Metabolism, Obesity and Diabetes

ea0077p39 | Metabolism, Obesity and Diabetes | SFEBES2021

Longitudinal clinical trajectory analysis of individuals before and after diagnosis of Type 2 Diabetes Mellitus (T2DM) indicates that vascular problems and asthma pre-date diabetes diagnosis by many years

Heald Adrian , Fachim Helene , Stedman Mike , Gibson Martin , Anderson Simon G , Peng Yonghong , Ollier WiIliam

Introduction: Type 2 diabetes mellitus (T2DM) frequently associates with increasing multi-morbidity/treatment complexity. Some headway has been made to identify genetic and non-genetic risk factors for T2DM. However longitudinal clinical histories of individuals both before and after diagnosis of T2DM are likely to provide additional insight into both diabetes aetiology/further complex trajectory of multi-morbidity.Methods: This study utilised diabetes p...

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ea0077p40 | Metabolism, Obesity and Diabetes | SFEBES2021

A randomised controlled pilot trial of oral 11β-HSD1 inhibitor AZD4017 for wound healing in adults with type 2 diabetes mellitus

Ajjan Ramzi , Hensor Elizabeth , Shams Kave , Galdo Francesco Del , Abbas Afroze , Woods Janet , Fairclough Rebecca , Pegg Lindsay , Freeman Adrian , Morgan Ann , Stewart Paul , Taylor Angela , Arlt Wiebke , Tahrani Abd , Russell David , Tiganescu Ana

Chronic wounds (e.g. diabetic foot ulcers) have a major impact on quality of life, yet treatments remain limited. Glucocorticoids impair wound healing; preclinical research suggests that blocking glucocorticoid activation by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) improves wound repair. This investigator-initiated double-blind, randomised, placebo-controlled parallel-group phase 2b pilot trial investigated efficacy, safety and feasibility of 11&...

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ea0077p41 | Metabolism, Obesity and Diabetes | SFEBES2021

Investigating 2-oleoylglycerol responsive neuronal pathways

Cheng Sijing , Norton Mariana , Roberts Anna , Martin Alonso Aldara , Phuah Phyllis , Tulloch Emily , Vinette Heloise , Ng Kaa-Yung , Owen Bryn , Hanyaloglu Aylin , Murphy Kevin

Dietary fat intake is an important source of energy and in excess can drive the development of obesity. Investigating how dietary fat intake alters neuronal activity in the brain and drives behavioural changes may help us understand the mechanisms behind high fat diet induced obesity. 2-oleoyglycerol (2-OG) is a naturally occurring unsaturated long chain fatty acid produced by fat digestion in the gut and a ligand of G protein-coupled receptor 119 (GPR119). Published data has ...

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ea0077p42 | Metabolism, Obesity and Diabetes | SFEBES2021

Chronic inflammation regulates androgen metabolism and exposure in Macrophages

Martin Claire S , Kalirai Matthew Singh , Crastin Ana , Turner Jason D , Schiffer Lina , Gilligan Lorna C , Taylor Angela E , Scheel-Toellner Dagmar , Raza Karim , Filer Andrew , Jones Simon W , Arlt Wiebke , Hewison Martin , Hardy Rowan S

Active androgens exert immunomodulatory actions at sites of inflammation and lower levels are implicated in the increased incidence of rheumatoid arthritis (RA) in females. However, inflammatory regulation of intracrine androgen metabolism within cell populations at sites of inflammation remain poorly defined. In this study we characterised immune and stromal cell androgen metabolism in RA patients and assessed their functional significance. Using the online Accelerating Medic...

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ea0077p43 | Metabolism, Obesity and Diabetes | SFEBES2021

5β-reductase is downregulated in patients with non-alcoholic fatty liver disease and hepatocellular carcinoma and controls metabolic and proliferative phenotype through LXR-dependent mechanisms

Nikolaou Nikolaos , Arvaniti Anastasia , Sanna Fabio , Saikali Michael , da Conceicao Ismael , Dempster Niall , Gathercole Laura , Cummins Carolyn , Tomlinson Jeremy

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from simple intrahepatic lipid accumulation to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). 5β-reductase (AKR1D1) is a liver enzyme that catalyses a fundamental step in bile acid (BA) synthesis. Both BAs and BA intermediates are established as potent regulators of metabolic and proliferative phenotype. We have hypothesised that AKR1D1 plays a crucial regulatory role in NAFLD and HCC. Hu...

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ea0077p44 | Metabolism, Obesity and Diabetes | SFEBES2021

11β-HSD1 determines the extent of muscle atrophy during an acute exacerbation of COPD

Michelle Webster Justine , Waaijenberg Kelsy , Worp Wouter van de , Lambrichts Sara , Lavery Gareth , Hardy Rowan S , Langen Ramon

Introduction: Muscle atrophy is a major clinical complication of acute exacerbations (AE) in chronic obstructive pulmonary disease (COPD). The enzyme 11 beta-hydroxysteroid dehydrogenase 1 (11β-HSD1) activates glucocorticoids (GCs) within muscle, is induced by inflammation, and has been shown to contribute towards GC-induced muscle wasting. In this study, we examined the role of 11β-HSD1 in this context using a murine model of COPD-AE in animals with transgenic globa...

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ea0077p45 | Metabolism, Obesity and Diabetes | SFEBES2021

PARP1 mediated ADP-Ribosylation events during myoblast fusion contribute to murine skeletal muscle phenotype

Tan Arnold , Evans Alexander , Creighton Jade , Boocock David , Weir Nick , Sale Craig , Doig Craig

The nicotinamide adenine dinucleotide (NAD+) dependent Poly-(ADP-ribosyl)polymerase 1 (PARP1) generates the post-translational modification ADP-Ribosylation (ADPR). Molecular studies have identified potential for NAD+ consuming enzymes to influence metabolic function. Given that PARP1 determines cellular NAD+ concentrations and ADPR shifts target protein activity, we sought to identify the molecular actions of PARP1 within skeletal muscle. Analysis of C2C12 lysates demonstrate...

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ea0077p46 | Metabolism, Obesity and Diabetes | SFEBES2021

AKR1C1 knock-down does not alter cell proliferation or response to chemotherapeutic agents in human hepatoma models

Conceicao Ismael , Arvaniti Anastasia , Hodson Leanne , Nikolaou Nikolaos , Tomlinson Jeremy

Hepatocellular carcinoma (HCC) is the 6th most common form of cancer and the 4th most common cause of cancer related death. AKR1C1 is a member of the aldo-keto reductase 1C (AKR1C) subfamily and has important roles in steroid hormone metabolism and in reducing lipid peroxides. AKR1C1 is ubiquitously expressed, with high levels of expression in the liver. Studies have identified differential expression in HCC with high levels of AKR1C1 expression associate...

