Endocrine Abstracts

Background: Obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS) are associated with significant comorbidities and commonly coexist. The primary aim of this study was to examine the relationship between OSA and quality of life (QoL) in women with PCOS.Study design: Observational cross-sectional study.Methods: Women with PCOS were recruited from a single secondary care centre in the UK. PCOS was diagnosed according to...

Introduction: Over 9000 bariatric surgeries are conducted annually in the UK and post-operative micronutrient deficiency is common. We report a case of dry beriberi secondary to thiamine deficiency following Roux-en-Y bypass surgery.Case presentationA 45-year-old Caucasian obese lady (155 kg, BMI 57) presented with progressive proximal limb weakness, upper and lower limb paraesthesia, ataxia and athetoid tremors 18 months following...

Aim: Manipulation of human brown adipose tissue (BAT) represents a novel therapeutic option for diabesity. The aim of our study was to develop and test a novel magnetic resonance imaging (MRI) based method to identify human BAT and delineate it from white adipose tissue (WAT), and validate it by providing immunohistochemical confirmation.Methods: Initial scanning with 18F-FDG PET–CT radiotracer uptake on a 25-year-old Caucasian female wit...

Glomus jugulare tumours are rare and often difficult to manage. A small proportion of these tumours (1–3%) can cause symptoms due to catecholamine secretion. Here we describe a patient with secretory glomus jugulare tumour treated with steriotactic radio surgery and its effect on catecholamine secretion.Case report: A 39-year-old lady was referred to ear specialists with the characteristic symptoms of pulsatile tinnitus and decreased hearing in the ...

Adipose tissue produces several hormones and cytokines termed ‘adipokines’ that have widespread effects on carbohydrate and lipid metabolism. They appear to play an important role in the pathogenesis of insulin resistance, diabetes, and atherosclerosis. Chemerin is a novel adipokine, highly expressed in obese, insulin-resistant subjects. Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. We assessed chemerin levels in sera and adipose...

Orexin-A and orexin-B orchestrate their diverse central and peripheral effects via two G-protein coupled receptors, OX1R and OX2R, which activate multiple G-proteins. They are involved in a host of physiological processes including, steroidogenesis, appetite control and energy regulation. Whilst some signalling mechanisms have been proposed for individual recombinant orexin receptors in generic mammalian cell types, it is clear that the peripheral effects of orexin are spatial...

Introduction: Autosomal dominant hypocalcemia (ADH) type 1 is a rare form of hypoparathyroidism, caused by heterozygous, inherited or de novo, activating mutations in the CASR. CASR is also expressed in the kidney and activating mutations lead to decreased calcium renal absorption. Activating mutations in the CasR, inhibits salt transport, leading to Bartteŕs syndrome (BS) type V which can co-exist with ADH1. Chronic myeloid leukemia (Cml) is characterized by the...

Introduction: Traditionally, obesity is thought to exert a positive impact on bone mineral density (BMD). However, the effect of adipose tissue on bone health is under investigation. Trabecular bone score (TBS) is a measure of bone texture, providing information on bone quality and microarchitecture, independently of BMD. Lower values of TBS indicate a worsening in bone quality and amplify fracture risk. Herein, we aimed to investigate the association of body composition and b...

Background: Growing evidence suggests that hypothalamic lipid sensing plays a key role in controlling food intake, fat deposition and energy balance and that its dysregulation could lead to obesity and type 2 diabetes (T2D). Recent investigations reported that sphingosine-1-phosphate (S1P) is involved in the hypothalamic control of energy homeostasis. Intra-cerebroventricular administration of S1P decreased food intake and increased energy expenditure in rodents.<p class="...

Vitamin D (vit-D) deficiency is common in patients with gastro-entero-pancreatic neuroendocrine tumours (GEP-NET) and has been linked to reduced survival in these patients. Vit-D status was assessed in 183 patients with GEP-NET, at the time of their first presentation in the ARDEN-NET-Centre; and following simple advice at routine 6-monthly follow-up appointments to increase vit-D intake using over-the-counter vit-D preparations (Colecalciferol (Vit-D3), 1000–2000 units/d...