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ea0073oc4.5 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2021

Lower level of sexual maturation rating and reduced concentrations of reproductive hormones, luteinizing hormone, follicle stimulating hormone, testosterone and estradiol in short stature children with mutations in growth hormone secretagogue receptor 1a

Kausar Nighat , Akram Maleeha , Shahid Gulbin , Qayyum Mazhar , Naseem Afzaal Ahmed , Tahir Fahim , Jahan Sarwat , KiranAfshan , Rafi Muhammad , Raza Rizvi Syed Shakeel

Puberty onset is sensitive to the energy reserves of the organism, especially in females where there is an association between obesity and early puberty. Studies have shown that in the presence of growth hormone secretagogue receptor 1a (GHSR1a) mutations, there is a decrease in ghrelin-mediated appetite, resulting in relatively low BMI, which contributes to the delayed onset of puberty. Furthermore, delayed puberty is observed in clinical conditions associated with low IGF1, ...

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Endocrine Abstracts

Lower level of sexual maturation rating and reduced concentrations of reproductive hormones, luteinizing hormone, follicle stimulating hormone, testosterone and estradiol in short stature children with mutations in growth hormone secretagogue receptor 1a

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