Endocrine Abstracts

A 52-year man came to Emergency Department with Atrial Fibrillation with rapid ventricular response due to amiodarone induced thyrotoxicosis (AIT). The patient was found tachi-arrhythmic (153 beats per minute), tachypnoic (27 breaths per minute) and with intense hyperidrosis. His first blood test documented thyroid stimulating hormone (TSH) <0.01 mUI/l, free triiodothyronine (fT3) 20.0 pmol/l and free thyroxine (fT4) over 100 pmol/l. Thyroid ultrasonography revealed an enl...

In 2009 a 39 year old gentleman presented to the Endocrine clinic with symptoms, signs and biochemistry consistent with severe glucocorticoid excess (urinary free cortisol level was significantly raised at >1380mol/24 hours, normal up to 124; early morning cortisol levels varying between 760nmol/land 1225nmol/lwith failure of suppression on a low dose dexamethasone suppression test). An ACTH level taken at this time was 43ng/l. He underwent an MRI pituitary gland which sho...

Objective: To investigate the prevalence of hyperuricemia in Chinese population, and the association between serum concentrations of uric acid and related metabolic disorders.Methods: This study was based on de-identified hospital information system (HIS) data collected from four tertiary hospitals in three provinces of China. A total of 432,002 patients with at least one medical visit recorded SUA measurement were screened and 374,506 were enrolled. Hyp...

Initial presentation: A 44 year-old Caucasian patient with severe and complex obesity and type 2 diabetes was referred to hospital diabetes clinic for optimal medication advice. Her BMI on presentation was 49 kg/m2, (148 kg) and HbA1c of 7.0%. Her treatment included metfomin, sulphonylurea, rapid acting insulin (total daily doses 30 unit), and long acting insulin (total daily doses 25 unit). She also suffers complications of hypertension, dyslipidaemia, osteoarthrit...

Objective: Decline in the number of D2 receptor (D2R) is considered as the reason of resistance to dopamine agonists (DA). PP4R2 gene was observed up-regulated in prolactinoma patients according to our previous genechip study. In this study, we demonstrated that PP4C was crucial for D2R expression and PRL secretion in rat pituitary MMQ cells.Methods: In this study, we used rat pituitary MMQ cells which could secrete abundant prolactin and express functio...

Despite numerous educational interventions and medical efforts efforts, modern society continues to suffer from obesity and its associated metabolic diseases, such as type 2 diabetes mellitus, and these diseases show little sign of abating. The brain, and in particular the hypothalamus, continues to gain attention as an important central target for the treatment of metabolic disease. However, most of the pharmaceutical approaches directly targeting the brain largely have faile...

Phaeochromocytoma is a rare tumour of the adrenal gland medulla characterized by excess catecholamine release. Classic presentation includes paroxysms of hypertension and adrenergic symptoms such as headache, sweating, shortness of breath, and tachycardia. In severe cases, patients might develop hypertensive crises and cardiomyopathy. We present a case of intestinal pseudo-obstruction as a rare complication of phaeochromocytoma which responded only to surgical resection of the...

Context: Distinct differences of clinical manifestations exist in hypertensive pheochromocytomas (HPs) and normotensive phaeochromocytomas (NPs), however the comparative analysis is lacking.Objective: The objective of the study was to assess the clinical symptoms, haemodynamics, metabolism, radiological and histological features of patients with HPs and NPs.Research design and methods: This retrospective study included 104 patients...

Introduction: In cases of emergent surgical conditions, pre-medication of patients with thyrotoxicosis is required to reduce the patient’s risk of thyroid storm in the perioperative and postoperative state. Perforated viscus with concurrent thyrotoxicosis is rarely reported. We report 2 cases of thyrotoxicosis and acute abdomen with perforated viscus.Case 1: A 27-year-old gentleman with underlying hyperthyroidism, presented with central epigastric p...

Introduction: Thyroid dysfunction is one of the commonest endocrine disorders with hypothyroidism being the most common thyroid dysfunction in the elderly population[1]. An elderly patient with thyroid dysfunction can be asymptomatic, or present with non-specific symptoms, making biochemical testing of thyroid function useful and essential. We reviewed the screening rate and prevalence of thyroid dysfunction in older medical patient patients admitted to an Irish sec...