Endocrine Abstracts

SSTR2 is one of the main pharmacological target for GH-secreting pituitary adenomas treatment and the cytoskeletal protein FLNA plays an important role in tumor responsiveness by regulating SSTR2 expression and signaling. Single-Molecule Imaging was used to investigate the spatial distribution of FLNA-SSTR2 at the plasma membrane level and the involvement of FLNA in SSTR2 mobility, receptor clustering organization/internalization. This method is based on labeling SNAP/CLIP-tag...

Introduction: Irisin is a newly discovered adipo-myokine, that has a significant influence on body metabolism. Available data about this peptide is still insufficient. The aim of the study is to provide some initial information about body distribution of irisin in rats.Methods: The studied group consisted of 27 10-week-old female Wistar rats, which received intraperitoneally ~0.7 mcCi of iodine-125 labeled irisin. The studied rats were divided on five su...

Introduction: Thyroid hemiagenesis (TH) is characterised by congenital absence of one thyroid lobe.Aim: To assess possible association between TH and concomitant alterations of other structures derived from pharyngeal apparatus, which might potentially impact calcium-phosphate balance.Materials and methods: Studied group: 20 patients with TH. Control group: 20 subjects with bilobed thyroid, matched for age and gender. Serum concent...

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as developmental failure of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism. In contrast, subjects presenting TH were only sporadically involved. In addition, whether the same factors are responsible for development of TH and other forms of thyroid dysgenesis is still to be elucidated. Recent stud...

Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as failure of the development of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism; in contrast, subjects presenting TH were only sporadically involved. Changes in transcription factor genes, including TTF1, TTF2 and PAX8, which play an important role in thyroid embryogenesis, have been postu...

Background: Given the general lack of descriptive epidemiological studies on thyroid storm, we aimed to estimate the incidence rate and case fatality of thyroid storm in Germany based on a large claims database.Methods: Using the German Pharmacoepidemiological Research Database (GePaRD) we identified patients with at least one inpatient discharge diagnosis of thyroid storm (International Statistical Classification of Diseases and Related Health Problems,...

Our laboratory works on Wnt/β-catenin signaling in precursor and stem cells of various organs. The data show that Wnt/β-catenin controls cell lineage specification in embryogenesis and organogenesis. General interest sparked anew by recent evidence suggesting that organ as well as cancer stem cells share core signaling and transcriptional modules. We used genetic mouse models to study the necessity of Wnt/β-catenin signaling in stem cells of the salivary gland. ...

Background: Bioresorbable screws for surgical fracture treatment are of great interest for the orthopaedic community. Such implants are designed to provide stability and compression of the fracture and should dissolve after healing, thereby making removal of surgical material obsolete. Magnesium implants are a new material option. So far, long-term follow-up of fracture healing and material decay has not been studied in human. Here, we present the results of the 2.5 year follo...

Introduction: A well known side effect of glucocorticoid treatment is abdominally centred weight gain due to increased sensation of hunger but the underlying mechanism is still only incompletely clarified. To elucidate whether the brain reward system is involved in this regulation we studied here the effects of an acute prednisolone infusion on brain centres responding to food stimulation by fMRI in healthy males and correlated these findings to the 24 h food intake of the sub...

Hypophosphatasia (HPP) is a rare, inherited, metabolic disorder caused by deficient tissue-nonspecific alkaline phosphatase activity. A heterogeneous presentation in adults includes musculoskeletal symptoms, impaired physical function, and reduced health-related quality of life (HRQoL). Asfotase alfa is the only approved treatment for pediatric-onset HPP. We evaluated, in a real-world setting, the long-term effectiveness of asfotase alfa on physical function and HRQoL among ad...