ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 EP87 | DOI: 10.1530/endoabs.63.EP87

Studying of a condition of reproductive function of patients with the inactive pituitary adenomas (IPA)

Dilorom Kholova & Zamira Khalimova

Republican Specialized Scientific and Practical Medical Center of Endocrinology, Tashkent, Uzbekistan.

At IPA development of a tumor leads to various of pituitary dysfunction, including violates the gonadotropic function of the pituitary gland and there are disorders of sexual and reproductive function. The purpose of our research was studying of a condition of sexual system and gonadotropic function of a hypophysis at patients with is IPA.

Results and discussion: In the analysis of a condition of sexual system at 126 women with it is IPA to 50-year age the following groups are revealed: 1) patients from the oligomenorrhea – 46/126 (36.5%), at 38 of which were present clinical and biochemical signs of a polycystic ovary syndrome (the small-cystic ovaries with ultrasound of the pelvic organs, a high rate of a ratio of LH/FSH raised or supranormal concentration of LH, 8 of them, according to ultrasonography, had a uterus hypoplasia); 2) patients from the secondary amenorrhea – 52/126 (41.3%), at 6 from which at ultrasound of bodies of a small p ultrasound of the pelvic organs the hypoplasia of ovaries and a hypoplasia of a uterus, at one — polycystic ovaries, and in blood serum - low concentration E is revealed; 3) patients with a preserved menstrual cycle and no changes in the pelvic organs at ultrasound (28/126 patients – 22.2%), but at the 3rd of them were raised concentration E and T, and at one the hirsutism was observed. Clinically men with it is IPA as well as women, depending on a condition of sexual system represent three groups: with a normal state of sexual glands (48.6%); hypogonadotropic hypogonadism (40.2%) and reduction of volume of small eggs (11.2%). Existence of high concentration of FSH in blood in combination with increase in volume of small eggs allows diagnosing an active gonadotropic tumor of a pituitary for men.

Conclusions: So, on a condition of sexual system at the time of establishment of the diagnosis it is IPA men and women can be presented by three groups: with a secondary hypogonadism (40.7%); with a normal state of sexual system (22.0%); with polycystic ovary syndrome (36.5% of women) and reduction of volume of small eggs (11.2% of men).

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