Endocrine Abstracts

Aim: The aim of investigation to study of the features of the Cushing’s subclinical syndrome in women (CS) with metabolic syndrome (MS)Material and methods: Under our supervision in the Department of neuroendocrinology of the Center of Endocrinology of MPH out-patient clinics with primary or secondary infertility in the period from September 2015 to July 2016 were examined 120 patients of childbearing age with metabolic syndrome in polycystic ovary ...

Acromegaly is an insidious disease that results from excessive growth hormone (GH) secretion from the pituitary tumor. Major advances have occurred in the understanding of some aspects of acromegaly, such as the biology of pituitary tumors, physiology, molecular mechanisms of GH secretion. In a point of GH producing pituitary adenoma, it was located in a pituitary gland, even though macroadenoma. Macroadenoma was bigger than normal pituitary, remnant normal pituitary gland exi...

At IPA development of a tumor leads to various of pituitary dysfunction, including violates the gonadotropic function of the pituitary gland and there are disorders of sexual and reproductive function. The purpose of our research was studying of a condition of sexual system and gonadotropic function of a hypophysis at patients with is IPA.Results and discussion: In the analysis of a condition of sexual system at 126 women with it is IPA to 50-year age th...

Introduction: Pituitary adenomas are considered to be benign tumors that are diagnosed by its sympthoms (secondary to compression or hormonal secretion) or incidentally in an imaging technique performed because of another reason. ‘Silent’ somatotrophinomas are very rare. This type of adenoma is typically large and despite it presents with mild or no acromegalic features it usually develops hormone secretion.A case report: A 29-year-old spanish ...

GH secreting adenomas could be associated with clinical acromegaly with or without hyperprolactinemia, being rare cases of non functioning adenomas. They correspond a 25–30%of pituitary adenomas, generaly presented as macroadenoma.Frequently, they have another hormones production, often prolactin and TSH. Almost 75% of cases are macroadenomas. A 48-year-old Caucasian patient admitted complaining of facial craniofacial alterations, polyarthralgia, holocranial headache and ...

Background: Pituitary metastasis are rare, however, not well-documented. They are usually encountered in elderly patients with disseminated malignant disease. The most frequent are metastases of breast and lung cancer. We herein report a case of an old patient with pituitary metastasis of a mediastinal lymphoma.Case report: A 88-year-old man with a history of treated prostate cancer and primary hypothyroidism presented to our emergency department with he...

Introduction: Acromegaly is a relatively uncommon disease and is frequently associated with thyroid diseases whose risk increases with the age of the disease.Objective: The purpose of our study was to determine the different thyroid abnormalities observed during acromegaly to improve their management.Patients and methods: Retrospective, descriptive study involving 43 acromegalic patients hospitalized at the Department of Endocrinol...

Introduction: Acromegaly is a rare endocrinopathy, potentially fatal by its metabolic, cardiovascular and neoplastic impact. The aim of this work is to study the cardiovascular impact of acromegaly and cardiovascular risk factors during acromegaly.Materials: This is a retrospective, descriptive study of 43 acromegalic patients admitted to the Department of Endocrinology, Diabetology and Metabolic Diseases CHU IBN ROCHD, Casablanca from January 2005 to De...

Introduction: Syndrome of Inappropriate Antidiuretic (SIAD) is the most frequent cause of hyponatremia in parenteral nutrition (PN) patients. Moreover, SIAD may be caused by multiple etiologies (drugs; pulmonary, neurological or abdominal disorders; malignant disease; idiopathic…). Our objective was to evaluate the main etiologies of SIAD in patients receiving PN.Methods: Prospective, non-interventional, multicenter study in 19 Spanish hospitals. F...

Thyroid hypophyseal adenomas correspond to about 0.5 to 1% of pituitary adenomas. Tumor hypersecretion of TSH may also be present in plurihormonal adenomas that simultaneously secrete growth hormone and/or prolactin or FSH and LH glycoprotein hormones. A 37-year-old patient complaining of ears, hands, feet and face growth for 1 year. He reported amenorrhea for 04 years, sweating and joint pains. Associated comorbidities: Systemic arterial hypertension for 4 years in the use of...

Objectives: Pituitary Apoplexy, either as a result of haemorrhage or infarction, remains a rare but serious Endocrine Disorder, requiring urgent clinical assessment and management. The British Endocrine Society (BES) has set out recommendations regarding the diagnosis and management of pituitary apoplexy, but there remains little published literature depicting this. The aim of this study was to compare our current Management practise of Pituitary Apoplexy with the recommendati...

Cushing’s syndrome (CS) is a relatively rare disease characterized by autonomous hypersecretion of cortisol. The incidence of CS is estimated to be equal to 2–3 cases per million inhabitants per year.The incidence of acromegaly is 3–4 patients per 1 000000 per year. The disease is caused by hypersecretion of growth hormone which is mainly caused by benign tumour of the pituitary gland. In our case report we present a 41 - year - old woman suffering from both Cus...

