Searchable abstracts of presentations at key conferences in endocrinology
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15th International & 14th European Congress of Endocrinology

ea0029p499 | Diabetes | ICEECE2012

Selective suppression of slow wave sleep does not affect insulin sensitivity in patients with type 1 diabetes

Donga E. , van Dijk M. , Lammers G. , van Kralingen K. , van Dijk G. , Corssmit E. , Romijn J.

Background: Human sleep is composed of different sleep stages, of which slow wave sleep (SWS) is an important modulator of glucose regulation. Curtailment of sleep duration in general and of slow wave sleep (SWS) in particular reduces glucose tolerance in healthy subjects. Previously, we have reported that a single night of partial sleep deprivation reduces insulin sensitivity by 15–20% in patients with type 1 diabetes. We hypothesized that this effect could be a conseque...

ea0029p500 | Diabetes | ICEECE2012

Evidence that abscissic acid participates in the response to hyperglycemia in humans

Ameri P. , Bruzzone S. , Briatore L. , Mannino E. , Basile G. , Ponta M. , Grozio A. , Magnone M. , Guida L. , Scarfi S. , Salis A. , Damonte G. , Sturla L. , Nencioni A. , Fenoglio D. , Fiory F. , Miele C. , Beguinot F. , Maggi D. , Cordera R. , Murialdo G. , De Flora A. , Zocchi E.

Abscissic acid (ABA) is a hormone best known for its role in plants. We previously showed that it is released by pancreatic beta-cells upon glucose stimulation, and autocrinally enhances insulin secretion.Here we additionally report that ABA promotes glucose uptake by rat L6 myoblasts and murine 3T3-L1 cells differentiated to adipocytes, at least partly by inducing GLUT-4 translocation to the plasma membrane.To determine whether AB...

ea0029p501 | Diabetes | ICEECE2012

Mitochondrial biogenesis is not significantly impaired in non obese asian indians with type 2 diabetes

Chattopadhyay M. , Roy I. , Baitalik D. , Mukhopadhyay S. , Chakrabarti S.

Introduction: Deranged mitochondrial biogenesis has been linked to obesity with or without type 2 diabetes but this association has not been reported in non obese type 2 diabetes subjects. This study attempts to identify the various alterations of mitochondrial biogenesis in adipose tissue in obese and non obese type 2 diabetes subjects.Methods & Design: Since type 2 diabetes is associated with elevated serum leptin and depressed serum adiponectin le...

ea0029p502 | Diabetes | ICEECE2012

Iron overload induces visceral adipose tissue insulin resistance

Dongiovanni P. , Ruscica M. , La Spina S. , Steffani L. , Borroni V. , Rametta R. , Recalcati S. , Cairo G. , Gatti S. , Magni P. , Fargion S. , Valenti L.

Excess body iron is associated with the metabolic syndrome, but whether it has a causal role in the pathophysiology of insulin resistance (IR) is not well understood. Aim of this study was to assess (a) the effect of dietary modulation of iron status on IR in Wild-type or ob/ob C57Bl/6 male mice fed a standard iron concentration (8 mg/kg) or an iron enriched diet (30 g/kg; IED), as well as in high-fructose diet (HFD) mice and (b) to investigate the mechanisms whereby. IED dete...

ea0029p503 | Diabetes | ICEECE2012

Comprehensive evaluation of type 2 diabetes susceptibility loci in the Japanese population by using 1000 Genomes Project data

Hara K. , Fujita H. , Horikoshi M. , Yamauchi T. , Maeda S. , Kadowaki T.

Although over 50 type 2 diabetes (T2D) loci have been identified through genome-wide association studies (GWAS), the vast majority of the genetic predisposition to T2D still remains to be clarified. One explanation is that despite the use of high-throughput genotyping arrays, only a small proportion of genetic variants in the human genome are actually surveyed, especially in non-European populations. We explored the comprehensive catalog of genomic variations provided by the 1...

ea0029p504 | Diabetes | ICEECE2012

Glycoalbumin is the best indicator for glycemic variability assessed by continuous glucose monitoring

Suh S. , Joung J. , Park S. , Cho Y. , Jin S. , Kim S. , Kim H. , Bae J. , Kim S. , Chung J. , Min Y. , Lee M. , Lee M. , Kim K. , Kim J.

Aims: We investigated the interrelationship between HbA1c, fructosamine, glycoalbumin (GA), 1,5-anhydroglucitol (1,5-AG) with glycemic variability data from continuous glucose monitoring system (CGMS).Methods: Seventy diabetic patients (mean age of 54 years including seven type 1 diabetes mellitus subjects) were enrolled, and all wore a CGMS for 72 hours. For the parameters of glucose excursion, mean glucose, standard deviation (SD) of glucose, the area ...

ea0029p505 | Diabetes | ICEECE2012

Nonalcoholic fatty liver disease is associated with atherosclerosis in middle-aged and elderly chinese

Huang Y. , Bi Y. , Xu M. , Li X. , Ning G.

Objective: To evaluate the associations between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis.Methods and Results: A total of 8971 participants aged 40 years and older from Baoshan district, Shanghai were included in the present study. The presence of NAFLD was evaluated by ultrasonography. Carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (ba-PWV) were measured in each participant. The prevalence of NAFLD was 30...

ea0029p506 | Diabetes | ICEECE2012

Altered Mitochondrial Bioenergetics Does Not Explain Increased Ros Production In Non-Obese Asian Indians With Type 2 Diabetes (T2D)

Chattopadhyay M. , Roy I. , Baitalik D. , Mukhopadhyay S. , Chakrabarti S.

Introduction: Deranged Mitochondrial bioenergetics is a key feature of type 2 diabetes and obesity but its status in non-obese type 2 diabetes patients is not known. The aim of the present study was to assess the status of mitochondrial oxidative phosphorylation and ROS metabolism in subcutaneous adipose tissue isolated from 4 groups of subjects: non-obese subjects with type 2 diabetes (NOT2D), non-obese non diabetic (C), obese non-diabetic (OB) and obese type 2 diabetes subje...

ea0029p507 | Diabetes | ICEECE2012

QRFP43 and its fragment 26RFa both promote β-cell survival but differently regulate insulin secretion and glucose uptake in pancreatic β-cells and human pancreatic islets

Trovato L. , Settanni F. , Gallo D. , Gargantini E. , Bergandi L. , Ong H. , Ghigo E. , Granata R.

RFamides are a family of peptides containing arginine-phenylalanine-amide at their C terminus. A novel 43-amino acid RFamide, named QRFP43, and a shorter endogenous peptide 26RFa, were discovered and identified as ligands of the G protein-coupled receptor GPR103. Different studies have shown that RFamides, such as neuropeptide FF and QRFP43 and 26RFa, play a role in food intake, thermogenesis and energy homeostasis. Here, we investigated the effects of QRFP peptides on surviva...

ea0029p508 | Diabetes | ICEECE2012

Influences of the 2011 Tohoku Earthquake on glycemic control in patients with diabetes mellitus in Tokyo

Kumagai N. , Muroya Y. , Shimodaira M. , Tsuzawa K. , Honda K.

Objectives: Huge 9.0 magnitude quake and tsunami attacked eastern areas of Japan, on March 11th 2011. They claimed more than 20,000 lives and destroyed the nuclear power plants. Although the property damage was very little in Tokyo, about 250 miles apart from the epicenter, the people in capital faced a lot of hard situations. For example, unusual food supply, the lack of the daily necessities, the limitation of the electricity supply, and a fear of hundreds of aftershocks and...

ea0029p509 | Diabetes | ICEECE2012

The impact of pioglitazone administration on circulating endothelial progenitor cells, inflammation and endothelial function of diabetic patients with and without coronary artery disease

Kampoli A. , Tousoulis D. , Pallantza Z. , Paterakis G. , Papageorgiou N. , Miliou A. , Stefanadis C.

Introduction: Glitazones’ admisitration has been proved to affect EPCs in peripheral circulation in endothelial function and inflammatory process. The purpose of this study was to further investigate if the administration of pioglitazone in diabetics can modify the number of EPCs in the peripheral blood and alter the inflammatory state and endothelial function of these patients.Methods: Twenty five diabetic patients were recruited and pioglitazone w...

ea0029p510 | Diabetes | ICEECE2012

The redution hypothalamic PP2A expression improve peripheral insulin sensitivity

Picardi P. , Caldeira E. , Caricilli A. , Saad M.

Protein phosphatase 2A (PP2A) is a multimeric serine/threonine phosphatase which has multiple functions. However, the potential involvement of PP2A in insulin’s metabolic signaling pathway is presently unknown. Brain insulin resistant state is characterized by disturbances in transducing the signal from IR/IRS/AKT, changing feeding behaviour and body weight. We showed that diet induced obese rats (DIO) have a marked increase in PP2A protein expression in the hypothalamus....

ea0029p511 | Diabetes | ICEECE2012

The new combination of risk factors determining a high risk of gestational diabetes mellitus

Popova P. , Kravchuk E. , Gerasimov A. , Shelepova E. , Tsoi U. , Grineva E.

Introduction: Gestational diabetes mellitus (GDM) is a common complication of pregnancy. Identification of early determinants of GDM is necesary to designate possible preventive strategies. The aim of this study was to reveal the most significant risk factors for GDM.Design: A total of 209 women with singleton pregnancies were included in the study. Maternal fasting glucose, anthropometric parameters and blood pressure were measured in the first trimeste...

ea0029p512 | Diabetes | ICEECE2012

Glycemic control influences CA19-9, CEA and ferritin levels in type 2 diabetes.

Ure O. , Ata N. , Kucukazman M. , Tutal E. , Caglar F. , Hokkaomeroglu M. , Akin K. , Dal K. , Yilmaz H. , Kizilca G. , Beyan E. , Ertugrul D.

Objective: Diabetes mellitus is associated with various types of cancer. Exocrine pancreas function is also influenced by diabetes.Materials/Subjects and Methods: In this study we aimed to investigate the effect of glycemic control on tumor and inflammatory markers. Sixty eight type 2 diabetic patients, and 70 healthy controls comprised the study population. We measured fasting blood glucose (FBG), postprandial blood glucose (PPBG), serum total cholester...

ea0029p513 | Diabetes | ICEECE2012

Effects of perindopril on circulating endothelial progenitor cells, inflammation and endothelial function of diabetic patients with and without coronary artery disease

Kampoli A. , Tousoulis D. , Paterakis G. , Pallantza Z. , Papageorgiou N. , Miliou A. , Stefanadis C.

Introduction: Endothelial progenitor cells (EPCs) seems to be reduced in patients with diabetes mellitus, however it is unknown whether treatment with ACE-I may modify the number of EPCs. Therefore, the purpose of this study was to investigate if the administration of perindopril in diabetic patients with and without coronary artery disease can modify the number of circulating EPCs and alter their inflammatory state and endothelial function.Methods: Twen...

ea0029p514 | Diabetes | ICEECE2012

Glycemic control in type 1 diabetic patients experience of a university hospital in tunis

Yazidi M. , Chihaoui M. , Lamine F. , Ftouhi B. , Kanoun F. , Slimane H.

Recent years have been marked by numerous advances in the quality of type 1 diabetes care. However, glycemic control remains suboptimal for many patients even in developed countries.The aim of this study was to assess glycemic control in a cohort of Tunisian type 1 diabetic patients and to identify factors associated with poor glycemic control.Methods: One hundred and eighty-eight type 1 diabetic patients admitted to the Endocrinol...

ea0029p515 | Diabetes | ICEECE2012

Progression to impaired fasting glucose, impaired glucose tolerance and diabetes in urban population during 8 years follow up

Piorowska N. , Piwonska-solska B. , Gilis-Januszewska A. , Hubalewska-Dydejczyk A. , Pach D.

Objective: To determine the progression rate to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes (DM2) in normal glucose tolerant (NGT) people during 8 years follow up using WHO 1999 criteria and new criteria (IFG-fasting glucose 5.6–6.9 mmol/l).Research design and methods: This is an eight year prospective study in a randomly selected urban population aged >=40 years living in Krakow, Poland. 1752 persons had NGT.b...

ea0029p516 | Diabetes | ICEECE2012

The role of sex hormone-binding globulin in the risk of incident metabolic syndrome: further evidence from a longitudinal population-based sample of adult men.

Haring R. , Volzke H. , Spielhagen C. , Nauck M. , Wallaschofski H.

Background: In the classic paradigm, the primary function of sex hormone-binding globulin (SHBG) was thought to passively bind and transport steroids and estrogens in the blood to access target tissues and to determine their bioavailable fraction. Now there is increasing evidence that SHBG plays an active role in steroid actions and is an actively contributes to many age-associated comorbidities including type 2 diabetes, obesity, and metabolic syndrome (MetS).<p class="ab...

ea0029p517 | Diabetes | ICEECE2012

Fracture predictors in diabetic postmenopausal women without hyperparathyroidism

Gusova A. , Pavlova M. , Melnichenko G. , Kavalersky G.

Introduction: The diabetes mellitus (DM) is the known risk factor of fractures. The aim was to determine predictors of fractures in type 2 diabetic postmenopausal women without hyperparathyroidism.Design: We analyzed local trauma clinic data for 3 sequential years from 2 662 diabetic persons who were entered The National Register of diabetes mellitus patients (133 subjects with type 1 diabetes mellitus and 1995 ones with type 2 DM). Afterward we examined...

ea0029p518 | Diabetes | ICEECE2012

Characteristics and prevalence of latent autoimmune diabetes in adults (LADA) in a diabetic population

Saboo B. , Chandarana H. , Joshi S. , Shah S.

Diabetes, one of the most commonly seen metabolic disorders, is affecting a major area of population in many developing as well as most of the developed countries and is becoming an alarming concern for the rising cost of the healthcare system. Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is less recognized and under diagnosed type of diabetes which appears to have characteristics of both type 1 (autoimmune in nature) and type 2 diabetes (adult age a...

ea0029p519 | Diabetes | ICEECE2012

Non Governmental Organizations [NGO's] & Diabetes- Advocacy for support services in resource-poor nations

Pramod S.

Background: Diabetes- support services facilities available only in few city hospitals. Especially diabetics in rural India lack comprehensive diabetes care plan. NGO’s play key role in psychosocial-support/Counseling/rehabilitation in remote towns of india. Our Project aimed to formulate policy for trained personals to give better & cost-effective Diabetes- support services.Methods: We mobilized training resources from local primary Health-cent...

ea0029p520 | Diabetes | ICEECE2012

Mesenchymal stem cells-derived microvesicles modulate cellular immune response to islet antigen GAD in type 1 diabetes.

Favaro E. , Deregibus M. , Camussi E. , Granata R. , Ghigo E. , Cavallo Perin P. , Zanone M. , Camussi G.

Background and aims: Mesenchymal stem cells (MSCs) exert an immunosuppressive effect on immune system and can abrogate in vitro the pro-inflammatory Th1 response to islet antigen GAD in type 1 diabetes by impairing the production of IFN-gamma. The mechanism may involve paracrine factors. Microvesicles (MVs) released from MSCs may account for this paracrine mechanism through a horizontal transfer of mRNA and microRNA. In the present study we evaluated whether MSC-derived...

ea0029p521 | Diabetes | ICEECE2012

Prevalence of autoimmune diseases in a Type 1 diabetic population

Marcelino M. , Castro S. , Santos A. , Amaral D. , Pina R. , Lopes L.

Background: Patients with type 1 diabetes (T1DM) are known to have a higher risk of developing other autoimmune diseases. The most common associated disorders are thyroid autoimmunity (Graves’ disease or Hashimoto’s thyroiditis) and celiac disease.The aim of this study was to investigate the prevalence of other autoimmune disorders in T1DM patients of our clinic.Methods: We reviewed 269 files of children and adolescents w...

ea0029p522 | Diabetes | ICEECE2012

Relation of glycemic control to Easter and summer holiday times

Pape M. , Smagadi A. , Haritonidis I.

Objective: Poor glycemic control in type-2 diabetes mellitus is a risk factor for the development of diabetes complications. The aim of this study was to evaluate the effect of the holiday (Easter time) and the season (summer) on the glycemic control in Greek diabetic subjects.Methods: 50 type-2 diabetic patients participated in the study. Each participant was followed up in primary care settings (Health Centre of Soxos) and underwent a physical exam, in...

ea0029p523 | Diabetes | ICEECE2012

Change in quality of life by multiple education program in type 1 diabetic patients

Saboo B. , Chandarana H. , Joshi S. , Shah S.

The aim of study was to recurrently follow quality of life in type 1 diabetes patients after multiple educations and counseling. Ninty six patients of the age group of “between” 10 to 25 were initially examined in 2004 and Eighty eight patients of them were reexamined in 2006 after multiple counseling with diabetologist and trained diabetes educator at dia care, Ahmedabad, Gujarat, India. Quality of life was defined as perceived well being and life satisfaction, glob...

ea0029p524 | Diabetes | ICEECE2012

Cystatin levels in diabetic and prediabetic patients

Akin S. , Ersoz Gulcelik N. , Yazgan Aksoy D. , Karakaya J. , Bayraktar M. , Usman A.

Background and aim: Serum Cystatin C has been shown to be associated with the progression to prediabetes and type 2 diabetes mellitus. High cystatin levels were also found to be associated with body mass index. The aim of this study was to evaluate cystatin C levels in diabetic and prediabetic patients ant its association with anthropometric measurements and insulin resistance.Methods: Twenty four patients with diabetes, 17 patients with prediabetes and ...

ea0029p525 | Diabetes | ICEECE2012

Psychoemotional state of diabetic women with fracture

Gusova A. , Pavlova M. , Melnichenko G. , Kavalersky G.

Background and aims: The aim was to determine psychoemotional state in diabetic and non-diabetic patients with or without fractures and its correlation with bone condition.Materials and methods: We examined 62 postmenopausal women with type 2 diabetes mellitus (DM), 29 of them had bone fracture within last month. The control group included 56 non-diabetic women, 26 within a group were recently fractured. Groups were comparable in body mass index, age, du...

ea0029p526 | Diabetes | ICEECE2012

Hypoglycemic and hyperglycemic patients in emergency room

Yucel N. , Sertkaya A. , Pepele S.

Aims: To evaluate the process of patients from emergency room (ER) admittance until discharge from the endocrinology service (ES) with hypoglycemia or hyperglycemia.Methods: Two hundred twenty two patients either with hypoglycemia or hyperglycemia were evaluated. Hyperglycemic patients were divided into three groups: Patients with type 1 diabetes, type 2 diabetes and patients without diabetic history. The complaints, laboratory findings, stay in ER, stay...

ea0029p527 | Diabetes | ICEECE2012

Diabetes risk in relation to weight loss, weight stability and degree of obesity - The Swedish Obese Subjects (SOS) study

Peltonen M. , Sjostrom L. , Carlsson L.

Objective: Among severely obese individuals, surgically induced weight loss reduces the risk for type 2 diabetes. The aim of this study was to analyse the incidence and remission of type 2 diabetes among individuals with different degrees of obesity losing weight, and compare them with obese individuals remaining weight stable during follow-up.Research design and methods: The ongoing non-randomized prospective controlled Swedish Obese Subjects (SOS) inte...

ea0029p528 | Diabetes | ICEECE2012

The role of Insulin Receptor in Cancer

Belfiore A.

The IGF-I receptor (IGF-IR) and its ligands (IGF-I and IGF-II) play a physiological role in growth and differentiation and are also involved in cancer growth and progression. The insulin receptor (IR), which shares high homology with the IGF-IR, has a predominant role in glucose metabolism. However, several studies have convincingly shown that the IR pathway is more intimately involved in cancer development and progression than previously thought. Recent evidences showing that...

ea0029p529 | Diabetes | ICEECE2012

Local effects of cytokine TNF-alpha on glucose, lipid and protein metabolism in the placebo controlled bilaterally perfused human leg

Bosnjak E. , Buhl M. , Nielsen R. , Hafstrom T. , Vandelbo M. , Tonnesen E. , Moller N.

