Searchable abstracts of presentations at key conferences in endocrinology

ea0101ps2-11-04 | Basic thyroid cancer research-1 | ETA2024

Downregulation of MIR-346 affects the expression of nuclear receptor-interacting protein 1 (NRIP-1) and estrogen receptors in follicular thyroid cancer

Nam Jisun , Suk Park Jong , Woo Ahn Chul , Kim Yu-Sik

Objectives: Evidence exists that estrogen receptor alpha (ERα) and beta (ERβ) may be involved in the pathogenesis of thyroid cancer. miR-341, a potent biomarker that distinguishes follicular thyroid cancer (FTC) from adenoma, has shown proliferative and metastatic effects in various cancers by regulating nuclear receptor-interacting protein 1 (NRIP1), which forms complexes with ERα. Thus, we investigated the role of miR-346 on estrogen-associated pathogenesis of...

ea0092ps1-02-05 | Graves’ Disease | ETA2023

Association between radioactive iodine treatment and cancer risk in graves’ disease: a nationwide cohort study

Jin Kim Kyeong , Lee Yeji , Won Park Da , Jin Kim Kyoung , Seon Park Min , Hyung Kim Joo , Young Kim Hee , Hoon Kim Nam , Choi Jimi , Yub Kim Hun , Baek Seung-kuk , Yoon Jung Kwang , Gon Kim Sin

Objectives: Radioactive iodine (RAI) therapy has potential therapeutic effects in treating Graves’ disease (GD). However, whether RAI therapy for GD can increase cancer risk remains a controversial issue in medicine and public health.Methods: Using the Korean National Health Insurance Service-National Health Information Database (NHIS-NHID, 2002–2020), we investigated hazard ratios (HRs) of overall and site-specific cancer associated with RAI i...

ea0092ps3-22-05 | Nodules 2 | ETA2023

Prevalence and incidence of thyroid nodule and its risk factors; a population-based prospective cohort study in iodine-sufficient area

Kang Sunyoung , Sung Choi Hoon , Hwangbo Yul , Kim Hana , Li Ying , Hoon Moon Jae , Wook Cho Sun , Hee Li Ka , Joon Park Do , Chul Jang Hak , Han Cho Nam , Joo Park Young

Objective: The aim of this study is to investigate the prevalence and incidence of thyroid nodules, and associated risk factors in population-based prospective cohort study.Methods: We investigated the prevalence of thyroid nodules using the data of 3,104 adults aged over 50 years, who were enrolled in the Korean Genome and Epidemiology Study and performed thyroid ultrasonography (US) in 2011-2012. Individuals have been performed US every 2 years, during...

ea0051oc5.8 | Oral Communications 5 | BSPED2017

Central hypothyroidism with extrathyroidal features due to a partial X-chromosome deletion involving the TBL1X locus

van Walree Eva , Park Soo-Mi , Bochukova Elena , Nicholas Adeline K , Lyons Greta , Chatterjee V Krishna , Schoenmakers Nadia

Introduction: Isolated congenital central hypothyroidism (CeCH) is a rare entity associated with mutations in IGSF1, TSHB, TRHR, or the coding region of TBL1X. We describe a female with CeCH and extrathyroidal features due to a partial X-chromosomal deletion involving TBL1X and other genes. Further studies showed markedly reduced TBL1X expression in patient-derived leukocytes and enabled linkage of particular clinical phenotypes to ...

ea0085p2 | Adrenal 1 | BSPED2022

Salivary adrenal biomarkers differ depending on age and sex in healthy children: preliminary data

Park Julie , Jones Lily , Dliso Silothabo , Bright Orla , Walker Laura , Grasim Ionela , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: Saliva is ideal for measuring free, biologically active hormones. Measurements of salivary androgens may be valuable in diagnosis and monitoring of adrenal disorders, however the diurnal profile and robust reference ranges in healthy children are currently undefined. We report salivary testosterone, androstenedione (A4), 11-ketotestosterone (11-KT), 11-β hydroxyandrostenedione (11β-OHA4) concentrations measured throughout the day in healthy children.<...