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ea0077p47 | Metabolism, Obesity and Diabetes | SFEBES2021

Leicestershire wide steroid safety programme 2019-21 and effectiveness of electronic alert on prescription software in a tertiary centre

Ahsan Masato , Zaman Sajnin , Mifsud Roberta B , Reddy Narendra L , Bremner Emma , Barrowcliffe Mary , Bhake Ragini C , Levy Miles J

Background: Omission of steroids and unsafe steroid prescription in Adrenal insufficiency (AI) patients during intercurrent illness or surgery is unfortunately common, and can lead to adrenal crisis and potentially death. Anna Mitchell et al, New Castle-upon-Tyne have demonstrated potential use of electronic automation with steroid alerts to minimise human error for ensuring patient safety.Objectives: 1. Similar use of artificial intelligence wa...

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ea0077p48 | Metabolism, Obesity and Diabetes | SFEBES2021

The neuroophthalmological manifestations of obesity

Westgate Connar , Hagen Snorre , Israelsen Ida , Hamann Steffen , Jensen Rigmor , Eftekhari Sajedeh

Introduction: Obesity is associated with a plethora of metabolic and physiological side effects. Excess adiposity is associated with raised intracranial pressure (ICP) in obesity, where raised ICP sequalae include headache and visual decline in humans. We aimed to assess the effects of diet induced obesity (DIO) on ICP and related neuroophthalmological outcomes of headache behavior and retinal anatomy in rats.Methods: Female Sprague-Dawley rats received ...

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ea0077p49 | Metabolism, Obesity and Diabetes | SFEBES2021

Interplay of NUCB2/Nesfatin-1 and inflammation in white adipose tissue

Gharanei Seley , Patel Vanlata , Shabir Kiran , Patel Ria , Randeva Harpal , Kyrou Ioannis

Background: Excess adipose tissue accumulation and obesity are characterised by a chronic, low-grade, systemic inflammation that contributes to obesity-related cardio-metabolic disease. Nestfatin-1 is a neuropeptide derived from the precursor protein nucleobindin-2 (NUCB2), which was initially reported to exert anorexigenic effects. We have previously shown that NUCB2/Nesfatin-1 is highly expressed in human and mouse subcutaneous white adipose tissue (Sc-WAT) and that circulat...

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ea0077p50 | Metabolism, Obesity and Diabetes | SFEBES2021

Lipocalin 2, a mediator or marker of adipocyte dysfunction?

Parenti Cristina , Lad Nikita , Williams C Neil , Sharpe Graham R , Nelson Carl P , Murphy Alice M , McTernan Philip G

Background: Lipocalin 2 (NGAL) is considered a pro-inflammatory adipokine. Noting the conflicting reports as to the role of Lipocalin 2 in metabolic disease, it remains unclear whether an acute or chronic state affects its impact on adipocyte function. In an attempt to address this our current studies investigated for the first time in humans, whether Lipocalin 2 in abdominal subcutaneous adipose tissue (AT) may influence mitochondrial function and browning of adipocytes, as c...

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ea0077p51 | Metabolism, Obesity and Diabetes | SFEBES2021

Can modulation of beta cell ER stress in the KINGS (Ins2^+/G32S) mouse abolish sex differences in diabetic phenotype?

Daniels Gatward Lydia Faith , King Aileen

Background: The Ins2+/G32S mutation in the KINGS mouse drives beta-cell endoplasmic reticulum (ER) stress. The result of this is sexually dimorphic; males develop overt diabetes by 5-weeks (>16.7mM) whilst females remain normoglycemic. Previous studies have shown that high-fat feeding increases beta-cell ER stress, whilst GLP1-receptor agonists reduce this. We investigated whether altering ER stress could promote diabetes development in female KINGS mic...

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ea0077p52 | Metabolism, Obesity and Diabetes | SFEBES2021

How would school children design a poster about diabetes, obesity, health technologies and emotional wellbeing awareness?

Narendran Alisha , Anthony Amarah , Kelly Graham , Xavier Gabriela Da Silva , Shahzad Atif , Arlt Wiebke , Gillett Caroline DT , Kempegowda Punith

Introduction: Knowledge about end-user perceptions is important to ensure educational resources have maximal impact.Objective: To understand school childrens perceptions and ideas about three endocrine topics.Methods: This activity was done as part of Society for Endocrinology public engagement grant. Years 5 and 6 school children (aged 10-11 years) from Nonsuch Primary School in Birmingham were invited to create posters on t...

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ea0077p53 | Metabolism, Obesity and Diabetes | SFEBES2021

DKA registry: Creating a single data collection system for DKA in the West Midlands has helped identify best practices across hospitals

Cooper Catherine , Birchenough Amy , Rengarajan Lakshmi , Abdall-Razak Ali , Owen Megan , Yousuf Quratulain , Khan Sungeen , Pierrepont Zachary , De Parijat , Krishnasamy Senthilkumar , Narendran Parth , Kempegowda Punith

Background: There are several good practices to improve DKA management across hospitals. However, the lack of a unified system limits comparisons and learning from each other.Objectives: To establish a DKA registry to identify best practices across centres in the West Midlands.Methods: All people admitted with DKA at four hospitals in the West Midlands (named A, B, C, D for anonymity) from 1st January 2020 to 31st December 2020 wer...

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ea0077p54 | Metabolism, Obesity and Diabetes | SFEBES2021

Central adiposity and diabetes are causally associated with kidney stone disease

Lovegrove Catherine , Wiberg Akira , Littlejohns Thomas , Allen Naomi , Turney Benjamin , Mahajan Anubha , McCarthy Mark , Thakker Rajesh , Furniss Dominic , Howles Sarah

Introduction: The pathogenesis of kidney stone disease (KSD) is poorly understood and has been linked to features of metabolic syndrome (MetS). Using conventional and genetic epidemiological analyses we studied associations of MetS phenotypes with risk of KSD.Methods: Multivariate Cox-proportional hazard models were used to assess association of BMI and waist-hip ratio (WHR) with KSD in 492,380 UK Biobank participants. Causal relationships between WHR, B...

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ea0077p55 | Metabolism, Obesity and Diabetes | SFEBES2021

A novel approach to serum multi-steroid profiling using ultra high-performance liquid chromatography-tandem mass spectrometry with post column infusion ammonium fluoride

Shaheen Fozia , Gilligan Lorna , Schiffer Lina , Storbeck Karl-Heinz , Hawley James , Keevil Brian , Arlt Wiebke , Taylor Angela

Comprehensive multi-steroid profiling offers a powerful tool for the investigation, diagnosis and management of steroidogenic disorders by simultaneously quantifying multiple steroids from several pathways of steroid biosynthesis and metabolism. Difficulties can arise when optimising chromatography and mass spectrometry conditions for many analytes in a single method. Low concentrations of ammonium fluoride have previously been shown to enhance the sensitivity of select analyt...

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ea0077p56 | Metabolism, Obesity and Diabetes | SFEBES2021

Novel regulation of GR mediated gene expression by PARP-1 in mouse skeletal muscle cells

Tan Arnold , Evans Alexander , Doig Craig

The glucocorticoid receptor is constitutively expressed and fundamental to life. Activity of GR is partially governed by interacting partners whose actions skew the frequency with which GR produces meaningful transcriptional outcomes. Moreover, the tissue-specific actions of GR are themselves defined, with binding patterns being distinct in various tissue types. These features mean full molecular understanding of this steroid hormone receptor remains incomplete. As glucocortic...