Introduction: Cytokine TNF-alpha has widespread metabolic actions, including induction of insulin resistance, lipolysis and cachexia. Systemic TNF-alpha administration, however, generates complex hormonal and metabolic scenario. No studies employing regional, placebo controlled TNF-alpha infusion exist. Our study was designed to test the hypothesis that local leg perfusion with TNF-alpha directly induces insulin resistance, lipolysis and protein breakdown.<p class="abstext...

ea0029p530 | Diabetes | ICEECE2012

Increased nuclear translocation of GAPDH in peripheral blood mononuclear cells (PBMCs) of diabetic patients.

Gougoura S. , Filliponi M. , Bargiota A. , Dritsa P. , Koukoulis G.

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) not only functions as a central glycolytic enzyme but also is implicated in the process of apoptosis and gene transcription moving between the cytosol and nucleus. Oxidative stress modifies the activity of GAPDH.The aim of the study was to determine whether oxidative stress (OS) in diabetics is associated with induction of the apoptotic process and higher GAPDH translocation to the nucleus in PBMCs.<p ...

ea0029p531 | Diabetes | ICEECE2012

Conserved mitochondrial coupling and adaptive substrate control in inuit and caucasians: acclimatization to active life styles in the arctic winter

Boushel R. , Saltin B. , Gnaiger E.

Mitochondria oxidize food substrates to generate energy for cellular work and heat is variably generated depending on the degree of coupling of electron transport to oxidative phosphorylation (OXPHOS). It has been hypothesized that climatic pressures exerted selection for mitochondrial haplogroup in arctic populations for a lower coupling of mitochondrial respiration to ATP production in favor of heat production. In this study muscle mitochondrial function was studied in Inuit...

ea0029p532 | Diabetes | ICEECE2012

Association of adiposity trajectories with insulin sensitivity and glycemic deterioration: a longitudinal study of rural chinese twin adults

Liu R.

Objective: To evaluate associations between adiposity trajectories over time and insulin sensitivity and glucose deterioration in a Chinese twin cohort.Research Design and Methods: This study focused on 341 males and 292 females who aged 20–50 years old at baseline and had physical, clinical examinations and oral glucose tolerance test(OGTT) at two time points with an average of 6 years apart. Body mass index (BMI), waist circumference (WC), percent...

ea0029p533 | Diabetes | ICEECE2012

Direct metabolic effects of locally administered lipopolysaccharide in the placebo controlled bilaterally infused human leg; decreased insulin sensitivity and insulin signaling with unaltered lipid and protein metabolism

Buhl M. , Bosnjak E. , Gjedsted J. , Nielsen R. , Jessen N. , Hafstrom T. , Vestergaard E. , Tonnesen E. , Moller N.

Introduction: In humans bacterial lipopolysaccharide (LPS/endotoxin) causes chronic low-grade and acute inflammatory responses, which decrease insulin sensitivity and may lead to chronic type 2 diabetes and acute stress diabetes. Systemic LPS invariably generates cytokine release, which triggers release of anti-insulin stress hormones and it is not known whether insulin resistance is secondary to stress hormones or LPS per se. Our study was designed to test whether local place...

ea0029p534 | Diabetes | ICEECE2012

Suppressive effect of hyperinsulinemia on serum interleukin 18 concentration in young healthy subjects

Straczkowski M. , Karczewska-Kupczewska M. , Adamska A. , Nikolajuk A. , Matulewicz N. , Zielinska M. , Gorska M. , Kowalska I.

Introduction: Interleukin 18 (IL-18) is a proinflammatory and proatherogenic cytokine which is associated with obesity, insulin resistance and cardiovascular disease. It is supposed that insulin has anti-inflammatory action. The aim of the present study was to estimate serum IL-18 concentration in young healthy population, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation.Methods: We studied 36 h...

ea0029p535 | Diabetes | ICEECE2012

The Association of the severity of nonalcoholic fatty liver disease with development of type 2 diabetes: A 4-year longitudinal study

Choi J. , Bae J. , Park S. , Rhee E. , Park C. , Oh K. , Park S. , Kim S. , Lee W.

Aims: Nonalcoholic fatty liver disease (NAFLD) is reported to contribute to the development of type 2 diabetes, but it is largely unknown whether such a relationship between NAFLD and incident diabetes relates to the severity of NAFLD or it is independent. We aimed to evaluate the association of the severity of NAFLD with development of type 2 diabetes in a retrospective cohort of Korean subjects.Methods: This study included 7,849 individuals without dia...

ea0029p536 | Diabetes | ICEECE2012

Predictive ability of prediabetes defined by fasting plasma glucose and HbA1c for progression to diabetes in Koreans

Kim C. , Kim H. , Kim E. , Bae S. , Park J.

Background: The predictive ability of prediabetes defined by HbA1c (5.7–6.4%) or fasting plasma glucose (FPG) criteria (5.6–6.9 mmol/l) for the development of diabetes may differ according to ethnic groups, but only limited longitudinal data are available in Asians. We examined the progression rate to diabetes in Korean adults diagnosed as prediabetes according to these two criteria.Methods: We analyzed data of 9432 Korean adults (age 20–7...

ea0029p537 | Diabetes | ICEECE2012

Relationship between serum levels of 1-84 parathormone (PTH1-84) and obesity, HOMA insulin-sensitivity or beta-cells function (HOMA-B) in type 2 diabetic patients

Belovici M. , Buysschaert M.

Introduction: PTHrP (Parathyroid hormone-related protein) is known to enhance beta cell function and proliferation. PTH levels predict myocardial and coronary heart disease in non-diabetic patients with normal calcium levels and no kidney failure. We aimed at determining in type 2 diabetes patients without kydney failure the relationship between serum levels of 1-84 parathormone (PTH1-84), obesity, HOMA insulin-sensitivity or beta-cells function (HOMA-B), but also between PTH1...

ea0029p538 | Diabetes | ICEECE2012

The burden of disease in elderly people with IFG

Lutgers H. , Campbell L. , Baune B. , Brodaty H. , Trollor J. , Sachdev P. , Samaras K.

Introduction: The prevalence of impaired fasting glucose (IFG) in the elderly approaches 50% in some community-dwelling cohorts. We examined whether IFG is associated with a higher burden of disease, cardiovascular risk factors and circulating low-grade inflammation than in normoglycemic elderly people.Methods/Design: Cross-sectional data of 929 participants of the Sydney Memory and Aging Study (MAS) were examined. MAS is a population-derived cohort of c...

ea0029p539 | Diabetes | ICEECE2012

GABA A receptor gene regulatory networks in peripheral blood TCD4+, TCD8+ AND CD14+ cells of recently diagnosed type 1 diabetes mellitus

Rassi D. , Evangelista A. , Brum D. , Deghaide N. , Foss-Freitas M. , Foss M. , Sakamoto-Hojo E. , Sanjeevi C. , Passos G. , Donadi E.

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter primarily produced by neurons and pancreatic beta cells. GABA functional receptors (GABR) are expressed in brain, pancreas and peripheral blood lymphomononuclear cells (PBMC). After evaluating the differential gene expression in PBMC of recently diagnosed type 1 diabetes mellitus patients (T1D), three GABRA networks were observed, modulating the expression dozen of genes. The study was conducted on T (CD4+ a...

ea0029p540 | Diabetes | ICEECE2012

Diagnosis of Metabolic syndrome in Saudi Arabia: implications for the importance of local criteria

Bahijri S. , Al Raddadi R.

Background and Objectives: Different definitions for the metabolic syndrome (MS) exist.Established criteria for diagnosis includes: raised blood pressure, dysglycemia, dyslipidemia, and obesity, but the used thresholds differed. Individual patients with MS need to be identified to reduce future complications. We aimed to determine the characteristics of subjects identified from healthy population to have MS by NCEP-ATP III, IDF and the consensus definition by IDF and AHA/NHLBI...

ea0029p541 | Diabetes | ICEECE2012

Comparison of plasma osteoprotegerin and related factors in two groups of pregnant women

Song A. , Nie M. , Wang Y. , Sun M.

Objective: The aim of the present study was to determine the plasma osteoprotegerin (OPG) levels in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) during the last trimester of pregnancy, and to investigate the relationship between OPG and some related factors.Method: In this study, 65 women with GDM and 65 women with NGT were enrolled. Plasma concentration of OPG was measured by enzyme linked immunosorbent assay (ELISA)...

ea0029p542 | Diabetes | ICEECE2012

Protein from Hevea brasiliensis latex rubber tree enhances wound healing in diabetic rats

Andrade T. , Caetano G. , Masson D. , Landim C. , Coutinho-Netto J. , Foss M. , Frade M.

The healing effects of Hevea brasiliensis latex biomembrane has been widely cited in the literature, mainly regarding its protein fraction F1 in patients with diabetes. The purpose of this study was to evaluate the wound healing mechanism of F1 in diabetic rats. Eighty Wistar rats were used for the experiments, where: 40 rats were induced to diabetes by streptozotocin 45 mg/kg (DM) and 40 rats were left non-diabetic (N). Two wounds were created on the dorsal of each rat using ...

ea0029p543 | Diabetes | ICEECE2012

Prevalence of Microalbuminuria in Galicia (NW Spain) and its association with risk factors: Hypertension, Type 2 diabetes mellitus and Pre-diabetes.

Tome M. , Lopez-Raton M. , Botana-Lopez M. , Cadarso-Suarez C.

Introduction: Microalbuminuria tends to appear in Type 2 diabetes (T2D) and reflecting underlying cardiovascular disease rather than diabetic nephropathy presented at diagnosis. The objective of this study was to evaluate the prevalence of microalbuminuria and its possible relations with T2D, pre-diabetes and hypertension, in a representative sample (n=2860) of the adult population (>18 years old) of Galicia (NW Spain).Material and methods: Subjects ...

ea0029p544 | Diabetes | ICEECE2012

Sarcopenic phenotype in patients with newly diagnosed type 2 diabetes

Son J. , Jeong H. , Lee S. , Kim S. , Kim D. , Yoo S.

Objective - Sarcopenic phenotype is associated with the increased risk of insulin resistance and type 2 diabetes. We investigated the proportion of sarcopenia and sarcopenic obesity (SO) and their clinical characteristics in patients with newly diagnosed type 2 diabetes.Research design and methods - We conducted a cross-sectional analysis of 133 (75 men, 58 women) patients with newly diagnosed type 2 diabetes. All patients underwent a 75 g oral glucose t...

ea0029p545 | Diabetes | ICEECE2012

Type 2 diabetes mellitus and Ramadan fasting: a continuous glucose monitoring (CGM) study of glucose excursions in a group of patients with good glycaemic control

Lessan N. , Hasan H. , Barakat M.

Introduction: Muslims including many patients with diabetes mellitus practice dawn to sunset fasting during the month of Ramadan. Using CGM recorded data we have investigated glucose excursions with Ramadan fasting in a group of patients with type 2 diabetes mellitus and good glycaemic control.Methods: Thirty-four patients with type 2 diabetes mellitus (8 female, 26 male, age 46.5±11.1 years, HbA1c 6.9±1.0%, BMI 29.5±6.5 kg/m2) ...

ea0029p546 | Diabetes | ICEECE2012

Abstract withdrawn....

ea0029p547 | Diabetes | ICEECE2012

High GADA titre: a marker of insulin dependence in adult onset autoimmune diabetes

Spoletini M. , Zampetti S. , Capizzi M. , Tiberti C. , Venditti C. , Campagna G. , Bosi E. , Buzzetti R. , Italian Society of Diabetes Nirad Study Group

Introduction: In latent autoimmune diabetes of adults (LADA), the progression to insulin-dependent diabetes is usually faster than in type 2 diabetes (T2DM) but the factors influencing this progression are not completely known. The aim of the present study was to determine whether GADA could be used as predictors of insulin dependence and whether GADA titre could define the risk of progression to insulin therapy in LADA patients. We looked for other biochemical and clinical pa...

ea0029p548 | Diabetes | ICEECE2012

Aerobic and resistance exercise have different short-term effects on glucose levels in type 2 diabetes subjects

Bacchi E. , Negri C. , Trombetta M. , Zanolin E. , Lanza M. , Bonora E. , Moghetti P.

Introduction: Aerobic (AER) and resistance (RES) exercise similarly improve HbA1c levels in type 2 diabetes subjects. However, it is still unknown whether exercise-induced acute changes in blood glucose differ according to exercise type. Our aim was to compare glucose level changes after a single bout of AER or RES exercise in trained diabetic subjects.Methods: Twenty-five subjects participating in the RAED2 Study, a RCT designed to compare the effects o...

ea0029p549 | Diabetes | ICEECE2012

Regulation of somatostatin/cortistatin and ghrelin systems under diet induced obesity conditions at the mouse endocrine pancreas

Martinez-Fuentes A. , Chanclon B. , Luque R. , Cordoba-Chacon J. , Pozo-Salas A. , de Lecea L. , Castano J. , Gracia-Navarro F.

Somatostatin (SST), Cortistatin (CORT), ghrelin, and their corresponding receptors (ssts and GHS-R) are closely interrelated systems involved in the regulation of essential hormones for metabolic homeostasis, like insulin, whose release is inhibited by SST/CORT and stimulated by ghrelin. To investigate the underlying mechanisms of this insulin regulation, we analyzed the expression of such systems at pancreatic level in wild type (WT) and CORT knock-out mice (CORT-KO) under bo...

ea0029p550 | Diabetes | ICEECE2012

Influence of iron metabolism indices on HbA1c in non-diabetic pregnant women with and without iron-deficiency anemia: effect of iron supplementation

Rafat D. , Rabbani T. , Ahmad J. , Ansari M.

Aims: Condition that influence erythrocyte turnover also affect HbA1c. Although many forms of anemia are associated with lowering of HbA1c, iron-deficiency anemia (IDA) tends to increase HbA1c. In this study, we examined the relationship between HbA1c and erythrocyte indices in non-diabetic pregnancy and assessed the effect of iron supplementation on HbA1c.Methods: 150 women were studied (30 non-diabetic, non-pregnant, non-anemic women in child bearing w...

ea0029p551 | Diabetes | ICEECE2012

Both β-cell dysfunction and insulin resistance are primary determinants of diabetes mellitus in patients with liver cirrhosis candidate to organ transplant

Grancini V , Lunati E , Boselli L , Masserini B , Zimbalatti D , Agnelli F , Bonadonna R , Beck-Peccoz P , Orsi E

Background: Impaired glucose (G) regulation (IGR) and diabetes mellitus (DM) are common in patients with liver cirrhosis. DM development has been associated to advanced liver disease (LD) and HCV infection. The relative roles played by insulin secretion and action, advanced LD and HCV infection in DM are somewhat unclear.Aim of the study: To assess in cirrhotic patients candidate to organ transplantation with no history of G abnormalities: i) prevalence ...

ea0029p552 | Diabetes | ICEECE2012

The effects of fat distribution and some adipokines on insulin resistance in prediabetic patients

Ekiz Bilir B , Guldiken S , Tuncbilek N , Demir M , Polat A

Introduction: In this study, we aimed to evaluate the effects of fat distribution and some adipokines on insulin resistance (IR) in prediabetic patients.Materials and Methods: cases were divided into three groups according to 75 gr-oral glucose tolerance test (OGTT) results [27 cases impaired fasting glucose (IFG), 36 cases impaired glucose tolerance (IGT) and 24 healthy control subjects]. Serum fasting insulin levels and lipid parameters were measured. ...

ea0029p553 | Diabetes | ICEECE2012

New fast and reversible leptin antagonist-induced mice model of metabolic syndrome and T2DM

Solomon G , Monsonego-Ornan E , Chapnik N , Smith E , Froy O , D'Alessio D , Gertler A

Obesity and its major consequence, type II diabetes mellitus (T2DM), is epidemic throughout Western society. T2DM accounts for 95% of the diabetes worldwide. One limitation to the development of new diabetes treatments has been a lack of effective animal models to use in research. There are no rodent models that recapitulate the pancreatic β-cell lesions of humans with T2DM. Moreover, animal models of obesity either require overfeeding which is expensive and takes weeks t...

ea0029p554 | Diabetes | ICEECE2012

High-fructose diet, an animal model of insulin resistance, causes mitochondrial dysfunction by altering the activity of respiratory chain complex I

Sanchez-Martin C , Sanz M , Detaille D , Recio-Cordova J , Peralta F , R-Villanueva G

Introduction: The current epidemic of Type 2 Diabetes Mellitus (T2DM) and obesity is positively correlated with a rise in consumption of high-fructose syrups and refined carbohydrates. Recent reports have showed that feeding rodent a high-fructose diet leads to insulin resistance, glucose intolerance and dyslipidaemia. Nevertheless, its mitochondrial effects has not been fully studied yet.Aim: We decided to explore the alterations in mitochondrial bioene...

ea0029p555 | Diabetes | ICEECE2012

Does the presence of thyroid antibodies affect the course and outcome of pregnancy in type1 diabetic women?