A 32-year-old woman presented with primary amenorrhea, prolactin (PRL) level of 154150 mIU/l (40–530 mIU/l) diagnosed with an endo-supra-infra-laterosellar giant pituitary adenoma measuring maximum 6.2 cm. The patient was prescribed a treatment with cabergoline (CAB) at an initial dose of 0.5 mg per week. The treatment decreased the tumour size and brought to normal the level of PRL. After 7 months of CAB treatment menarche was achieved, after 12 months the patient became...

Introduction: Somatostatinanalogues (SSAs) are the largest contributor to the direct medical cost of acromegaly management worldwide. The aim of this review was to expose our experience and report available evidence on the effectiveness of SSAs in the treatment of acromegaly.Methods: This is a retrospective study including ten acromegalic patients followed in the Endocrinology - Diabetology Department at Mohamed VI University Hospital in Oujda, Morocco.<...

A 37-year-old female, referred by gynaecologist with low prolactin and free T4 after work up for secondary amenorrhea despite removal of contraceptive coil 18 months ago. Her only daughter was born seven years ago with no complications. Patient admitted to have tiredness and dizziness for a few years but denied headache or visual symptoms. Pituitary hormone profile confirmed secondary hypothyroidism, secondary hypogonadism, low prolactin, low IGF-1 level but normal adrenal axi...

Background: Patients with acromegaly usually presented symptoms of the hypersecretion of growth hormone (GH). GH may increase insulin-like growth factor 1 (IGF-1), affect energy homeostasis, and cause complications in cardiovascular, skeletal, or metabolic systems. Follistatin is a glycoprotein with various biologic functions that plays a role in adipocyte differentiation, muscle stimulation, anti-inflammation and energy homeostasis. We evaluated the serum levels of follistati...

Introdution: Pituitary apoplexy (PA) is a rare clinical syndrome caused by sudden hemorrhage or infarction of the pituitary gland. PA may be the form of presentation of a pituitary tumor or occur during follow-up of a previously diagnosed macroadenoma. A high suspicion índex is required to establish a timely diagnosis.Case report: A 54-year-old man was referred to Endocrinology department (04/2015) due to a pituitary macroadenoma. He reported sexual...

Introduction: Thyrotropin-secreting pituitary adenomas represent less than 1% of all pituitary adenomas. Usually, patients present mild or moderate signs of hyperthyroidism and Hormonal evaluation shows increased free thyroid hormone concentration with detectable, normal or increased serum thyrotropin (TSH) level. Herein we report three cases of thyrotropin adenomas with particular clinical and biological features.Observations: Three patients, aged 25 38...

Introduction: The non-functional pituitary adenoma (NFPA) is a benign tumor, which has a progressive development but it is a severe tumor by its neuro-ophthalmological and endocrine repercussions.Patients and methods: It is about a descriptive and retrospective study conducted in 35 patients collected in the endocrinology department of Sfax between January 2000 and December 2017. The diagnosis of NFPA was based on the presence of pituitary adenoma on hyp...

Introduction: Cushing Syndrome have long been recognised to predispose patients to infection diseases, a consequence of the immunosuppression induced by corticosteroids. There is a predisposition to viral, bacterial, parasitic and especially fungal diseases. Opportunistic infections, particularly invasive fungal infections, represent a serious complication associated with an increased risk of mortality.Clinical case: We represent a 55 years-old woman, po...

Introduction: Thyrotropin-secreting pituitary adenomas are rare tumors accounting for 1–2% of all pituitary adenomas and the diagnosis is based on the combination of high fT4 levels with normal to high TSH concentration in the presence of a pituitary adenoma. About one third co-secrete other hormones, of which, most frequently growth hormone (16%) followed by prolactin and gonadotropins.Case report: A 60 years-old male patient presented in 2016 afte...

Pituitary resistance to thyroid hormone (PRTH) is a rare, genetic cause of hyperthyroidism. It is characterized by a high concentration of free thyroid hormones, coexisting with elevated or normal concentration of thyroid stimulating hormone. The most prevalent features of this syndrome are typical symptoms of hyperthyroidism and goitre. Diagnosis of this condition does not exclude other comorbidities of the thyroid gland, including these of autoimmune origin. We present the c...

Introduction: Pituitary Stalk Interruption Syndrome (PSIS) is characterized by the presence of a thin or absent pituitary stalk, associated with hypoplastic or aplastic anterior pituitary and ectopic posterior pituitary (EPP) on magnetic resonance imaging (MRI). The objective of this study is to describe the clinical, hormonal and radiological aspects of PSIS.Patients and methods: This is a retrospective longitudinal study of 9 cases of PSIS collected in...

Introduction: Central diabetes insipidus (DIC) is defined by the excretion of large volume of diluted urine, secondary to an absolute or relative deficiency of endogenous vasopressin. We report three observations of children with central diabetes insipidus.Results: This study reports the case of three patients whose average age was thirteen years old (11, 13 and 15 y). The occurrence of polyuria-polydipsia syndrome was the main reason for consultation an...

Idiopathic short stature (ISS) is a condition characterized by a height more than 2 standard deviations below the corresponding average height for a given age, sex and population, without any identifiable systemic, endocrine, nutritional, or chromosomal disorder, and normal stimulated growth hormone (GH) levels. We report a case of a 17-years-old female, admitted to the hospital for endocrinology reevaluation. She was firsty reffered to endocrinologist for short stature at the...

