Endocrine Abstracts

Background: Pregnancy and lactation-related osteoporosis can be associated with fractures during the last trimester or early postpartum period. During lactation, a 3–10% bone loss in the lumbar vertebrae has been detected within 3–6 months. When lactation is reduced bone mineral density(BMD) values reach early postpartum levels within 6–18 months. Certain comorbidities, such as hypercalciuria, premature ovarian failure, low body mass index, oligoamenorrhea, seve...

Osteoporosis is a skeletal condition of low bone mass and increased risk of fractures and occurs most commonly in postmenopausal women. Severe osteoporosis is characterised by the presence of fragility fractures and high mortality and morbidity. We present the case of a 21-year-old female with primary hyperparathyroidism (pHP) who, despite her young age, surprisingly presented with severe osteoporosis. The 21-year-old female was hospitalised due to a recurrent flare of Still&#...

Background: red blood cells (RBC) membrane fluidity in patients with type 2 diabetes mellitus (T2DM) can be influenced by various factors like oxidative stress, aging, glycosylation, lipid homeostasis and exposure to nutrients.Objective: To analyze RBC membrane fluidity in patients with long-duration T2DM (more than 10 years), looking for any differences between patients without and with macroangiopathy (vascular diabetic foot).Met...

Introduction and objective: The research was conducted with the aim of highlighting the awareness and understanding of the disease among diabetic patients.Methods: The study included 85 patients with type 2 diabetes, aged 40+ years old, who had been monitoring their blood glucose levels and HbA1c levels in the previous 4 months. Patients were presented a questionnaire with 5 questions about diabetes. The patients’ responses were classified and expre...

Background: Metformin is one of the first line drugs used to treat type 2 diabetes mellitus, even though there are still many gaps on how exactly metformin works. This is due to many years of research using various concentrations of metformin and also, not considering the conditional effect that glucose can have in its action.Objectives: Study the effect of different concentrations of metformin and glucose in cell culture.Methods: ...

Latent autoimmune diabetes of adulthood (LADA) is the most common form of autoimmune Diabetes diagnosed in Adults. Approximately 5–12%of cases in Europeans with apparent type2Diabetes are in facts misdiagnosed LADA. This is a heterogeneous condition that presents with clinical and laboratory manifestations common to type1diabetes and type2 diabetes. Its main feature is the presence of diabetes-associated autoantibodies (mostly autoantibody against glutamicaciddecarboxylas...

Background: Diabetes is the commonest cause of ketoacidosis, with alcoholic and starvation ketoacidosis encountered less frequently. We present a case of high anion gap metabolic acidosis whose features were not categorigal for usual causes.Case presentation: A 42-year-old female patient was admitted with a 3 day history of nausea, vomiting and abdominal pain, that begun 1 day after binge alcohol intake, on the background of alcohol excess. AKI, transami...

Background: Although most solid primary tumors can metastasize to the adrenal glands, lung cancer is the most common, followed by renal cell carcinoma, melanoma and colorectal cancer. However endometrial cancer metastasis to adrenal gland is very rare. There are only a few case in literature. Endometrial cancer is the most common gynecological malignancy. In this case, we present a case of adrenal gland metastasis of endometrial cancer.Case presentation:...

Background: Pituitary apoplexy is a rare complication of pituitary adenomas, especially nonfunctioning tumors. It is associated with severe headache, which may be accompanied by visual disturbances or ocular palsy. Here we present two patients who suffered from pituitary adenoma apoplexy while receiving anticoagulation therapy with non-vitamin K antagonists.Case presentation: A 74-year old woman was diagnosed with a non-functioning pituitary macroadenoma...

Cushing Syndrome (CS) is associated with a 18-fold higher risk of venous thromboembolism (VTE) when compared to the general population with the similar demographic characteristics. Despite numerous studies on hypercoagulability in CS, the unequivocal recommendations regarding timing and dosing of thromboprophylaxis in hypercortisolism are still lacking. We present a case series of patients with CS and VTE, hospitalized in the Endocrinology Department of University Hospital in ...

Background: There is preliminary evidence that prenatal maternal stress (PNMS) is a risk factor for attention deficit hyperactivity disorder (ADHD). Vitamin D deficiency during critical periods of development could lead to persistent brain alterations. Some studies support the hypothesis that prenatal Testosterone exposure contributes to the development of ADHD in children. This study aimed to investigate the hypothesis, that presence of prenatal maternal stress, increased lev...

Background: Premenstrual syndrome (PMS) and mental health disturbances have been identified as cardiovascular risk factors.Objectives: To determine the effects of Sars-CoV-2 infection on PMS and mental health.Methods: An anonymous survey about reproductive and mental health was shared with women of reproductive age between May and December, 2022. All women used their menstrual cycle (MC) diary while filling out the survey. Surveys ...