Sarantopoulou V , Philippou G , Vasileiou V , Lymberi P , Sarika L , Alevizaki M , Anastasiou E

Introduction: In the literature there are only three papers so far, addressing the impact of thyroid antibodies (Anti-TPO) on pregnancy in Type1 Diabetic Women (DM1) and these present conflicting results. The aim of the study is to evaluate the presence of Anti-TPO in DM1 pregnant women and whether these are related with differences in thyroid function, metabolic control and pregnancy outcome.Methods: In 78 DM1 women with singleton pregnancies Anti-TPO, ...

ea0029p556 | Diabetes | ICEECE2012

The association between insulin-like-growth-factor I and insulin resistance: a general population study in danish adults

Friedrich N , Thuesen B , Jorgensen T , Juul A , Spielhagen C , Wallaschofski H , Linneberg A

Objective: IGF1 has almost 50% amino acid sequence homology with insulin and elicits nearly the same hypoglycaemic response. Studies showed that low and high IGF1 levels are related to impaired glucose tolerance and to a higher risk of type two diabetes. The aim of the present study was to evaluate the association between IGF1 level and insulin resistance in a Danish general population.Research Design and Methods: From the cross-sectional Health2006 stud...

ea0029p557 | Diabetes | ICEECE2012

Abstract withdrawn...

ea0029p558 | Diabetes | ICEECE2012

Alterations in fecal lactobacillus and bifidobacterium species are associated with differences in cholesterol metabolism in type 2 diabetic patients

Hui H , Cai D , Le K , Li Y , Xu X , Liu T , Yang W , He F , Zhao X , Su K , Pandol S , Go V

Background: Type 2 diabetic (T2D) patients have alterations in the gut microbiota composition, compared to healthy individuals. Such alterations may play a role in the pathogenesis of T2D and insulin resistance. Bifidobacteria and Lactobacillus are among the most predominant bacteria found in human gut. They can also easily be added in probiotic preparations, thus making them ideal agents for therapeutic interventions. In this study, we aimed to determine if there were alterat...

ea0029p559 | Diabetes | ICEECE2012

Low testosterone is associated with decreased expression of glut-4 and hexokinase 2 in muscle of the testicular feminised mouse

McLaren D , Kelly D , Akhtar S , Channer K , Jones T

Testosterone deficiency is a common in men with type two diabetes (T2D). We have shown testosterone replacement therapy (TRT) improves insulin resistance and glycaemic control. The mechanisms by which testosterone mediates this action are unknown but may be due to a combination of effects on muscle, liver and adipose tissues. This study investigates the expression of Glut4 and HK2, (two key proteins involved in insulin sensitivity) in muscle tissue of the testicular feminised ...

ea0029p560 | Diabetes | ICEECE2012

Serum visfatin is differentially regulated by insulin and non-esterified fatty acids in healthy men

Kowalska I , Karczewska-Kupczewska M , Adamska A , Nikolajuk A , Kaminska N , Zielinska M , Otziomek E , Gorska M , Straczkowski M

Introduction: Visfatin is a protein secreted by adipose tissue which was discovered as a protein with insulin-mimetic properties. Experimental and clinical studies demonstrated that visfatin can be involved in the pathogenesis of insulin resistance. It was demonstrated that plasma visfatin is elevated in insulin resistant states i.e. obesity, type two diabetes mellitus, PCOS. In vitro study showed that insulin inhibits visfatin release from adipocytes. The aim of the pr...

ea0029p561 | Diabetes | ICEECE2012

Mitochondrial impairment and oxidative stress in leukocytes from type 2 diabetic patients

Victor V , Banuls C , Bellod L , Rovira S , Falcon R , Rocha M , Hernandez-Mijares A

Diabetes is associated with oxidative stress. This study evaluated the rates of oxidative stress and mitochondrial impairment in type 2 diabetes patients. The study population consisted of 182 diabetic patients and 50 body-composition- and age-matched controls. We assessed anthropometric and metabolic parameters and mitochondrial function by evaluating mitochondrial oxygen (O2) consumption, reactive oxygen species (ROS) production, glutathione (GSH) levels, GSH/GSSG ratio, mit...

ea0029p562 | Diabetes | ICEECE2012

High prevalence of autoimmunity in adult onset diabetes subjects with high GADA titre

Zampetti S , Capizzi M , Spoletini M , Campagna G , Cipolloni L , Petrone A , Tiberti C , Di Pietro S , Locatelli M , Falorni A , Bosi E , Buzzetti R , Nirad Study Group (Italian Society of Diabetes)

Introduction: LADA is a heterogeneous population of diabetes subjects wherein subgroups can be identified based on their autoimmune status: the titre of autoantibodies to GAD.The aim of the study was to correlate, in LADA subjects, GADA titre, with the presence of other organ and non organ specific autoantibodies.Methods: LADA subjects (n=191) and type 2 diabetes (T2DM) subjects (n=382) were selected from the Non Insu...

ea0029p563 | Diabetes | ICEECE2012

Testing of type 2 diabetes risk locus rs7578597 in THADA gene in the czech population

Halkova T , Bradnova O , Vankova M , Vejrazkova D , Lukasova P , Vcelak J , Kvasnickova H , Stanicka S , Bendlova B

Introduction: The SNP rs7578597 (Thr1187Ala) of THADA gene was identified in GWA studies as a novel type 2 diabetes risk locus. Nevertheless, subsequent studies of this SNP effect have been inconclusive. In some studies, rs7578597 has been associated with insulin secretion but no significant correlation with type 2 diabetes has been reported. Product of THADA gene is considered to be involved in apoptosis. Whether rs7578597 affects insulin secretion throught the apoptosis of p...

ea0029p564 | Diabetes | ICEECE2012

Impact of diabetes on length of stay and inpatient mortality for elderly patients presenting with proximal fracture of the femur

Nirantharakumar K , Wijesinghe H , Mastan M , Srikantharajah M , Bhatta S , Westwood D , Marshall T , Coleman J

Aim: To compare inpatient length of stay (LOS) and mortality of diabetic and non-diabetic patients aged ≧65 years admitted in a single UK hospital with fractured proximal femur.Methods: Patients with a fractured proximal femur at University Hospital of Birmingham (2007–2010) were identified from administrative data with ICD 10 discharge diagnostic codes S720, S721 and S722 as the primary diagnosis. A discharge diagnostic code for diabetes or ...

ea0029p565 | Diabetes | ICEECE2012

Screening of latent autoimmune diabetes in insulin requiring diabetic adults

Ben Said R , Kammoun I , Oueslati I , Htira Y , Bouzid C , Ben Salem L , Ben Slama C

Introduction: Latent autoimmune diabetes in adults (LADA) is a genetically linked, autoimmune form of type 1 diabetes mellitus (DM) that accounts for 2–12% of all cases of diabetes.The goal of our study is to detect LADA among patients who were diagnosed as type 2 DM and who became insulin requiring.Methods: Our study included 45 patients (15 men, 30 women) diagnosed as type 2 DM, who had a poor glycemic control on oral hypogl...

ea0029p566 | Diabetes | ICEECE2012

Epidemiological study of patients attended the pediatric outpatient clinic of national institute of diabetes & endocrinology

El Hefnawy M

Background: Diabetes mellitus is the most common endocrine metabolic disorder of childhood. It is widely spread all over Egypt as its prevalence was found to be 1.09 per 1000 among school aged children.Aim of the work: The aim of this work was to do a retrospective epidemiological study of the records of diabetic children attended the outpatient pediatric clinic in NIDE.Subjects & Methods: The files 0f 3000 diabetic children we...

ea0029p567 | Diabetes | ICEECE2012

Clinical and histopathology tumor characteristics of patients with invasive breast carcinoma on insulin glargine compared with other types of basal insulin

Satej N , Mori Lukancic M , Besic N

Background and aims: In vitro studies on breast cancer cell lines showed that the serum of diabetic patients was stronger mitogenic when using glargine as compared to other types of insulin. The aim of this retrospective study was to examine if the patients with diabetes mellitus (DM) using insulin glargine have a higher tumor stage of breast carcinoma in comparison to patients using other types of insulin.Patients and Methods: Altogether 174 pati...

ea0029p568 | Diabetes | ICEECE2012

Evaluation of clinical care in young type 1 diabetes subjects: a nationwide multicenter study in brazil

Gomes M , Matheus A , Calliari L , Luescher J , Manna T , Cobas R , Tschiedel B , Ramos A , Fonseca R , Araujo N , Almeida H , Melo N , Jezini D , Negrato C

Introduction: The increasing incidence of type 1 diabetes (T1D) is a matter of concern because it negatively impacts both the quality of life and its duration, due to the great morbidity and mortality caused by its chronic complications.Objective: To evaluate clinical care provided to Brazilian youths with T1D in daily practice, according to the American Diabetes Association’s guidelines.Methods: This was a cross-sectional, mu...

ea0029p569 | Diabetes | ICEECE2012

Abstract withdrawn....

ea0029p570 | Diabetes | ICEECE2012

DNA methylation influenced β-arrestin 2 expression in type 2 diabetes patients

Zhong W

Background: Hyperglycemia and glucose intolerance are perhaps the most common pathophysiologies associated with diabetes. β-Arrestin 2, component of G-protein coupled receptor signaling, has been shown to be down-regulated in insulin resistant and type 2 diabetic mouse models. However, if this down-regulation also existed in diabetic humans, and the possible mechanisms of this differential expression in normal and type 2 diabetes were not clear.Meth...

ea0029p571 | Diabetes | ICEECE2012

Innervation and vascularization into islets of langerhans in the presence or absence of proglucagon-derived peptides

Hayashi Y , Tanaka H , Sanzen N , Sekiguchi K , Murata Y

Introduction: Islets of Langerhans are well innervated and vascularized, however, the regulatory mechanisms for innervation and vascularization are not well clarified. In mice deficient for proglucagon-derived peptides (Gcg–gfp/gfp: GCGKO), islet cells that express green fluorescent protein (GFP) under the control of glucagon promoter (‘α”-cells) display hyperplasia and number of islets is increased. The present study was aimed to clarify role of the proglu...

ea0029p572 | Diabetes | ICEECE2012

Expression of ghrelin and its receptor genes is tissue specific in streptozotocin treated piglets

Pierzchala-Koziec K , Zubel J , Oclon E , Kuta M

Ghrelin is protein hormone originally isolated from the stomach and it is the endogenous ligand for the growth hormone secretagogue receptor (GSH-R 1a). It is well established that ghrelin plays roles in appetite regulation, gut function, metabolic disorders and inflammation. Ghrelin and its receptor is expressed in brain and peripheral tissues sensitive to inflammation such as heart and spleen. As a part of study dealing with the role of ghrelin in the development of inflamma...

ea0029p573 | Diabetes | ICEECE2012

Empowering patients with diabetes: a qualitative study focusing on knowledge of self-care behaviors amongst asians in south florida

Imran T , Jauhari S , Chaudhry N , Bengali S , Huq Z , Uddin S , Uddin D , Jaffer A

Background: South Asians have a higher prevalence of diabetes and increased complications compared to other ethnic minorities, leading to poorer health outcomes. There is a lack of evidence about knowledge of diabetes self-care behaviors amongst this group. Having such knowledge is crucial in preventing complications and providing effective health services.Objectives: The aim of this study was to identify knowledge of self-care behaviors and factors comp...

ea0029p574 | Diabetes | ICEECE2012

Circulating ghrelin and leptin concentrations in metabolic disorders of obese and lean piglets

Pierzchala-Koziec K , Zubel J , Oclon E

Ghrelin as well as leptin are involved into regulation of food intake, development of obesity, diabetes (DM I, DM II) and inflammation. However, in spite of many experiments, the correlation between their effects are not fully established. As a part of study dealing with the interaction of ghrelin and leptin in metabolic disorders the present study was carried out to assess the effect of statin, DMI, DMII on the ghrelin and leptin plasma levels in lean and obese piglets. Anima...

ea0029p575 | Diabetes | ICEECE2012

Effective utilization of anti-GAD measurement

Prosser C. , Grason R. , Chow M.

Introduction: Responsible use of healthcare resources dictates that judicious test ordering be encouraged. Although the appearance of anti-GAD antibodies is known to precede and predict the development of autoimmune diabetes, its use as a screen for risk of developing diabetes is not warranted. Results are useful in determining treatment, however, when it is difficult to distinguish type 1 from type 2 diabetes or when the probability of progression from type 2 to type 1 is hig...

ea0029p576 | Diabetes | ICEECE2012

The relationship between the level of knowledge of physicians on guidelines and the degree of glucometabolic control in type 2 DM patients in Turkey

Satman I , Imamoglu S , Yilmaz C , on behalf of ADMIRE Study Group

Introduction: Clinical practice guidelines on diabetes mellitus (DM) was created by The Society of Endocrinology & Metabolism, Turkey (SEMT). The ADMIRE Project is designed to evaluate the effect of implementation activities to increase physicians’ awareness on guidelines.Methods: A total of 180 physicians from national representative diabetes clinics kept medical records of 885 T2DM patients for 6 months, without any interference to their routi...

ea0029p577 | Diabetes | ICEECE2012

Previous history of gestational diabetes mellitus and flow mediated dilation of brachial artery

Alatab S , Fakhrzadeh H , Sharifi F , Mirarefein M , Badamchizadeh Z , Ghaderpanahi M , Hashemi Taheri A , Larijani B

Background: Gestational diabetes mellitus (GDM) is a common pregnancy condition which is associated with long term complications. In this study we examined the levels of inflammatory mediators, adiponectin, hemocystein and insulin resistance index in women with and without previous GDM (pGDM). Also association between these factors and early atherosclerosis process was evaluated.Methods: Serum levels of IL6, hs-CRP, adiponectin, homocystein and other bio...

ea0029p578 | Diabetes | ICEECE2012

Frequency and outcome of follow-up testing after a positive gestational diabetes screen

Prosser C , Chik C

Objective: In Edmonton, universal screening of all pregnancies is performed using a 50 g gestational diabetes screen (GDS). Canadian Diabetes Association (CDA) Practice Guidelines recommend a 75 g 2 h oral glucose tolerance test (OGTT) if the GDS glucose result is between 7.8 and 10.2 mmol/l. This study is designed to assess the frequency of OGTT requests in response to a positive GDS and the prevalence of normal OGTT in this population.Methods: All GDS ...

ea0029p579 | Diabetes | ICEECE2012

Relationship vitamin D levels and glycemic control in type 2 diabetic patient

Oz Gul O , Gul B , Cander S , Eroglu A , Keni N , Ersoy C , Imamoglu S

Objective: Vitamin D deficiency has been shown to alter insulin synthesis and secretion in both humans and animal models. However, less is known on the association between vitamin D and type 2 diabetes mellitus. In the current study we aimed to analyze the relationship between vitamin D levels with glycemic control in type 2 diabetic patients.Material and methods: Three hundred and twenty diabetic patients who are follow up at least 6 months for diabetes...

ea0029p580 | Diabetes | ICEECE2012

Association between educational level with glycemic and risk factor control in type 1 diabetes: results from DIACAM 1 study

Sastre J , Pines P , Moreno J , Quiroga I , Delagado M , Calderon D , Herranz S , Lozano J , Lopez J

Objective and aims: This study was designed to investigate the clinical characteristics of a representative group of type 1 diabetic (T1D) population in Castilla La Mancha, a region in central Spain. The aim of this report is to evaluate the relationship between the educational level and cardiometabolic risk in adult patients with T1D.Patients and methods: This is an observational, cross-sectional, prospective and multicentre study of 1465 patients who r...

ea0029p581 | Diabetes | ICEECE2012

Basal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of various treatments

Celer O , Efe B

The pathophysiology of type 2 DM is complex and involves insulin resistance, pancreatic beta cell dysfunction and visceral adiposity. The levels of free fatty acids (FFA) increases in obese persons and diabetic patients. Elevated levels of FFAs may cause resistance and deficient insulin secretion. Our aim in this study was to investigate the change of FFA levels, glucose, insulin and triglyceride in fasting and postprandial state in 15 healthy controls and 45 diabetic patients...

ea0029p582 | Diabetes | ICEECE2012

Measles and new onset type 1 diabetes presented with bilateral facial paralysis: report of a case

Demir Onal E , Polat B , Balkan F , Kaya G , Deniz O , Ersoy R , Cakir B

Introduction: Measles virus infections generally occur in childhood, but infections in adolescence and adulthood can lead to complications.Case report: A previously well 28-year-old woman had suffered from nausea, vomiting and generalized fatique for one day before being transferred to our emergency department in a confused state. A diagnosis of type 1 diabetes mellitus (T1D) complicated by ketoacidosis was made based on markedly decreased serum C-peptid...

ea0029p583 | Diabetes | ICEECE2012

Identification of dipeptidyl peptidase-4 inhibitors among boioactive peptides derived from whey proteins

Tulipano G , Faggi L , Caroli A , Cocchi D

Preclinical and clinical studies suggest that whey protein intake can ameliorate postprandial glucose control and potentiate insulin release in both type-2 diabetic patients and healthy subjects.Most likely, the insulinotropic effect of whey occurs by multiple pathways, including the potentiation of incretin activity through inhibition of DPP-4 in the proximal bowel, with the outcome of increasing intact incretin levels.During last...

ea0029p584 | Diabetes | ICEECE2012

Decreased sucrose preference in humans and rodents with diabetes

Yu J , Kim M

Objective: Craving of sweet foods and sucrose may be a big obstacle for glycemic control of diabetic patients. It is generally believed that diabetic patients may prefer sweet taste. However, few studies have examined sucrose preference in diabetic patients. Therefore, we investigated changes in sucrose preference in diabetic condition.Research design and methods: We performed two-alternative staircase methods and forced-choice tracking procedures to ass...

ea0029p585 | Diabetes | ICEECE2012

Regulatory T cells number and function in patients with LADA

Nikonova T , Pekareva E , Gorelysheva V , Apanovich P , Karpuhin A , Dedov I

CD4+CD25+lymphocytes (Tregs) play a crucial role in self-tolerance and autoimmunity. LADA is associated with the loss of immune tolerance to β-cell autoantigens similar to classic type 1 diabetes mellitus. The aim of the study was to evaluate changes in terms of Tregs number and function (FOXP3 expression) in LADA patients.Material and methods: We examined 74 patients with LADA at different stages of the disease. Fifty-six healthy subjects (control ...

ea0029p586 | Diabetes | ICEECE2012

Depression as a predictive factor for glycemic control and family functioning in Japanese patients Swith type 2 diabetes: a 6-month follow-up study

Saeki T , Takaishi M , Ishida K , Komo T , Tazuma S , Yamawaki S

Purpose: To investigate the impact of depression for diabetes-related quality of life and glycemic control among Japanese patients with type 2 diabetes and their family members.Methods: Ambulatory patients with type 2 diabetes were drawn consecutively from the inpatient population participated in a 2-week educational intervention program at two general hospitals affiliated with Hiroshima University. Written informed consent for the study was obtained fro...

ea0029p587 | Diabetes | ICEECE2012

What arises from the decrease of visceral adiposity in Japanese diabetic patients with visceral fat accumulation?

Ohoshi T , Hiromine Y , Yamauchi T , Kishitani Y , Ogawa K , Akamizu T , Nanjo K

Aim: To clarify what arises from the decease of visceral adiposity in Japanese diabetic patients with visceral fat accumulation.Patients: Diabetic patients (n=30) whose visceral fat areas (V), determined with abdominal CT, were larger than 100 cm2.Methods: V was followed at every 6 month, and clinical profiles and course were compared of eight patients (group D), whose changes of V(ΔV=(<i...

ea0029p588 | Diabetes | ICEECE2012

Outcome of a young adolescent diabetes transition clinic in an inner city ethnic population in Birmingham: an audit

Cutler J , Munir B , Hudson L , Ashton J , Holmes S , Plunkett M , De P

Introduction: Management of adolescent diabetes is challenging due to a complex interplay of physiological and psychological factors.Aims: To audit the outcome of our local hospital adolescent diabetes clinic.Method: Adolescents aged 16–24 years are seen by our multi-disciplinary team (adult and paediatric diabetes consultant, diabetes specialist nurses and a dietician) every 4 months after transfer from paediatric service. We...

ea0029p589 | Diabetes | ICEECE2012

Microcirculatory disorders in adolescents with type 1 diabetes mellitus

Nikolaeva N , Bolotova N , Filina N , Kompaniets O

Aim: To study microcirculatory disorders in adolescents with type 1 diabetes mellitus (T1DM).Patients and methods: Eighty-five adolescents 12–17 years with T1DM were examined. The duration of T1DM was: <1 year – in 29 (HbAc1 7.1±0.4%) – group 1, from 1 to 5 years – in 26 (HbAc1 9.2±1.1%) – group 2, more then 5 years – in 30 patients (HbAc1 10.7±1.1%) – group 3. The indexes of tromboresistance of vesse...

ea0029p590 | Diabetes | ICEECE2012

Screening for unknown diabetes mellitus or IFG in a population of South Italy

Caretto A. , Cannalire F. , Piscitelli P. , Argentiero A. , Sturda A. , Menga C. , Lagattolla V.

The importance of early detection of diabetes mellitus helps to prevent the development of related chronic complications.Screening, which lasted a week, has been implemented in 31 pharmacies in the territory of the Province of Brindisi (Apulia–Italy) on a random sample of 1048 people. Blood glucose was measured by glucometer; a questionnaire was administered with anthropometric data and medical history and evaluation of the lifestyle of exercise and...

ea0029p591 | Diabetes | ICEECE2012

Adiponectin among markers of low grade inflammation in gestational diabetes mellitus

Matuszek B. , Burska A. , Malecha-Jedraszek A. , Lenart-Lipinska M. , Nowakowski A. , Donica H.

Background and aims: The subclinical inflammation connected with hypoadiponectinaemia and inflammatory pattern may favor the development of gestational diabetes mellitus (GDM).Methods: In total, 66 pregnant women were enrolled in the study during systematic testing for GDM between 24 and 28 weeks of gestation. GDM was diagnosed in 42 cases, 24 were normal glucose tolerant control group (NGT). In blood serum concentration of glucose, insulin, adiponectin ...

ea0029p592 | Diabetes | ICEECE2012

Comparative analysis of adiponectin isoforms distribution in pregnant women with gestational diabetes mellitus and after delivery

Matuszek B. , Burska A. , Leszczynska-Gorzelak B. , Donica H. , Nowakowski A.