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ea0077p57 | Metabolism, Obesity and Diabetes | SFEBES2021

Transcriptomic profiling of human enteroendocrine cells in primary ileal and duodenal organoid culture

Bakar Rula Bany , Smith Christopher A. , Lu Van B. , Goldspink Deborah A. , Gribble Fiona M. , Reimann Frank

Introduction: Enteroendocrine cells (EECs) are hormone-secreting cells within the intestinal epithelium that play an important role in regulating food absorption, insulin secretion and appetite. To understand the molecular mechanism governing the function of EECs, it is important to investigate cell-type-specific gene expression. The aim of this study was to identify the transcriptome of human EEC populations from organoid culture.Methods: To label the f...

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ea0077p58 | Metabolism, Obesity and Diabetes | SFEBES2021

Outcomes of postmenopausal women with non-alcoholic fatty liver disease (NAFLD)

Izzi-Engbeaya Chioma , Forlano Roberta , Mullish Benjamin H , Tan Tricia M , Yee Michael , Manousou Pinelopi , Dhillo Tricia S

Background: Non-alcoholic fatty liver disease (NAFLD), encompasses hepatic steatosis alone (NAFL), steatohepatitis (NASH), NAFL/NASH with fibrosis and cirrhosis. Severe fibrosis and cirrhosis are associated with increased risk of morbidity and mortality (due to cardiovascular events, end-stage liver failure and cancer). Postmenopausal women are a high-risk group of patients that have worse outcomes, but the specific factors that place them at higher risk are incompletely under...

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ea0077p59 | Metabolism, Obesity and Diabetes | SFEBES2021

Acidosis reduces 11β-HSD1 activity in human primary muscle cell cultures

Sagmeister Michael , Nicholson Thomas , Harper Lorraine , Jones Simon , Hardy Rowan

Background: Acidosis activates the hypothalamic-pituitary-adrenal (HPA) axis and induces glucocorticoid-mediated atrophy of skeletal muscle. The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inactive cortisone to active cortisol and modulates glucocorticoid signalling locally within skeletal muscle. Here, we address a gap in knowledge how acidosis affects 11β-HSD1 activity in human skeletal muscle cells.Methods: Quadrice...

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ea0077p60 | Metabolism, Obesity and Diabetes | SFEBES2021

Mimicking chronic hyperglycaemic conditions in primary human endothelial cell cultures using pathophysiological concentrations of glucose in prediabetes and type 2 diabetes

Luk Cheukyau , Haywood Natalie J , Kearney Mark T

Introduction: In the UK alone, diabetes affects nearly 4 million people and an additional 13.6 million people are estimated to be at high risk of developing type 2 diabetes (T2DM). Diabetes is associated with vascular complications which path the development of cardiovascular diseases such as strokes and heart attacks. Previous studies have shown various pathways in which hyperglycaemia leads to endothelial dysfunction and insulin resistance. However, current reports of <e...

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ea0077p61 | Metabolism, Obesity and Diabetes | SFEBES2021

The Effect of Bariatric Surgery on the proteome of people achieving remission of Type 2 Diabetes

Iqbal Zohaib , Fachim Helene , Gibson John , Baricevic-Jones Ivona , Campbell Amy , Geary Bethany , Donn Rachelle , Hamarashid Dashne , Syed Akheel , Whetton Anthony , Soran Handrean , Heald Adrian

Background: Bariatric surgery (BS) results in metabolic pathway recalibration. When major metabolic change occurs, blood protein components have a key role and can be altered significantly. We set out to identify potential biomarkers of change in plasma following BS in people achieving remission of type 2 diabetes mellitus (T2DM).Methods: Longitudinal analysis was performed on serum samples from 10 individuals who all achieved remission of T2DM following...

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ea0077p62 | Metabolism, Obesity and Diabetes | SFEBES2021

Hypoglycaemia in non-diabetics. An Endocrinologist’s perspective

Sharaf Giselle , Bhagi Ridhi , Morgan Georgia , Cozma S. Lawrence , Roy Chowdhury Sharmistha

Hypoglycaemia, a life threatening complication, occurs as part of a wide variety of disease processes. Though a common side effect of diabetes medications, it can be secondary to other factors including, endocrine and, metabolic disorders, severe sepsis, rare malignancies and non-diabetic medications. We present a case series of 3 non-diabetic patients who presented to Princess of Wales, Bridgend with Hypoglycaemic Episodes (HE):1. 23 year old student nu...

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ea0077p63 | Metabolism, Obesity and Diabetes | SFEBES2021

Polygenic lipid risk as a precipitant in Type III hyperlipidaemia

Pieri Kyriaki , Trichia Eirini , Neville Matt J , Taylor Hannah , Bennett Derrick , Karpe Fredrik , Koivula Robert W

Background: Type III hyperlipidaemia (T3HL) is characterised by equimolar increases in plasma triglyceride and cholesterol on an APOE2/2 genotype background and conveys a high risk of early-onset cardiovascular disease (CVD). Phenotypic penetrance of T3HL is <10% and precipitated by several endocrine/metabolic disorders such as obesity, diabetes and hypothyroidism. We explored the effect of triglyceride-raising polygenic score precipitating T3HL, in the context of...

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ea0077p64 | Metabolism, Obesity and Diabetes | SFEBES2021

The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval

Heald Adrian , Holland David , Stedman Michael , Duff Chirstopher J , Green Lewis , Scargill Jonathan , Hanna Fahmy WF , Wu Pensee , Fryer Anthony A

Introduction: Worldwide guidance advocates regular HbA1c testing for people with diabetes mellitus, usually 2-4/yr. We previously showed that HbA1c testing frequency is linked to outcome in terms of HbA1c control. Here we examine the effect of variability (standard deviation = SD) in test interval on change in HbA1c over 7 yrs (Jun 2012-Jul 2019) using laboratory data.Methods: We focused on people with HbA1c within the first 2 years who also had a HbA1c ...

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ea0077p65 | Metabolism, Obesity and Diabetes | SFEBES2021

Meeting the Challenge of Bariatric Surgery during the first wave of Covid -19 in a patient with a BMI >100kg/m²

Larsen Niels , Hughes David

Introduction: The super-super-obese category of patient (BMI >60) tend to respond poorly to conservative weight interventions. Bariatric surgery is therefore considered the best form of intervention. Only a few UK centres have expertise to manage patients with a BMI >100kg/m2 and careful counselling is essential as those standing to benefit the most from these procedures (through reduced risk of cardiovascular disease, diabetes and malignancy) also face the ...

