy allows localizing most parathyroid adenomas. Because intrathyroidal parathyroid adenomas mimic thyroid nodules the diagnosis can be challenging, requiring eventually the realization of a fine-needle cyto-puncture. We report here a case of an intrathyroidal parathyroid adenoma diagnosed via a combination of ce...

ea0081ep226 | Calcium and Bone | ECE2022

Osteitis fibrosa cystica as index presentation of severe vitamin D deficiency

Jeeyavudeen Mohammad , Oniscu Anca , Hicks Matthew , Arunagirinathan Ganesh

Introduction: Osteitis fibrosa cystica (OFC) or brown tumour is a non-neoplastic fibrocystic expansile lytic bone lesion caused due to excess parathormone (PTH). Brown tumour is classically known to occur in severe primary or secondary hyperparathyroidism due to end-stage renal failure with very high PTH level. OFC presenting as a mass due to nutritional vitamin D deficiency (NVD) is exceedingly rare. Case presentation: 47-year-old Caucasian gentleman pr...

ea0081ep227 | Calcium and Bone | ECE2022

Non-functioning parathyroid cystic tumour: a diagnostic and therapeutic challenge

Sellami Moncef , Thabet Wadii , Mnejja Malek , Hammami Bouthaina , Kallel Souha , Charfeddine Ilhem

Introduction: Parathyroid cysts (PCs) are uncommon lesions. They represent less than 0.5% of parathyroid lesions. Cysts are divided into two groups, functional and non-functional, in relation to their hormonal characteristics. Non-functioning ones make up 80 – 90% of PCs.We discussed three cases of non-functioning parathyroid cysts that we surgically excised.Methods: We report 3 cases of non-functioning PCs treated in our department.<p class="ab...

ea0081ep228 | Calcium and Bone | ECE2022

Pseudohypoparathyroidism type I-b: a rare entity

Silva Eugenia , Ferreira Rute , Marques Bernardo , Santos Francisco Sousa , Manuel Sequeira Duarte Joao

Introduction: Pseudohypoparathyroidism (PHP) is a rare disorder characterized by parathormone (PTH) resistance, caused primarily by genetic defects involving the alpha-subunit of the stimulatory G protein. Biochemical and molecular analysis classify pseudohypoparathyroidism into types I-a, I-b, I-c and 2. We report a case of PHP I-b in an adolescent presenting with a neurological disorder.Case Report: 11 years old female patient, with no relevant persona...

ea0081ep229 | Calcium and Bone | ECE2022

Multifactorial causes of secondary osteoporosis: a case report

Fortes Delfina Indira , Barbosa Ana Paula

Introduction: Osteoporosis is a metabolic bone disease, characterized by reduction and changes in the bone mass quantity and quality, leading to an increased risk of fractures. It can be divided in primary (postmenopausal or senile), secondary and idiopathic. In the presence of osteoporotic fractures, particularly in men before the age of 65, it is essential to investigate the presence of secondary causes in order to establish an etiological therapy.Case...

ea0081ep230 | Calcium and Bone | ECE2022

Association between musculoskeletal manifestations in hemodialysis patients and depression

Tekaya Ramy Ben , Hachfi Haifa , Brahem Mouna , Jomaa Olfa , Hariz Amal , Atti Zohra , Younes Mouhamed

Introduction: Musculoskeletal pain is a major problem for hemodialysis patients. So, we have to control it, to ameliorate their life quality.Aim: The purpose of this study was to evaluate the prevalence musculoskeletal symptoms and their relation with chronic hemodialysis.Methods: This is a cross sectional study conducted in rheumatology department of Taher Sfar university hospital in mahdia, Tunisia. The study involved 61 patients...

ea0081ep231 | Calcium and Bone | ECE2022

Association between serum magnesium levels and physical performance tests in patients with primary osteoporosis

Iulia Greere Daniela Ioana , Voicu Gabriela , Manda Dana Alice , Poiană Cătălina

Introduction: Osteoporosis is the most frequent metabolic bone disease worldwide affecting primarily the senior population. The associated bone loss in combination with a decline in physical performance lead to increased incidence of falls and fragility fractures. Thus, improving physical performance is key to preventing osteoporotic fractures.Methods: A total of 140 participants were inrolled in a cross-sectional study. Secondary causes of osteoporosis ...

ea0081ep232 | Calcium and Bone | ECE2022

Hypoparathyroidism: about 61 cases

Fatma Mnif , Zargni Asma , ARBI Kawthar El , Elleuch Mouna , Trigui Raida , Charfi Nadia , Mnif Mouna , Majdoub Nabila Rekik , Kacem Akid Faten Haj , Abid Mohamed