Objective: The aim of the study was to evaluate distribution of circulating adiponectin (AdipoQ) isoforms at pregnant women with gestational diabetes mellitus (GDM) and comparison analysis of isoform distribution changes 12 months after delivery.Design: The study was conducted on 64 pregnant women who underwent routine pre-natal tests for GDM between 24 and 28 week of gestation and 30 of them 12 months after delivery. The study group included 36 women di...

ea0029p593 | Diabetes | ICEECE2012

Three novel mutations in maturity-onset diabetes of the young genes in Spain

Palmeiro R. , Luna R. , Seoane I. , Trigo C. , Sanchez P. , Lopez Y. , Penin M. , Paramo C. , Garcia-Mayor R.

Introduction: Maturity-onset diabetes of the young (MODY) is a genetically, metabolically and clinically heterogeneous subtype of diabetes mellitus characterized by an early onset, an autosomal dominant inheritance, and a primary defect in insulin secretion. They are caused by mutations in a reduced number of β-cell genes. Mutations in glucokinase gen (MODY 2) and hepatic nuclear factor 1α (HNF 1α) (MODY 3) are the most common.Materials an...

ea0029p594 | Diabetes | ICEECE2012

Proteomic identification of plasma biomarkers in type 1 diabetes mellitus: an implication of hemopexin overexpression in diabetes mellitus

Lee Y. , Chen C. , Chen Y. , Lu Y. , Lee W. , Lu C. , Chen Y. , Chou H. , Timms J. , Chan H.

Type 1 diabetes mellitus (T1DM) not only is congenital disease that known as insulin-dependent diabetes, often occurs in children and adolescents. Recent advances in quantitative proteomics including fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) and matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) have offered opportunities to discover plasma proteins as biomarkers for tracking the progression and for underst...

ea0029p595 | Diabetes | ICEECE2012

Comparative incidence of type 1 diabetes mellitus in school-aged children between immigrated families and the background population living in Piedmont or in Morocco, 2005–2009: a role for vitamin D?

Savastio S. , Prodam F. , Perino A. , Balafrej A. , Monzani A. , Lera R. , Fontana F. , Cerutti F. , Bona G. , Cadario F.

Introduction: The aim was to compare the incidence of type 1 diabetes between immigrant Moroccan and Romanian children and background population in Piedmont, Italy, and between Moroccan children living in Italy and their counterpart in Morocco.Patients and methods: All new cases of type 1 diabetes aged 6–13 years in Piedmont and Morocco in 2005–2009 were retrieved by regional registries. Numbers of children regularly registered to primary and m...

ea0029p596 | Diabetes | ICEECE2012

HbA1c as a tool for the diagnosis of type 2 diabetes in 208 premenopausal women with polycystic ovary syndrome

Velling Magnussen L. , Mumm H. , Andersen M. , Glintborg D.

Objective: To study HbA1c as a tool for diagnosing diabetes and to study HbA1c as a cardiovascular risk marker in patients with polycystic ovary syndrome (PCOS).Methods: A retrospective observational study at an academic tertiary-care medical center. In total, 208 premenopausal women with PCOS participated. Patients underwent clinical evaluation (Ferriman–Gallwey score, body mass index, waist, blood pressure), hormone analyses (testosterone, sex hor...

ea0029p597 | Diabetes | ICEECE2012

Non-HDL and LDL cholesterol in type 2 diabetes mellitus patients at tertiary care hospital of Pakistan

Ram N. , Abdul J.

Objective: The objective of this study was to determine level of non-HDL and LDL cholesterol in type 2 diabetic patients with or without coronary artery disease irrespective on lipid lowering therapy and the common factors associated with elevated non-HDL cholesterol.Study design: cross-sectional study: Place and duration of study: diabetic clinic, Aga Khan University Hospital, Karachi. Data of Type 2 diabetes mellitus patients attended clinics during 20...

ea0029p598 | Diabetes | ICEECE2012

Prevalence of diabetes-associated antibodies and impaired insulin response to glucose in first degree relatives of diabetic patients Ebtissam M. Salah*, Hesham El-Hafnawy**, Mona Anwar*, Samar M. E. Salem*, Mai M. Youssef*, Atef Bassyoni** and Marry Aziz**

El Hefnawy M.

Type 1 diabetes is a chronic autoimmune disease with a subclinical prodromal period characterized by the presence of circulating antibodies to various islet cell proteins. Our main objective is to estimate the prevalence of diabetes-associated autoantibodies in a group of 1st degree relatives, compared to healthy control subjects. Also, we tried to assess the insulin secretory capacity in subjects having multiple antibodies using first phase insulin response (FPIR) to intraven...

ea0029p599 | Diabetes | ICEECE2012

Is there a seasonal variation in the incidence of gestational diabetes mellitus?

Vasileiou V. , Kyratzoglou E. , Athanasiadou A. , Giakoumi A. , Mouzakioti S. , Alevizaki M. , Anastasiou E.

Introduction: GDM seasonability has been rarely addressed, with conflicting results. The aim of the study is to evaluate monthly GDM incidence in a large group of Greek women.Methods: 7618 pregnant women underwent 100g OGTT during the third trimester (GDM: ADA 2000 criteria). Seasonal, monthly GDM incidences and mean seasonal glucose levels during OGTT were calculated. Mean month temperature data were obtained from the Greek Meteorological Service.<p...

ea0029p600 | Diabetes | ICEECE2012

We can do better: activity report of ambulatory educative sessions for the patients treated with external pumps

Baillot-Rudoni S. , Brunner C. , Crevisy E. , Vaillant G. , Verges B.

Since the end of 2006 in France we have the obligation to evaluate yearly the educational level in diabetic patients treated with pumps. In 2007 we created bimonthly ambulatory group sessions for these patients (six persons per group). After receiving an explanation letter, the patients have to register by calling the service. The aim of the study was to evaluate quality and quantity of the sessions we have been performed.Methods: We conducted analyses b...

ea0029p601 | Diabetes | ICEECE2012

Diagnostic value of cytogram analysis of different types of oral cavity mucous epithelium in type 2 diabetes mellitus elderly patients

Yuy Tsun-Shu R. , Mansharipova A. , Mulkibaeva S. , Semchenkova S. , Kruglikovskaya T. , Tusupova N.

Objective: To define diagnostic value of cytogram analysis of different types of oral cavity mucous epithelium in type 2 diabetes mellitus patients using cytological methods.Material and methods: Material for cytological analysis was oral cavity mucous swab in 22 healthy people and 41 sick ones with type 2 diabetes mellitus at subcompensational stage. The group under study was homogenous in age, sex and biorhythmic type. Oral swabs were fixed in spirit&#...

ea0029p602 | Diabetes | ICEECE2012

Socio-demographic factors associated with pediatric diabetic ketoacidosis admissions in Southern West Virginia

Lewis K. , Bendre S. , Clark C. , Wiley D.

Background: Diabetic ketoacidosis (DKA) is a well-known complication in children with type 1 diabetes (T1DM) with a mortality rate estimated at 2%. Sparse data are available from the literature describing socio-demographic factors associated with DKA admissions in children. A previous study identified that children of non-Caucasian race and Medicaid, with T1DM, had increased incidence of DKA admissions.Aims: To identify the socio-demographic factors asso...

ea0029p603 | Diabetes | ICEECE2012

Hypersomatotropism and glucose metabolism disorders

Belhimer F. , Namani S. , Lyazidi A. , Chentli F.

Introduction: Glucose metabolism disorder (GMD) is a classic complication of acromegaly, but its frequency varies from study to study.Aim: We aimed to analyze GMD frequency in our population, and predictive factors such as: family history of diabetes mellitus (DM), age, gender, and GH rates.Subjects and methods: It is a prospective study where 75 hypersomatotropic subjects were analyzed. They all had fasting and postprandial blood ...

ea0029p604 | Diabetes | ICEECE2012

Questionnaire survey about a hospital adolescent transition diabetic clinic

Cutler J. , Plunkett M. , De P.

Introduction: Our adolescent transition diabetes clinic (16–24 years) is run by a multi-disciplinary team (adult and paediatric diabetes consultant, diabetes specialist nurses and a dietician) every 4 months.Aim: Questionnaire survey of patients understanding of their diabetes and satisfaction about the running and set-up of this unique transition clinic.Method: A two-page questionnaire given to patients attending clinic or po...

ea0029p605 | Diabetes | ICEECE2012

Celiac disease, autoimmune thyroiditis, vitamin B12 deficiency and adrenal failure among adult Turkish patients with type 1 diabetes mellitus

Anaforoglu I. , Pulak S. , Livaoglu A. , Karagol S. , Asik M. , Ustaoglu M. , Algun E.

Introduction: Autoimmune polyglandular syndromes are characterized by the coexistence of at least two autoimmune endocrinopathies. Organ-specific autoimmunity is frequent in patients with type 1 diabetes mellitus (T1DM). The aim of this study was to estimate the prevalence of celiac disease and other autoimmune diseases like thyroiditis, pernicious anemia and adrenal failure among adult patients with T1DM.Methods/design: Sixty-nine, asymptomatic patients...

ea0029p606 | Diabetes | ICEECE2012

Correlation of fasting blood glucose with menopausal status in middle aged women with their obesity status

Ashok P. , Joshi A.

Introduction: The association between type 2 diabetes mellitus and obesity is very close. Obesity is common in women aged between 45 and 49 years. Prevalence of prediabetes, i.e. impaired fasting glucose also seems to be higher in women than men in the Indian population. The present work is planned to study the prediabetic status in preobese and obese in pre- and post-menopausal women with the help of estimation of fasting blood glucose (FBG) levels.Mate...

ea0029p607 | Diabetes | ICEECE2012

Insulin resistance and C reactive protein level

Dimic D. , Velojic Golubovic M. , Radenkovic S. , Stojic D. , Antic S.

C reactive protein is a sensitive marker of subclinical inflammation. C-reactive protein is associated with obesity, diabetes mellitus and increased cardiovascular risk. The mechanism of elevated CRP levels could have connections with insulin resistance. Inflammation seems to have significant role in pathogenesis of diabetes and cardiovascular disease. The aim of this study is to show that the subjects with greater insulin resistance, measured by HOMA-IR have higher levels of ...

ea0029p608 | Diabetes | ICEECE2012

The antropometric characteristic of type 1 diabetic patients in Kragujevac

Mladenovic V. , Djukic A. , Petrovic J. , Sipetic S.

Background: Diabetes mellitus is a condition of chronic hyperglicemia (as well as metabolic disorders of the other carbohydrates, lipids and proteins), as a result of absolute and/or relative lack of insulin or lack of insulin effects. The aim of the research presented in this study is examination of antropometric characteristics of patients suffering from type 1 diabetes in Kragujevac depending on gender.Material and method: We examined 206 patients wit...

ea0029p609 | Diabetes | ICEECE2012

Resolution of type 2 diabetes following IFN-α therapy for chronic hepatitis C

Kim D. , Park J.

We report on a patient whose type 2 diabetes resolved following interferon-α (IFN-α) therapy for hepatitis C virus (HCV). A 57-years-old man, presented with fatigue, polyuria and polydipsia. He was newly diagnosed with type 2 diabetes. During the hospital day, he was also diagnosed with chronic hepatitis. Serological studies for chronic hepatitis demonstrated presence of hepatitis C, type 2a/2c genotype. He was started on subcutaneous insulin and IFN-α. After 24...

ea0029p610 | Diabetes | ICEECE2012

Art and its role in therapeutic patient education

Kurashvili R. , Shelestova E. , Kurtsikashvili L. , Tsutskiridze L.

Art-painting, poetry, music, is an inexhaustible source of inspiration and motivation. Patient education (TPE) in chronic diseases is a long and tedious process. To achieve high motivation one must use all existing possibilities. Art is the most potent tool to influence the conscious and subconscious of a person to motivate him/her to adhere to treatment and healthy lifestyle. Literature, and mainly W. Shakespeare, could be used for TPE, as deep understanding of existing healt...

ea0029p611 | Diabetes | ICEECE2012

The antropometric characteristic of type 2 diabetic patients in Kragujevac

Petrovic J. , Mladenovic V. , Djukic A. , Sipetic S.

Introduction: Diabetes mellitus is a condition of chronic hyperglicemia (as well as metabolic disorders of the other carbohydrates, lipids and proteins), as a result of absolute and/or relative lack of insulin or lack of insulin effects.The aim of the research presented in this study is examination of antropometric characteristics of people suffering from type 2 diabetes in Kragujevac.Material and method: We examined 3108 patients ...

ea0029p612 | Diabetes | ICEECE2012

Prevalence of microvascular complications in youth with type 2 diabetes: systematic review and meta-analysis

McLennan C. , Cho Y. , Donaghue K. , Craig M.

Introduction: Type 2 diabetes (T2D) has increased in youth and complications rates may be higher than type 1 diabetes (T1D).Aims: To estimate the prevalence of complications and hypertension in youth with type 2 diabetes and compare complication rates between T2D and T1D.Design and methods: Systematic review and meta-analysis of observational studies, analysed with random effects models.Data sources: Medline ...

ea0029p613 | Diabetes | ICEECE2012

The intake of fiber suppresses the high fat high carbohydrate meal induced endotoxemia, oxidative stress and inflammation

Ghanim H. , Batra M. , Dhindsa S. , Green K. , Abuaysheh S. , Chaudhuri A. , Dandona P.

Our previous work has shown that the intake of a high fat high carbohydrate (HFHC) meal results in an increase in endotoxin (LPS) and LPS binding protein (LBP) concentrations concomitant with an increase in the expression of TLR-4, the receptor for LPS, and CD-14, which facilitates the binding of LPS to its receptor. In addition, there is an increase in ROS generation, NFkB binding and the expression of TNF-α and IL-1β. Our work has also demonstrated that an equicalo...

ea0029p614 | Diabetes | ICEECE2012

Blocking Notch pathway improves wound healing in diabetic mice

Sunkari V. , Botusan I. , Grunler J. , Brismar K. , Catrina S.

Aim: We have proposed to study the modulation of the Notch pathway in diabetes having in mind the essential role played by the Notch system in the regulation of cell differentiation and angiogenesis.Methods: The effect of hyperglycemia on Notch system was studied in vitro and in vivo using western blot, reporter gene assay or evaluation of target genes (qRT-PCR). The functional consequences of the Notch system modulation were studied by the...

ea0029p615 | Diabetes | ICEECE2012

The role of AMP-activated protein kinase in myocardial tolerance to ischemia in rats with diabetes mellitus type 2 and its relation to metformin therapy

Kravchuk E. , Grineva E. , Galagudza M. , Kostareva A.

Introduction: The aim of our experimental study was to investigate the effect of both T2DM and metformin treatment on myocardial tolerance to ischemia-reperfusion injury and cardiac AMP-activated protein kinase (AMPK) activity.Methods: The protocol included four groups: i) controls (n=13) – non-diabetic rats treated with i.p. vehicle injections for 3 days prior to the heart perfusion, ii) controls+metformin (CM; n=12) – non-diabet...

ea0029p616 | Diabetes | ICEECE2012

A novel case of diabetes mellitus and aniridia in a Caucasian family

Chen D. , Jenkins A. , Campbell L.

Introduction: We describe a novel case of familial congenital aniridia in a Caucasian woman with associated insulin requiring diabetes mellitus. This human combination has been described in Asian families in association with a heterozygous Paired Box 6 (PAX6) mutation (1) with subsequent evidence supporting that the mutation in this transcription factor causes decreased Proconvertase 1/3 function in the pancreas and a high proinsulin to insulin ratio (2). Our case does not hav...

ea0029p617 | Diabetes | ICEECE2012

Experience of diabetic dyslipidemia correction in patients with ischemic heart disease and type 2 diabetes mellitus using α-lipoic acid in combination therapy

Lopina N. , Zhuravlyova L.

Purposes: To investigate the effects of α-lipoic acid (ALA) on diabetic dyslipidemia, endothelial dysfunction, levels of adiponectin and proinflammatory mediators in combination therapy of patients with ischemic heart disease (IHD) and type 2 diabetes mellitus (T2DM).Methods: We examined 40 patients with IHD and T2DM (19 males, age 60.5±4.7 years). Baseline characteristics of patients included history of IHD (7.2±2.3 years), T2DM (4.7&#177...

ea0029p618 | Diabetes | ICEECE2012

Changes of NO concentration in the cause of streptozotocin diabetes mellitus and under action of different NOS inhibitors in streptozotocin rats

Sokolovska J. , Sharipova J. , Lauberte L. , Baumane L. , Kalvins I. , Sjakste N.

Background: Diabetes mellitus (DM) and its complications cause numerous health and social problems throughout the world. Pathogenic action of nitric oxide (NO) is responsible to a large extent for development of complications of the disease. Thus modification of NO production in DM patients appears to be an option for treatment of DM complications.Objective: To study changes in NO concentration in diabetic rats after administration of different compounds...

ea0029p619 | Diabetes | ICEECE2012

Cardiac dyssynchrony as a pathophysiological mechanism of heart failure development and progression in type 2 diabetic patients

Lopin D. , Lopina N. , Rodionova J. , Vlasenco M. , Volkov D.

Objectives: Diabetes mellitus (DM) is an independent predictor of new onset heart failure (HF) and adverse outcomes among patients with already existing HF. However mechanisms leading to impaired cardiac performance due to DM are still unclear.The purpose of investigation was to assess the influence of cardiac dyssynchrony (DYS) on systolic and diastolic function in patient with type 2 diabetes mellitus (T2DM) with concomitant stable coronary artery dise...

ea0029p620 | Diabetes | ICEECE2012

Possible risk factors of type 2 diabetes and role of long term oral hypoglycemic agent, metformin

Chakraborty A. , Chaudhury S. , Bhattacharyya M.

Introduction: Over the past decades diabetes emerged as epidemic dimension due to person’s genetic pre disposition and environmental condition. Despite significant advancement in the development of oral hypoglycemic agents, an ideal drug for treating T2DM and its complication is still a distant reality. Hyperglycemia has a variety of toxic effects, including elevated generation of ROS nitrosative stress and inflammation. This work attempts to explore the role of oxidative...

ea0029p621 | Diabetes | ICEECE2012

Complex ventricular arrhythmias with early repolarization in type 2 diabetes mellitus

Kopaleishvili A. , Akhobadze T. , Kurashvili R. , Dundua M. , Inashvili E.

Background and aims: Mortality rate from cardiovascular disease (CV) including sudden death (SD) is pronounced in type 2 diabetic (T2DM) patients with cardiac autonomic neuropathy (CAN) and/or complex ventricular arrhythmias (CVA). Early repolarization (ER) is also considered to be a significant risk factor for SD. The aim of the study was to evaluation the relation between CAN, CVA and ER in T2DM patients.Materials and methods: Participants were 44 T2DM...

ea0029p622 | Diabetes | ICEECE2012

Diabetic nephropathy in pregnant women with type 1 diabetes mellitus

Themeli Y. , Bajrami V. , Idrizi A. , Zaimi K. , Mustafaraj K. , Shtylla A. , Peci E. , Gjoshe J.

Background: Diabetic nephropathy represents one of the most common causes of end-stage renal disease. During pregnancy it is associated with an increased perinatal morbidity as a striking result of the consistently high rate of preterm deliveries, mainly due to the frequent development of pre-eclampsia.Aim: To describe pregnancy outcome in type 1 diabetic women with normoalbuminuria, microalbuminuria, or diabetic nephropathy after implementation of an in...

ea0029p623 | Diabetes | ICEECE2012

Effects of chronic administration of Vardenafil on endothelial function in patients with type 2 diabetes mellitus. A longitudinal, randomized, placebo-controlled, double blind, non-sponsored clinical trial

Santi D. , Guidi A. , Granata A. , Simoni M. , Carani C.