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ea0077p66 | Metabolism, Obesity and Diabetes | SFEBES2021

Challenges in the management of severe hypertriglycridaemia causing acute pancreatitis

Aung Ei Thuzar , Wilmington Rebekah , Cannell Stephen , Srinivas-Shankar Upendram

Pancreatitis has multiple aetiologies of which commonest are gall stones and alcohol. Hypertriglyceridaemia is a less common (1-14 %) cause of pancreatitis. We present three case histories of acute pancreatitis due to severe triglyceridaemia and its management challenge in people with diabetes.Case history: 1. A 33-year-old man with BMI of 41 kg/m2 with Hodgkin lymphoma, thyrotoxicosis and diabetes, but no history of alcohol use was diagnosed ...

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ea0077p67 | Metabolism, Obesity and Diabetes | SFEBES2021

Association of Vitamin D and Adiposity in Children and Adolescents with type 1 diabetes: a case-control study

Majeed Maria , Siddiqui Mohsin , Lessan Nader

Background: Vitamin D (25(OH)D) deficiency is a global public health issue. An association with obesity and diabetes has been described in adult and paediatric populations. This study investigates the prevalence of 25(OH)D deficiency and its correlates in population of Emirati children and adolescents attending a large diabetes centre in the United Arab Emirates.Methods: Participants aged 4-19 years were selected based on diabetes status [type 1 diabetes...

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ea0077p68 | Metabolism, Obesity and Diabetes | SFEBES2021

Rhino-orbital-cerebral mucormycosis in diabetes patients with COVID-19

Muneer Muhammad , Akbar Ijaz

During the second wave of COVID-19 pandemic in some parts of the world especially in India there were significant numbers of rhino-orbital mucormycosis cases were reported. These cases were remarkably found in COVID-19 patients with diabetes, new-onset diabetes, DKA, stress hyperglycaemia, high ferritin levels, concomitant corticosteroid therapy defective phagocytic activity due to diabetes itself or immunosuppressive agents. COVID-19 is witnessed with widespread manifestation...

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ea0077p69 | Metabolism, Obesity and Diabetes | SFEBES2021

Persistent Lactic Acidosis after resolution of DKA in Young Patients with Poorly Controlled Diabetes Mellitus

Jadoon Nauman , Noor Sajjad , Khan Muhammad

Background: Lactic acidosis is a common finding in critically ill patients. In patients with poorly controlled diabetes for a prolonged period of time, Glycogenic hepatopathy (GH), can cause lactic acidosis which is a rare condition that develops due to excessive accumulation of glycogen in the hepatocytes.Cases: Two cases with poorly controlled diabetes and glycogenic hepatopathy are presented. First patient was a 28 year old female with 20 year history...

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ea0077p70 | Metabolism, Obesity and Diabetes | SFEBES2021

Real-world metabolic outcomes of semaglutide use in patients with type 2 diabetes: a retrospective study from a single centre in the United Arab Emirates

Allum Matthew , Buckley Adam , Lessan Nader , Mohammed Nagi , Suliman Mohamed , Suliman Sara , Elsheikh Mohgah

Background: The Glucagon-like peptide-1 receptor agonist (GLP1RA) semaglutide has shown improvements in glycaemia and other metabolic parameters for patients with type 2 diabetes (T2D) in clinical trials. Published real-world data are sparse and there are none from the Middle East where semaglutide became available in 2020.Method and Results: We retrospectively gathered data for 289 patients (median age 50 years (IQR 42-57), 36% female, 87% Emirati and 8...

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ea0077p71 | Metabolism, Obesity and Diabetes | SFEBES2021

Lipopolysaccharide signalling modulates brown fat transcriptome and cytokine secretion

Omran Farah , Murphy Alice , McTernan Philip , Christian Mar

Background: Brown adipose tissue (BAT) thermogenesis offers an appealing prospect to combat obesity. Obesity is characterised by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory-cytokines. Our previous work has highlighted that a gut-derived inflammatory agent, lipopolysaccharide (LPS), reduces brown adipocyte activity, insulin sensitivity and mitochondrial-function and is increased with obesity and type 2 diabetes mellitus...

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ea0077p72 | Metabolism, Obesity and Diabetes | SFEBES2021

Impact of PCSK9 Inhibitors on hypercholesterolaemic patients at a tertiary centre lipid clinic

Israni Alisha , Jones Ben , Salem Victoria , Bravis Vassiliki

Background: Elevated low-density lipoprotein cholesterol (LDL-C), which arises due to genetic and environmental factors, has a causal role in the pathogenesis of cardiovascular disease (CVD). Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are approved for patients with familial hypercholesterolaemia (FH) and patients at high risk of CVD due to non-familial hypercholesterolaemia (non-FH). In clinical trials, PCSK9 inhibitors are well-tolerated and lead to redu...

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ea0077p73 | Metabolism, Obesity and Diabetes | SFEBES2021

Beer Potomania Hyponatraemia: a discordant medley of symptoms of osmotic demyelination syndrome with ataxia and dysarthria

Wong Eleanor , Ahmed Aftab , Yin Win , Oboubie Kofi , Ershaid Dana , Al-Ansari Aseel

A 41 year old gentleman presented with collapse and vomiting for one week was found to be hyponatraemic with sodium of 103. He was treated with a sodium chloride 0.9% over 100 ml/hour and once sodium was increased to 118 in less than 24 hours. He was deescalated from intensive care on day3. He had developed severe ataxia, slow speech and was highly emotional. He was previously high functioning, maintaining a job and independent. It had transpired that he had been drinking 18 c...

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ea0077p74 | Metabolism, Obesity and Diabetes | SFEBES2021

Long-term follow-up of hemichorea-ballism syndrome associated with acute hyperglycemic crisis

Das Liza , Dutta Pinaki , Singh Amit Shankar , Singh Paramjeet , Kamal Ahuja Chirag

Background: Diabetic striatopathy (DS) is a rare dyskinetic syndrome associated with acute decompensated hyperglycemia that commonly presents as hemichorea-ballism. Its natural history following resolution of the hyperglycemic crisis is not well delineated.Methods: The study was a prospective evaluation of the long-term clinico-radiological outcomes of patients presenting with DS. Neuroimaging (CT/MRI) was performed at baseline and follow-up (>3 mont...

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ea0077p75 | Metabolism, Obesity and Diabetes | SFEBES2021

“The eyes have it”: a case of treatment-induced neuropathy of diabetes

Nicholson Martha , Morrison Emily , Page Oliver , Hammond Christopher , Lim Jonathan , Wilding John , Cuthbertson Daniel , Ooi Cheong , Malik Rayaz , Alam Uazman

A male in his 40s diagnosed with type 2 diabetes in 2011 (BMI:20.7kg/m2) was admitted with DKA (Dec 2018) after a period of poor glycaemic control on oral hypoglycaemic agents (Feb 2017: HbA1c-105mmol/mol, Nov 2018: HbA1c-115mmol/mol). There was dramatic improvement in glycaemic control after commencing him on subcutaneous insulin (April 2019: HbA1c-56mmol/mol). GAD65 antibodies were positive (24u/mL; normal<5u/mL) and a diagnosis of latent autoimmune diab...

