SFEBES2021 Poster Presentations Metabolism, Obesity and Diabetes (78 abstracts)
Gender-specific prevalence of hyperuricemia and association with metabolic disorders in China: a hospital population based retrospective real-world study
Shuguang Pang 1 , Qiang Jiang 1 , Sun Pei 1 , Yi Li 2 , Yanhua Zhu 2 , Jin Liu 2 , Ting Chen 3 , Xiaoran Ye 3 & Wenjun Yang 4
1Jinan Central Hospital affiliated to Shandong University, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, China; 2Jiangsu Hengrui Medicine Co., Ltd, Shanghai, China; 3Shanghai Palan DataRx Co, Ltd, Shanghai, China; 4The Affiliated Hospital of Shandong University of TCM, Shanghai, China
Objective: To investigate the prevalence of hyperuricemia in Chinese population, and the association between serum concentrations of uric acid and related metabolic disorders.
Methods: This study was based on de-identified hospital information system (HIS) data collected from four tertiary hospitals in three provinces of China. A total of 432,002 patients with at least one medical visit recorded SUA measurement were screened and 374,506 were enrolled. Hyperuricemia was defined as SUA ≥7.0 mg/dl in male or ≥6.0 mg/dl in female.
Results: Among enrolled subjects, 49.7% was male while 50.3% was female. The total prevalence of hyperuricemia and gout were 14.8% and 0.5%. Significant differences were observed between genders where prevalence in male was higher than in female (17.6% vs 12.0%, 0.8% vs 0.1%, both P < 0.001). Higher SUA level groups had significantly increased adjusted OR of dyslipidemia and chronic kidney disease in both genders, while difference was observed with type 2 diabetes mellitus. In the cohort study, the change of SUA from baseline was negatively correlated with the change of eGFR and HbA1c (r = -0.319 and -0.074, both P < 0.001) and positively correlated with the change of TC, TG, LDL-C, HDL-C (r = 0.110, 0.144, 0.082, and 0.012 respectively, all P < 0.05) among males. After adjustment of covariates, SUA change was still significantly negatively associated with eGFR and HbA1c, while with TC, TG, LDL-C and glucose positively (all P < 0.001). Similar outcomes were observed in female objects.
Conclusion: Gender-specific prevalence of hyperuricemia was observed in Chinese population. Hyperuricemia was associated with dyslipidemia, CKD in both genders, cross-sectionally and longitudinally.
Volume 77
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Endocrine Abstracts
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