Introduction: The endothelium produces molecules regulating vascular function, such as nitric oxide (NO). NO protects blood vessels from endogenous injury and causes vasodilation through activation of second messengers. In diabetes mellitus (DM), hyperglycemia provokes oxidative stress, reduction of NO and increased synthesis of vasoconstrictors (e.g. endothelin). Cyclic nucleotide phosphodiesterases (PDEs) are enzymes, controlling the rate of degradation of second messengers....

ea0029p624 | Diabetes | ICEECE2012

Pattern of chronic complications among Nigerian patients with DM: the need for focused prevention initiatives

Kayode O. , Odukoya O. , Odeniyi I. , Fasanmade O. , Ohwovoriole A.

Introduction: The prevalence of diabetes mellitus among Nigerian adults has been increasing over time. A considerable number of chronic complications of DM can be adequately prevented, however, the proportion of patients presenting with chronic complications of DM in our setting is still relatively high.Objectives: This study was carried out to assess the pattern of chronic diabetic complications among patients attending the diabetic clinic of Lagos Univ...

ea0029p625 | Diabetes | ICEECE2012

The correlation between metabolic syndrome and albuminuria in type 2 diabetes mellitus

Themeli Y. , Bajrami V. , Barbullushi M. , Idrizi A. , Teferici D. , Muka L. , Ktona E.

Background: Diabetic nephropathy (DN) represents the leading cause of end-stage renal disease (ESRD). It is known that patients with ESRD have the highest risk of cardiac morbidity and mortality. Thus, identifying and treating risk factors associated with cardio-vascular disease in diabetes may offer the best approach for preventing and delaying adverse renal and cardiovascular outcomes.Aim: To determine the relationships between metabolic syndrome (MS),...

ea0029p626 | Diabetes | ICEECE2012

Diabetic nephropathy and risk factors associated with DM in newly diagnosed type 2 diabetics

Themeli Y. , Bajrami V. , Barbullushi M. , Idrizi A. , Teferici D. , Muka L. , Ktona E.

Objective: Nephropathy is a common complication in diabetes mellitus (DM), with significant morbidity and mortality. Diabetic nephropathy (DN) is more likely to develop in the presence of some risk factors associated with type 2 diabetes mellitus, even in newly diagnosed diabetics.Aim: To study the incidence of diabetic nephropathy in newly diagnosed type 2 diabetics and to study the relationship of development of nephropathy with various risk factors as...

ea0029p627 | Diabetes | ICEECE2012

Clinical experience of gel testosterone in men with diabetes type 2 and late-onset hypogonadism

Vasilkova O. , Mokhort T.

Aim: To study the effect of testosterone replacement treatment in the aging male with T2DM.Material and methods: Twenty-six hypogonadal men with T2DM and late-onset hypogonadism between the age 50–65 years (55.00 (50.00; 58.00)) were treated with a 1% testosterone gel within 12 months.Results: Testosterone levels increased from 4.65 (2.70; 6.10) nmol/l at baseline to 13.65 (12.60; 15.20) nmol/l after 48 weeks of treatment (...

ea0029p628 | Diabetes | ICEECE2012

Influence of planning pregnancy in pregestational diabetes

Gonzalez Romero S. , Vallejo Mora R. , Gonzalez Molero I. , Garcia-Torres F. , Palomo M. , Soriguer F.

Introduction and objective: The pregnancies in women with pregestational diabetes are associated with increased risk of abortion, birth defects, complications of pregnancy and perinatal morbidity and mortality. Pregnancy planning would be associated with better metabolic control, and therefore better obstetric and perinatal outcomes. The objetive of this study has been to evaluate the obstetric results of women with pregestacional type 1 diabetes and compare planned with not p...

ea0029p629 | Diabetes | ICEECE2012

Diabetic nephropathy and retinopathy: complications in pregnancy and labor

Themeli Y. , Bajrami V. , Barbullushi M. , Idrizi A. , Zaimi K. , Mustafaraj K. , Lulo J. , Shtylla A. , Gjoshe J. , Peci E.

Background: Diabetes microangiopathy is an important negative factor, that affects directly the maternal and neonatal morbidity.The objective: To determine the risk factors for the morbidity of the mothers and their fetus in patients with diabetic retinopathy and/or nephropathy.Methods and design: We followed the course of 50 pregnancies in diabetic woman with nephropathy and/or retinopathy and 50 other pregnancies in diabetic woma...

ea0029p630 | Diabetes | ICEECE2012

Quality of life of people with diabetes living in rural area

Abdoli S. , Abdoli S. , Mirzayi M.

Introduction: Diabetes with a high prevalence in Iran could affect all aspects of the individual life. Iranian people with diabetes living in rural area have access to health care system and family physician through the health care homes which offer health related care and education to the population. The services are provided by family physician and assistant health provider for remote rural area by weekly visiting tour to provide the opportunity to use health care system&#14...

ea0029p631 | Diabetes | ICEECE2012

Insulin resistance: policy plan to address burning issue by NGO from rural India

Pramod S

Issues: Newer anti-diabetic therapies out of reach of >84% populations of Asia. Pharmaceuticals donot provide price discounts in resource-constrained-countries. incidence of insulin resistance neglected issue in resource-poor nations. Diabetes forums failed to address this concern. Hence we formed liaison study group of four clinics to analyse this issue and make policy paper. Resource poor nations have little technical expertise/manpower to study insulin resistance. Lack ...

ea0029p632 | Diabetes | ICEECE2012

Seeking a new identity: the empowerment process in Iranian people with diabetes

Abdoli S , Ashktorab T , Ahmadi F , Parvizi S

Facilitating empowerment among people with diabetes is the responsibility of all health care providers. However, research suggests that the health care providers do not have the knowledge and skills to facilitate empowerment. As a result, many Iranian people with diabetes experience low levels of empowerment. The aim of the study was to explore and understand how empowerment occurs in people with diabetes in Iran. Grounded theory method using in-depth interviews, field notes, ...

ea0029p633 | Diabetes | ICEECE2012

Prevalence of Charchot arthropathy after the introduction of electronic foot ulcer patient record

Marolt I , Kosmina Novak V , Mankoc S

Introduction: Loss of protective sensation, inflammation and trauma may lead in predisposed diabetics with peripheral neuropathy to Charcot foot.Methods: Regular foot screening enables identification of those individuals who are at highest risk for foot ulceration. Special attention must be paid to infection. Differentiation between osteomyelitis and Charcot arthropathy is mandatory, the two conditions may coexist. Basic conservative treatment for Charco...

ea0029p634 | Diabetes | ICEECE2012

Development of a high-sensitive urinary albumin immunosensor based on MCM-41-PVA nanocomposite and AuNPs

Omidfar K , Gholizadeh F

Accurate and sensitive detection of the biomarkers is important both for preclinical research fields such as biochemistry, biomedicine, and clinical diagnostics. Immunosensors are the miniaturized analytical devices that combine high specificity of immunological reaction with sensitivity of detection techniques.In this study, we developed a new competitive immunosensor with employing antibody (Ab) labeled AuNP (Ab-AuNP) and mobile crystalline material-41...

ea0029p635 | Diabetes | ICEECE2012

Metformin-associated lactic acidosis: prevention is the real challenge!

Safraou M , Altman J

Introduction: More than 50 years after its introducing in 1957 (1996 in USA), metformin is used today in more than 90 countries. It is the most efficient, safe and costless anti-hyperglycemic agent in the treatment of type 2 diabetes mellitus. Its principal risk remains metformin-associated lactic acidosis (MALA), subject of controversies as reported in a recent Cochrane database review in 2010.Patients and methods: We present personal series of all case...

ea0029p636 | Diabetes | ICEECE2012

Oxidative stress and histopathological differences on the skin of diabetes mellitus compromised rats

Andrade T , Malachias V , Caetano G , Masson D , Jordao A , Landim C , Frade M

Background: Several studies on diabetes mellitus and cutaneous wounds have been reported. However, only few studies show the influence of diabetes on the skin regarding its oxidative stress, antioxidants mechanisms and histopathological aspects.Objectives: The aim of this study was to evaluate these parameters by comparing them to non-diabetic rats skin.Methods: Ten Wistar rats were assigned to groups: diabetic rats (induced by str...

ea0029p637 | Diabetes | ICEECE2012

Relationships between hyperglycemia and the oxidative stress in type 2 diabetes

Itoh M , Hiratsuka I , Hanashita J , Kimura M , Kondo M , Yoshida K , Kuroyanagi Y , Takayanagi T , Hirai H , Makino M

A continuous glucose monitoring (CGM) provides a good tool to investigate the influence of glucose fluctuation on oxidative stress regarding as the pathogenesis of arteriosclerosis in type 2 diabetes (T2DM). The CGM can detect min-to-min glucose fluctuation under the daily activity and eating habit. We measured various indexes for oxidative stress and compared with the glycemic factors detected by the CGM.Methods: T2DM (n=25) and healthy controls ...

ea0029p638 | Diabetes | ICEECE2012

Somatostatin eye drops prevent retinal neurodegeneration in experimental diabetes

Simo R , Corraliza L , Garcia-Ramirez M , Ponsati B , Hernandez C

Introduction/aim: There is growing evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). Somatostatin (SST) has a neuroprotective action and we previously found a downregulation of SST associated with the hallmarks of retinal neurodegeneration (glial activation and apoptosis) in human retinas. The aim of the study was to test the hypothesis that SST is useful in preventing retinal neurodegeneration.<p class="...

ea0029p639 | Diabetes | ICEECE2012

Serum high sensitivity c-reactive protein as predictor of metabolic syndrome and its relationship with albuminuria in type 2 diabetes mellitus

del Canizo-Gomez F , Moreno-Ruiz I , Silveira-Rodriguez B , De Gorospe C , Gonzalez-Losada T , Segura-Galindo A

The high sensitivity C-reactive protein (hs-CRP), mediator of atherosclerotic disease, is known to be a sensitive predictor of coronary heart disease in type 2 diabetes mellitus (T2DM).Aims: To evaluate the relationship of hs-CRP levels to metabolic syndrome (MS) and albuminuria in T2DM.Methods: Four hundred and eighty-eight T2DM subjects were recruited. Patients with hs-CRP ≥10 mg/l, creatinine ≥1.4 mg/dl, chronic infl...

ea0029p640 | Diabetes | ICEECE2012

Relationship between hyponatremia and diabetes mellitus

Duran A , Cuesta M , Runkle I , de Miguel P , Sotres G , Marco J

Aims: Our aim is to retrospectively analyze the diagnosis of hyponatremia in the discharge sheets of a tertiary hospital during 5 years and its relationship with type 1 and 2 diabetes mellitus.Methods: Data from the MBDS (Minimum Basic Data Set) of the discharged patients from the Hospital Clínico San Carlos (Madrid) between the years 2005 to 2009 was analysed. The 5th Edition of the ICD-9-CM was used for the codification of the diagnoses and proced...

ea0029p641 | Diabetes | ICEECE2012

The relationship between daytime, nighttime and total heart rate with albumin and protein excretion in newly diagnosed type 2 diabetic patients

Afsar B

Introduction: Autonomic nervous system dysfunction has been widely observed in patients with type 2 diabetes. Twenty-four hour ambulatory heart rate measurements (AHRM) have been found to associate with autonomic dysfunction in patient with type 2 diabetes. Since albumin excretion is also related with autonomic dysfunction; in the current study, we analyzed whether 24-h AHRM were related with 24 h urinary albumin excretion (UAE) and urinary protein excretion (UPE) in newly dia...

ea0029p642 | Diabetes | ICEECE2012

Cystatin C and TGF-β as a biomarker of diabetic nephropathy in normo and microalbuminuric patients

Dogruk Unal A , Takir M , Hulya P , Tarcin O , Bayraktar N , Erdogan E , Guvener Demirag N

Background and aims: This study was done to predict renal impairment in type 2 diabetic patients with normo or microalbuminuria by detection of serum cystatin C, serum and urinary TGF-β levels.Material and methods: Seventy-eight patients were categorized into four groups depending on urinary albumin excretion and eGFR: eGFR <60 ml/min per 1.73 m2 with normoalbuminuria in group 1; eGFR was <60 or >60 ml/min per 1.73 m2</su...

ea0029p643 | Diabetes | ICEECE2012

The impact of hyperinsulinemia on the serum IL12p40 subunit concentration

Nikolajuk A , Adamska A , Karczewska-Kupczewska M , Matulewicz N , Zielinska M , Gorska M , Kowalska I , Straczkowski M

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL12 is a proinflammatory cytokine with proatherogenic properties. IL12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL12. The aim of the present study was to investigate the influence of ...

ea0029p644 | Diabetes | ICEECE2012

Association of cardio-ankle vascular index with diabetes mellitus-related peripheral arterial disease in chronic hemodialysis patients

Okamura A , Furuya F , Akiyama D , Shimura H , Motosugi A , Haraguchi K , Kobayashi T

Introduction: Peripheral arterial disease (PAD) is increased associated with an accumulation of patients with end stage kidney disease and diabetes. Recently, the cardio-ankle vascular index (CAVI) has been developed as an index reflecting the stiffness of the aorta independently of blood pressure. The aim of this study was to assess the prevalence of PAD in hemodialysis patients with diabetes.Methods: To examine the usefulness of CAVI to screen for the ...

ea0029p645 | Diabetes | ICEECE2012

Pituitary function in patients with autoimmune type 1 diabetes evaluated by CRH test

Simunkova K , Duskova M , Starka L , Hill M , Kubatova J , Vondra K

This work aimed at acquiring data on pituitary response to CRH test in autoimmune type 1 diabetics with adult onset with/without thyroid autoimmunity. Our previous study showed 25% of such diabetic patients without clinical and immunological signs of adrenal insufficiency had lower response to the Synacthen test with normal basal levels of ACTH and cortisol.Twenty-seven diabetics were investigated; age 44±10 years (mean±S.D.), ag...

ea0029p646 | Diabetes | ICEECE2012

Microvascular complications in type 1 diabetes mellitus: prevalence and associated risk factors in DIACAM 1 study

Lopez J , Aguirre M , Lopez L , Roa C , Gomez I , Aranda S , Lamas C , Vicente A , Sastre J

Background and aims: DIACAM1 study was designed to investigate the clinical characteristics of a representative group of type 1 diabetic (T1D) population in Castilla-La Mancha (Spain). The aim of this report is to describe the prevalence of microvascular complications and the factors associated with such complications.Materials and methods: This is an observational, cross-sectional, prospective and multicentre study of 1465 patients who received assistan...

ea0029p647 | Diabetes | ICEECE2012

Urinary pentosidine concentration in patients with type 2 diabetes and risk of vascular complications

Tanaka M , Takeda S , Kawai T , Meguro S , Irie J , Saisho Y , Itoh H

Aims: We investigated the association between urinary pentosidine concentration (UPC) and vascular complications.Methods: UPC was measured in 66 patients (31 men and 35 women) with type 2 diabetes. We compared UPC between patients with and without diabetic microangiopathy, and between patients with and without macroangiopathy (cerebral infarction (CI), coronary artery disease, and peripheral arterial disease). Stepwise regression analysis was performed t...

ea0029p648 | Diabetes | ICEECE2012

The mechanisms of anemia development in patients with early stages of diabetic nephropathy

Pchelin I , Shishkin A

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It may result from various factors including erythropoietin (EPO) deficiency, iron and vitamin deficiencies, systemic inflammation, adverse effects of some drugs and others. However, the clinical significance of each factor is not fully known. The aim of this study was to assess the relative contribution of EPO deficiency, iron deficiency and systemic infla...

ea0029p649 | Diabetes | ICEECE2012

Non-alcoholic fatty liver disease and cardiovascular disease in type 2 diabetic patients with metabolic syndrome

Nelaj E , Sadiku E , Gjata M , Tase M

Background: Type 2 diabetes is often associated with non-alcoholic fatty liver disease (NAFLD). Patients with NAFLD may be at greater risk for CVD than those without. The relationship between NAFLD and metabolic syndrome (MS) is very well recognized. The aim is to determine the association of NAFLD and the CVD between type 2 diabetic patients with and without MS.Materials and methods: One hundred and thirty type 2 diabetic patients (M: 71, F: 59, mean ag...

ea0029p650 | Diabetes | ICEECE2012

Microalbuminuria and blood pressure in normotensive subjects with type 2 diabetes mellitus

Nelaj E. , Gjata M. , Tase M.

Objective: Albuminuria has been shown to predict cardiovascular disease in populations with diabetes mellitus. The aim of this study was to assess the mean pressure values and the circadian rhythm of blood pressure during its ambulatory monitoring in normotensive diabetic patients, dividing them according to the presence of microalbuminuria.Methods: The study group comprised of 77 type 2 diabetic patients. Their mean age was 56.5±6.7 years, and the ...

ea0029p651 | Diabetes | ICEECE2012

The relationship Between Self-Reported Nocturnal Sleep Duration, Daytime Sleepiness and 24-hour urinary Albumin and Protein Excretion in Newly Diagnosed Type 2 Diabetic Patients

Afsar B

Aim: Few studies demonstrated that self-reported nocturnal sleep duration (NSD) were related with urinary protein excretion. However no previous study has specifically addressed the relationship between 24-hour urinary albumin excretion (UAE) and 24-hour urinary protein excretion (UPE) in newly diagnosed type 2 diabetic patients.Methods: All patients underwent history taking, physical examination, blood pressure (BP) measurement, 12 lead electrocardiogra...

ea0029p652 | Diabetes | ICEECE2012

Office hypertension and masked hypertension and their association with left ventricular hypertrophy and diastolic dysfunction in patients with type 2 diabetes and hypertension

Leiria L. , Ledur P. , Severo M. , Becker A. , Aguiar F. , Massierer D. , Freitas V. , Gus M. , Schaan B.

Background: The association between isolated office hypertension (IOH) and masked hypertension (MH) with left ventricular hypertrophy (LVH) and diastolic dysfunction cannot be the same, determining different increased cardiovascular risk.Aims: To evaluate the prevalence of MH and IOH in treated hypertensive patients with type 2 diabetes and their association with LVH and diastolic dysfunction.Methods: A cross-sectional study was co...

ea0029p653 | Diabetes | ICEECE2012

Dynamics of insulin-like growth factor-1 concentrations during diabetic ketoacidosis

Danciulescu R. , Margina D. , Poiana C. , Musat M.

Background and Aim: Clinical and experimental studies demonstrated that total insulin-like growth factor 1 (IGF-1) levels are reduced in the patients with poorly controlled diabetes. The aim of the present study was to investigate the levels of IGF-1 in patients with acute metabolic acidosis.Materials and Methods: 17 patients with thype 1 diabetes and moderate or severe metabolic acidosis were recruited for this study. Serum levels of IGF-1 were determin...

ea0029p654 | Diabetes | ICEECE2012

Diabetic peripheral arterial occlusive disease is associated with microvascular complications but coronary atherosclerosis might not be associated with them

Tesic D. , Kovacev-Zavisic B. , Mitrovic M. , Popovic V. , Vukovic B. , Novakovic-Paro J.

Background and aims: The distribution of arterial occlusive disease is not fully explained in diabetes. The aim of this study was to examine the prevalence of CHD and PAD in diabetic patients complicated by abnormal test of distal autonomic function (Neuropad®) and large fibre neuropathy.Materials and Methods: 237 patients were analysed, M/F 111/126, age (mean±SD) 61.3±9.5years (ys), diabetes duration 16.4±10.6ys., type 1 n=22 (9.3%),...

ea0029p655 | Diabetes | ICEECE2012

Predictors of Cardiovascular Risk: Metabolic Syndrome vs. Diabetes Mellitus and Hypertension

Isailovic T. , Petakov M. , Ognjanovic S. , Elezovic V. , Macut D. , Popovic B. , Bozic I. , Bogavac T. , Damjanovic S.