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ea0077p76 | Metabolism, Obesity and Diabetes | SFEBES2021

Anaemia among patients with type 2 diabetes mellitus in Kano, Northwestern Nigeria

Fakhraddeen Muhammad , Adenike Enikuomehin

Introduction: Anaemia is the most prevalent haematological complication among patients with type 2 diabetes mellitus. It has an adverse effect on the development and progression of microvascular and macrovascular complications among these patients. Despite this problem, there is paucity of data on the condition in Kano, Northwestern Nigeria. Hence the need for the baseline research.Methodology: The study was a cross-sectional hospital-based study which r...

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ea0077p77 | Metabolism, Obesity and Diabetes | SFEBES2021

Relationship Between β-cell Function and Proteinuria in a Cohort of Type 2 DM Patients at OAUTHC Ile-Ife, Nigeria

Adetunji Tajudin , Ikem Rosemary , Kolawole Babatope , Soyoye David , Owolabi Funmilayo , Yusuff Olaoluwatomi , Okechukwu Ezekpo , Adetunji Ummulkhair , Udo Chinyere

Background: T2DM has been described as a complex mix bag of insulin resistance and β-cell defects in varying proportions. Several works have described in quantitative terms insulin resistance among diabetics and its relationship with proteinuria, the relative contribution of β- cell dysfunction have largely been extrapolated. This work is an attempt to provide the missing link in our clime.Objectives: The study aims to describe, in quantitative...

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ea0077p171 | Metabolism, Obesity and Diabetes | SFEBES2021

The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

Thomas Benjamin , Suckacki Karla , Fyfe Claire , Tavares Adriana , Sulston Richard , Lovdel Andrea , Woodward Holly , Han Xuan , Mattiucci Domenico , Brain Eleanor , Alcaide-Corral Carlos , Gray Gillian , Whitfield Phillip , Stimson Roland , Morton Nicholas , Johnstone Alexandra , Cawthorn William

Caloric restriction (CR) is a nutritional intervention that reduces the risk of age-related diseases in numerous species, including humans. CRs metabolic effects, including decreased fat mass and improved insulin sensitivity, play an important role in its broader health benefits, yet many aspects of the CR response remain poorly understood. In particular, sex differences in metabolic function are increasingly well recognised, but the extent and basis of sex differences i...

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ea0077p172 | Metabolism, Obesity and Diabetes | SFEBES2021

ATP-Binding Cassette Subfamily C Member 1 (ABCC1) influences adiposity, glucose homeostasis and insulin sensitivity

Villalobos Elisa , Chua EE June , Miguelez-Crespo Allende , Morgan Ruth , Andrew Ruth , Nixon Mark , Walker Brian

Background: Glucocorticoids (GCs) modulate glucose homeostasis by acting on metabolic tissues including liver, adipose, and skeletal muscle. ABCC1 is a transmembrane drug-resistance transporter expressed in adipose tissue and skeletal muscle with previously unknown physiological function. We recently showed that ABCC1 modulates intracellular GC concentrations and action in adipose. Here, we tested the hypothesis that Abcc1 regulates GC concentrations in skeletal mu...

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ea0077p173 | Metabolism, Obesity and Diabetes | SFEBES2021

Associations between reduction in body mass index (BMI) and proteins linked to neural function after 12 months of bariatric surgery

Fachim Helene , Iqbal Zohaib , Gibson Martin , Baracevic-Jones Ivonna , Campbel Amy , Geary Bethany , Donn Rachelle , Syed Akheel , Whetton Antony , Soran Handrean , Heald Adrian

Background: Bariatric surgery (BS) can have significant effects on multiple body systems and has been an effective intervention for morbid obesity, improving many comorbid medical conditions that are associated with mental health and cognitive dysfunction. It was previously shown that cognitive impairment was partly reversible in obese patients after BS [1], however, the effects of BS on proteins associated to central nervous system (CNS) still unknown. We evaluated if there a...

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ea0077p174 | Metabolism, Obesity and Diabetes | SFEBES2021

Vitamin D status in horses and its association with adiposity

Dosi Miranda , Mellanby Richard , Hurst Emma , McGorum Bruce , Keen John , Morgan Ruth

Obesity and metabolic syndrome are highly prevalent in horses and ponies worldwide. Equine Metabolic Syndrome (EMS) shares much of the same pathophysiology with its human counterpart including adipose tissue dysfunction and insulin dysregulation. Vitamin D deficiency is strongly associated with obesity and insulin resistance in humans and supplementation is often recommended. In horses our understanding of vitamin D biology is limited and its association with EMS unknown. The ...

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ea0077p175 | Metabolism, Obesity and Diabetes | SFEBES2021

Pressure from pericytes: angiotensin II induced neuropathic pain development as a complication of hypertension

Hardowar Lydia , Sheavyn Matt , McTernan Philip , Bates Dave , Hulse Richard

The renin angiotensin system (RAS) is targeted as means of medical intervention for hypertensive associated complications of stroke, heart failure and obesity. Ultimately, the inhibition of Angiotensin II(ANGII)/Angiotensin II type 1 (AT1) receptor complex has been key in reducing raised blood pressure. Diabetic neuropathic pain (NP) is highly prevalent in the United Kingdom, associated with an increasingly aged population. There is growing acknowledgment that the vascular com...

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ea0077p176 | Metabolism, Obesity and Diabetes | SFEBES2021

Asprosin impact on mitochondrial metabolism in obese adipose tissue, a tale of two depots?

Lad Nikita , Murphy Alice M , Parenti Cristina , Nelson Carl P. , Williams Neil C. , Sharpe Graham R. , McTernan Philip G.

Background: In an obese state, pro-inflammatory adipokines can lead to mitochondrial dysfunction and reduced brown adipocytes properties in white adipocytes (BRITE adipocytes), all of which contribute to the pathogenesis of obesity and type 2 diabetes mellitus (T2DM). A recent novel adipokine, asprosin, that influences appetite and glucose homeostasis, appears to drive inflammation in obesity. However, asprosin expression in human adipose tissue (AT) depots, its impact on mito...

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ea0077p177 | Metabolism, Obesity and Diabetes | SFEBES2021

Obesity-induced upregulation of chemokine Ccl4 in mouse visceral adipose tissue: effects on β-cell function

Ashik Tanyel , Atanes Patricio , Lee Vivian , Persaud Shanta

Introduction: Adipose tissue-derived peptides, known as adipokines, act as key regulators of metabolic homeostasis, but little information is available on adipokine-mediated cross-talk with β-cells via islet GPCR interactions, nor whether this is altered in obesity. The expression profile of islet GPCR peptide ligand mRNAs in visceral adipose tissue from lean and diet-induced obese mice was therefore defined and the functional effects of Ccl4 on β-cells were characte...

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ea0077p178 | Metabolism, Obesity and Diabetes | SFEBES2021

Abstract withdrawn...