Introduction: Hypoparathyroidism (HPT) is an often under-diagnosed condition. It is imperative to diagnose it at an early stage and to initiate prompt treatment given the evolving potential of the disease.The aim of our study is to describe the epidemiological, clinical and paraclinical features of HPT.Patients and Methods: This is a retrospective study of 61 observations of HPT collected at the endocrinology department during a 12-year period.<p cla...

ea0081ep233 | Calcium and Bone | ECE2022

Persistent hypophosphataemia due to gastrointestinal losses

Tauni Rahat , Ali Nida , Khan Amjad

A 49-year-old lady was referred to the endocrine clinic for hypophosphataemia. Apart from tiredness, she had no other symptoms. Past medical history was significant for bronchiectasis, obstructive sleeps apnoea, caudaequina syndrome, migraine and anxiety. She had frequent hospitalisations due to bronchiectasis exacerbations requiring systemic steroids. Usual medications included azithromycin, gabapentin, omeprazole, antacids, laxatives, carbocisteine, fluoxetine, montelukast, ...

ea0081ep234 | Calcium and Bone | ECE2022

Clinical, biological and evolutionary comparison of postsurgical hypoparathyroidism and non-postsurgical hypoparathyroidism

Soomauroo Siddiqa , Mnif Fatma , Mohamed Ahmed Mohamed Abdellahi , Kacem Akid Faten Haj , Charfi Nadia , Mnif Mouna , Abid Mohamed

Introduction: Hypoparathyroidism (HPTH) is an uncommon condition resulting in the production of insufficient amounts of parathyroid hormone (PTH) by the parathyroid glands consequently affecting the calcium phosphate balance. The most frequent etiology of HPTH is the damage to or removal of the parathyroid glands due to a surgery for another condition. Other causes, including autoimmunity and genetic disorders may be responsible for HPTH. Our aim is to compare the different cl...

ea0081ep235 | Calcium and Bone | ECE2022

Association between primary hyperparathyroidism with severe bone disease and osteomalacia: A case report.

Khiari Hager , Rojbi Imen , Smadhi Houaida , Mekni Sabrine , Lakhoua Youssef , Nacef Ibtissem Ben , Khiari Karima

Introduction: Primary hyperparathyroidism is associated with multiple complications: severe bone disease is one of them. Osteomalacia is by definition a metabolic bone disease characterized by a softening of the bones. We herein report a rare case of an association between primary hyperparathyroidism with osteitis fibrosa cystica and osteomalacia caused by a severe vitamin D deficiency.Observation: A 37-year old woman was referred for investigation of we...

ea0081ep236 | Calcium and Bone | ECE2022

Sporadic multiple-gland disease in primary hyperparathyroidism

Ayedi Sirine , Thabet Wadii , Chaabouni Mohamed Amine , Mallouli Manel , Mnejja Malek , Charfeddine Ilhem

Introduction: In 80–90% of cases, the cause of sporadic primary hyperparathyroidism is adenoma of one parathyroid gland. Multiple-gland disease (MGD) is defined in patients with more than one pathological parathyroid gland. The frequency of occurrence of MGD is from 7% to 33%.Our aim is to report a case of primary hyperparathyroidism with MGD and to describe its diagnostic and therapeutic features.Case Report: A 55-year-old man presented with 1-year...

ea0081ep237 | Calcium and Bone | ECE2022

Particularities of primary hyperparathyroidism in multiple endocrine neoplasia type 1: Tunisian data

Fatma Mnif , Arbi Kawthar El , Lajmi Yosra , Zargni Asma , Salah Dhoha Ben , Trimeche Oumeyma , Elleuch Mouna , Charfi Nadia , Mnif Mouna , Majdoub Nabila Rekik , Kacem Akid Faten Haj , Kammoun Hassen , Abdelhedi Fatma , Abid Mohamed

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized mainly by the association of: Primary hyperparathyroidism (PHP), gastro-entero-pancreatic tumors (GEP) and pituitary tumors. The aim of our work is to specify the particularities of PHP in MEN1 among Tunisian population.Patients & Methods: It is a retrospective descriptive study of 7 cases of MEN1, including 3 familial cases, during a 28-year period.<p...

ea0081ep238 | Calcium and Bone | ECE2022

Primary hyperparathyroidism and rheumatoid arthritis

Athanassiou Lambros , Kostoglou-Athanassiou Ifigenia , Mavroudi Maria , Tsakiridis Pavlos , Koukosias Nikolaos , Athanassiou Panagiotis

Rheumatoid arthritis is a systemic autoimmune inflammatory disease characterized by severe pain, if left untreated. Primary hyperparathyroidism is a systemic disorder characterized by disordered calcium metabolism leading to increased serum calcium and PTH levels. Primary hyperparathyroidism may be due to the presence of a parathyroid adenoma or parathyroid hyperplasia. The aim was to present a cohort of patients with rheumatoid arthritis who presented with primary hyperparath...

