Endocrine Abstracts

Objective: To study the spectrum of chromosomal anomalies in three cases as related to the phenotypic variability of patients with anomalies of disorder of sexual development.Female 18 years old with secondary amenorrhea, stigmata of Turner’s syndrome, Tanner stage II. Ultrasound showed streak gonads. Hormonal analysis revealed elevated levels of FSH, LH and a low plasma estradiol level. The chromosomal investigation showed gonosomal mosaicism 45,X(...

Purpose: The purpose of this study was to evaluate the histologic spectrum of stromal–epithelial patterns of invasion in ovarian serous and mucinous tumors of low malignant potential.Materials and methods: We retrospectively analyzed 31 cases of borderline ovarian serous and mucinous tumors diagnosed of the Pathology Department of County Hospital Timisoara in a period of 5 years, between 2003 and 2007. Epithelial architecture, the patterns of stroma...

Introduction: The MEN1 syndrome is caused by inactivating mutations of MEN1, a tumor suppressor gene encoding menin. A sporadic presentation is relatively rare (8-14%) and could be due to de novo mutations.Aim: To present an MEN1 case diagnosed following a routine consultation for amenorrheaCase presentation: A 44-year-old female presented with secondary amenorrhea and a history of complicated renal lithiasis requiring rep...

Introduction: Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor that originates from the parafollicular thyroid cells (C cells); MTC occurs as both a hereditary disease (25% of all cases), when MTC in a manifestation of multiple endocrine neoplasia type 2 or 3 (MEN 2/3) and as sporadic disease. The hereditary type is a consequence of germline mutation in the rearranged during transfection (RET) proto-oncogene, which can undergo oncogenic activation through both ...

The coexistence of Graves disease (GD) and thyroid carcinoma used to be considered uncommon, but association between the two is being progressively acknowledged. Case report: We present the case of a 69-year-old woman with a 10 year history of GD who was referred to our clinic for fatigue, sweating, palpable cervical mass and weight loss. She was treated only in the previous 5 months with block and replace therapy. Laboratory workup at admission showed s...

Background: Recent data highlight the role of anti-Müllerian hormone (AMH) to trigger the neuroendocrine abnormalities involving GnRH and secretion of gonadotropins in polycystic ovary syndrome (PCOS).Aim: To study factors significantly correlated with neuroendocrine dysfunction in PCOS, with focus on AMH.Subjects and methods: We performed a cross-sectional study in 137 patients with PCOS selected by Rotterdam 2003 criteria an...

Hyperthyroidism in the course of Graves’ disease leads to intensification of oxidative processes resulting in increased oxidative stress.Objectives: The effect of supplementation with vitamin E was monitored on the speed of attaining euthyroidism and on the oxidative stress parameters in patients with Graves’ disease, treated with thiamazole.Patients and methods: We examined 43 hyperthyroid patients and 12 euthyroid healt...

Introduction: The mammary cancer is the most frequent malign tumor encountered in females, characterized by a high distant metastasis tendency. Among the potential prognosis factors, we mention the biomarkers that measure or are associated with biologic processes involved in the tumorous progression. The study analyzes the p53 protein’s positivity in correlation with the mammary cancer’s classical prognosis factors: the hystologic type, the histopathologic degree, th...

Introduction: The mammary cancer is the most frequent malign tumor encountered in females, characterized by a high distant metastasis tendency. Among the potential prognosis factors, we mention the biomarkers that measure or are associated with biologic processes involved in the tumorous progression. The study analyzes the p53 protein’s positivity in correlation with the mammary cancer’s classical prognosis factors: the hystologic type, the histopathologic degree, th...

Background: Multiple endocrine neoplasms (MEN) are a rare hereditary syndrome, caused by an autosomal dominant mutation due to germline mutation in the rearranged during transfection (RET) proto-oncogene. According to the new WHO guidelines, MEN type 2 (formerly known as MEN 2A) is characterised by medullary thyroid cancer (MTC), paragangliomas, primary hyperparathyroidism (PHP) and cutaneous lichen amyloidosis.Objectives: To present the clinical and par...