Introduction: Metabolic syndrome (MS) is an independent risk factor of coronary artery disease (CAD). We investigated how influenced this risk is by the definition of MS, and whether the risk is greater than that conferred by its components.Methods: We analyzed 200 consecutive patients (35–79 years, mean 59.23±8.6, men 132, women 68) who underwent coronary angiography due to suspected myocardial ischemia. MS was obtained by several definitions:...

ea0029p656 | Diabetes | ICEECE2012

Risk Factors and Therapeutic Management of type 2 Diabetes in Georgia

Akhobadze T. , Kurashvili R. , Paghava K. , Avazashvili M.

Background and aims: Cardiovascular disease (CVD) is a leading causes of death in type 2 diabetes mellitus (T2DM), thus prevention of CVD is of utmost importance. Our aim was to determine whether the ESC/EASD guidelines on CVD prevention in T2DM patients are followed in clinical practice in Georgia.Materials and methods: In total, 824 T2DM patients (age <80 yrs) with no history of coronary or other atherosclerotic disease, who entered Georgian Diabet...

ea0029p657 | Diabetes | ICEECE2012

Effects of Hyperglycemia on Oxidative Stress and Antioxidant Potential in Patients with Type 2 Diabetes

Ikebuchi M. , Nishio Y. , Maegawa H. , Kashiwagi A.

Background: Many in vitro studies have suggested that oxidative stress induced by hyperglycemic condition has pivotal role for pathogenesis of vascular complications in diabetics. This study intended to evaluate oxidative stress and antioxidant potential in patients with type 2 diabetes mellitus (DM), and to clarify the relation between oxidative stress and metabolic derangements including chronic hyperglycemia.Materials and methods: We measured t...

ea0029p658 | Diabetes | ICEECE2012

Serum vitamin D and parathormone (PTH) concentrations as predictors of the development and severity of diabetic retinopathy.

Naguib R. , Abdel Fattah M.

Introduction: Vitamin D is suggested to be an inhibitor of angiogenesis. The degree of severity of Diabetic retinopathy (DR) may be related to serum Vitamin D concentration so this study aims at investigating vitamin D and parathormone (PTH) concentrations as predictors of the development and severity of diabetic retinopathy.Material and methods: Levels of vitamin D [25(OH) D3 and Calcitriol] and PTH were measured in 200 diabetic patients presenting with...

ea0029p659 | Diabetes | ICEECE2012

Epidemiology of Diabetic Ketoacidosis in National Institute of Diabetes and Endocrinology (NIDE) by:Bassyouni, A.; El Ebrashy, I.; El Hefnawy, H

El Hefnawy M.

Background: Diabetic ketoacidosis (DKA) is the most serious acute metabolic complications of diabetes. Unfortunately, there is a dearth of published data on this entity from Egypt. The aim of our work was to determine the clinical characteristics, precipitating causes and mortality rate of patients with diabetic ketoacidosis in National Institute of Diabetes and Endocrinology.Methods: Our work is a retrospective study in which we reviewed and analyzed th...

ea0029p660 | Diabetes | ICEECE2012

Evaluation of capillary Beta-hydroxybutyrate measurement In diabetic ketoacidosis By: Hesham El Hefnawy By:El Hefnawy, H.*; Bassyouni, A.** and Emara, I.*** From: *Pediatric, **Internal Medicine and ***Biochemistry departments, National Institute of Diabetes & Endocrinology (NIDE)

El Hefnawy M.

Background: Current criteria for the diagnosis of diabetic ketoacidosis (DKA) are limited by their nonspecificity (serum bicarbonate [HCO3] and pH) and qualitative nature (the presence of ketonemia/ketonuria). A new method is now available to measure capillary levels of beta-hydroxybutyrate (beta -0HB), It is a quantitative and enzymatic test that uses the same equipment as for home capillary blood glucose determination but with specific strips. Aim of the work: The aim of thi...

ea0029p661 | Diabetes | ICEECE2012

Clinical characteristics of diabetic peripheral neuropathy in past and present in Korea

Kim C. , Kim S.

Diabetic peripheral neuropathy (DPN) is a most common complication of diabetes mellitus. Patients with DPN have chronic, painful symptoms that disrupt sleep, depressed mood and can lead to diminish quality of life. We evaluated clinical characteristics of diabetic peripheral neuropathy in past and present in KoreaWe performed the study to determine the prevalence and to understand the clinical characteristics of diabetic peripheral neuropathy in Koreans ...

ea0029p662 | Diabetes | ICEECE2012

The effects of metoprolol,diltiazem and pilocarpine in Prolonged QTc interval caused by insulin induced hypoglycemia in rats

Erbas O.

Introduction: Insulin induced Prolonged QTc interval cause severe ventricular arrhythmias and sudden cardiac death.The purpose of this study is to reveal the effects of metoprolol,diltiazem and pilocarpine on insulin induced prolonged QTc interval(Bazett)Material-Method: In this study 24 Sprague-Dawley adult male rats were used.Before application under anesthesia ECG were taken in derivation(D)I and normal QTc interval was determin...

ea0029p663 | Diabetes | ICEECE2012

Proximal upper and lower extremities severe pain, muscle weakness in a young diabetic male with multiple chronic complications. A rare and unusual clinical presentation

Torres O. , Palermo C. , Padilla M. , Martinez J. , Davila K. , Miranda M. Gonzalez E. , Mangual M. , Laboy I. , Tirado R. , Chinea I. , Miranda M.

A 49 years old male patient with 12 years history of poorly controlled type 2 diabetes mellitus on insulin therapy, complicated with neuropathy, nephropathy, retinopathy, peripheral arterial disease (right toe amputation), hypertension and dyslipidemia. He presented with upper extremities proximal muscle and upper back moderate pain that progressed to excruciating pain with restriction of motion, weakness, and stiffness of 3 days of evolution. He denied trauma, abnormal exerci...

ea0029p664 | Diabetes | ICEECE2012

Risk factors for cardiovascular diseases in T1DM

Mokhort T. , Rusalenko M. , Davydova I. , Shilova N. , Sharshakova T. , Rozhko A.

Rationality: T2DM is a component of the metabolic syndrome, the occurrence of overweight, arterial hypertension (AH), and dyslipidemia in T1DM is variable according to the literature.Objective: Study of the occurrence of overweight, AH and dislipidemy in T1DMMaterials and methods: Total 726 patients with T1DM (348m, 378f), mean age (M±σ) 34.71±0.58 yrs (1–78), age of T1DM manifestation 12.41±0.36 yrs and sp...

ea0029p665 | Diabetes | ICEECE2012

Relationship Between HbA1c and Asymptomatic Coronary Artery Disease in Type 2 Diabetes Patients

Dundua M. , Akhobadze T. , Kurashvili R. , Kopaleishvili A.

Background: Patients with type 2 diabetes mellitus (T2DM) have elevated risk of coronary artery disease (CAD) development. In this population CAD often proceedsasymptomatically, especially if cardiac autonomic neuropathy (CAN) is present. Our aim was to assess relation between glycemia control and asymptomatic CAD inT2DM pts. Materials and methods: Participants were 160 T2DM patients without documented CAD divided into four groups (Gr.) according to HbA1c levels: Gr. 1 -HbA1c6...

ea0029p666 | Diabetes | ICEECE2012

Treating depression in type 2 diabetic patients improves depressive symptoms and quality of life but not metabolic control

Nicolau Ramis J. , Frances Artigas C. , Rivera Irigoin R. , Olivares Alcolea J. , Gil Palmer A. , Gomez Gomez L. , Rodriguez Rodriguez I. , Chacartegui Quetglas B. , Quevedo Juanals J. , Masmiquel Comas L.

Introduction:Type 2 Diabetes (T2DM) almost doubles the risk of comorbid depression, with lifetime prevalence up to 29%. It is important to recognize and treat depression in T2DM because its association with hyperglycemia, increased diabetic complications and poor quality of life (QoL) is well established. However, currently available medical therapy for depression is effective in reducing depressive symptoms, but does not consistently improves HbA1c levels. Aims:Determine the ...

ea0029p667 | Diabetes | ICEECE2012

Cardiorespiratory fitness is decreased and not correlated with C-Reactive Protein levels in adults with Diabetes Mellitus

Francisco C. , Catai A. , Moura S. , Lopes S. , Del Vale A. , Leal A.

Diabetes Mellitus (DM) has been associated with lung dysfunction and impairment of cardiorespiratory fitness and increasing evidences have suggested that comorbidities and systemic inflammation may be involved in these derangements. However, the results regarding cardiopulmonary dysfunction and its underlying mechanisms in DM are still controversial. In this study, we evaluated the relationship between metabolic variables and inflammation marker, including hemoglobin A1C (HbA1...

ea0029p668 | Diabetes | ICEECE2012

Evaluation of Brainstem Auditory Evoked Potential in Diabetics

Chaudhary S.

Background: Brainstem auditory evoked potentials (BAEP) have been used for electrophysiological assessment of central neuropathy in diabetes. However, the role of this test in documenting the abnormality, the site of abnormality and relation of these abnormalities with metabolic control of diabetes are not clear as yet. The present study was done to explore the presence of abnormalities, if any, in the test parameters and relation of these with diabetic status.<p class="ab...

ea0029p669 | Diabetes | ICEECE2012

The Loss of Work Productivity in Type 2 Diabetes Mellitus in Turkey

Satman I. , Akalin S. , on behalf of Cost of Diabetes Study Group S.

Introduction: An update of health economics analysis of diabetes mellitus (DM) in Turkey was performed. The primary objective was to collect and calculate the healthcare resources utilized for the management of DM.Methods: Thirty-one out of 40 randomly chosen centers completed the study. Medical files were reviewed for the data recorded for at least two years prior to the study. Collected data included laboratory tests, treatments, inpatient/outpatient f...

ea0029p670 | Diabetes | ICEECE2012

The Relationship between Cognitive Function and Microalbuminuria in Elderly Type 2 Diabetic Patients

Oz Gul O. , Gul C. , Hartavi M. , Bayindir A. , Cander S. , Ersoy C. , Imamoglu S.

Objective: The prevalence and incidence of diabetes mellitus (DM) are increasing at all ages, including older populations. Several studies have shown that elderly diabetics have impaired cognitive function compared to age-matched non-diabetics, as well as a higher risk of dementia. In the current study we aimed to analyze relationship between microalbuminuria and cognitive dysfunction in elderly patients with type 2 diabetes.Material and Methods: One hun...

ea0029p671 | Diabetes | ICEECE2012

Is skin tag associated with diabetic macro and microangiopatyh? Preliminary Report

Koyuncu B. , Karaca M. , Sari R.

Introduction: Although skin tag is associated with diabetes mellitus, no data in the literature show that the presence of skin tag is associated with diabetic macro and microangiopathy. The purpose of this study was to investigate frequency of hypertension, dyslipidemia, obesity, macro and micro angiopathy in type 2 diabetic patients with and without skin tag.Methods/Design: We evaluated 99 (40 female and 59 male) type 2 diabetic patients. All patients w...

ea0029p672 | Diabetes | ICEECE2012

Incidence and mortality of diabetic ketoacidosis in Benghazi-Libya

El Mehdawi R. , Ehmida M. , Elmagrehi H. , Alaysh A.

Background: Diabetic ketoacidosis is a frequent cause of morbidity and mortality among diabetics. The annual incidence and the mortality from this condition in Libyan diabetics have not been studied before. Aim and objectives: The aim of this study was to estimate the incidence of diabetic ketoacidosis and the its mortality rate at Benghazi city. Patients and methods: a descriptive retrospective analysis of the records of all patients admitted with diabetic ketoacidosis to all...

ea0029p673 | Diabetes | ICEECE2012

Drugs or insulin used in diabetics not associated with increased risk of malignancy

Aydin Y. , Erden M. , Kutlucan A. , Onder E. , Celbek G. , Kir S. , Coskun H. , Aydin L.

Aim: The aim of the present study is to determine the effects of the diabetes mellitus (DM) treatment regimens on malignancy retrospectively.Material-Method: 655 DM patients were enrolled in this study. Patients receiving diabetes therapies for at least one year were assessed with physical examination, detailed medical and family history, habits, demographic characteristics and laboratory tests and divided into two groups according to the diabetes treatm...

ea0029p674 | Diabetes | ICEECE2012

Polyneuropathy in diabetic patients based on the clinical and paraclinical findings

Afkhamizadeh M. , Reza B.

Introduction: Prevalence of diabetic neuropathy is between 10 to 90% in different studies base on the method of it evaluation(clinical or paraclinical).Objective: Evaluation of frequency of diabetic polyneuropathy indiabetic persons in endocrinology clinic of mashad endocrinand metabolic research center based on symptoms,signs and electrodiagnostic study.Method: The study was cross-sectional; 110 diabetic patients were enrolled.pat...

ea0029p675 | Diabetes | ICEECE2012

Not all neuropathies in people with diabetes are due to diabetic neuropathy - a case of chronic inflammatory demyelinating polyneuropathy(CIDP) in a type 1 diabetic

Eboh C.

46yr old gentleman. Recently diagnosed with late-onset type 1 diabetes.HBA1C of 12% (108 mmol/molHb) at diagnosis. Also Vit B12 deficient. Normal TSH, Normal 9am cortisol, Normal TTG antibodies. On Novomix 30 Insulin.No diabetic end-organ complication. Smokes 8g tobacco/day. Moderate alcohol intakePresented with a year history of painful neuropathy,started with his left toes and progressed in an ascending manner to involve the whol...

ea0029p676 | Diabetes | ICEECE2012

High burden of comorbid disease and complications in underprivileged type 1 diabetes children

Kalra S. , Agrawal N. , Chatley G. , Kalra B.

This multicentric cross sectional study, conducted in northern India, aimed to assess the clinical profile of socioeconomically underprivileged children and adolescents, aged below 18 years, with type 1 diabetes. A structured questionnaire was distributed to OPD patients, after taking informed written consent. These patients hailed from six states of India, thus providing a comprehensive picture of the burden of disease. Data was collected regarding their clinical history and ...

ea0029p677 | Diabetes | ICEECE2012

Effects of acute hyperglycaemia on ANP levels in diabetic patients

Villar R. , Becerra A. , Alameda C. , Gonzalez P de Villar N. , Canovas G. , Cancer E. , Rodriguez A. , Perez-Lopez G. , Menacho M.

Introduction: Mechanism underlying glucose-mediated development and progression of diabetic complication are incompletely understood. Atrial natriuretic peptide (ANP) is a hormone released by atrial myocytes in response to acute and chronic extracellular volume expansion. Moderate hyperglycaemia (>400 mg/dl) in diabetic rats is associated with an elevation in circulating ANP levels and in GFR (glomerular filtration rate), (1) and play a role in the development of microalbu...

ea0029p678 | Diabetes | ICEECE2012

Hyperhomocysteinemia as Risk’s Factor of Diabetic Nephropathy in the Patients with Diabetes Mellitus Type 1 and Depression

Navmenova Y. , Savasteyeva I. , Kapliyeva M. , Mokhort T.

The aim was to evaluate the space of hyperhomocysteinemia presence with depression and diabetic nephropathy (DN) in diabetic mellitus type 1 (DMT1) patients.Materials and methods: it was examined 147 patients with DMT1 (57.1% of males, 42.9% - females) and duration of disease was 11.17 [9.07;12.26] years. Moderate age was 40.08 [30.44; 48.79] years. DN of 3–5 stages was diagnosed in 43 patients (29.3%). To provide analysis it used blood serum creati...

ea0029p679 | Diabetes | ICEECE2012

No influence of the chronic poor clycaemic control on ANP levels in diabetics with microvascular illness

Villar M. , Alameda C. , Becerra A. , Menacho M. , Lopez-Perez G.

Introduction: Atrial natriuretic peptide (ANP), a member of the natriuretic peptide family, regulates several physiologic parameters including diuresis and natriuresis, and lowers arterial, blood pressure.It has been reported that plasma concentrations of ANP rise in response to acute hyperglycaemia in diabetes (1) (2) and this may indicate a neurohormonal response to limit target organ damage (3).We investigate if in situation chr...

ea0029p680 | Diabetes | ICEECE2012

Nephropathy could be a main factor in the increased levels of ANP in diabetes

Villar M. , Becerra A. , Alameda C. , Lopez-Perez G. , Menacho M.

Introduction: Its has been suggested that atrial natriuretic peptide (ANP) may contribuye to the development of microalbuminuria in diabetes mellitus.Plasma ANP concentration have been reported to be elevated in association with microalbuminuria, all of wich predict the future development of overt nephropathy in diabetes (1).Key players in neurohormonal activation include neuropeptides and their receptors wich include the ANP (2).<...

ea0029p681 | Diabetes | ICEECE2012

Quality of life and its dimensions among the type2 diabetes patients referred to the diabetes center of Zanjan University of medical science (Vali-e-Asr Hospital)-2010

Moraveji M.

Introduction: One of the most important methods for evaluation of treatment and care of diabetic patients is to assess the quality of life (QOL). The aim of this study is assess QOL and this dimensions and relational pattern between demographic characteristic.Method: This study is cross-sectional study wit convenience random sampling. The sample consisted 161 patients with type2 diabetic who refferd to diabetes center of Zanjan. Research instruments was ...

ea0029p682 | Diabetes | ICEECE2012

Sexual weakness: Different demographic and clinical features & cost-effective management

Ashraf S. , Latif Z.

Introduction: The inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse is a distressing and common symptom in Bangladeshi Diabetic subjects.Aims and Objectives: The purpose of this study is to present a framework for cost effective evaluation & treatment. Because many of the diabetic subjects usually suffers from psychological stress since he is detected as diabetic and many of them believe in Myths that diabet...

ea0029p683 | Diabetes | ICEECE2012

Role of education in prevention and delay of complications in type 2 diabetic patients

Ahmeti I. , Petrovski G. , Bitoska I. , Milenkovic T. , Lumani S.

Aim: To assess the impact of education of people with T2DM and complications. Patients and methods. Observational study, 100 T2DM patients of age 35–75 years, both sex, duration of DM >1 year.Results. From 100 T2DM 47% were male sex and 53% female. Mean age 60.45±8y, duration of DM 10.45y±3 y. Average A1c 8%±0.6, BMI 27%, systolic BP 140±6 mmHg, TG 2.2±0.3 mmol/L, LDL 4.0±0.6 mmol/L. Education (diet, physical activities, drug compliance) ...

ea0029p684 | Diabetes | ICEECE2012

Structured outpatient education and treatment program in type 1 diabetes patients during preconception care and pregnancy

Inashvili E. , Asatiani N. , Kurashvili R. , Shelestova E. , Dundua M. , Kopaleishvili A.

Our aim was to evaluate the efficacy of a structured outpatient education and treatment program (SOETP) in type 1 diabetes patients (T1DM) patients during preconception care (PC) and pregnancy, and its effect on pregnancy outcomes. Study Methods: In total 173 women with T1DM were supervised. Maternal age was 28±8 yrs and diabetes duration - 12±7yrs. SOETP combined group and individual training. Stage 1 - preconception care (group and individual training). Stage 2 - i...

ea0029p685 | Diabetes | ICEECE2012

A Randomized controlled trial of the effect of internet based mentoring program for type 1 diabetes patients with inadequate glycemic control

Suh S. , Park S. , Cho Y. , Joung J. , Jin S. , Kim S. , Kim H. , Bae J. , Kim S. , Chung J. , Min Y. , Lee M. , Lee M. , Kim K. , Kim J.

Introduction: Widespread availability of internet makes it an attractive communication tool among patients and providers. However, the clinical benefit of telemedical support on diabetes care remains inconclusive. This study is to determine whether an internet based mentoring program can improve glycemic control in type 1 diabetes (T1DM) patients with inadequate glycemic control.Methods: Patients with T1DM on intensive insulin therapy and with HbA1c &#x2...

ea0029p686 | Diabetes | ICEECE2012

Type 1 diabetic women treated with insulin pumps or multiple daily injections of insulin: pregnancy outcome and glycemic control

Gonzalez Romero S. , Gonzalez-Molero I. , Vallejo Mora R. , Ruiz de Adana M. , Dominguez Lopez M. , Sanchez Reyes I. , Palomo M. , Soriguer F.

