Endocrine Abstracts

Background: Parathyroid carcinoma (PC) is uncommon and occurs in only 1–5% cases of primary hyperparathyroidism. The histological diagnosis of parathyroid tumors can be challenging, and beneficial histological markers are not available for diagnosis or predicting the prognosis of patients. In this study, we investigated the expression of Ki-67, parafibromin, p27, and Rb protein in parathyroid tumors and assessed the correlation between histological diagnosis or prognosis,...

Context: Prior to thyroidectomy for Graves’ disease, thyroid function should be adequately controlled to avoid complications such as thyroid storm. However, preoperative thyroid function control is sometimes difficult.Objective: This study assessed the postoperative risks are increased or not if biochemically hyperthyroid patients undergoing total thyroidectomy in comparison to euthyroid patients.Methods: A retrospective, coho...

Background: Papillary thyroid microcarcinoma (PTMC) has low malignant potential and an extremely good prognosis. However, surgical findings of asymptomatic PTC, can occasionally reveal tumor invasion into the recurrent laryngeal nerve (RLN). The present study assessed the feasibility of evaluating tumor invasion into the RLN using ultrasonography (US) and computed tomography(CT).Materials and methods: Of 7,916 patients with a PTC who underwent surgery at...

Purpose: Molecularly targeted drugs are indispensable therapeutic tools for the treatment of unresectable differentiated thyroid cancer. Lenvatinib (LEN) is listed as a preferred regimen in the NCCN guidelines, and is a highly effective anti-tumor agent, but is also associated with a high rate of adverse events (AEs), which may be related to prognosis. AE management is key to LEN therapy. Although there is no recommendation in the package insert regarding the recommended time ...