ea0049gp56 | Cardiovascular &amp; Lipid Endocrinology | ECE2017

PCSK9 in relation to coronary damage severity in patients with cardiovascular disease

Bae Kwi Hyun , Jung Gwon Soo , Kim Mi Jin , Choi Yeon Kyung , Seo Jung Beom , Park Keun Gyu

Proprotein convertase subtilisin/kexin type 9 (PCSK9), a circulating protein that promotes degradation of the low density lipoprotein (LDL) receptor, has been emerged as a novel therapeutic target for the dyslipidemia. It is well known that the pathogenesis of cardiovascular disease (CVD) involves lipid metabolism alteration, but the predictive value of circulating PCSK9 level concerning coronary disease severity is largely unknown. The main objective of this study is to deter...

ea0041gp236 | Thyroid Cancer (1) | ECE2016

Utility of ultrasound shear wave elastography for diagnosis of malignant thyroid nodules: evaluation of maximum and standard deviation elasticity values

Kim Hye Jeong , Kwak Mi Kyung , Park Hyeong Kyu , Byun Dong Won , Suh Kyoil , Yoo Myung Hi

Background: Shear wave elastography (SWE) is an emerging technique that can be used to evaluate malignancy in many organs. The aim of this study was to address the role of elasticity indices as a possible predictive marker for detecting papillary thyroid carcinoma (PTC) and quantitative assessment of SWE for differential diagnosis of benign and malignant thyroid nodules.Methods: One hundred and nineteen patients with thyroid nodules undergoing SWE before...

ea0070ep82 | Bone and Calcium | ECE2020

NCKX3 deficiency impairs to motor function and social behavior in mice

Yi Donglin , Nam Tran Dinh , Mi Park Seon , Thuy Vo Thi Bich , Jung Eui-Man , Jeung Eui-Bae

Ca2+ homeostasis has been reported to play important roles in various cell systems. In central nerves system, the dysregulation of Ca2+ homeostasis can induce the excitotoxic and neurodegeneration. NCKX3 (Sodium/potassium/calcium exchanger 3), a novel member of the family of K+-dependent Na+/Ca2+ exchangers, is an important component of intracellular Ca2+ homeostasis. In addition, NCKX3 highly expressed in tha...

ea0029p1226 | Obesity | ICEECE2012

Curcumin inhibits the upregulation of cathepsin L by palmitate in fat

Yoo J. , Lee Y. , Kim J. , Kang S. , Nam J. , Park J. , Ahn C. , Song Y. , Kim K.

Objective: Cathepsin L can control adipogenesis and relate to acute coronary syndrome. However, it is not clear whether cathepsin L can be affected by saturated fatty acid and decrease by curcumin. We examined the hypothesis that palmitate upregulates cathepsin L expression in adipose tissue and curcumin can be block that effect.Methods: 3T3-L1 cells were fully differentiated for 8 to 10 days and treated with palmitate, LPS, IL6, TNF-α, IL6 neutrali...

ea0029p1331 | Pituitary Basic | ICEECE2012

A recessive mutation resulting in a disabling amino acid substitution (T194R) in the LHX3 homeodomain causes combined pituitary hormone deficiency

Malik R. , Park S. , Bechtold-Dalla Pozza S. , Hiedl S. , Roeb J. , Lohse P. , Duran-Prado M. , Rhodes S.

LHX3, a LIM-homeodomain transcription factor, plays a critical role in pituitary and nervous system development. Mutations in the LHX3 gene are associated with combined pituitary hormone deficiency disease (CPHD). Two female siblings with neonatal complications were diagnosed with CPHD resulting from a novel, recessive mutation in LHX3. The index patient presented with classical symptoms of CPHD, featuring deficiencies of GH, LH, FSH, prolactin, TSH and later onset ACTH defici...