ECE2023 Eposter Presentations Calcium and Bone (99 abstracts)
Infection with the human immunodeficiency virus is characterized by a downregulation of the inverse relationship between irisin and parathyroid hormone independently of vitamin D status
Spyridon Karras 1 , Theocharis Koufakis 1 , George Dimakopoulos 2 , Eleana Zisimopoulou 1 , Petros Mourampetzis 1 , Elena Manthou 1 , Eirini Melidou 3 , Paraskevi Karalazou 4 , Katerina Thisiadou 4 , Olga Tsachouridou 5 , Pantelis Zebekakis 1,5 , Kali Makedou 4 , Symeon Metallidis 5 & Kalliopi Kotsa 1
1Aristotle University of Thessaloniki, AHEPA University Hospital, Division of Endocrinology and Metabolism, First Department of Internal Medicine, Greece; 2BIOSTATS, Ioannina, Greece; 3Aristotle University of Thessaloniki, AHEPA University Hospital, Division of Endocrinology and Metabolism, First Department of Internal Medicine, Thessaloniki, Greece; 4Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Laboratory of Biological Chemistry, Thessaloniki, Greece; 5Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Infectious Diseases Division, First Department of Internal Medicine, Thessaloniki, Greece
Background: Infection with the human immunodeficiency virus (HIV) predisposes to endocrine disorders, manifesting as a metabolic phenotype that affects the entire adipose-musculoskeletal unit (AMS). The present cross-sectional study aimed to investigate differences in irisin and adiponectin concentrations between people living with HIV and healthy controls, as well as to explore potential correlations between the levels of the aforementioned adipokines and markers of calcium homeostasis.
Methods: 46 HIV-infected individuals (all men), with a mean age of 52.85±8.48 years and a body mass index (BMI) of 25.76±2.65 kg/m2 and 39 healthy controls (all men) with a mean age of 45.44±9.17 years and a BMI of 28.44 ±6.29 kg/m2 were included in the study. Anthropometric data, adipokine levels, 25-hydroxyvitamin D [(25(OH)D)] status and parathyroid hormone (PTH) concentrations were evaluated in the two groups. The Mann Whitney U test was used to assess differences between the HIV group and the control group. Pearson’s correlations and partial correlations for the relationship between adiponectin, irisin, and PTH levels were examined. The results were adjusted for several confounders, including 25(OH)D levels, body fat, muscle mass, and mean exposure to ultraviolet B radiation during the previous 45 days before blood sample collection.
Results: The HIV group had a lower body fat mass (20.76±6.18 vs 33.55±7.60 kg, P<0.001) and a higher muscle mass (59.09±8.13 vs 50.71 vs 12.08 kg, P=0.009) compared to the control group. Mean adiponectin concentrations were significantly lower in the HIV group compared to the control group: 5868±3668 vs 9068±4277 ng/ml, P=0.011. The same was applicable to irisin concentrations: 8.31±8.17 (HIV) vs 29.27±27.23 (controls) ng/ml, P=0.013. A statistically significant and negative correlation was observed between irisin and PTH in the control group (r=-0.591; P=0.033). In contrast, no significant correlation was observed between PTH and irisin in the HIV group (P=0.898).
Conclusion: Our results suggest a possible down-regulation of the inverse relationship between PTH and irisin in HIV patients and highlight that AMS dyshomeostasis could be involved in the development of skeletal and adipose HIV-related morbidities.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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