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ea0077p179 | Metabolism, Obesity and Diabetes | SFEBES2021

Impact of α-MSH on glucose tolerance in healthy participants: The first in human randomized, double-blind, placebo-controlled, physiological study

Sahar Bashar , Johnson Brett , Samarasinghe Suhaniya , Shwan Patrick , Docherty Neil , Roux Carl Le , Choudry Tasnia , Miras Alex

This abstract has been withdrawn at the request of the first author and Imperial College London. 08/06/2022...

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ea0077p180 | Metabolism, Obesity and Diabetes | SFEBES2021

Neurotensin improves glucose tolerance via activation of peripheral NTSR1-expressing neurons

Roberts Anna , Norton Mariana , Martin Alonso Aldara , Phuah Phyllis , Cheng Sijing , Smitherman-Cairns Tobias , Hanyaloglu Aylin , Murphy Kevin

Neurotensin is a 13-amino acid peptide expressed in both the brain and the gastrointestinal tract where it acts as a neuropeptide and gut hormone, respectively. Centrally, neurotensin plays a role in appetite, analgesia and thermoregulation, whereas peripheral neurotensin regulates lipid absorption, gastric emptying and exocrine pancreatic secretion. The role of neurotensin in the control of glucose homeostasis currently remains unclear. We found peripheral administration of n...

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ea0077p181 | Metabolism, Obesity and Diabetes | SFEBES2021

Bio informatic Analysis Reveals Hundreds of Differentially-Expressed lncRNAs with Potential Roles in β-Cell Proliferation

Wilson Maya , Pullen Timothy

Background and Aims: As a loss of functional β-cell mass contributes to type 2 diabetes (T2D), increasing β-cell proliferation is a potential therapy to compensate for impaired insulin output. Long non-coding RNAs (lncRNAs) regulate several key β-cell genes and the presence of more than 1100 human β-cell enriched lncRNAs raises the potential for wider roles. Here we have identified 5 independent studies that capture the β-cell transcriptome during adap...

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ea0077p182 | Metabolism, Obesity and Diabetes | SFEBES2021

Rat primary hypothalamic, but not cortical, astrocytes increase use of glutamate to fuel metabolism after recurrent low glucose

Potter Paul Weightman , Randall Andy , Ellacott Kate , Beall Craig

Aims: A critical function of astrocytes is to recycle glutamate to neurons as glutamine to sustain glutamatergic neurotransmission. In the hypothalamus, this is required for effective counterregulatory hormone release in response to hypoglycaemia. However, after recurrent hypoglycaemia in vivo, this is attenuated. The aim of this study was to characterise how rat primary hypothalamic and cortical astrocytes adapt to recurrent low glucose (RLG) with repeated exposure t...

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ea0077p183 | Metabolism, Obesity and Diabetes | SFEBES2021

The influence of metabolic states and a high fat meal on circulating chemerin

Murphy Alice , Dumbell Rebecca , Varma Madhu , Helfer Gisela , McTernan Philip

Background: Chemerin is a multifunctional adipokine involved in pathogenesis of metabolic disease by regulating inflammation, adipocyte plasticity and glucose metabolism. It is known to be influenced by age, adiposity and triglycerides, and supports important roles in systemic lipid and glucose metabolism.However, the direct acute effects of circulating chemerin on varying metabolic disease states given a highsaturated fat meal has not been addressed.<p clas...

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ea0077p184 | Metabolism, Obesity and Diabetes | SFEBES2021

Does human serum impact differentiation and mitochondrial function of human LHCN-M2 skeletal muscle cells?

Turner Mark , Saini Amarjit , Brown Holly , Anisi Sara , Stewart Claire , Renshaw Derek

Introduction: Skeletal muscle cells enable investigation of myogenesis and metabolic function in vitro. Exposure to human serum can provide insight into the impact of endocrine factors upon differentiation and mitochondrial function of skeletal muscle. The aim of these experiments was to optimise the culture conditions using human serum, which it was hypothesised would enhance myogenesis and mitochondrial function of LHCN-M2 human skeletal muscle cells.<p class="a...

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ea0077p185 | Metabolism, Obesity and Diabetes | SFEBES2021

Measurements of skin temperature in lean and obese humans at thermoneutrality and following cold exposure

Choong Kwok T’ng , Ramage Lynne E , Kelman Alexandra , Semple Robert K , Stimson Roland H

Background: Infrared thermography (IRT) can assess human brown adipose tissue (BAT) activity non-invasively. However, it remains unclear if skin temperature is altered in obesity. We compared skin temperatures of lean and obese individuals following cold exposure and studied its relationship with energy expenditure (EE).Methods: 10 lean (age 28.3±2.1y, BMI 21.5±0.4kg/m2) and 10 obese (age 28.2±2.1y, BMI 36.2±1.3kg/m2</...

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ea0077p186 | Metabolism, Obesity and Diabetes | SFEBES2021

Predictors of adverse outcomes in COVID-19: A retrospective cohort study comparing the first two waves of COVID-19 hospital admissions in London, with a focus on diabetes

Hashmi Durreshahwar , Shaikhali Yusuf , Cassin-Scott Rebecca , Eng Pei , Distaso Walter , Tan Tricia , Salem Victoria , Izzy-Engbeaya Chioma

Introduction: Diabetes has been associated with poorer outcomes with COVID-19 infection, but precise predictors of mortality in patients with diabetes remain unclear. We assessed predictors of adverse outcomes in patients hospitalised with COVID-19 in Imperial College Healthcare NHS Trust (ICHNT) hospitals during the first and second waves of COVID-19 to determine if outcomes for patients with diabetes have evolved with new variants and treatments.Method...

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ea0077p187 | Metabolism, Obesity and Diabetes | SFEBES2021

Asprosin induces acute pro-inflammatory effects on THP-1 macrophages

Shabir Kiran , Brown James , Randeva Harpal , Kyrou Ioannis

Introduction: Asprosin is a novel adipokine that is released in response to fasting and can elicit orexigenic and glucogenic effects. Circulating asprosin levels are elevated in a number of cardio-metabolic diseases, including obesity and type 2 diabetes mellitus. In vitro studies have reported pro-inflammatory effects of asprosin in pancreatic β-cells and skeletal muscle cells, which appear to be mediated via a toll-like receptor 4 (TLR4) mediated pathway, and m...

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ea0077p188 | Metabolism, Obesity and Diabetes | SFEBES2021

Exploring the translational potential of the NPY Y4 receptor for treating Type 1 Diabetes

Haq Naila , Toczyska Klaudia , Olaniru Oladapo , Atanes Patricio , Beck-Sickinger Annette , Bewick Gavin

Type 1 diabetes (T1D) is an autoimmune, heterogenous disease caused by immune-mediated destruction of insulin-producing β-cells in the pancreas. The only approved treatment strategies are exogenous insulin replacement therapy and islet transplantation. Leading experimental approaches have focussed on suppression and/or modulation of the immune system. However, efforts to increase β-cell survival are also of great interest. Recent studies in our lab have identified ne...

