Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep855 | Clinical case reports - Pituitary/Adrenal | ECE2017

A case of pituitary apoplexy in a patient with Cushing’s disease due to corticotroph macroadenoma

Sava Elisabeta , Leca Bianca , Sirbu Anca , Georgescu Olivia , Cima Luminita , Florea Suzana , Fica Simona

Corticotroph macroadenomas are exceptionally found in Cushing’s disease. Pituitary apoplexy is a rare endocrine emergency condition caused by either hemorrhage or infarction of the pituitary gland. We report a case of a 56-year-old female diagnosed with type 2 diabetes in 2008. One year after, at the periodical follow up, she presented with uncontrolled diabetes (HbA1c=12.26%) and clinical manifestations suggestive for hypercortisolism, therefore insulin therapy was initi...

ea0049ep943 | Pituitary - Clinical | ECE2017

Success rates of pituitary surgery in acromegaly – a tertiary centre experience in Romania

Betivoiu Minodora , Soare Iulia , Martin Sorina , Sirbu Anca , Albu Alice , Barbu Carmen , Fica Simona

Background: Pituitary surgery is the first treatment option for acromegaly. The reported success of pituitary surgery varies between 75 and 95% for microadenomas and 45 and 68% for macroadenomas. The aim of this study was to report our experience regarding the remission rate after pituitary surgery in acromegaly patients.Methods: This retrospective study included 70 patients diagnosed with acromegaly in our clinic between 2009 and 2016. The criteria used...

ea0037gp.14.03 | Diabetes and obesity – Clinical diabetes | ECE2015

Clinical and biological determinants of metabolically healthy obese status

Sirbu Anca , Martin Sorina , Barbu Carmen , Florea Suzana , Copaescu Catalin , Fica Simona

Introduction: While the unfavourable metabolic consequences of obesity have been clearly demonstrated at a population level, there is a wealth of evidence indicating the existence of individuals somehow protected from developing complications, named ‘metabolically healthy obese’. The aim of our study was to identify clinical and biological parameters independently associated with ‘metabolically healthy’ status.Patients and methods: 44...

ea0037ep615 | Obesity and cardiovascular endocrinology | ECE2015

Neutrophil to lymphocyte ratio: relationship with anthropometric and metabolic parameters in morbidly obese patients

Serbanescu Cristina , Topor Liliana , Gheorghe-Fronea Ivona , Nila Alexandra , Sirbu Anca , Fica Simona

Introduction: Obesity is generally associated with a chronic state of subclinical inflammation. The assessment of the inflammatory status is routinely made by measuring circulating levels of nonspecific proinflammatory markers. Neutrophil to lymphocyte ratio (NRL) is a new simple inflammatory marker which can be reliable in evaluating the inflammatory status occurring in morbidly obese patients. The aim of this study was to investigate the relationship between NLR as an index ...

ea0037ep634 | Obesity and cardiovascular endocrinology | ECE2015

Bone and calcium markers in relation to cardiovascular risk in patients with osteoporosis

Barbu Carmen Gabriela , Florea Suzana , Sirbu Anca , Albu Alice , Martin Sorina , Fica Simona

Aim of the study was to evaluate the relationship between biochemical bone turnover markers, calcium homeostasis parameters and the cardiovascular risk in patients with osteoporosis.Materials and methods: Subjects were 246 patients (mean age of 56.64) diagnosed with osteoporosis referred to the endocrine department of Elias Hospital, between 2009 and 2013, and who agreed with the terms of the study. Data collection consisted of clinica...

ea0070ep96 | Bone and Calcium | ECE2020

Epilepsy – Fahr syndrome – Primary hypoparathyroidism: A diagnostic journey

Maria Popa Miruna , Popa Liviu , Petrescu Simona , Pana Monica-Mirela , Sirbu Anca , Simona Fica

Background: Fahr syndrome is a rare entity characterized by symmetrical bilateral brain calcifications, involving basal ganglia (mainly), thalami, dentate nuclei and the cerebral and cerebellar white matter. Progressive neurologic dysfunction and other neuropsychiatric disorders are characteristic. Endocrine disorders which may present with Fahr syndrome include parathyroid dysfunction (hypoparathyroidism especially, but also pseudohypoparathyroidism, pseudopseudohypoparathyro...

ea0070ep299 | Pituitary and Neuroendocrinology | ECE2020

Non-functioning pituitary adenomas – clinical presentation and management, experience of a tertiary centre in Romania

Mustata Theodor , Martin Sorina , Mihop Delia , Predescu Andrada , Parfeni Ovidiu , Sirbu Anca , Barbu Carmen , Fica Simona

Background and Aim: Non-functioning pituitary adenomas (NFPAs) are hormonally inactive adenohypophyseal tumors. The absence of hormone hypersecretion and the lack of clinical manifestations delay the diagnosis and therefore symptoms of mass effect are frequently seen in NFPAs. The primary endpoint of this study was to evaluate the clinical presentation of patients with NFPAs and their therapeutic management. The secondary endpoint was to identify how gender and tumor size impa...

ea0032p763 | Obesity | ECE2013

Preoperative metabolic status is associated with adiponectin levels attained 6 months after laparoscopic sleeve gastrectomy, independently of the degree of weight loss

Sirbu Anca , Martin Sorina , Barbu Carmen , Copaescu Catalin , Florea Suzana , Fica Simona

Introduction: Adiponectin is an adipocyte-derived hormone with an important role in regulation of glucose and lipid metabolism. Its variation might mediate an ameliorated metabolic profile associated with weight loss after bariatric surgery. The aim of our study was to evaluate adiponectin change as early as 6 months after laparoscopic sleeve gastrectomy (LSG) and to indicate preoperative factors that might influence its dynamic.Methods: A number of 88 e...

ea0020p485 | Obesity and Metabolism | ECE2009

Carotid IMT values are related to insulin resistance and visceral disposition of adiposity in obese patients

Sirbu Anca , Nicolae Horia , Arbanas Tudor , Gologan Serban , Barbu Carmen , Reghina Aura , Lenghen Claudia , Fica Simona

The aim of our study was to assess the relation between common carotid intima-media thickness, a marker of subclinical atherosclerosis and other metabolic risk factors, in a group of obese patients.Patients and methods: Of 142 obese patients (47 male, 95 female, mean age 39.74±11.41 years, and mean BMI 46.88±8.85 kg/m2) were clinically and biologically evaluated. BMI and waist circumference were measured and a complete patient histor...

ea0016p549 | Obesity | ECE2008

The relationship between alteration in plasma inflammation, metabolic biomarkers and severe steatosis in a group of morbidly obese patients

Sirbu Anca , Barbu Carmen , Botusan Ileana , Arbanas Tudor , Albu Alice , Fica Simona

Aim: The aim of the study was to evaluate the relation between anthropometric measurements, plasma biomarkers of inflammation, metabolic and adipokines pattern and the presence of severe steatosis, in a group of patients with morbid obesity.Materials and methods: We evaluated a group of 40 patients (25 F, 15 M) with morbid obesity and indication for bariatric surgery. Anthropometric measurements (waist circumference, BMI determination) were performed and...