ea0081ep239 | Calcium and Bone | ECE2022

How we managed malignant hypercalcemia in a hyperparathyroid in heart failure in the emergency room

Halouache Ali , Yassine Errahali , Sanae Chakdoufi , Jad Isouani , Anas Guerboub

Introduction: We report a case of malignant hypercalcemia complicated by acute pancreatitis, in a patient whose cardiac insufficiency obliged us to use an unconventional therapeutic means: calcimimeticsCase Report: Mrs. Halima, 74 years old, had a history of arterial hypertension complicated by ischemic heart disease at the stage of heart failure. She consulted the emergency room for typical pancreatic pain, the biological workup found a lipasemia at 30 ...

ea0081ep240 | Calcium and Bone | ECE2022

Post covid 19 vaccine cramps in a patient followed for hypoparathyroidism: who is to charge?

Abidi Ihssane , Rifai Kaoutar , Hinde Iraqi , Gharbi Mohamedelhassan

Introduction: COVID-19 is a pandemic related to SARS-COV-2 virus infection. It is most often manifested by an influenza-like syndrome with other symptoms that are more specific such as loss of smell and taste.Its severity is highly variable, ranging from asymptomatic to severe or prolonged forms.We report the case of a 47-year-old female patient, who is being followed for hypoparathyroidism, who developed severe and persistent cramps after the COVID-19 vaccine.<p class="ab...

ea0081ep241 | Calcium and Bone | ECE2022

Pseudohypoparathyroidism discovered in adulthood

Besrour Chayma , Imen Rojbi , Sabrine Mekni , Marwa Majdoub , Youssef Lakhoua , Ibtissem Ben Nacef , Karima Khiari

Introduction: Pseudohypoparathyroidism (PHP) is a part of a very rare heterogeneous group of endocrine disorders. It is caused by alterations in the PTH receptor, which is encoded by the GNAS1 gene inducing target tissue resistance to PTH. Pseudohypoparathyroidism typically gets discovered during early childhood, rare are the cases discovered in adulthood.Observation: Herein the case of a 35-year-old man, descendant of a non-consanguineous marriage, with...

ea0081ep242 | Calcium and Bone | ECE2022

Primary vs tertriary hyperparathyroidism in a patient with medullary nefrocalcinosis and chronic renal failure

Shehu Tea , Hoxha Violeta , Ylli Dorina , Cerma Adishah , Ylli Agron

Background: Nephrocalcinosis is characterized by the deposition of calcium products in kidney parenchyma and tubules. It may cause acute or chronic kidney injury or be incidentally detected radiographically in a patient with normal kidney function. Most patients with nephrocalcinosis do not progress to end-stage kidney disease, but with certain underlying conditions, may be associated with progressive kidney dysfunction.Methods: The patient was diagnosed...

ea0081ep243 | Calcium and Bone | ECE2022

Paralytic sciatica revealing hyperparathyroidism: a case report

Camara M'ballou , Rafi Sana , Mghari Ghizlane EL , Ansari Nawal EL

Introducing: Primary hyperparathyroidism (HPT1) is a frequent endocrinopathy. Diagnosed incidentally or in front of a urinary or bone symptomatology, we report a case of primary hyperparathyroidism in the mode of revelation makes the originality “a paralyzing sciatica”.Observation: The patient was 44 years old and was undergoing neurosurgery for chronic low back pain that was resistant to etiological treatment. In view of the persistent and hyp...

ea0081ep244 | Calcium and Bone | ECE2022

Symptoms alleviation of primary hyperparathyroidism intensified by COVID-19 pandemic effects using a balanced diet: a case report

Kashanivahid Narges , Tabesh Hadi , Bazrafshan Hamid

Introduction: Hyperparathyroidism happens when one or more of parathyroid glands secret excessive parathyroid hormone, causing calcium levels in blood to rise. A diagnosis may be missed or delayed because there are no symptoms or they are vague, like depression, tiredness, losing your appetite in addition to hypercalcaemia symptoms e.g. vomiting, bone and joint pain, dehydration, hypertension, etc. Surgery to remove the parathyroid gland is usually the only way of treating pri...

ea0081ep245 | Calcium and Bone | ECE2022

A recurrent hypercalcemia after subtotal parathyroidectomy revealing a Munchhausen syndrome

Kamoun Elyes , Nacef Ibtissem Ben , Mekni Sabrine , Lakhoua Youssef , Mchirgui Nadia , Rojbi Imen , Khiari Karima

Introduction: Primary hyperparathyroidism is the most common manifestation of multiple endocrine neoplasia (MEN) type 1, with a frequent involvement of all the parathyroids. In cases where the four glands weren’t resected, a close monitoring should be performed for an early diagnosis of recurrence. Elevated calcium levels with elevated parathormone (PTH) levels in this context makes the physician suspect an adenoma or a hyperplasia of the remaining parathyroid. We herein ...