Endocrine Abstracts

Several lines of evidence fuel concerns about endocrine disruptors and human health: First, there are increasing trends of endocrine-related disorders such as endocrine cancers, neurodevelopmental disorders, diabetes, thyroidal diseases, and congenital malformations. Second, several widely used chemicals have been linked to such disorders in epidemiological studies and experiments with laboratory animals. Although human exposures involve many endocrine disruptors simultaneousl...

The Hypothalamic Pituitary Thyroid (HPT) axis is well-known as a classic endocrine negative feedback loop: increased levels of thyroxine (T4) in the blood are associated with a reduction of thyroid stimulating hormone (TSH) production and vice versa. However, the thyroid hormone (TH) system is sensitive to alterations by a number of endocrine disrupting chemicals (EDCs). Intriguingly, exposure to specific EDCs can decrease the levels of T4 but this might be not followed by the...

Certain endocrine disrupting chemicals (EDCs) are known to disrupt the thyroid hormone system. Thyroid hormone (TH) levels are physiologically regulated by the hypothalamic–pituitary–thyroid (HPT) axis, a tight feedback loop, whereby low levels of T4 stimulate an upregulation of TSH, and conversely if T4 levels are raised. Low levels of T4 (with chronic upregulation of TSH) can lead to thyroid hyperplasia – an outcome that is recognised by regulatory groups for ...

The Hypothalamic Pituitary Thyroid (HPT) axis is well-known as a classic endocrine negative feedback loop: increased levels of thyroxine (T4) in the blood are associated with a reduction of thyroid stimulating hormone (TSH) production and vice versa. However, the HPT axis is sensitive to alterations by a number of endocrine-disrupting chemicals (EDCs). Exposure to specific EDCs can deregulate the negative feedback loop and alter the TH/TSH levels. The intrinsic mechanisms for ...