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ea0077p189 | Metabolism, Obesity and Diabetes | SFEBES2021

BMI category-specific waist circumference thresholds for predicting the risk of cardiometabolic diseases: A nationwide population-based study

Son Jang Won , Lee Seong-Su , Kim Sungrae , Kwon Hyuk-Sang , Jib Yoo Soon

Background: There is no existing longitudinal study to support ethnicity-specific and body mass index (BMI) category-specific waist circumference (WC) thresholds and their potential clinical utility to assess the risk of obesity-related diseases.Methods: We performed a prospective assessment of 5,852,702 subjects in large-scale population-based cohort dataset obtained from the Korea National Health Insurance System. BMI was categorized into 6 subgroups (...

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ea0077p190 | Metabolism, Obesity and Diabetes | SFEBES2021

Outcomes of Bariatric surgery in adolescents and youth in an Arab population: a single centre experience

Radha Saradalekshmi Koramannil , Ali Tomader , Baqer Amal , Lessan Nader

Background: Obesity is increasing in prevalence in younger people, including children and adolescents. Bariatric surgery (BS) is well-established and efficacious treatment for morbid obesity in adults. BS is being performed in younger age groups more frequently.Objective: To describe outcomes of BS under the age of 25 in Emirati individuals having follow-up at Imperial College London Diabetes Centre (ICLDC).Methods: Patients recrui...

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ea0077p191 | Metabolism, Obesity and Diabetes | SFEBES2021

How does FreeStyle Libre Glucose management indicator (GMI) compare with HbA1c and fructosamine in patients with type 1 diabetes and what are the determinants of the difference?

Jain Manushri , Sarkar Priya , Kalaria Tejas , Healey Brett , Raghavan Rajeev , Gama Rousseau

Objective: To compare FreeStyle Libre Glucose management indicator (GMI) with HbA1c and fructosamine and assess factors related to the difference.Methods: Persons with type 1 diabetes on FreeStyle Libre from a single diabetes centre whose sensor was active >70% of the time were included. Baseline characteristics, latest HbA1c, fructosamine, full blood count, total protein and albumin were collected from medical records. Ambulatory glucose profile dat...

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ea0077p192 | Metabolism, Obesity and Diabetes | SFEBES2021

N-acetylmuramoyl-L-alanine amidase is a biomarker for remission of type 2 diabetes after bariatric surgery

Iqbal Zohaib , Fachim Helene , Gibson John , Baricevic-Jones Ivona , Campbell Amy , Geary Bethany , Donn Rachelle , Syed Akheel , Wetton Anthony , Soran Handrean , Heald Adrian

Aims: We used sequential window acquisition of all theoretical fragment ion spectra Mass Spectrometry (SWATH-MS) to identify proteins acting as markers of remission of type 2 diabetes (T2DM) in patients who lost weight after bariatric surgery.Background: Bariatric surgery results in remission of T2DM in up to 80% of patients. The mechanisms underpinning are largely unknown. N-acetylmuramoyl-L-alanine amidase (PGLRYP2) is an immune response enzyme that br...

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ea0077p193 | Metabolism, Obesity and Diabetes | SFEBES2021

Magnesium: The forgotten sibling of electrolytes. A study of two audits conducted over 4 years

Sharma Bhavna , Ojo Ohiowele , Qureshi Asjid , Rahman Mushtaqar , Seetho Ian , Hui Elaine , Seechurn Shivshankar , Deore Mahesh M

The role of magnesium in electrolyte homeostasis is well established. ATP/ADP structure, refractory hypokalemia and calcium homeostasis are some of the established roles in literature, well known to Endocrine. However, currently no NICE guidelines exist for low magnesium. Our first audit in 2018 focused on patient admissions during January 2018. We found 49 patients with Mg < 0.5. Majority were care of the Geriatrics, 8 under Gastroenterology, 4 under Endocrinology. 31 pat...

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ea0077p194 | Metabolism, Obesity and Diabetes | SFEBES2021

Abstract withdrawn...

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ea0077p195 | Metabolism, Obesity and Diabetes | SFEBES2021

Diabetes and Young COVID: A two country and two wave study of associations

Sharma Bhavna , Sharma Angelica , Sharma Indu

Authors agree that although mortality for COVID 19 is low, comorbidities may contribute to severe disease and mortality. Chinese center for disease control and prevention reported three times higher mortality in patients with diabetes. However, most studies do not take into account age of patients. Our study aimed to evaluate association of COVID in patients lesser than 65 years of age in two countries, India and United Kingdom with diabetes. We excluded patients with co-morbi...

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ea0077p196 | Metabolism, Obesity and Diabetes | SFEBES2021

Studies of the novel essential invadolysin metalloprotease in human blood

Feng Linda , Heck Margarete

The classic Drosophila model system has been utilized by the Heck laboratory for the characterization of novel and conserved genes essential for cell cycle and cellular physiology. The invadolysin mutation was first identified in D. melanogaster, which gave rise to abnormally-condensed chromosomes and had a lethal effect on the late larval stages. Invadolysin is a novel zinc-metalloprotease that we have shown to link cell division and cell migration ...

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ea0077p197 | Metabolism, Obesity and Diabetes | SFEBES2021

Case report of a Patient With Maturity Onset Diabetes of the Young 6: a novel NEUROD1 mutation

Colosimo Santo , Baracco Bianca , Brodosi Lucia

Introduction: Maturity onset diabetes of the young (MODY) is a group of monogenic, autosomal, dominant diseases characterized by a single genetic mutation that results in beta-cells disfunction with consequent hyperglycemia. It Accounts for 1-5% of all cases of diabetes. At the moment, optimal treatment has not been established and it relies on the individual response. A mutation of NEUROD1 gene, a transcription factor expressed by pancreatic and nervous tissues, has been foun...

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ea0077p198 | Metabolism, Obesity and Diabetes | SFEBES2021

Corticosterone excess alters metabolic rate in male and female C57BL/6J mice

Heaselgrave Samuel , Heising Silke , Morgan Stuart , Morton Nicholas , Lavery Gareth

Introduction: Glucocorticoids are vital for regulating metabolic processes, as well as use in medical treatments. However chronic glucocorticoid excess is known to cause negative metabolic effects including hyperglycaemia, muscle atrophy and fat accumulation. The effect on energy metabolism and metabolic rate remains undefined and merits investigation in both male and female mice.Methods: 20 male and 20 female C57BL/6J mice were randomly assigned to a co...

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ea0077p199 | Metabolism, Obesity and Diabetes | SFEBES2021

Paraneoplastic Insulin Resistance Syndrome: a case of Fibromatosis (Desmoid Tumour)

Chohan Muhammad Tahir , Iqbal Khan Irfan , Ahmad Waqar , Spence Tina , Presgrave Marie , Nag Sathyajit , Macauley Mavin

Introduction: Paraneoplastic endocrine syndrome such as hypercalcemia in malignancy is well-known. However, paraneoplastic insulin resistance is rarely described and its management is challenging.Case history: A 33 years old teetotal gentleman with BMI of 37.5 kg/m2 and histological diagnosis of desmoid tumour presented with osmotic symptoms, weight loss, hyperglycemia and normal ketones. He was hemodynamically stable with no clinical or bioch...