Introduction: Pregestational diabetes is a threatening condition for pregnancy; a strict glycemic control can decrease some pregnancy complications. That control can be achieved while on multiple daily insulin injections (MDI) treatment or with subcutaneous insulin infusion systems (CSII). Up to now no benefits of CSII treatment over MDI on pregnancy outcomes have been proved.Design: Case control retrospective study, comparing glycemic control and pregna...

ea0029p687 | Diabetes | ICEECE2012

DPP-4 inhibitor vildagliptin reduces urinary albumin excretion in type 2 diabetic patients with microalbuminuria

Watanabe M. , Furuya F. , Kobayashi T.

Introduction: A potent and selective DPP-4 inhibitor improves islet function by enhancing α- and β-cell responsiveness to glucose in the diabetic patients. Renal impairment is a common complication of type 2 diabetes mellitus (T2DM). Vildagliptin is used to treat T2DM as monotherapy or in combination with other antidiabetic drugs, since that it efficiently decreases glycated hemoglobin (HbA1c) values. Additionally, vildagliptin has been shown to be safe in patients w...

ea0029p688 | Diabetes | ICEECE2012

Insulin protocol for hospital management of diabetes: a retrospective evaluation one year after the implementation

Garcia Torres F. , Valdes S. , Gonzalez-Molero I. , Gonzalo Marin M. , Rubio I. , Garcia Arnes J. , Munoz A. , Olveira G. , Ruiz de Adana M. , Soriguer F.

Introduction: Protocols for identifing and managing hyperglycemia and diabetes in hospital are necessary. Glycemic goals in non critical inpatients are:140 mg/ml(preprandial) and 180(posprandial),oral antidiabetic drug(OADs) withdrawn, avoid hypoglycemias, basal/bolus insulin (nor sliding scale) and request glycosylated haemoglobin.Aims: To evaluate the implementation of a protocol for management of diabetes(PHD) during the years 2009 and 2010 in our Hos...

ea0029p689 | Diabetes | ICEECE2012

Analysis of fasting glycemia variability in patients with type 1 diabetes mellitus undergoing different types of basal insulin therapy: glargine vs. NPH

Mashkova M.

The goal of this research was to analyze fasting glycemic variability in patients with DM1 depending on the type of basal insulin therapy - insulin NPH versus Glargine.Material and methods: The glucose levels 24-hour monitoring was performed applying the CGMS. Glargine group - 19 and NPH group - 24 patients.Results: In the glargine group there have been no episodes of severe fasting hypoglycemia (<2.8 mmol/L), LBGI=2.42±1....

ea0029p690 | Diabetes | ICEECE2012

To evaluate and compare the outcome of pregnancies in women with type 1 diabetes treated with continuous subcutaneous insulin pump or multiple insulin injections

Saboo B. , Chandarana H. , Joshi S. , Shah S.

The study was aimed to compare the outcome of pregnancies in women with type 1 diabetes treated with continuous subcutaneous insulin infusion pump (CSII) or multiple insulin injections (MDI). Total 14 patients were treated with insulin pump and 20 patients were treated with multiple injections; were mainly investigated for HbA1c, incidence of hypoglycemia, fetal outcome, rates of pregnancy induced hypertension and cesarean section. HbA1c with insulin pump was significantly bet...

ea0029p691 | Diabetes | ICEECE2012

Antihyperglycemic effects of sodium orthovanadate and Trigonella foenum graecum in diabetic rats

Kumar P. , Kale R. , Baquer N.

Objectives: Oral administration of vanadate to diabetic animals have been shown to stabilize the glucose homeostasis and restore altered metabolic pathways. The present study explored the prospect of using low doses of vanadate with Trigonella foenum graecum, seed powder (TSP), another antidiabetic agent, and to evaluate their antidiabetic effect in diabetic rats. The effect of these antidiabetic compounds was examined on general physiological parameters, monoamine oxidase act...

ea0029p692 | Diabetes | ICEECE2012

Therapy with analogous of glp 1 and basal insulin in patients with diabetes mellitus type 2. Our experience.

Perez Rodriguez J. , Morales Portillo C. , Garcia Garcia C. , Fernandez Pena I. , Hernando Jimenez V. , Serrano Olmedo I. , De la Cuesta Mayor C. , Sendon Perez

Objectives: Evaluate the impact of the therapy with GLP-1 analogues (exenatide) toguether with basal insulin in glycemic control and weight of patients with type 2 diabetes mellitus poorly controlled.Materials and methods: We analyzed 37 patients with type 2 diabetes with poor glycemic control and obesity, treatment with exenatide and basal insulin. As pre-treatment 56.7% of our patients were with basal insulin, 10.8% with insulin mixtures and 32.4% with...

ea0029p693 | Diabetes | ICEECE2012

Variations in insulin daily dose and weight with continuous subcutaneous insulin infusion therapy

Belo S. , Esteves C. , Pereira M. , Neves C. , Carvalho D.

Introduction: Intensive diabetes type 1 management can be achieved either with multiple daily insulin injection therapy or with continuous subcutaneous insulin infusion (CSII). The former is becoming increasingly popular do to its positive effects on glycemic control.Objectives: Evaluate the evolution of total daily insulin dose (TDID) and weight on patients with CSII.Methods: Patients with CSII of our department were included. Dat...

ea0029p694 | Diabetes | ICEECE2012

Insulin therapy requirement in ESRD patients (Our experience)

Eltobgi A. , Abuharba A.

Diabetes (DM) is the leading cause of end-stage-renal disease (ESRD). Majority of T2DM patients (Pts) with ESRD need insulin. Kidneys play significant role in exogenous insulin metabolism. Chronic renal disease is associated with alterations in insulin metabolism and glycemic control. As renal function starts to decline, insulin requirement needs to be adjusted to reach euglycemia.A good metabolic control is not only important in the early phase of diabe...

ea0029p695 | Diabetes | ICEECE2012

Comprehensive approach to Paediatric diabetes management: NGO initiatives in developing country India.

Pramod S.

Issues: In developing nations diagnosis of diabetes brings mental-trauma/depression in family. Focused treatment for pediatric age-group is unavailable in developing-countries. 26% of diagnosed diabetics are children’s. Adequately trained physicians/Nurses in issues of pediatric-diabetes provide continuity of care, relief from depression and smooth transition from diagnosis to treatment. Qualitative collaborative relationship between these makes diabetics life bearable. O...

ea0029p696 | Diabetes | ICEECE2012

Renal sodium dependent glucose co-transporter 2 (SGLT2): A neoteric target for treatment of type2 diabetes mellitus

Ahmed D.

Contemporary therapies to rationalize the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. Kidney emerges out as a novel and potential target to trim down the T2DM. The filtered glucose is reabsorbed principally through the sodium glucose co-transporter-2 (SGLT2), a low affinity transport system, which are present at the luminal surface cell...

ea0029p697 | Diabetes | ICEECE2012

Management of Diabetes in Hospital

Mirzayi M. , Esfahanian F. , Abdoli S.

Introduction: People with type 1 or type 2 diabetes mellitus are frequently admitted to a hospital, usually for treatment of conditions other than the diabetes. Whether in hospital or not, glycemic control is likely to become unstable in these patients because of the stress of the illness or procedure, the concomitant changes in dietary intake and physical activity, and the frequent interruption of the patient’s usual antihyperglycemic regimen. Once in the hospital, the l...

ea0029p698 | Diabetes | ICEECE2012

Relation between glucose daily profile (CGMS) and graft function after islet transplantation for type 1 diabetes mellitus

Vantyghem M. , Raverdy V. , Balavoine A. , Defrance F. , Caiazzo R. , Kerr-Conte J. , Hazzan M. , Pattou F.

Context: The influence of beta cell replacement on daily glucose profile in Type 1 diabetes mellitus (T1DM) is not firmly established.Objective: To examine the influence of islet transplantation (IT) on the various component of dysglycemia in T1DM patients.Design, setting and patients: Single arm open labeled study. Twenty-three consecutive patients with T1DM, 11 males and 12 females, 14 non uremic and 9 uremic with a previous kidn...

ea0029p699 | Diabetes | ICEECE2012

Evolution of macro-angiopathy 5-years after islet transplantation (IT) in type 1 diabetes

Vantyghem M. , Balavoine A. , Defrance F. , Douillard C. , Van Belle E. , Foucher C. , Gautier C. , Kerr-conte J. , Noel C. , Pattou F.

Long-term benefit-risk ratio of IT remains poorly evaluated. The aim of this work was to determine the evolution of macroangiopathic complications 5 years after IT.21 out of the 36 prospectively followed islet-transplanted patients in a single center, had at least 5 years of follow-up and were included. Their initial features were: duration of C-peptide negative diabetes: 28±9years; age: 43±7years; BMI: 24±0.2 kg/m2; 8/21 kidney-transplant...

ea0029p700 | Diabetes | ICEECE2012

Sustained Exendin-4 secretion through gene therapy targeting salivary glands in Zucker fa/fa rats and high fat diet fed mice.

Dicembrini I. , Di Pasquale G. , Raimondi L. , Pagano C. , Egan J. , Cozzi A. , Cinci L. , Manni E. , Loreto A. , Berretti S. , Morelli A. , Baum B. , Maggi M. , Vettor R. , Chiorini J. , Rotella C. , Mannucci E.

Background: Exendin-4 (Ex-4) is a GLP-1 receptor agonist approved for the treatment of Type 2 Diabetes (T2DM). Aim of this study was to characterize the effects of Ex-4 expressed continuously from salivary glands (SG), following adeno-associated virus-mediated (AAV) gene therapy in two different model of obesity and T2DM. Several trials support an AAV good safety and little toxicity profile. Serotype 5 (AAV5) presented enhanced gene transfer activity in SG and an efficient pro...

ea0029p701 | Diabetes | ICEECE2012

A Hydrophilic Derivative of Probucol, Probucol-(glutaric branched-triglycerol)2 (ProBGL2) Ameliorates Glucose Tolerance and Insulin Sensitivity by Independent Mechanism of the Canonical Potency of Probucol in HFD-fed mice.

Miyamoto L. , Kono M. , Nakagawa T. , Hattori H. , Ishizawa K. , Yoshimura Y. , Nemoto H. , Tsuchiya K.

Probucol is a traditional anti-hyperlipidemic agent harboring marked antioxidant activity. While probucol is highly hydrophobic, its succinic acid ester, succinobucol, was reported as a water-soluble derivative and was in clinical trials. Succinobucol was shown to be more potent in lipid-lowering, anti-inflammatory and anti-atherogenic effects than probucol in animal models. In addition, succinobucol reduced HbA1c in diabetic patients. Although the clinical trials finally ende...

ea0029p702 | Diabetes | ICEECE2012

Simultaneous Pancreatic Kidney Transplant Experience in The South West of Ireland between 2001–2011

Slattery D. , Hussain T. , O'Cathail M. , Tuthill A. , Plant W. , O'Halloran D.

Introduction: Simultaneous pancreatic kidney transplantation (SPK) has become the therapy of choice in patients with type 1 diabetes mellitus (DM) and end stage diabetic nephropathy.Methods: An analysis was performed of type 1 diabetic patients with end stage diabetic nephropathy who received treatment with SPK between 2001–2011 in the South West of Ireland, population 663,176 with a prevalence of type 1 DM in this region estimated to be 0.3%. Data ...

ea0029p703 | Diabetes | ICEECE2012

Implementation of the principles of the personalized medicine in the clinical practice: a pilot study for type 2 diabetes

Zarina L. , Tarasova L. , Nikitina-Zake L. , Kempa I. , Cirse M. , Klovins J. , Geldnere K. , Konrade I. , Lejnieks A. , Pirags V.

Background: Many patients with type 2 diabetes (T2D) are not reaching glycemic targets even by using different combinations of antidiabetic drugs, including insulin. On the other hand, intensified multidrug therapy is associated with increased risk of severe side effects and individualized selection of medication is essential. The aim of our study is to evaluate efficiency of personalized pharmacotherapy according to the genotype and phenotype of T2D patients.<p class="abs...

ea0029p704 | Diabetes | ICEECE2012

Pathway Integration of Pro-Inflammatory Cytokines, 12-Lipoxygenase and NADPH Oxidase in Beta Cell Dysfunction; Protection by Novel Selective 12-Lipoxygenase Inhibitors.

Taylor-Fishwick D. , Weaver J. , Ganesha B. , Holman T. , Jadhav A. , Maloney D. , Nadler J. , Simeonov A.

In this study we explore and integrate a pathway for loss of functional beta cell mass in diabetes. Inflammatory cytokines induce human islet dysfunction, elevate expression of 12-lipoxygenase, increase cellular reactive species and induce NADPH oxidase. These pathways are elevated in islets from diabetic donors.NADPH oxidase-1 (NOX-1) is significantly induced in either human donor islets, primary mouse islets or homogeneous beta cell lines following sti...

ea0029p705 | Diabetes | ICEECE2012

GLP-1 agonists enhance stress-induced corticosterone release

Volke V. , Runkorg K. , Krass M.

Introduction: Currently, there are two glucagon-like peptide 1 (GLP-1) receptor agonists approved for the treatment of type 2 diabetes.While the primary pharmacological actions of GLP-1 agonists are antihyperglycaemic effect and weight reduction, these drugs may influence other neural and hormonal processes. Animal studies have indicated that GLP-1 receptors are involved in the regulation of stress, anxiety, learning and memory as well as regulation of c...

ea0029p706 | Diabetes | ICEECE2012

Bile acid binding resins affect diverse molecules to improve metabolic control.

Morimoto K. , Watanabe M. , Houten S. , Kaneko-Iwasaki N. , Sugizaki T. , Horai Y. , Mataki C. , Arita E. , Schoonjans K. , Auwerx J. , Itoh H.

Introduction: Bile acid binding resins (BABRs), anion exchange resins developed as medication for hypercholesterolemia, have been reported to improve glycemic control in patients and animal models with type 2 diabetes mellitus. Although the mechanism has not been clarified yet, we suspect that diverse factors including peripheral bile acid composition and incretins play significant roles in the effect. Besides BABRs, bile acids (BAs) administration has been recently reported t...

ea0029p707 | Diabetes | ICEECE2012

A novel beneficial effect of liraglutide: the reduction in subclinical atherosclerosis in patients with type-2 diabetes

Rizzo M. , Patti A. , Di Bartolo V. , Giglio R. , Montalto G. , Rizvi A.

Introduction: There is currently high interest in the non-glycemic effects of incretin-based therapies, specifically glucagon-like peptide 1 (GLP-1) analogues, such as those on cardiovascular system. Liraglutide has been approved in Italy since one year to be prescribed in combination with oral hypoglycemic agents; it has several non-glycemic properties, but its effect on carotid intima-media thickness (IMT), a recognized marker of subclinical atherosclerosis, is still unknown...

ea0029p708 | Diabetes | ICEECE2012

The Sodium Glucose Cotransporter-2 Inhibitor Empagliflozin Does Not Alter ECG Endpoints in a Thorough QT (TQT) Study

Ring A. , Brand T. , Macha S. , Breithaupt-Groegler K. , Simons G. , Walter B. , Woerle H. , Broedl U.

Empagliflozin is a potent, highly selective sodium glucose cotransporter-2 inhibitor in development for treatment of type 2 diabetes mellitus. This randomized, placebo-controlled, double-blind study assessed the effects of empagliflozin on the QT interval. Thirty healthy subjects (14/16 female/male; mean [range] age 34.5 [18–52] years) received single doses of 25 mg (within therapeutic range) and 200 mg (supratherapeutic) empagliflozin and 400 mg moxifloxacin as positive ...

ea0029p709 | Diabetes | ICEECE2012

Safety and efficacy of linagliptin in type 2 diabetes (T2D) patients (pts) with common renal and cardiovascular risk factors

von Eynatten M. , Gong Y. , Emser A. , Woerle H.

Introduction: Vascular complications are the leading cause of morbidity and mortality in T2D. Hypertension and/or microalbuminuria predict renal and cardiovascular outcome. This large pooled analysis from a global development program aimed to evaluate the safety and efficacy of linagliptin in this particularly high-risk population.Methods: Data of 1982 pts from 3 randomized, double-blind, placebo(PBO)-controlled phase 3 trials were analyzed. Pts with mic...

ea0029p710 | Diabetes | ICEECE2012

Effects of flaxseed oil on anti-oxidative system and membrane deformation of human erythrocytes in high glucose level

Yang W.

Aim: The erythrocyte membrane lesion is a serious diabetic complication. Although most available data demonstrated by earlier studies that n-3 fatty acid was a potent agent in this complication of diabetes. Realization about protection effects of flaxseed oil on antioxidative capacity and against to membrane deformation of human peripheral blood erythrocytes in high glucose model is limited.Main methods: In this study, erythrocytes were treated with 50 m...

ea0029p711 | Diabetes | ICEECE2012

Rapidly and strong suppression of human acylated ghrelin serum concentrations during infusion of des-acyl ghrelin in obese diabetic subjects.

Ozcan B. , Neggers S. , Reifel Miller A. , Yang H. , Delhanty P. , Allas S. , Abribat T. , van der Lelij A.

Aim: To assess the effects of a continuous overnight infusion of two doses of UAG (3&10 μg UAG/ versus placebo in a double blind cross-over study on AG levels, as well on glucose and insulin response to a standard breakfast meal (SBM) in 8 overweight patients with type 2 diabetes (HbA1c 6.5-7.5%).Methods: During these 3 admissions, in randomized order, all subjects received either placebo, or UAG 3 μg/ or UAG 10 μg/

ea0029p712 | Diabetes | ICEECE2012

Educating educators - the way to improve health outcomes of people with diabetes

Shelestova E. , Kurashvili R. , Tsutskiridze L.

Background and Aims: Diabetes causes immeasurable personal suffering and costs to the society, though diabetes and its complications are largely preventable. There are proven, affordable preventions available, that can stop or delay diabetes/complication development. Political Declaration adopted by UNO stresses importance of educational measures to promote health education and literacy. IMAGE Project/Toolkit on Type 2 Diabetes Prevention in Europe outlines education as corner...

ea0029p713 | Diabetes | ICEECE2012

Reducing Residual Vascular Risk Through combination Therapy with Fenofibrate and Alpha-Lipoic Acid in Patients with Ischemic Heart Disease and Type 2 Diabetes Mellitus

Zhuravlyova L. , Lopina N.

Purposes: To investigate effects of combination therapy with fenofibrate and α-lipoic acid (ALA) on atherogenic dyslipidemia, which determines the residual vascular risk and endothelial dysfunction, levels of proinflammatory mediators in patients with ischemic heart disease (IHD) and type 2 diabetes mellitus (T2DM).Methods: We examined 42 patients with IHD and T2DM (19 males, age 60.5±4.7 years). Baseline characteristics of patients included hi...

ea0029p714 | Diabetes | ICEECE2012

Antidiabetic therapies and malignancy: a retrospective study in oncological cases.

Anil C. , Demir C. , Erismis B. , Can S. , Yalcin S. , Altundag O. , Gunes G. , Bascil Tutuncu N.

Introduction: Despite the relation between Type 2 Diabetes Mellitus (DM) and development of malignancy is well known, data on antidiabetic drugs and cancer risk is contradictory. Thesis which have suggested that analogue insulins, especially glargine, increase cancer risk, has not been validated. The present study aimed to evaluate the possible contributions of diabetes durations and medications to the type and course of malignancy in patients with both diabetes and malignancy...

ea0029p715 | Diabetes | ICEECE2012

Adding Liraglutide to insulin treated obese type 2 diabetics improves glycaemic control with sustained weight reduction and low hypoglycaemia rate

Jindal R. , Gupta N. , Gupta M. , Siddiqui M. , Wangnoo S.

