Endocrine Abstracts

Introduction: Covid -19 can cause serious or severe illness in anyone but those with chronic health conditions are at greater risk. Adrenal insufficiency (AI) is assumed to be associated with an increased Covid-19 infection risk, which could trigger an adrenal crisis. We conducted a retrospective study at district general hospital to assess the incidence of COVID-19 in Adrenal insufficiency patients.Method and material: Retrospective review of 43 patient...

Objectives: To determine the association between adverse pregnancy outcomes with each of the 75 g OGTT cut-off values prescribed by the World Health Organization (WHO), Philippine Obstetrical and Gynecological Society (POGS), and the International Association of Diabetes in Pregnancy Study group (IASDPG) criteria to help define more appropriate glycemic cut-off levels for Filipinas.Methodology: Retrospective Cohort study of pregnancy deliveries in De La ...

Introduction: Pasireotide long acting release (LAR) is approved for second line treatment of acromegaly. We present 3 patients with aggressive acromegaly treated with a personalized de-escalation approach.Case 1: A 61-year-old female affected by acromegaly reisistant on first-line SSAs. In 2015 therapy was switched to pasireotide LAR 60 mg every 28 days. After two years, the IGF-I level touched the lower age range and therapy was downscaled to pasireotid...

A 48-year-old gentleman, father of 3 children, was referred to our endocrinology clinic, with sexual dysfunction and hypergonadotrophic hypogonadism. He had a history of severe Coronovirus-Disease-2019(COVID-19) pneumonitis for which he received prolonged ventilatory support. Post extubation, he experienced testicular pain and swelling. A testicular ultrasound showed a left-sided hydrocele, multiloculated epididymal-cyst and a right testicular cyst. He also described new sympt...

A 27 year old lady with Graves’ thyrotoxicosis (fT4 50.3 pmol/L, fT3 25.0 pmol/L, TSH<0.05 mU/L) failed to respond adequately to carbimazole (40 mg BD) or propylthiouracil (250 mg QDS). Three months later, following 10 days of potassium iodide to render her biochemically euthyroid, she underwent a total thyroidectomy. Pre-operative bone profile revealed Ca(c) 2.34 mmol/L (NR 2.15–2.60 mmol/L), phosphate 1.36 mmol/L (NR 0.8–1.4 mmol/L), PTH 3.4 pmol/L (NR 1.1...

Case report: A 7-year-old girl presented with short stature following removal to the UK from China, where she had been diagnosed with GH deficiency on blood testing, for which GH treatment had been recommended. She had reportedly not grown well over the previous 2 years, and though the oldest in her class, she was the smallest. She had a poor appetite but otherwise was well. She had no constipation, normal activity levels, and was doing well in school. She was born at term wei...

A 52-year-old, previously well Indian lady was admitted in May 2008 with pneumonia. Concurrently, she was diagnosed with diabetes mellitus (blood glucose 20 mmol/l). Her BMI was 19 kg/m2 and she was initially commenced onto sulphonylurea therapy. She had a further admission in July 2008 with dizzy episodes, falls, postural hypotension (systolic postural drop 75 mmHg) and erratic blood glucose levels (range 1.1–30 mmol/l). Blood ketones were 3.6 mmol/l without a...

Introduction: Kallmann-de Morsier Syndrome is a rare genetic disorder characterized by the combination of hypogonadotropic hypogonadism and anosmia or hyposmia. It is more prevalent in males compared to females. In this case report, we present the case of an adolescent with Kallmann-de Morsier Syndrome.Case Presentation: An 18-year-old patient was referred to our endocrinology clinic by gynecologists for the investigation of pubertal delay. The patient&#...

Introduction: De Quervain’s thyroiditis, also known as subacute granulomatous thyroiditis, is a self-limiting inflammatory disorder of the thyroid gland. It is presumed to be caused by a viral infection and many patients have a history of an upper respiratory infection 2-8 weeks prior to the onset of thyroiditis. It is the most common cause for neck pain or discomfort, and it usually has a predictable course of thyroid function evolution. On ultrasonography the thyroid gl...

Cortisol-based therapy is still the most potent anti-inflammatory treatment available for skin conditions such as psoriasis and atopic dermatitis. Previous studies have demonstrated the presence of components of the steroidogenic pathway in keratinocytes, though surprisingly none have reported that these cells, which form up to 90% of the epidermis are able to synthesise cortisol1,2. Here, we demonstrate that primary human keratinocytes (PHK) are capable of de no...