Endocrine Abstracts

Diabetic ketoacodosis (DKA) is a serious complication of diabetes mellitus, especially type 1, and its secondary consequences account for a large proportion of diabetes-related hospitalizations and mortality in children with type 1 diabetes.

Aim of the work: The aim of this study was to compare between the outcomes of application of ISPAD (International Society of Pediatric & Adolescence Diabetes) versus ADA, (American Diabetes Association) guidelines for management of diabetic ketoacodosis in type 1 diabetic children attending the National Institute oof Diabetes & endocrinology in Cairo, Egypt (NIDE). Each protocol had been applied on 100 dibetic children with DKA with no significant difference between both groups as regarding, age, sex, acidity represented by ph. and serum bicarbonate and anion gap or coma score. The results showed that there was no statistical difference as regarding all outcome results as duration of recovery of acidosis or dehydration or the morbidity or mortality results. While the results of the change in potassium was better in ISPAD protocol. The Net results showed that there is no great difference between both groups. It could be recommended to apply any of the ISPAD or ADA protocols for managment of DKA in type 1 diabetic children but it will be more benificial to delay the insulin therapy for 1 hour after giving the intravenous fluid therapy as had been recommended by the ISPAD guidelines.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.