ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2008) 16 P330

Ovarian serous and mucinous tumors of low malignant potential: patterns of stromal invasion

Simona Costi, Alis Dema, Ioana Golu, Marioara Cornianu, Sorina Taban, Anca Muresan & Elena Lazar


University of Medicine and Pharmacy, Timisoara, Romania.


Purpose: The purpose of this study was to evaluate the histologic spectrum of stromal–epithelial patterns of invasion in ovarian serous and mucinous tumors of low malignant potential.

Materials and methods: We retrospectively analyzed 31 cases of borderline ovarian serous and mucinous tumors diagnosed of the Pathology Department of County Hospital Timisoara in a period of 5 years, between 2003 and 2007. Epithelial architecture, the patterns of stromal invasion, number of invasive foci, size of individual invasive foci, and the extent of the nondestructive foci were reviewed.

Results: Five patterns of invasion were identified: (1) cell clusters and individual, detached eosinophilic cell (27/31, 87%), (2) simple individual papillae and simple branching papillae (8/31, 25.8%), (3) cribriform pattern (6/31, 19.35%), (4) complex branching micropapillae (2/31, 6.45%), (5) inverted macropapillae (5/31, 16.12%). Most cases contained a mixture of stromal–epithelial patterns.

Conclusions: The distinction between ovarian serous and mucinous tumors of low malignant potential and low-grade serous and mucinous carcinoma can be quite difficult because former type present a variety of stromal–epithelial alteration. The most common stromal–epithelial pattern of invasion on this study was the individual intra-stromal eosinophilic cell and cell cluster pattern.

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