ECE2021 Eposter Presentations General Endocrinology (11 abstracts)
Autoimmune polyglandular syndrome type 3: a case report
Chayma Besrour , Imen Rojbi , Rihab Laamouri , Youssef Lakhoua , Nadia Mchirgui , Ibtissem Ben Nacef & Karima Khiari
Hospital Charles Nicolle, Endocrinology-Diabetology, Tunis, Tunisia
Introduction
Autoimmune polyglandular syndrome (APS) is a rare endocrinopathy, characterized by the coexistence of two or more glandular autoimmune diseases that can appear at different intervals of time.
Observation
Herein the case of a young woman descendant of first degree consanguineous marriage, diagnosed since the age of six with celiac disease (CD) where gluten-free diet was not respected due to poor socio-economic conditions, and an important retardation regarding the pondero-statural development was present. She consulted at the age of 33 year-old for recent onset of diabetes mellitus (DM), the anti-GAD antibodies were positive at 36 UI/ml, in favor of the diagnosis of latent autoimmune diabetes in adults (LADA). The biological exploration of the hypophyseal function revealed a primary hypothyroidism (TSH b 100 µU/ml), with negative TPO antibodies. And on the cervical ultrasound, the thyroid gland appeared to be atrophic.
Conclusion
This association of auto-immune thyroiditis to other auto-immune disorders represent the autoimmune polyglandular syndrome type 3 (APS 3: APS3A with DM, APS 3C with CD), it is an autoimmune condition that affects the body’s endocrine glands. The cause is still unknown, but multifactorial mecanisms are to be involved (genetic and environmental).
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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