Searchable abstracts of presentations at key conferences in endocrinology

ea0063p929 | Diabetes, Obesity and Metabolism 3 | ECE2019

Idiopathic versus autoimmune type 1 diabetes – long-term differences

Catarino Diana , Silva Diana , Pereira Claudia , Ribeiro Cristina , Ruas Luisa , Cunha Nelson , Fadiga Lucia , Guiomar Joana , Lavrador Mariana , Vieira Ines , Cardoso Luis , Paiva Isabel , Bastos Margarida

Introduction: The American Diabetes Association proposed two subcategories for type 1 diabetes: autoimmune type 1 diabetes (ADM) and idiopathic type 1 diabetes (IDM). The absence of β-cell autoimmune markers and lack of association with HLA haplotypes define the second category, whose pathogenesis remains unclear. Only a minority of patients with type 1 diabetes fall into this subcategory which is considered by several authors similar to type 2 diabetes.<p class="abst...

ea0063ep104 | Pituitary and Neuroendocrinology | ECE2019

Corticotroph adenoma associated with a rare infection – case report

Catarino Diana , Ribeiro Cristina , Cunha Nelson , Fadia Lucia , Silva Diana , Guiomar Joana , Lavrador Mariana , Vieira Ines , Saraiva Joana , Rodrigues Dircea , Paiva Isabel , Gomes Leonor , Bastos Margarida

Introduction: Cushing Syndrome have long been recognised to predispose patients to infection diseases, a consequence of the immunosuppression induced by corticosteroids. There is a predisposition to viral, bacterial, parasitic and especially fungal diseases. Opportunistic infections, particularly invasive fungal infections, represent a serious complication associated with an increased risk of mortality.Clinical case: We represent a 55 years-old woman, po...

ea0049ep1356 | Thyroid (non-cancer) | ECE2017

TSH receptor stimulating immunoglobulins – performance of an automated immunoassay

Tavares Patricia , Machado Catarina , Pedroso Jose Carlos , Vieira Joana , Rocha Gustavo , Monteiro Sara , Sousa Ana Margarida , Rodrigues Pedro , Lira Agostinho , Oliveira Maria Joao

Introduction: Graves’ disease (GD) hyperthyroidism is caused by autoantibodies against TSH receptor (TRAb). Three varieties of TRAb are now recognized: stimulating (TSI), blocking and neutral antibodies. Current TRAb immunoassays detect and quantify serum immunoglobulins that interact with the TSH receptor but without discriminating their function. An automated immunoassay for the detection and quantification of TSI is available.Objective: Our study...

ea0070aep93 | Adrenal and Cardiovascular Endocrinology | ECE2020

Type 1 neurofibromatosis and malignant pheochromocytoma

Vieira Inês , Catarino Diana , Fadiga Lúcia , Silva Diana , Guiomar Joana , Lavrador Mariana , Pinheiro Sara , Moreno Carolina , Rodrigues Dírcea , Paiva Isabel

Introduction: Neurofibromatosis type 1 is a disease caused by mutations in the tumor suppressor gene NF1.Although pheochromocytoma is a rare manifestation in these patients (~0.1–5.7%), the incidence is significantly higher than that of the general population.Results (case description): A 50 years old female patient had a clinical diagnosis of neurofibromatosis type 1 since she was 5 years old. She received follow-up in ...

ea0070aep117 | Adrenal and Cardiovascular Endocrinology | ECE2020

Diagnosis, treatment and survival of adrenocortical carcinoma: 28 years of experience

Catarino Diana , Silva Diana , Guiomar Joana , Moreno Carolina , Ribeiro Critina , Gomes Leonor , Fadiga Lucia , Lavrador Mariana , Vieira Inês , Caetano Rui , Figueiredo Arnaldo , Paiva Isabel

Introduction: Adrenocortical carcinoma is a rare endocrine disease characterized by an aggressive behaviour with a poor prognosis. Clinical experience, even with a little number of patients, has enhanced knowledge about this malignancy, in most cases challenging.Objective: Characterization of patients with adrenocortical carcinoma followed at the endocrine department of a hospital centre, between 1991 and 2019.Methods: Retrospectiv...

