Endocrine Abstracts

Background: Hypothyroidism is a clinical condition caused by a deficiency of thyroid hormones or a decrease in their biological activity. Premature ventricular contractions (PVCs) are early depolarizations of the myocardium originating in the ventricles. Rhythms with frequent and apparently idiopathic PVCs are considered to be a benign condition that can be managed with conservative measures. Beta blockers are considered to be quite effective.Objective: ...

Background: Autoimmune thyroid diseases (AITD) are multifaceted conditions in which the thyroid gland is infiltrated by lymphocytes resulting in the production of thyroid-specific auto-antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb). Iron deficiency (ID) is considered to be the most common nutritional deficiency worldwide and has multiple effects on thyroid metabolism.Aim: The goal of this study is to measure the prevalence of auto...

A 65-year-old patient was hospitalized three times over a two-year period for severe acute pancreatitis. After the first hospitalization, cholecystectomy was performed. During the second hospitalization she was treated in the ICU because of the development of necrotizing emphysematous pancreatitis with the development of sepsis. During the third hospitalization the patient presents clinically with general weakness, agitation, visual hallucinations, disorientation and damaged c...

Introduction: Nearly 10% of all women have experienced hirsutism with hyperandrogenism at some stage in their life. Endogenous sources of androgen excess include ovarian tumours, ovarian hyperthecosis, and adrenal tumors. We present a case highlighting the work-up of hyperandrogenism.Case report: A 47-year-old female, with background of type 2 diabetes, hypertension, polycystic ovarian syndrome (PCOS), obesity, was noted to have significant androgenisati...

Background and objective: Human recombinant growth hormone (hrGH/GH) is an injectable medication used commonly for growth hormone deficiency (GHD) and other health conditions that reduce growth and adult height. Daily GH injections can burden families and result in poor adherence. This study was conducted to investigate caregivers’ experiences, attitudes and preferences regarding pediatric GH treatment. At the time of data collection, the long-acting GH products were not ...

Introduction: Liver Steatosis (LS) can be one of the metabolic complications of Cushing Syndrome (CS). The data on the impact of cortisol on liver function are very limited, according to one study the prevalence of LS in CS is 20%. However, the frequency seems to be much higher. Hepatic Steatosis Index (HSI) predicts LS based on ALT, AST, BMI, sex and co-existence of diabetes mellitus/impaired glucose intolerance. It can identify candidates for further liver examinations.<...

Cushing Syndrome (CS) is associated with a 18-fold higher risk of venous thromboembolism (VTE) when compared to the general population with the similar demographic characteristics. Despite numerous studies on hypercoagulability in CS, the unequivocal recommendations regarding timing and dosing of thromboprophylaxis in hypercortisolism are still lacking. We present a case series of patients with CS and VTE, hospitalized in the Endocrinology Department of University Hospital in ...

Introduction: Liver Steatosis(LS) can be one of the metabolic complications of Cushing Syndrome(CS). The data on the impact of cortisol on liver function are very limited, and there is only one study reporting a prevalence of LS of roughly 20%. Hepatic Steatosis Index (HSI) predicts LS based on ALT, AST, BMI, sex and co-existence of diabetes mellitus/impaired glucose intolerance.Objectives: To evaluate the prevalence of LS in patients with CS at the time...

A case presents a 35 year old woman with a history of Cushing Disease (CD) diagnosed in 2014, who developed multiple complications of long lasting hypercortisolemia- obesity (BMI 55), poorly controlled diabetes mellitus (DM), heart failure, hypertension, hypercholesterolemia, mental disturbances and significant hepatic impairment. She underwent a non-radical pituitary adenoma removal in 2014 with subsequent radiotherapy in 2018. Choice of pharmacological treatment was challeng...

Introduction: According to the literature, the CRH test has the highest specificity in excluding ECS (ACTH 93.9%, cortisol 89.4%). A combination of the high dose dexamethasone test (HDDST) and CRH/desmopressin test (CRH/desmopressinT) is used to increase the discriminatory capacity in ACTH-dependent CS.Objectives: This study aims to investigate the response to dynamic tests in ECS patients.Methods: 35 consecutive ECS patients were ...