Introduction: Silent corticotroph adenomas (SCAs) are uncommon pituitary tumors, immunoreactive for ACTH, but without clinical evidence of hypercortisolism and present with local mass effects and some endocrine dysfunction. Case 43 years old male patient was diagnosed with pituitary tumor which was 5×3 cm in size. In history, 6 months ago he applied to another hospital with syncope and operated transsphenoidally. But these datas are unreachable. He had been suffering from...

Background: Primary autoimmune hypophysitis (PAH) is a rare chronic inflammatory condition of the pituitary gland that occurs more commonly in females during pregnancy or in the post-partum period. It is strongly associated with other autoimmune disorders. The various forms of hypophysitis are misdiagnosed as pituitary adenoma in 40% cases.Objective: First of all, we propose to present a case of PAH associated with other autoimmune diseases. Our second a...

Objective: Pituitary stalk interruption syndrome (PSIS) is a rare congenital abnormality of the pituitary that is responsible for multiple anterior pituitary hormone deficiencies with the estimated incidence of 0. 5/100,000 live births. We report the a case of PSIS from Saudi Arabia.Case report: A 16 year old Saudi boy with short stature and undescended testis, status post bilateral orchidopexy presented to our endocrine clinic. He was delivered by caesa...

The aim: To examine the case of relapse, the growth of non-functional pituitary macroadenoma (NFPA).Material and methods: Under our supervision was a patient Bekieva Karomat, born in 1985 with the diagnosis: Macroadenoma of the pituitary gland with a total growth option. (NFPA) State after the transnasal hypophysisectomy (23.01.08, TGE). Continued growth of the tumor. Re TGE (26.11.11). Hypopituitarism. Secondary hypogonadism, secondary hypocorticism, se...

Introduction: Pituitary adenomas are benign intracranial tumors. However, some of them are resistant to multiple medical treatments and are clinically considered to be aggressive.Case report: Twenty years old male patient presented with symptomatic hyperglycemia and general weakness. With suspected diagnosis of type 1 diabetes patient was hospitalized in Kauno Klinikos, Endocrinology Department. In further clinical observation acromegalic appearance noti...

Introduction: Lymphocytic hypophysitis is a rare inflammatory disorder of the pituitary gland with autoimmune origin, related to a diffuse infiltration of the pituitary gland, sometimes resulting in severe hypopituitarism. It is common in young women in late pregnancy or postpartum, however, its occurrence in men is rare with only a few cases reported in the literature. We report the case of a lymphocytic hypophysitis in a young male patient who presented for a pituitary macro...

Introduction: Rapid progression of atherosclerosis is classicaly described after e.g. percutaneous transluminal coronary angioplasty or it is defined as an diameter reduction of a preexisting stenosis. However, both initiation and perpetuation mechanisms are rarely descibed in patients on supraphysiological dosages of glucocorticoids (GCs).Case report: We present male patient, 53-year old, after transsphenoidal operation of hypophysis pp. craniopharyngeo...

A female patient was first referred to the Endocrinology department due to primary amenorrhea at age 37. She mentioned trans-sphenoidal surgery at age 15 due to a craniopharyngioma and the indication to be supplemented with hydrocortisone (HC) and DDAVP, that she adhered to until age 20, when she abandoned all appointments. Apart from that, she mentioned normal pubertal development and said she was generally healthy. She denied any episodes compatible with Addisonian crises. F...

Introduction: When hypoglycemia is deep and repeated, it can induce various neurological disorders, including epileptic seizures. The link between hypoglycemia and epileptic phenomena is complex and poorly explained. We report 3 cases of epilepsy induced by repeated episodes of deep hypoglycemia.Cases report: Mr D.M, 48 years old, with a history of 3 episodes of hypoglycemic coma, admitted for status epilepticus with a blood glucose level of 0.4 g/l; cer...

Introducion: Pituitary apoplexy is an endocrine emergency that is a rare complication of pituitary adenomas and exceptional in ACTH adenomas. We report a case of apoplexy on corticotropic adenoma with intermittent secretion.Case report: The patient was 41 years old woman, she presented in 2012 a period of symptomatic hypercortisolism. Urinary free cortisol was elevated to 113 μg/24 h, Low-dose dexamethasone testing was negative, ACTH was elevated to...

Introduction: Cushing’s syndrome (CS) is rare in children. The most common cause of CS in children is exogenous or iatrogenic CS. The most common cause of endogenous CS is Cushing disease (CD). Pediatric CD is almost always caused by a pituitary microadenoma. Here we present a rare case of (CD) related to pituitary macroadenoma.Clinical observation: An 11 year old boy presented with complaints of excessive appetite and progressive weight gain. He ha...

Aims: To present the case of a 69-year-old female patient who was diagnosed with acromegaly two years following the initial onset of facial and acral symptoms, having already developed colonic hyperplastic polyps, one of the complications associated with acromegaly, one year prior to diagnosis.Material: Case report and literature review.Method: Acromegaly was diagnosed based on clinical suspicion, raised IGF-1 level, absence of GH ...