Endocrine Abstracts

Background: Primary hyperparathyroidism (PHPT) is associated with various musculoskeletal complaints. It is difficult to evaluate muscle strength as it is hard to extract objective data due to lack of definite methods for measurement.Objective: To assess the differences between PHPT patients and healthy controls regarding maximum foot force and plantar pressure distribution by using platform pressure measuring system [Footscan (RSscan)].<p class="abs...

Aim: To investigate the relationship between oxidative stres markers and carotis intima media thickness in diabetic patients with microvascular complications.Material and methods: 112 patients with type 2 diabetes mellitus and 44 healthy control subjects were included in the study. The presence of diabetic retinopathy was investigated by ocular examination. Neurological examinations were performed for neuropathy. In addition, catalase (CAT), superoxide d...

Background: ChatGPT, an advanced language model, employs sophisticated deep learning techniques to generate human-like responses. It stands as one of the most extensive publicly accessible language models. Despite the longstanding application of Artificial Intelligence (AI) in diverse domains, its application in healthcare raises concerns about the reliability of information. It is equally important to assess whether the provided information is supported by dependable referenc...

Background: Proton-density fat fraction (PDFF), derived from chemical shift encoding-based water-fat magnetic resonance imaging, has emerged as an important surrogate method for calculation of fat composition in a number of tissues including liver, vertebrae and muscles. This study aims to determine whether fat composition of these tissues, as well as visceral and subcutaneous adiposity differ between women with PCOS and healthy controls.Methods: 17 lean...

Background: Immune function and responses are tightly regulated by the circadian clock system and hypothalamic-pituitary-adrenal (HPA) axis. Accumulating evidence supports that there is a strong mutual relationship between these two regulatory systems at multiple levels. Recent publications suggest that the clock system may also regulate glucocorticoid release from adrenal glands by altering the sensitivity of the adrenal cortex to adrenocorticotropic hormone (ACTH).<p cla...

Background: Circadian rhythmicity is generated by a set of genes including Period3. Changes in the expression of Period3 and other clock genes have been linked with regulation of the immune system. Period3 polymorphisms have been associated with circadian disruption and so immune system dysregulation and altered secretion of several cytokines, which can lead to inflammatory and autoimmune disorders.Aim: To investigate the influence of a polymorphism in P...

Background and aim: Acromegaly is a rare endocrine disease and is associated with an increased prevalence of colorectal cancer and pre-malignant tubular adenomas, and also may be associated with other organ malignancies such as breast and thyroid. We report a rare case of acromegaly concomitant with adenocarcinoma arising from pancreas.Case report: A 52-year-old man who was diagnosed with acromegaly two years ago referred our outpatient clinic. After dia...

Introduction: Adrenocortical oncocytomas are rare seen tumours. Most of these tumours are benign and non-functioning. We present here a case of oncocytic adrenocortical tumour, detected incidentally, presented with Cushing’s syndrome.Case: A 41-year-old male patient, while investigating for abdominal pain, bilateral adrenal masses were detected in abdominal ultrasonography and was admitted to Endocrinology Clinic. He had no history of hypertension. ...

Aim: To evaluate the effect of androgen replacement therapy on lipid profile and platelet aggregation in in male patients with isolated hypogonadotropic hypogonadism (IHH).Material and methods: 36 male patient, mean age 32.2 (18–54)with IHH, admitted to the outpatient clinic of Endocrinology and Metabolism were included to the study. Patients in the study were divided into two groups as Testosterone (n=18) and human chorionic gonadotropin (...

Aim: In this case report we present a newly diagnosed, underweight type 1 diabetes mellitus (DM) patient developed insulin oedema following high dose insulin therapy.Case: A 18-year-old male patient was admitted to the hospital with a 1-month history of excessive water consumption, pollakiuria, polyuria, and weight loss 6 kg. In laboratory examination, hyperglycaemia and ketonuria were detected; arterial blood pH was 7.38. Patient was hospitalised to the...