Endocrine Abstracts

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and skeletal systems and prevent evolvement to overt hyperthyroidism.Material and methods: We treated 630 patients, aged 30–70 years; 85% of them were female and 15% male; 220 patient with multinodular goitre (MNG), and 310 patient with autonomous nodule (ATN). Some of the p...

Despite a wide spectrum of imaging diagnostics, GEP-NETs often stay undetectable until the time of dissemination. Removing of a primary tumour together with disseminated lymph nodes even with the presence of liver metastases is the most appropriate treatment to delay progression of the disease. SRS followed by RGS gives a possibility to detect occult GEP-NET intra-opratively. 99mTc-HYNIC/EDDA-octreotate, a somatostatin analogue with high affinity to sst2 was applied...

Neuropeptides and adipocytokines influence metabolic homeostasis and food intake. Deregulation in their secretion leads to insulin resistance or metabolic syndrome. Adiponectin possesses anti-diabetic and insulin sensitizing properties. Expression of this gene remains under control of nuclear peroxisome proliferator-activated receptor (PPAR)-gamma. Ghrelin, an endogenous ligand for GH secratagogue receptor (GHSR), modulates metabolic homeostasis. A high amino-acid homology and...

Introduction: Thyroid autoimmunity (TAI) commonly defined as the presence of thyroperoxidase antibodies (TPOAbs) and/or thyroglobulin antibodies (TgAbs) affects up to 15 percent of women of reproductive age and is a well-known risk factor of pregnancy loss. One of the possible explanations of obstetrical complications might be the disturbed process of placentation caused by thyroid antibodies. To test this hypothesis, we evaluated placental hormonal function and placental angi...

Introduction: Paragangliomas are rare neuroendocrine neoplasms arising from chromaffin cells in the sympathetic or parasympathetic neural paraganglia that may appear in many places throughout the body. These might be benign or malignant tumors. We report an interesting case of disseminated paraganglioma, the diagnosis of which began with the metastasis to the thyroid gland.Case presentation: A 69-year-old patient with a history of toxic multinodular goit...

Introduction: Hormone macromolecules are complexes of hormones with other compounds, most often with IgG immunoglobulin. They show variable immunoreactivity in immunochemical tests (IRMA, ELISA, CLIA, ECLIA) and usually have a weak biological effect. They can interfere with immunological assays of various hormones. Some known hormone macrocomplexes are: BB-PRL (24% - 34%), macro-TSH (0.6% - 1.2%) and very rare macromolecules of various hormones: calcitonin, PTH, insulin (singl...

Introduction: Medullary thyroid carcinoma (MTC) accounts for 3.5-5% of thyroid cancers. The biochemical diagnosis of MTC is based on the determination of concentration of a sensitive and specific biomarker - calcitonin (CT) as well as CEA and procalcitonin (PCT). Neuroendocrine cells have the ability to produce various proteins and neuropeptides (e.g. granin proteins and INSM-1), which are secreted into the circulation with calcitonin and can be measured in the blood as so-cal...

Introduction: Saliva is an interesting alternative to blood in clinical evaluation of endocrine function. Certain advantages of saliva collection must be considered, when comparing with conventional blood sampling. Vital arguments are that procedure is easy, non-invasive and stress-free. The studies on correlation between salivary and serum thyroid hormones are scarce and contradictory. The goal of our research was to assess if salivary thyroid hormone levels reflect serum con...

Objectives: In the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors thyroid tumors are divided into several new categories that allow for a clearer understanding of the cell of origin, pathologic features, molecular classification, and biological behavior. According to this classification there are some borderline nodules -the group of low-risk follicular cell-derived neoplasms - such as noninvasive follicular thyroid neoplasm with papillary-like nu...

Background: Primary aldosteronism (PA) is the most common endocrine cause of secondary hypertension. It occurs in 5%-10% of hypertensive patients. PA is a group of disorders associated with semi-autonomous hypersecretion of aldosterone. Laboratory diagnosis in patients with suspected PA consists of screening tests aimed at determination of serum/plasma aldosterone concentration, direct renin concentration (DRC) and calculation of the aldosterone/direct renin ratio (ADRR). The ...