Endocrine Abstracts

Malignant pheocromocytoma is a rare and problematic disease because it is diagnosed only in the presence of metastases, with no definitive histological or cytological criteria of malignancy. It typically metastasizes to bone, liver, lung and lymph nodes.A 38-year-old woman presented for hypertension (max sBP=160 mmHg), palpitation and dyspnea, with family antecedents of mammary cancer. Clinical examination was normal with the exception of palpable adenop...

Introduction: Autoimmune thyroid disease affects 1% of the population and comprises several disorders, including Graves’ disease(GD). Local and serum cytokines are increased in patients with Graves disease, play a central role in co-ordinating immune reactions and have immunolgical and functional effects on thyroid cells.Aim: To investigate serum inflammatory and cytokines profile in untreated patients with Graves’ disease at diagnosis, when th...

The aim of our study was to investigate de relationship between anthropometric and body composition parameters and thyroid function (measured with TSH and free T4), as well as thyroid volume, in patients with obesity.Methods: This is a cross-sectional study including patients with obesity consecutively referred to our tertiary endocrine center for diverse pathologies. TSH and free T4 was measured in all patients and thyroid ultrasound was performed by an...

Obesity has been associated with a status of subclinical inflammation. Neutrophil to lymphocyte ratio (NRL) is a widely available and inexpensive inflammatory marker which can be reliable in evaluating the inflammatory status occurring in patients with severe obesity The aim of our study was to investigate the association between NLR and anthropometric and body-composition parameters, in a group of patients with obesityPatients and Methods: 737 patients ...

Introduction: Paragangliomas are neuroendocrine tumors that are derived from the embryonic neural crest cells. Because the paraganglia are widespread through the body, paragangliomas can be found in unusual anatomic locations and the diagnosis can be hard to establish. Case presentationWe present the case of an 72 year-old, hypertensive woman who arrived at the hospital for pain in the right hypochondrium. General examination revealed an abdomen without signs of peritoneal irr...

Introduction: Functioning gonadotroph adenomas (FGA) are adenomas secreting and expressing biologically active gonadotropins and causing distinct clinical manifestations. The vast majority of the immunohistochemically confirmed gonadotroph adenomas are hormonally silent (presenting only with mass effects), clinically FGA’s being very rare; whereas their exact prevalence is not known.Case study: A 46 years old male patient presents to our clinic afte...

Introduction: Morbidly obese patients raise many problems in therapeutic attitude, sometimes associating a cluster of obesity-related abnormalities: hypogonadotropic hypogonadism, metabolic syndrome, respiratory insufficiency, and high risk for cardiovascular disease. These afflictions can be reversed through weight loss, especially in young patients.Case presentation: We present the case of a 41 year old male patient, smoker, with morbid obesity (BMI =6...

Background: Malignancy and hyperthyroidism used to be considered mutually exclusive, but increased association was observed. These two conditions incidence is variable, ranging between 0 and 9%, Graves’ disease is especially linked to differentiated thyroid carcinoma type.Case presentation: We report the case of a 33 year old, female, smoker, diagnosed with Basedow–Graves disease in may 2015, on methimazole 20 mg/day. She was admitted to our de...

Introduction: Decreased bone mass is associated with inflammatory bowel disease (IBD), due to multiple factors, including endocrine disturbances, deficits in calcium and vitamin D, malnutrition, drugs (corticosteroids), chronic inflammation. If in older man and postmenopausal women, the treatment is well established, for young patients is not a general consensus.Case report: We report the case of a 20-year-old, male, nonsmoker, diagnosed with Crohn disea...

Introduction: Cushing’s syndrome (CS) is associated with central obesity, hypertension, insulin resistance, dyslipidemia, prothrombotic state, manifestations which form a metabolic syndrome. Accelerated vascular senescence, due to metabolic and vascular changes, increases, in CS, the cardiovascular risk and the mortality rates compared to age- and gender-matched population. On the other hand, obesity itself is associated with numerous comorbidities, including hypertension...