ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 EP85 | DOI: 10.1530/endoabs.63.EP85

The frequency of subclinical cushing's syndrome in women with polycystic ovaries syndrome

Zamira Khalimova1, Ashley Grossman2, Miles Levy3, Marta Korbonits4, Vladimir Pankiv5 & Yulduz Urmanova6

1Republican Specialized Scientific Practical Medical Center of Endocrinology of Republic of Uzbekistan named by Ya.Kh.Turakulov, Tashkent, Uzbekistan; 2 University of Oxford Research Fellow, Green Templeton College, Oxford, UK; 3University Hospital of Leicester NHS, Leicester, UK; 4Saint Bartholomew’s Hospital, (London, UK), London, UK; 5Ukraine State Medical Institute, Kiev, Ukraine; 6Tashkent Pediatric Medical Institute, Department of child Endocrinology, Tashkent, Uzbekistan.

Aim: The aim of investigation to study of the features of the Cushing’s subclinical syndrome in women (CS) with metabolic syndrome (MS)

Material and methods: Under our supervision in the Department of neuroendocrinology of the Center of Endocrinology of MPH out-patient clinics with primary or secondary infertility in the period from September 2015 to July 2016 were examined 120 patients of childbearing age with metabolic syndrome in polycystic ovary syndrome (PCOS). The average age of patients was 25.5±4, 3 years. 20 healthy women of the appropriate age were included in the control group. All patients underwent a set of studies, including the clinical (General blood and urine analysis), biochemical (blood glucose, glucose tolerance test), hormonal (LH, FSH, prolactin, estradiol, progesterone, free testosterone, dehydroepiandrostenedione (DHEA), 17-oxyprogesterone (17 OKS), antimuller hormone (AMG), insulin on day 14), determination of the cycle), cortisol in the blood and free cortisol in the daily urine.

Results: It was found that the patients were divided into three groups: 1 Gy. - patients with primary PCOS-23 cases (19%), 2 Gy. - patients with secondary PCOS in obesity-89 cases (74%), 3 g. - patients with secondary PCOS and subclinical SC - 8 cases (7%). In 1 group of patients there was a significant decrease in both pituitary and ovarian hormones in the background of hyperandrogenemia. Further, in the second group of patients was also revealed a significant decrease in pituitary hormones on the background of hyperandrogenemia, while ovarian function was within normal limits. In the third group of patients was also revealed a significant decrease in pituitary hormones on the background of hyperandrogenemia, hypercortisolemia, hyperinsulinemia.

Summary: Thus, in all groups on the 14th day of the cycle, there was a significant decrease in the basal values of LH, FSH, IGF-1, progesterone, estradiol against the background of hyperandrogenemia. At the same time, hyperinsulinemia was observed in groups 2 and 3. Only patients of group 3 had significantly increased values of DHEA, 17 OKS and cortisol of blood. Mean values of prolactin, AMH was normal.

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