Endocrine Abstracts

Introduction: Recent studies report the presence of KLK3 in women serum, KLK3 is excreted by Skene glands, it is involved in the production of cervical-vaginal fluid (CVF). Activation of KLK3 is pH depending, it has been hypothesized to have antimicrobial, immuno-regulator activity and vaginal and cervical epithelial desquamation. We intend to verify if KLK3 is present in female serum, in which menstrual cycle phases KLK3 ...

Introduction: Recent studies report the presence of KLK3 in women serum, KLK3 is excreted by Skene glands, it is involved in the production of cervical-vaginal fluid (CVF). Activation of KLK3 is pH depending, it has been hypothesized to have antimicrobial, immuno-regulator activity and vaginal and cervical epithelial desquamation. We intend to verify if KLK3 is present in female serum, in which menstrual cycle phases KLK3 ...

Background: Active smoking has been associated with alterations of the hypothalamic-pituitary-adrenal axis. A role in the pathogenesis of adrenal tumors has also been proposed previously. No data investigating the relationship between smoking and hormonal secretion of adrenal tumors are yet available.Aim: To investigate the association between smoking habit with morphology and hormonal pattern of adrenal tumors.Methods: We retrospe...

Background: Adrenal incidentalomas (AI) are classified into mild autonomous cortisol-secreting (MACS) and non-secreting (NS) based on the 1mg-dexamethasone suppression test (DST). However, the latter test fails to detect alterations in the cortisol rhythm, which might be present in both MACS and NS.Aim: To characterize the cortisol secretion in terms of daily rhythm and exposure in healthy controls (HC) and patients with AI.Methods...

Background: Adrenal endothelial tumors are mainly represented by adrenal cavernous hemangiomas (ACHs) and adrenal cystic lymphangiomas (ACLs). They are rare incidental findings, with about 160 cases of both ACHs and ACLS reported in the literature. They are usually unilateral, benign, non-functioning, and asymptomatic, although abdominal pain and life-threatening retroperitoneal hemorrhage may occur if tumor size increases. Radiological features often overlap with malignant ad...