Endocrine Abstracts

Introduction: Persistent hypocalcemia after surgery for severe hyperparathyroidism are not uncommon and may be secondary to transient or permanent hypoparathyroidism but may also be due to bone pathology.Observation: Patient of 44 years old was hospitalized for fractures of the pelvis, and shaft of left femur, spontaneous without trauma turned out. Laboratory tests shows severe hypercalcaemia to 156 mg/l, serum phosphorus at 22 mg/l, elevation of PTH to ...

Medullary thyroid cancer (MTC)is a very polymorphic tumour, it remains difficult to diagnose, especially in cytology. The MTC is characterized by a polymotphic cell population, the amyloid stroma is found in 43 to 81% of cases. In this retro and prospective study carried out over 5 years, we included 45 lesions (8 nodules, 35 lymph nodes and 2 cervical masses) these lesions were punctured and the cytological results were compared with the definitive histology. On cytology, 13 ...

Background: Diabetes mellitus is the most common endocrine metabolic disorder of childhood. It is widely spread all over Egypt as its prevalence was found to be 1.09 per 1000 among school aged children.Aim of the work: The aim of this work was to do a retrospective epidemiological study of the records of diabetic children attended the outpatient pediatric clinic in NIDE.Subjects & Methods: The files 0f 3000 diabetic children we...

Type 1 diabetes is a chronic autoimmune disease with a subclinical prodromal period characterized by the presence of circulating antibodies to various islet cell proteins. Our main objective is to estimate the prevalence of diabetes-associated autoantibodies in a group of 1st degree relatives, compared to healthy control subjects. Also, we tried to assess the insulin secretory capacity in subjects having multiple antibodies using first phase insulin response (FPIR) to intraven...

Background: Diabetic ketoacidosis (DKA) is the most serious acute metabolic complications of diabetes. Unfortunately, there is a dearth of published data on this entity from Egypt. The aim of our work was to determine the clinical characteristics, precipitating causes and mortality rate of patients with diabetic ketoacidosis in National Institute of Diabetes and Endocrinology.Methods: Our work is a retrospective study in which we reviewed and analyzed th...

Background: Current criteria for the diagnosis of diabetic ketoacidosis (DKA) are limited by their nonspecificity (serum bicarbonate [HCO3] and pH) and qualitative nature (the presence of ketonemia/ketonuria). A new method is now available to measure capillary levels of beta-hydroxybutyrate (beta -0HB), It is a quantitative and enzymatic test that uses the same equipment as for home capillary blood glucose determination but with specific strips. Aim of the work: The aim of thi...

Diabetic ketoacodosis (DKA) is a serious complication of diabetes mellitus, especially type 1, and its secondary consequences account for a large proportion of diabetes-related hospitalizations and mortality in children with type 1 diabetes.Aim of the work: The aim of this study was to compare between the outcomes of application of ISPAD (International Society of Pediatric & Adolescence Diabetes) versus ADA, (American Diabetes Association) guidelines...

Background: Diabetic ketoacidosis (DKA) is a life-threatening condition that requires hospitalization in children with type 1 diabetes. Many reports have indicated that low-dose insulin therapy is quite effective regardless of the route of administration, whether, intramuscular, or subcutaneous.Aim of the work: The aim of this study was to look for technical simplification and economic efficiency in the treatment of diabetic ketoacidosis (DKA) with subcu...

Obesity is a major risk factor for chronic non communicable diseases and plays a central role in the insulin resistance or metabolic syndrome, which includes hyperinsulinemia, hypertension, hyperlipidemia, type 2 diabetes mellitus, and an increased risk of adult onset obesity and atherosclerotic cardiovascular disease (1). Insulin resistance is a state in which a given concentration of insulin produces a less than expected biological effect. The metabolic syndrome is a cluster...

Autoimmune thyroiditis (AIT) is a group of inflammatory thyroid disorders with either hyperthyroid, euthyroid or hypothyroid state. The aim of this study is to detect the subclinical thyroiditis among the Egyptians type 1 diabetic patients and to study the relation of the thyroid antibodies to different metabolic control indices of diabetes. The study group consisted of 50 type 1 diabetic patients aged from 8 to 18 years. They were selected from the out-patient daily clinics o...