ETA2023 Poster Presentations Nodules 2 (9 abstracts)
Prevalence and incidence of thyroid nodule and its risk factors; a population-based prospective cohort study in iodine-sufficient area
Sunyoung Kang 1 , Hoon Sung Choi 2 , Yul Hwangbo 3 , Hana Kim 4 , Ying Li 4 , Jae Hoon Moon 4 , Sun Wook Cho 4 , Ka Hee Li 4 , Do Joon Park 4 , Hak Chul Jang 4 , Nam Han Cho 5 & Young Joo Park 4
1Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Department of Internal Medicine, Uijeongbu-Si, Korea, Dem. People’s Rep. of; 2Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gwang-Myeong Si, Republic of Korea; 3Center for Thyroid Cancer, National Cancer Center, Goyang, Republic of Korea; 4Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; 5Department of Preventive Medicine, Ajou University School of Medicine, Suwon, Republic of Korea
Objective: The aim of this study is to investigate the prevalence and incidence of thyroid nodules, and associated risk factors in population-based prospective cohort study.
Methods: We investigated the prevalence of thyroid nodules using the data of 3,104 adults aged over 50 years, who were enrolled in the Korean Genome and Epidemiology Study and performed thyroid ultrasonography (US) in 2011-2012. Individuals have been performed US every 2 years, during 8 years of follow-up. The incidence of thyroid nodules and associated risk factors were analyzed among adults who did not have thyroid nodule at baseline and followed-up with US more than once. We compared the incidence of thyroid nodules among 4 groups according to the changes of metabolic syndrome (MS) status during 8 years of follow-up: MS0, adults who never had MS; MS1, adults who developed to MS; MS2, adults recovered from MS; MS3, adults having MS consistently.
Results: The mean age of the study population was 64.9 ± 8.5 years, and 56.9% were women. The age-adjusted prevalence of thyroid nodules was higher in women: 0.3-0.59 cm, 15.6% vs 12.4%; 0.6-0.99 cm, 16.2% vs 7.7%; ≥1 cm, 20.9% vs 9.4%. The prevalence was also associated with older age, higher body mass index (BMI) and waist circumference (WC), and MS. The age-adjusted incidence was also higher in women: 0.3-0.59 cm, 25.2% vs 17.5%; 0.6-0.99 cm, 8.8% vs 5.2%; ≥1 cm, 2.1% vs 1.0%. In logistic regression model, the association between the MS and the prevalence of thyroid nodule ≥ 1 cm was significant (odds ratio [OR], 1.657, 95% confidence interval [CI] 1.334-2.057, P < 0.001). In cox regression models, MS still significantly increased the risk of the incidence of thyroid nodule, even after adjustment for age, sex, smoking, alcohol consumption, thyroid dysfunction (HR 2.169, 95% CI 1.128-4.173, P = 0.020). The risk for the incidence of thyroid nodules ≥1 cm was significantly higher in MS3 group compared to that in the MS0 group (HR 3.427, 95% CI 1.500-7.828, P = 0.003), in multivariable adjusted model.
Conclusion: To our knowledge, this was the first study reporting the prevalence and incidence of thyroid nodules based on the prospective cohort study in general population. MS increased the risk of prevalence and incidence of thyroid nodules independent of multiple variables.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more