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Endocrine Abstracts (2012) 29 P555

ICEECE2012 Poster Presentations Diabetes (248 abstracts)

Does the presence of thyroid antibodies affect the course and outcome of pregnancy in type1 diabetic women?

V Sarantopoulou , G Philippou , V Vasileiou , P Lymberi , L Sarika , M Alevizaki & E Anastasiou


Alexandra hospital, Athens, Greece.


Introduction: In the literature there are only three papers so far, addressing the impact of thyroid antibodies (Anti-TPO) on pregnancy in Type1 Diabetic Women (DM1) and these present conflicting results. The aim of the study is to evaluate the presence of Anti-TPO in DM1 pregnant women and whether these are related with differences in thyroid function, metabolic control and pregnancy outcome.

Methods: In 78 DM1 women with singleton pregnancies Anti-TPO, Anti-Tg, TSH, FT4I (T4/TBC) were measured each trimester. At each visit (every 1–2 weeks) blood glucose, HbA1c, BMI, units of insulin/kg were recorded, as were complications and pregnancy outcome.

Results: 27/78 women (34.6%) presented with positive Anti-TPO Abs. Clinical data of Anti-TPO positive and negative women are as shown in the table.

First trimester TSH levels were statistically different between the two groups.

There were no differences in the prevalence of diabetic complications, gestational hypertension-preclampsia, abortions or preterm deliveries.

Conclusion: One third of DM1 pregnant women presented with positive Anti-TPO Abs. However their presence is not related with worse metabolic control or adverse pregnancy outcome. It seems that early treatment of thyroid dysfunction and stricter metabolic control a plays more important role than the presence of thyroid antibodies with regard to the pregnancy outcome.

Table 1
Anti-TPO positive (n=21) Anti-TPO negative (n=57)
S.D.S.D.P
Age(years)29.1±4.528.8±4.9NS
Duration(years) 11.2±8.211.6±7.7NS
BMI(kg/m2)23.7±0.923.9±2.9NS
TSH 1st trimester(μIU/ml)2.4±1.61.3±1.00.005
TSH 2nd trimester(μIU/ml)2.5±1.81.7±1.10.0058
TSH 3rd trimester(μIU/ml) 1.5±0.81.7±0.9NS
FT4I 1st trimester95.0±12.7101.2±20.8NS
FT4I 2nd trimester112.6±24.5110.3±24.1NS
FT4I 3rd trimester106.1±14.4105.1±18.1NS
HbA1c 1st trimester(%) 6.5±1.26.5±1.7NS
HbA1c 2nd trimester(%) 5.3±0.95.4±0.9NS
HbA1c 3rd trimester(%) 5.2±0.85.2±0.6NS
Ins 1st trimester(IU/kg) 0.7±0.30.7±0.2NS
Ins 2nd trimester(IU/kg) 0.9±0.50.8±0.3NS
Ins 3rd trimester(IU/kg)1.1±0.71.0±0.4NS
Birth weight(g) 3215.0±408.33092.3±688.0NS

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Volume 29

15th International & 14th European Congress of Endocrinology

European Society of Endocrinology 

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