Aims: To evaluate the effect of Liraglutide on clinical parameters in obese Type 2 diabetic patients with inadequate glycemic control despite treatment with oral hypoglycaemic agents (OHAs) and insulin.Methods: Three hundred and fifty three (M:232, F:121) obese (according to Asian-Indian criteria) type 2 diabetic patients with inadequate glycemic control (HbA1c>7% & <10%) attending outpatients clinic on insulin and OHAs were initiated on lira...

ea0029p716 | Diabetes | ICEECE2012

Clinical and Patient Reported Outcomes over the 24 Months of Insulin Therapy in Patients with Type 2 Diabetes in Greece: Data from The Instigate Study

Aloumanis K. , Benroubi M. , Sourmeli S. , Drossinos V.

Aims: We present final Hellenic data from the INSTIGATE study which assessed direct costs, resource utilisation, and clinical outcomes in the first 24 months of insulin therapy in type 2 diabetic (T2D) patients.Methods: INSTIGATE was a prospective European observational study of patients with type 2 diabetes who had initiated insulin during usual care. Data were collected at baseline, when subjects initiated insulin (visit T1), then 3 (T2), 6 (T3), 12 (T...

ea0029p717 | Diabetes | ICEECE2012

The outcome of Beta cell function after early insulin therapy in the recently diagnosed type 2 diabetes (in Egyptian population) our experience in EL-Minia university hospital

Mousa Y. , Mohamed A. , Kamel M.

The purpose of this prospective cohort study was to evaluate whether early insulin therapy is more advantageous in achieving long-term optimal glycemic control with improved B cell function than oral drugs in the recently diagnosed type 2 diabetes mellitus. Methods: Sixty consecutive patients with recently diagnosed type 2 diabetes mellitus were divided into 3 groups.The 1st group received 2 SC injections of premixed insulin. The 2nd group received bed time NPH and 3 injection...

ea0029p718 | Diabetes | ICEECE2012

Gender differences in metabolic outcomes of continuous subcutaneous insulin infusion therapy

Esteves C. , Neves M. , Belo S. , Pereira M. , Sousa Z. , Carvalho D.

Introduction: The continuous subcutaneous insulin infusion (CSII) is an alternative to multiple daily injection therapy in type 1 diabetes and its use is increasingly common due to the beneficial effects on the glycemic control of the patient.Aims: To find differences on outcomes of CSII therapy between genders. Patients and methods: Patients on CSII therapy in our department were included in the study and we recorded outcomes regarding the following set...

ea0029p719 | Diabetes | ICEECE2012

Continuous subcutaneous insulin infusion systems: experience in 92 patients with type 1 diabetes

Saraiva J. , Carrilho F. , Barros L. , Batista C. , Melo M. , Gomes L. , Vieira A. , Alves M. , Gouveia S. , Moreno C. , Carvalheiro M.

Background: Continuous subcutaneous insulin infusion (CSII) using an external pump is an alternative intensive diabetes therapy recognized to improve metabolic control and glycemic instability in selected type 1 diabetic (T1DM) subjects. The aim of this study was to examine the clinical effectiveness and safety of CSII systems over a 5-year follow-up period in T1DM patients.Materials and methods: We performed a retrospective observational study of T1DM p...

ea0029p720 | Diabetes | ICEECE2012

A 52-week efficacy and safety profile of sitagliptin in Japanese type 2 diabetic patients in clinical settings

Matsuda A. , Hamada K. , Misaka A. , Matsuda M.

Background of Study: Some medications for the treatment of type 2 diabetes mellitus fail to achieve a continuous favorable glucose control in the long run during clinical use. Therefore we examined the durability of dipeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin which is relatively new to Japanese type 2 diabetic patients in clinical settings.Objectives and Methods: 117 subjects (M/F=65/52, Age: 66±10 y.o., duration of diabetes 12±8 y. b...

ea0029p721 | Diabetes | ICEECE2012

Short-term liraglutide therapy as compared with basal insulin therapy on restoration effect of insulin secretion in Japanese patients with type 2 diabetes

Kaneko S. , Yoshimi K. , Tahara Y. , Sato Y. , Tashima M.

Objective: To investigate whether restoration of insulin secretion and long-term optimal glycemic control can be achieved by short-term liraglutide (a glucagon-like peptide-1 receptor agonist) therapy compared with basal insulin therapy in Japanese patients with type 2 diabetes.Research Design and Methods: Japanese subjects with type 2 diabetes had a short-term, 3 week course of basal insulin therapy (n=114) or liraglutide therapy (n=29) to...

ea0029p722 | Diabetes | ICEECE2012

Vitamin B-12 deficiency associated with metformin treatment of type 2 diabetes mellitus in daily practice: Clinical consequences

Jungmann E. , Bolle J. , Schmitz C. , Jungmann G.

In a recent study, vitamin B-12 deficiency was observed in 10% of metformin-treated type 2 diabetic patients, but neurological status of the patients was not defined. Thus, potential consequences of this observation remained subject to controversy. Therefore, we decided to examine to which extent a vitamin B-12 deficiency can be detected in metformin-treated diabetic patients in daily practice and which impact vitamin B-12 deficiency – if present – could have on the ...

ea0029p723 | Diabetes | ICEECE2012

A comparison of pharmacokinetics and pharmacodynamics of insulin aspart, biphasic insulin aspart 70, biphasic insulin aspart 50 and human insulin: a randomized, quadruple crossover study

Ma Z. , Parkner T. , Frystyk J. , Laursen T. , Lauritzen T. , Christiansen J.

Aims: To compare the pharmacokinetic and pharmacodynamic profiles of insulin aspart, biphasic insulin aspart 70 (BIAsp70), biphasic insulin aspart 50 (BIAsp50) and soluble human insulin under experimental conditions.Methods: In this randomised, four-period crossover study, 19 type 1 diabetic patients received subcutaneous injections of identical doses (0.2 U/kg) of either insulin aspart, BIAsp70, or BIAsp50 immediately before a standardized meal, or huma...

ea0029p724 | Diabetes | ICEECE2012

Resource utilization and patient satisfaction associated with switching insulin in Greece (Subanalysis of the SWING study).

Aloumanis K. , Tentolouris N. , Reaney M. , Dafni C. , Drossinos V.

Purpose: Diabetic patients (T2D) switch from short-acting insulin to rapid-acting analogue (H-A) and less commonly from A-H. The SWING study was designed to assess treatment costs, glucose control, satisfaction, and quality of life in T2D following H-A or A-H switches.Methods: SWING was a multinational, prospective, observational study of previously mentioned parameters associated with switching in either direction between any rapid-acting analogue insul...

ea0029p725 | Diabetes | ICEECE2012

Inpatient Hypoglycaemia Management

Sobajo C. , Rao-Balakrishna P.

Introduction: Inpatient hypoglycaemia management remains a significant challenge. An audit in 2009 revealed poor understanding (“recognition” by frontline staff) of the need to treat and manage hypoglycaemia. Consequently a management protocol, documentation sheet and hypoboxes with standardized quantities (15 g) of dextrose in various forms were introduced throughout the hospital.Aims: We re-audited inpatient hypoglycaemia management and the i...

ea0029p726 | Diabetes | ICEECE2012

Study of the outcomes of application of ISPAS versus ADA guidelines of diabetic Ketoacidosis in type 1 diabetic children

El Hefnawy M.

Diabetic ketoacodosis (DKA) is a serious complication of diabetes mellitus, especially type 1, and its secondary consequences account for a large proportion of diabetes-related hospitalizations and mortality in children with type 1 diabetes.Aim of the work: The aim of this study was to compare between the outcomes of application of ISPAD (International Society of Pediatric & Adolescence Diabetes) versus ADA, (American Diabetes Association) guidelines...

ea0029p727 | Diabetes | ICEECE2012

Subcutaneous use of rapid insulin analog: an alternative treatment for patients with mild to moderate diabetic ketoacidosis

El Hefnawy M.

Background: Diabetic ketoacidosis (DKA) is a life-threatening condition that requires hospitalization in children with type 1 diabetes. Many reports have indicated that low-dose insulin therapy is quite effective regardless of the route of administration, whether, intramuscular, or subcutaneous.Aim of the work: The aim of this study was to look for technical simplification and economic efficiency in the treatment of diabetic ketoacidosis (DKA) with subcu...

ea0029p728 | Diabetes | ICEECE2012

Planning Treatment of Diabetic Patients with Chronic Renal Disease Using Pre-mixed Insulins Having Higher Proportion of Soluble Insulin

Nikhra V.

Diabetes mellitus is a leading cause of chronic renal insufficiency and later end-stage renal failure; on the other hand, chronic renal disease has been linked with alterations in carbohydrate and insulin metabolism. The pharmacokinetics of various insulin preparations has not been well studied in patients with varying degrees of renal dysfunction. There exist sparse guidelines regarding appropriate dosing adjustment of insulin. Further, chronic renal insufficiency is associat...

ea0029p729 | Diabetes | ICEECE2012

Study on cases with hypoglycemia carried to the emergency room in the last two years

Kudo T. , Kasai N.

Recently, many cases with hypoglycemia who take oral hypoglycemic agents and/or insulin therapy are carried to the emergency room in our hospital due to hypoglycemia. Pharmacotherapy for patients with diabetes mellitus occasionally can causes severe hypoglycemic attack. In this study, we investigated 69 type 2 diabetics on clinical features (26 outpatients of our hospital, 43 outpatients of other clinics) among 100 patients who were carried to the emergency room due to hypogly...

ea0029p730 | Diabetes | ICEECE2012

Treatment of obese type 2 Diabetes Mellitus patients with CSII Humulin U-500 Regular Insulin infusion vs. CSII Aspart insulin infusion coupled with basal insulin and metformin

Herscovici S.

We describe 10 obese patients with longstanding type 2 diabetes mellitus treated with a combination of basal insulin coupled with insulin Aspart and oral metformin. Average age was 59.5 years. Average BMI was 31.82 and Hemoglobin A1c 8.71%. Average Total Daily insulin dose (TDD) was 157.1 IU. EGFR was >60 in all patients. No patient underwent weight reduction surgery.Patients were randomized into 2 groups of 5 patients each. One group(1) received only Humulin U-500 Regular...

ea0029p731 | Diabetes | ICEECE2012

Effects of DPP-IV inhibitors on the changes of glycemic and lipid control of type 2 diabetes patients at the great east Japan earthquake

Yamagishi T.

Purpose: The effects of the Great East Japan Earthquake, a life-threatening event, on glycemic and lipid control in type 2 diabetic patients were examined. The influence of the DPP-IV inhibitors on glycemic and lipid levels was studied.Method: Three hundred fifty type 2 diabetes outpatients (age 63 years old) who followed careful diet regimen on a normal condition were divided into the two groups: the administrated group (A group), 175 patients who were ...

ea0029p732 | Diabetes | ICEECE2012

Exenatide versus insulin glargine in type 2 diabetes inadequately treated with metformin

Karagianni P. , Polyzos S. , Kartali N. , Zografou I. , Sambanis C.

Introduction: The recent ADA and EASD algorithm for the treatment of type 2 DM suggests addition of basal insulin or GLP-1 agonist to pre-existing treatment when glycemic control is not achieved.Aim: Compare efficacy and safety of exenatide (E) versus insulin Glargine (G) added after metformin monotherapy.Patients and methodOur study was open labeled, non- randomized, retrospective and included 48 patients, 1...

ea0029p733 | Diabetes | ICEECE2012

Vitamin D3 deficiency effect on the HbA1c in type 2 diabetic Population

Coskun H. , Aydin Y. , Kutlucan A. , Yildirim H. , Kudas O. , Kir S. , Celbek G. , Turgut M.

Introduction: Aim is to determine vitamin D level in patients with Type 2 DM and to evaluate the relationship between vitamin D level and glycemic control.Methods: We evaluated 107 women and 63 male patients with Type 2 DM whose mean age was 55±0.81. Patients fasting blood glucose (FBG), postprandial blood glucose (PPBG), HbA1c and 25(OH)D3 level were measured. The cases were divided into three groups according to measured 25(OH)D3 level (Vitamin D ...

ea0029p734 | Diabetes | ICEECE2012

Salsalate effect on BRACHIAL FLOW-MEDIATED DILATION in early diagnosed Diabetes mellitus

Khalili N. , Faghih Imani E.

Objective: Obesity and fat deposition in tissues along with inflammatory response may induce insulin resistance and finally type 2 diabetes mellitus Salsalate, a prodrug form of salicylate can inhibit IKKβ and NF-kappaB inflammatory pathway as a potential pharmacologic target in diabetes. The aim of this study was to determine the efficacy of salsalate as an anti-inflammatory drug to resolve endothelial dysfunction in diabetic patients.Methods: This...

ea0029p735 | Diabetes | ICEECE2012

Differences in health related resource use and costs before and in 24 months after insulin initiation in patients with type 2 diabetes: final data from instigate study

Aloumanis K. , Benroubi M. , Drossinos V. , Polydorakis A.

Aims: We present final Hellenic data from the INSTIGATE study on direct costs of care and resource use, over the 24 months after insulin initiation, in type 2 diabetic (T2D) patients.Methods: INSTIGATE, a prospective European observational study involving T2D patients who initiated insulin during usual care, assessed direct costs of care over the 6 months prior to and for the intervals from baseline to 6 months, 6–12, 12–18 and 18–24 month...

ea0029p736 | Diabetes | ICEECE2012

Clinical Findings on the Effect of Early Insulin Therapy in Newly Diagnosed Type 2 Diabetes

Wu Ming-Chin , Hu Ya-Hui

Several recent studies have shown that early intensive insulin therapy can improve β-cell function in newly diagnosed type 2 diabetes. However, in clinical practice, insulin therapy has not been widely used in out-patients due to the fact that insulin therapy is perceived by the patients as the strongest and the last remedy and patients fear that, once on that therapy, they will have to remain on it for life. In fact, based on our clinical data, out-patients, who were new...

ea0029p737 | Diabetes | ICEECE2012

The effect of nighttime glargine with morning NPH in type 2 DM.

Kim Y. , Shin D.

Recently basal insulin is the first recommended step when failed with oral medication, and adding morning NPH is one of step 1 intensive insulin treatment regimen when failed with basal insulin alone and post-lunch glucose level is high. But morning NPH or premixed insulin alone was the usual first step before basal insulin was available. When once a day morning insulin failed to reach target, next option was splitting twice a day injection. But many patients don’t agree ...

ea0029p738 | Diabetes | ICEECE2012

Telemedicine and Type 1 diabetes: A pilot project

Arrais R. , Diniz J. , Valentim R.

Type 1 diabetes is among the top rising problems in public health, since its incidence is growing in almost all series studied, all over the world. The gold standard for its control is based on achieving good metabolic control, through insulin, diet and regular physical activities, and it is delivered by a multiprofessional team in tertiary centers, which have enough resources (material and personnel). Scheduled visits are ideally programmed three to four times annually, but m...

ea0029p739 | Diabetes | ICEECE2012

The State of Therapeutic Patient Education in Diabetes

Tsutskiridze L. , Shelestova E. , Kurashvili R. , Asatiani N.

Background: It is impossible to provide qualified diabetes care without patient education (TPE). Effect of education on treatment outcomes was demonstrated in 1972. Unfortunately in 1970-ies we lived in society, where many progressive ideas were not acceptable. Though progress at the end of 1980-ies leading Centers started to implement TPE. Methods: In Georgia first “5-day in-patient education course” was initiated. It was carried out at our Center. The Course was ba...

ea0029p740 | Diabetes | ICEECE2012

Diabetes mellitus management in elderly over 80 years old.

Crea T. , Rosati S. , Malvaux S. , Cuny P.

Introduction: The prevalence of diabetes mellitus increases with age in all population. With the demographic transition and population aging, diabetes mellitus will be a major public health problem in all countries.Aims: to study the specific management of diabetes in very old subjects with multiple co morbidities and functional disabilities.Patients and Methods: We described a population of 199 diabetic patients aged 80 years and ...

ea0029p741 | Diabetes | ICEECE2012

Improving health numeracy: utilizing objective parameters to improve shared decision making for insulin initiation

Kalra S. , Agrawal N. , Kalra B.

Background: Health numeracy is the ability to understand, and act upon quantitative data, in an appropriate and effective manner. Health numeracy is distinct from health literacy. Health numeracy is associated with better self-management.Aims and objectives: This study was performed at two endocrine centres in north India, to assess and improve the health numeracy of patients with type 2 diabetes, with an aim to improving the quality of shared decision m...

ea0029p742 | Diabetes | ICEECE2012

Challenges and problems in the management of glycemia in patients with co-existing diabetes mellitus and a malignant disease in the Gerontology Institute - Hospice “Sue Ryder”-Skopje in the period of 2009–2011

Mitevska A. , Jakimovska J.

Objectives: Pointing out all the problems and challenges that the medical staff encounters in the management of the patients with a terminal malignant disease with co-existing diabetes mellitus.Methods: Medical documentation, laboratory results, US (Ultra Sound) etc.Results: The study included patients hospitalized in the Gerontology Institute - Hospice “Sue Ryder”-Skopje, with a capacity of 75 beds, in the period of 2009...

ea0029p743 | Diabetes | ICEECE2012

Efficacy and Safety of Insulin Glargine in Type-2 Diabetes Mellitus Patients with Moderate Renal Failure

Niafar M. , Nakhjavani M. , Esteghamati A. , Ziaie A. , Azmandian J. , Jahed A. , Khamseh M. , Yousefzadeh G. , Gozashti M. , Malek M.

Background and aims: Due to increasing risk of hypoglycemia, tight control of glycemia is difficult to achieve in the diabetic patients with diabetic nephropathy. Also, there are no absolute guidelines defining appropriate dosing adjustments of insulin in such patients. This study was aimed to determine the safety and efficacy of insulin glargine in type 2 diabetic patients with diabetic nephropathy.Methods: A total of 89 subjects with type 2 diabetes (m...

ea0029p744 | Diabetes | ICEECE2012

The weight reduction could be achieved on DPP-IV inhibitors in very obese T2D patients

Smirnov I. , Zhuravlyova L.

Incretin-based therapy can improve glucose control in type 2 diabetes (T2D) with no weight gain. Usually dipeptidyl peptidase-IV (DPP-IV) inhibitors considered as weight neutral and glucagon-like peptide-1 receptor agonists are associated with weight loss. Some trials showed non-remarkable weight-lowering effect on DPP-IV inhibitors. We aimed to identify patients on DPP-IV inhibitors which are likely to achieve both outcomes either good glycaemic control or weight loss.<p ...

ea0029p745 | Diabetes | ICEECE2012

Diabetes Mellitus Control Status of Turkish Diabetic Patients

Kudas O. , Aydin Y. , Kutlucan A. , Onder E. , Gokhan C. , Coskun H. , Kir S. , Yildizhan E.

Introduction: Our aim was to collect demographic data of diabetes mellitus (DM) patients to determine the patients education, follow-up and treatment priorities.Material-Method: 500 patients with diagnosis of DM followed up at least 6 months were included the study. Datas containing patients demographic characteristics, treatment modalities, biochemical parameters were retrospectively reviewed. On the day of admission patients; fasting blood glucose (FBG...

ea0029p746 | Diabetes | ICEECE2012

Insulin analogues in the treatment of diabetes

Lozanovska O. Lozanovska O.

Nowadays the human insulines and insuline analogues are used in the treatment of diabetes.The Advantages of modern insulinesBetter glycemic control;Reduction of hypoglycemiaThe reduction of the weight;Low variability of developing of the complication.The objective of the survey is to come up to the specific functional benefits about modern i...