Endocrine Abstracts

Background: Well-differentiated neuroendocrine tumors (NETs) are characterized by the overexpression of somatostatin receptors (SSTRs). To efficiently engage and activate tumor infiltrating lymphocytes against NET cells, we designed a novel bispecific T-cells engager (BiTE) composed of 2 molecules of somatostatin-14 (SST14), the hormone that physiologically binds SSTRs, linked with a single chain variable fragment (scFV)-based anti-CD3.Methods: The optim...

Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic disease (Covid-19) is associated with the onset of thyroid dysfunction via multiple mechanisms. Patients hospitalised for severe Covid-19 disease may develop painless atypical thyroiditis coexisting with non-thyroidal illness syndrome, which determines transient thyrotoxicosis with quick restoration of euthyroidism during the following weeks. However signs of thyroiditis at ultrasound and sci...

GH secreting adenomas could be associated with clinical acromegaly with or without hyperprolactinemia, being rare cases of non functioning adenomas. They correspond a 25–30%of pituitary adenomas, generaly presented as macroadenoma.Frequently, they have another hormones production, often prolactin and TSH. Almost 75% of cases are macroadenomas. A 48-year-old Caucasian patient admitted complaining of facial craniofacial alterations, polyarthralgia, holocranial headache and ...

Thyroid hypophyseal adenomas correspond to about 0.5 to 1% of pituitary adenomas. Tumor hypersecretion of TSH may also be present in plurihormonal adenomas that simultaneously secrete growth hormone and/or prolactin or FSH and LH glycoprotein hormones. A 37-year-old patient complaining of ears, hands, feet and face growth for 1 year. He reported amenorrhea for 04 years, sweating and joint pains. Associated comorbidities: Systemic arterial hypertension for 4 years in the use of...

Background: Hashimoto’s thyroiditis (HT) is a common autoimmune disorder of the thyroid (AITD) which affects about 1–2% of the European population. The disease often clusters in families, which is why many attempts have been undertaken to find the genetic background that would underly the predisposition to HT. In contrast to another AITD - Graves’ disease, results of genetic analyses have been ambiguous and have failed to find a major genetic locus that would be...

Introduction: BRAFV600E mutation is the most frequent alteration in papillary thyroid carcinoma (PTC). Although its relation to factors of poor prognosis was demonstrated in many studies the use of BRAF as a predictive marker in clinical treatment of PTC patients is controversial. The aim of our study was to analyze molecular consequences of BRAFV600E mutation in a transgenic mouse model performed for this purpose and to refer the obtained results to...

Introduction: Fine needle aspiration cytology (FNACC) is the basic tool used in the diagnosis of thyroid cancer (TC) in nodular goitre. FNACC does not allow for the establishment of a clear diagnosis in 15–30% of cases (mainly follicular lesions). Molecular biology techniques can be useful, allowing for the detection, in FNACC smears, of the known mutations involved in the oncogenesis.Aim: To evaluate the usefulness of the detection of the BRAF muta...

Surgery is the only effective therapy for insulinoma patients, therefore there is a necessity to develop diagnostic strategies in cases of unknown tumour location, possibly through the use of new biomarkers. 99mTc labelled glucagon-like peptide 1 analogue (99mTc-GLP1) scintigraphy has been developed in our centre as an imaging technique of insulinoma. Labelled GLP1 analogue might also be applied in diagnosis of various forms of nesidioblastosis allowing t...

Introduction: The aim of this study was to assess the diagnostic efficiency of [Lys40(Ahx-HYNIC-99mTc/EDDA)NH2]-exendin-4 scintigraphy in the detection of hardly detectable or not diagnosed by other available method insulinomas.Materials and methods: 37 patients (24 women and 13 men, mean age 46.5±17.8 years, min. 16.0 years, max. 77.0 years) were enrolled in this study. There were 32 patients with clinical and bioch...

Background: FGF21 is a critical metabolic regulator with beneficial effects on lipid and glucose metabolism. FGF21 is produced primarily by the liver and stimulates fatty acids oxidation, which prevents hepatic triglycerides accumulation and nonalcoholic fatty liver disease (NALFD). FGF21also increases insulin sensitivity and glucose uptake in adipose tissue. Paradoxically FGF21 is elevated in insulin resistance states e.g. NALFD, obesity and type 2 diabetes. It is not determi...