Endocrine Abstracts

Androgen secreting adrenal tumor is a rare cause of androgen excess in women. There are only few case-reports of androgen producing adenoma in a patient with congenital adrenal hyperplasia.Our patient, 61 year old woman was referred to our department for progressive hirsutism and androgenic alopecia. She did not mention neither excessive facial hair growth nor balding until age of 59 when rapidly progressive balding and overt hirsutism started. She has h...

We already know that woman with PCOS face increased risk of glucose intolerance, diabetes, metabolic syndrome and cardiovascular disease. However, it seems that it doesn’t apply to all women with PCOS and depends on their phenotypes.Aim of the study: Evaluation of tissue glucose utilization and lipid’s profile in different PCOS phenotypes.Materials and Methods: 69 PCOS women were divided into ten phenotypes groups, accord...

Aim: To assess lipid levels in patients with PCOS and normal body weight.Materials and methods: 139 patients admitted to the Gynaecologic Endocrinology Clinic of the Jagiellonian University’s Collegium Medicum agreed to take part in this research, and PCOS, according to the Rotterdam criteria, was found in 96 of them. The control group consisted of 43 patients with FAI <5. All of the 96 patients had a normal (BMI <25) body weight. This index...

Aim: To assess lipid levels in patients with PCOS and BMI >25.Materials and methods: 102 patients admitted to the Gynaecologic Endocrinology Clinic of the Jagiellonian University’s Collegium Medicum agreed to take part in this research, and PCOS, according to the Rotterdam criteria, was found in 87 of them. The control group consisted of 15 patients with FAI <5. All of the 87 patients had BMI >25. This index, as well as blood samples, we...

Objective: Changes of hypothalamic-pituitary-adrenal (HPA) axis activity, in particular decreased production of adrenal androgens, have been observed in patients with rheumatic diseases. However, data on adrenal steroid status in patients with psoriatic arthritis (PsA) are scarce. The present study was aimed at evaluation of HPA status in context of chronic inflammation in glucocorticoid-naïve premenopausal females with PsA.Subjects and methods: Con...

Introduction: Impaired fertility in women with Crohn’s disease compared to healthy women seems to be a consequence of Crohn’s disease, according to older studies. However, data are not consistent, and it is not clear why could the reduced fertility occur. Influence on ovarian reserve might be one of the answers.Patients: The study group consisted of women with Crohn’s disease. The control group consisted of age and BMI matched healthy wome...

Background: Although recombinant human TSH (rhTSH) is widely used to aid radioiodine treatment of differentiated thyroid cancer (DTC), however, there are data on its effectivness in children and adolescents with DTC.The aim of our retrospective study was to evaluate effectiveness and safety of rhTSH aided radioiodine treatment in DTC patients 18 years of age or younger.Material and Methods: Fifty five children/adolescents (median a...

Occurence of mycotoxins in various food and feed commodities is a worldwide problem. T-2 toxin is one of the most toxic trichothecene mycotoxin, produced mainly by Fusarium species. Poultry belongs to very sensitive species which are very often explored to toxic effects of mycotoxins. The aim of our in vitro studies was to examine secretion activity of ovarian granulossa cells to produce progesterone P4 after T-2 toxin and its combinations with res...

Introduction: Male hypogonadism is one of the most common endocrine disorders affecting 5.6% of men aged between 30–79 years. Testosterone deficiency (TD) is an independent risk factor for multiple cardiovascular risk factors including obesity, diabetes mellitus, hypertension, dyslipidaemia and endothelial dysfunction. The aims of testosterone replacement treatment (TRT) in hypogonadism are to improve or ameliorate the clinical features and to restore the serum T to physi...

The routine use of adjuvant RAI treatment in low-risk DTC remains controversial due to the lack of unequivocal evidences of its effectiveness in radically operated subjects. The aim of the study was a retrospective evaluation of long-term outcomes of combined DTC treatment to evaluate the impact of adjuvant RAI therapy in the low risk group. Primary hypothesis was: ‘if adjuvant RAI treatment was unnecessary, a delay in RAI administration would have no impact on long-term ...