ECE2022 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (318 abstracts)
Neurodegeneration type and severity have linkage with plasma insulin in DM patients
Talat Saatov 1 , Timur Alimov 2 , Elvira Ibragimova 1 , Takhir Ishankhodjaev 3 , Zafar Ibragimov 3 , Gulnora Artikbaeva 3 , Mukhammadjon Mustafakulov 1 , Dilnoza Saidova 3 & Zulaykho Shamansurova 1,4
1Institute of Biophisics and Biochemistry at the NUUz, Metabolomics, Tashkent, Uzbekistan; 2Republican Specialised Scientific Practical Medical Centre of Hematology, Tashkent, Uzbekistan; 3Institute of Biophisics and Biochemistry at the NUUz, Tashkent, Uzbekistan; 4Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan
Background: In Pathogenesis of Neurodegeneration in Diabetes Mellitus (DM) addition to insulin resistance, glycemic control and blood plasma lipid levels existing other mechanisms were proposed. We investigated plasma insulin level in patients according to severity of diabetic neuropathy.
Materials and methods: In 32 people with DM2 glycemia, HbA1c, blood plasma insulin, blood total cholesterol, triglycerides, Low Density Lipoproteins (LDLP) levels were measured and compared regarding to DN severity by stages in DN1 and DN2 groups.
Results: People with DN1 and DN2 have the same age and disease duration. Glycemia and HbA1c level were also comparable between groups. Although, body weight and BMI (in 1.32 times), blood total cholesterol (in 1.3 times), triglycerides (in 1.32 times), LDLP (in 1.4 times) levels were significantly higher in DN2 group than DN1, blood plasma insulin was higher in DN2 group and suggested about involvement of insulin resistance into pathogenesis of DN. However, people in DN2 group used metformin with combination of sulfonilureas, whereas DN1 group mostly used metformin for lowering blood sugar.
Conclusion: DM2 patients with severe DN have higher BMI, blood lipids and plasma insulin level. Plasma insulin level have a linkage with DN severity in DM2 and play a role in the development of neurodegeneration.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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