Endocrine Abstracts

IntroductionGraves orbitopathy is the main extra thyroidal manifestation of Graves’ disease, though severe forms are rare (< 5%). Management of Graves orbitopathy is often suboptimal, largely because available treatments do not target pathogenic mechanisms of the disease. The aim of our study was to evaluate different treatment modalities and assess their impact on the outcome of Graves orbitopathy.Patients and methods...

IntroductionAutoimmune polyglandular syndrome (APS) is a rare endocrinopathy, characterized by the coexistence of two or more glandular autoimmune diseases that can appear at different intervals of time.ObservationHerein the case of a young woman descendant of first degree consanguineous marriage, diagnosed since the age of six with celiac disease (CD) where gluten-free diet was not respected due to poor soci...

IntroductionGrave’s disease is an autoimmune disease characterized by hyperthyroidism. It is in some cases associated to more autoimmune organs dysfunction. The antithyroid drugs are the first line treatement, and sometimes they are responsible for severe adverse effects.ObservationWe report the case of a 34 year-old man, treated for his grave’s disease with thiamazol for two years. Two weeks after ...

Background: Primary hyperparathyroidism is a common endocrine disorder characterized by hypercalcemia, resulting from excessive secretion of parathyroid hormone. Parathyroidectomy, is considered as the definitive treatment for this condition, leading in most cases to remission and resolution of hypercalcemia. However, some patients experience surgical failure. Persistent hyperparathyroidism is defined as persistence of hypercalcemia after parathyroidectomy or recurrence of hyp...

Background: Primary hyperparathyroidism, is defined by hypercalcemia associated with an elevated or inappropriately normal parathyroid hormone(PTH) levels stemming from hyperfunctioning parathyroid glands. It’s a prevalent endocrine disorder. Parathyroidectomy, the surgical excision of affected glands, stands as the definitive treatment, typically resulting in remission and normalization of calcium levels. However, persistent elevation of serum PTH post-parathyroidectomy ...

Introduction: Subclinical hyperthyroidism (SH) is defined by normal thyroid hormone levels and reduced thyroid-stimulating hormone (TSH) concentration. It still raises intriguing questions about its clinical impact, management and outcomes. The aim of our study was to determine the underlying etiologies of SH, its clinical features and its outcomes in Tunisian patients.Methods: We conducted a retrospective study at Charles Nicolle Hospital, including 46 ...

IntroductionVon Hippel-Lindau (VHL) syndrome is an autosomal dominant disease resulting in a susceptibility to develop central nervous system and retinal hemangioblastomas, endolymphatic sac tumors, renal clear cell carcinoma and pheochromocytoma. Pheochromocytoma occurs usually at a younger age and tends to be bilateral in VHL syndrome. Herein, we describe a case of VHL syndrome with cerebellar hemangioblastoma, bilateral pheochromocytoma and kidney tum...

IntroductionThe adrenocortical carcinoma(ACC) is a rare malignant tumor arising from the adrenal cortex, it is usually associated to abnormal hormone secretion, but sometimes it is nonfunctioning, leading to a delayed diagnosis with a locally advanced and/or a metastatic disease. ObservationWe report the case of a 42 year-old woman with no medical history who consulted for chronic epigastralgia. On physical e...

IntroductionPituitary stalk interruption syndrome is an entity radiologically defined by the association of an absent or thin pituitary stalk, an ectopic posterior lobe and a hypoplasia or aplasia anterior lobe. It can manifest as a several of hormonal deficiencies. The circumstances of discovery are multiple. This case illustrates a pituitary stalk interruption syndrome revealed by a growth retardation.Case presentation<p clas...

IntroductionLymphocytic hypophysitis is an autoimmune inflammatory pathology of the pituitary gland responsible for partial or global hypopituitarism. In this context, we report a clinical case illustrating this entity.Clinical caseA 31-year-old woman with a family history of hypothyroidism and a personal history of vitiligo was seen in the 8th month of pregnancy for headaches that have progressed rapidly in ...