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ea0077p200 | Metabolism, Obesity and Diabetes | SFEBES2021

Management of the common within the uncommon: Euglycemic ketoacidosis in Bloom’s syndrome

Nair Nalini , Awala Orighomisan , Thadani Puja , Yasear Zhainab , Rao Ranganatha , Murthy Narasimha , Sankar Sailesh , Randeeva Harpal

Background: Blooms syndrome is a rare autosomal recessive disorder due to chromosomal instability. It is associated with endocrinopathies such as growth deficiency, insulin resistance, type 2 diabetes, dyslipidemia and hypothyroidism. We present a case to highlight the challenges in management of diabetic emergencies in patients with complex syndromes.Case report: A 38-year-old male of Asian descent known to have Blooms syndrome presented to ...

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ea0077p201 | Metabolism, Obesity and Diabetes | SFEBES2021

Phospho-regulation of Acetyl-CoA-Carboxylase (ACC1) in Pancreatic Beta Cells

Bany Bakar Rula , Liberatori Sabrina , Veprik Anna , Tebeka Nchimunya Nelisa , Mohammed Shabaz , Cantley James

Background: Acetyl-CoA-Carboxylase (ACC1), the rate-limiting enzyme of de novo lipogenesis, plays a critical role in beta cell growth and insulin secretion. In spite of plethora evidence for the role of ACC1 in insulin secretion and beta cells function both in vivo and in vitro, very little is known about how ACC1 activity is regulated in pancreatic beta cells. The aim of the current study was to screen for novel phospho-sites that may regulate ACC1 activity ...

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ea0077p202 | Metabolism, Obesity and Diabetes | SFEBES2021

Estimation of body fatness in obesity and partial lipodystrophy in relation to eligibility for bariatric surgery: What should be measured?

Efthymiadis Agathoklis , Vasan Senthil K , Tan Garry D , Karpe Fredrik

Introduction: Eligibility for bariatric surgery in the Unighted Kingdom is based on specific body mass index (BMI) thresholds and the presence of obesity-associated complications. Patients with partial lipodystrophy (LD) often have an abundance of metabolic and cardiovascular complications, but their abdominal adiposity does not always substantially increase BMI. The consequence is that patients with LD may be inappropriately excluded from obesity treatments when judged by BMI...

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ea0077p203 | Metabolism, Obesity and Diabetes | SFEBES2021

An Audit assessing Management of COVID patients on Dexamethasone with High Capillary Blood Glucose (CBGs) from 01/01/21 to 19/3/21

Choy Bennett , Mannan Imran

Dexamethasone reduces mortality in COVID patients who require oxygen therapy. Dexamethasone-related hyperglycaemia however is a known complication. Capillary blood glucose (CBGs) above 10.0 mmol/l have been linked to increased mortality in COVID patients. Approximately a third of COVID patients with dexamethasone-related hyperglycaemia may develop diabetes later. It is therefore important to manage acute episodes of hyperglycaemia effectively and identify these patients for fo...

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ea0077p204 | Metabolism, Obesity and Diabetes | SFEBES2021

Early detection of Peripheral Diabetic Neuropathy – A correlative study of symptoms with Digital Biothesiometry

Joseph Mettayil Jeevan

Aim: To assess the utility of early detection of diabetic peripheral neuropathy using Vibration perception threshold (VPT) via digital Biothesiometer and correlation with patient reported symptoms. Type of study: Audit of peripheral neuropathy assessment in all diabetes patients Standard: NICE guideline on Diabetic foot problems (NG 19- Updated October 2019)Methods: The NICE guidelines recommend neuropathy assessment on all patients with Type 2 Diabetes....

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ea0077p205 | Metabolism, Obesity and Diabetes | SFEBES2021

Assessing and Improving junior doctors’ knowledge and confidence in managing Diabetes Mellitus in the end-of-life setting

Tansey David J. , Tiernan Eoin , Moran Carla

An anonymised online survey was created to evaluate junior doctors competency and confidence with decision-making scenarios in managing patients with diabetes at the end-of-life. 26 doctors working at the Beacon Hospital completed the online survey. A structured education programme was then delivered to the junior doctors where the critical information pertaining to the management of diabetes at the end-of-life was discussed, based on the ABCD 2011 and Diabetes UK 2013 a...

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ea0077p206 | Metabolism, Obesity and Diabetes | SFEBES2021

A quality improvement project to assess the management of diabetes in out-patient clinic as per the NICE guidelines

Ali Anyat

Purpose: The aim of diabetes management is to prevent the micro/macrovascular complications. We have designed a quality improvement project to monitor how we are doing in term of glycaemic control and overall management of diabetes in our out-patient facility and how can we improve the outcome further.Methods: Parameters checked (HbA1C, blood pressure, lipid profile, annual fundus examination, podiatry, urine for ACR). Retrospective study of 112 patients...

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ea0077p207 | Metabolism, Obesity and Diabetes | SFEBES2021

Omeprazole induced hypomagnesemia leading to hypocalcemia

Thacker Jeet , Das Gautam

Case History: A 58 year old female was referred by the GP to hospital for symptoms of tingling and numbness in fingers and toes, muscle cramps in arms and legs and swollen legs. The patient had a history of gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), hypertension, fibromyalgia, iron deficiency anaemia, knee osteoarthritis, and heart failure.Investigations: On admission, a corrected calcium level was 1.9 mmol/l and serum magnes...

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ea0077p208 | Metabolism, Obesity and Diabetes | SFEBES2021

The unmasking of chronic diabetes mellitus, presenting as severe diabetic ketoacidosis following traumatic pancreatic injury, without pancreatitis

Zhuang Choo Alwyn Yung , Yong Tan Zhi

A 43-year-old gentleman with no known medical illnesses presented with progressive abdominal distension and pain. This happened following a fall from 2-metre height with direct impact on his abdomen. On examination he had signs of abdominal peritonism and was managed as a trauma case. He was haemodynamically stable. CT of his abdomen showed suspected large pancreatic haematoma, consistent with significant pancreatic injury with no evidence of active haemorrhage or pancreatitis...

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ea0077p209 | Metabolism, Obesity and Diabetes | SFEBES2021

Gender-specific prevalence of hyperuricemia and association with metabolic disorders in China: a hospital population based retrospective real-world study

Pang Shuguang , Jiang Qiang , Pei Sun , Li Yi , Zhu Yanhua , Liu Jin , Chen Ting , Ye Xiaoran , Yang Wenjun

Objective: To investigate the prevalence of hyperuricemia in Chinese population, and the association between serum concentrations of uric acid and related metabolic disorders.Methods: This study was based on de-identified hospital information system (HIS) data collected from four tertiary hospitals in three provinces of China. A total of 432,002 patients with at least one medical visit recorded SUA measurement were screened and 374,506 were enrolled. Hyp...

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Society for Endocrinology BES 2021

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