Endocrine Abstracts

Semen quality and reproductive hormones may be affected in men with testicular neoplasia (TN) and lymphoproliferative disorders (LD). We evaluated these parameters before, 6, 12 and 24 months after the end of the oncological treatments in 60 patients with TN, and in 35 patients with LD. The patients were divided on the bases of the basal sperm concentration (A< and B≥ 10 million/ml). FSH, LH, testosterone (T) and inhibin B levels and sperm parameters were evaluated i...

Acylated ghrelin (AG) participates in the modulation of the hypothalamic-pituitary-gonadal axis functions, with a predominantly inhibitory effect upon the reproductive system in animals. Animal studies have shown that ghrelin suppresses LH secretion in vivo, decreases LH responsiveness to GnRH in vitro and partially delays the timing of puberty in males. Aim of this study was to evaluate the effects of AG infusion on spontaneous and stimulated gonadotropin secret...

Background: The clinical burden of Klinefelter Syndrome (KS) is not limited to the impairment of gonadal function and an increased prevalence of cardio-metabolic, endocrinological and oncological diseases, but also involve several cognitional, behavioural and psychological issues. Because of the wide heterogeneity in clinical phenotype, the diagnosis of KS is still challenging, resulting in a significant number of patients to remain undiagnosed or to have a late diagnosis. Ver...