ea0070ep21 | Adrenal and Cardiovascular Endocrinology | ECE2020

Singularities of the undertreatment of congenital adrenal hyperplasia in adults

Lavrador Mariana , Lages Adriana , Catarino Diana , Fadiga Lúcia , Alexandra Festas Silva Diana , Reis Guiomar Joana , Vieira Inês , Barros Luísa , Paiva Isabel

Introduction: Congenital Adrenal Hyperplasia (CAH) results from enzymatic defects caused by autossomal recessive hereditary mutations characterized by deficient cortisol synthesis and, in most cases, increased androgen synthesis. 90–95% of the cases are originated by deficits in 21-hydroxylase and, in about 75% of the cases, there is evidence of mineralocorticoid deficiency.Case report: A 37-year-old patient was referred to an Endocrinology departm...

ea0070ep60 | Bone and Calcium | ECE2020

GNAS mutation and affection of the endocrine system and bone: An analysis of 3 clinical cases

Vieira Inês , Catarino Diana , Fadiga Lúcia , Silva Diana , Guiomar Joana , Lavrador Mariana , Pinheiro Sara , Bastos Margarida , Rodrigues Dírcea , Paiva Isabel

Introduction: Activating and inactivating mutations of the GNAS gene (encoding the Gsα protein) cause McCune–Albright Syndrome and Albright’s Hereditary Osteodystrophy, respectively. In both, the bone and the endocrine system are often affected. In McCune–Albright Syndrome the most common endocrine manifestation is precocious puberty, but thyroid lesions and hormonal overproduction are also described. In Albright’s Hereditary Osteodystrophy there m...

ea0070ep471 | Thyroid | ECE2020

Risk factors in graves’ disease recurrence after treatment with radioactive iodine

Reis Guiomar Joana , Lemos Luís , Moreno Carolina , Catarino Diana , Fadiga Lúcia , Silva Diana , Vieira Inês , Lavrador Mariana , Costa Gracinda , Paiva Isabel

Introduction: Radioactive iodine (131I) therapy is a safe and cost-effective choice in Graves’ disease (GD). Usually only one treatment with 131I is sufficient, however, individual characteristics of the disease can lead to its recurrence. The aim of this study is to determinate the risk factors that influence the recurrence of GD after 131I.Materials and methods: Retrospective cohort study in 528 patients with GD who did <sup...

ea0029p412 | Clinical case reports - Thyroid/Others | ICEECE2012

Pseudo malabsorption of levothyroxine

Alves M. , Rodrigues D. , Baptista C. , Ribeiro C. , Oliveira P. , Vieira A. , Gouveia S. , Saraiva J. , Moreno C. , Bastos M. , Carvalheiro M.

Background: Therapy with levothyroxine (L-T4) is essential in hypothyroidism treatment. The marked elevation of thyrotropin (TSH) in patients treated with appropriate doses of L-T4 is rare and can result from malabsorption, drug interaction or poor adherence. The non-adherence, omitted by the patient, is called pseudo malabsorption.Clinical report: ACCS, female, 30 years old, hospitalized for persistent...

ea0029p719 | Diabetes | ICEECE2012

Continuous subcutaneous insulin infusion systems: experience in 92 patients with type 1 diabetes

Saraiva J. , Carrilho F. , Barros L. , Batista C. , Melo M. , Gomes L. , Vieira A. , Alves M. , Gouveia S. , Moreno C. , Carvalheiro M.

Background: Continuous subcutaneous insulin infusion (CSII) using an external pump is an alternative intensive diabetes therapy recognized to improve metabolic control and glycemic instability in selected type 1 diabetic (T1DM) subjects. The aim of this study was to examine the clinical effectiveness and safety of CSII systems over a 5-year follow-up period in T1DM patients.Materials and methods: We performed a retrospective observational study of T1DM p...