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Endocrine Abstracts (2022) 81 P208 | DOI: 10.1530/endoabs.81.P208

ECE2022 Poster Presentations Thyroid (136 abstracts)

Estimating incidence and case fatality of thyroid storm in Germany between 2007 and 2017: A claims data analysis

Arulmani Thiyagarajan 1 , Katharina Platzbecker 1 , Till Ittermann 2 , Henry Völzke 2 & Ulrike Haug 1,3

1Leibniz Institute for Prevention Research and Epidemiology-BIPS, Department of Clinical Epidemiology, Bremen, Germany; 2 University Medicine Greifswald, Institute for Community Medicine, Greifswald, Germany; 3 University of Bremen, Faculty of Human and Health Sciences, Bremen, Germany

Background: Given the general lack of descriptive epidemiological studies on thyroid storm, we aimed to estimate the incidence rate and case fatality of thyroid storm in Germany based on a large claims database.

Methods: Using the German Pharmacoepidemiological Research Database (GePaRD) we identified patients with at least one inpatient discharge diagnosis of thyroid storm (International Statistical Classification of Diseases and Related Health Problems, 10th revision, German modification; ICD-10-GM E05.5) between 2007 and 2017 and calculated age-standardized and age-specific incidence rates in males and females. We defined deaths occurring within 30 days of the diagnosis as thyroid storm-associated and determined case fatality by sex and age group.

Results: Overall, we identified 1.690 patients with an incident diagnosis of thyroid storm (72% females). Mean age was 60 years (standard deviation: 18.6 years). The age-standardized incidence rate per 100.000 persons per year was 1.4 (95% confidence interval [CI] 1.2 to 1.7) in females and 0.7 (95% CI 0.5 to 0.9) in males. In females ≤60 and >60 years of age, the incidence rate was 0.9 (males 0.4) and 2.7 (males 1.7), respectively. The case fatality of thyroid storm was 1.0% in males ≤60 years (females: 1.4%) and 16.7% in males >60 years of age (females: 10.9%).

Conclusion: Incidence rates of thyroid storm were markedly higher in females than in males and were three times higher in persons >60 years compared to younger age groups. Case fatality was below 2% in persons aged ≤60 years and markedly higher in older persons (males: 17 times, females: 8 times).

Keywords: thyroid storm; incidence; case fatality; Germany

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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