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Endocrine Abstracts (2023) 93 P22 | DOI: 10.1530/endoabs.93.P22

1Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, National Centre for Infertility and Endocrinology of Gender, Belgrade, Serbia; 2Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia, National Centre for Infertility and Endocrinology of Gender, Belgrade, Serbia, Belgrade, Serbia; 3Faculty of Medicine, University of Belgrade, Belgrade, Serbia, Belgrade, Serbia; 4Ukcs, Ukcs, Belgrade, Serbia; 5Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, National Centre for Infertility and Endocrinology of Gender, Belgrade, Serbia, Belgrade, Serbia; 6Clinical Hospital Centre ‘Dragisa Misovic’, Faculty of Medicine, University of Belgrade, Belgrade, Serbia, Department of Obstetrics and Gynecology, Belgrade, Serbia; 7Kbc Dr. Dragisa Misovic Dedinje, Clinical Hospital Centre ‘Dragisa Misovic’, Department of Obstetrics and Gynecology, Belgrade, Serbia, Belgrade, Serbia; 8Upstate Medical University, Syracuse, Ny, USA, Department of Psychiatry and Behavioral Sciences, Syracuse, United States, Syracuse, United States; 9Clinic For Endocrinology, Diabetes and Metabolic Disease, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia, National Centre for Infertility and Endocrinology of Gender, Belgrade, Serbia, Belgrade, Serbia.


Background: Premenstrual syndrome (PMS) and mental health disturbances have been identified as cardiovascular risk factors.

Objectives: To determine the effects of Sars-CoV-2 infection on PMS and mental health.

Methods: An anonymous survey about reproductive and mental health was shared with women of reproductive age between May and December, 2022. All women used their menstrual cycle (MC) diary while filling out the survey. Surveys were stratified based on RT-PCR/Antigen test results: positive (CP) or negative (CN). All reported changes in CP referred to time after the Sars-CoV-2 infection and in CN to a pandemic period in general.

Results: 704 women completed the survey. Based on inclusion, exclusion, and complete data availability 461 surveys were taken into the final analysis: 129/28% CN-mean age 28.8±9.7, mean BMI 22.5±4.1 kg/m2, and 332/72% CP, mean age 28.3±8.7, mean BMI 22.3±3.7 kg/m2, with no difference in age or BMI between the groups (P>0.05). 94/20.3% of CP reported shortening of MC length (P=0.001) and worsening of PMS (wPMS) (P<0.001). 61/64.9% CP with wPMS reported worsening of their mental health (P=0.02); 42/44.7% CP women with wPMS reported low mood (P=0.02), 34/36.2% anxiety (P<0.001), 37/39.4% poor sleep (P<0.001), 33/35.1% diminished concentration (P<0.001), and 26/27.7% reported repeated partner/family conflict (P=0.004). 26/27.7% CP with wPMS reported increased appetite (P=0.001), 42/44.6% decreased physical activity (P<0.001), and 56/59.5% reported weight gain (P=0.017); these changes weren’t observed in CN. In 73/67% CP wPMS was still present (P<0.05) with an average duration of 280 days. In CP, Sars-CoV-2 infection was the only wPMS predictor (P=0.001, B=1.046, OR 2.847; 95% CI=1.544–5.250).

Conclusions: Sars-CoV-2 infection leads to PMS worsening associated with weight gain and mental health disturbances, further adding to the already established COVID-19 cardiovascular risk. Identification of these patients and timely treatment could prevent potential cardiovascular events.

Volume 93

ESE Young Endocrinologists and Scientists (EYES) 2023

European Society of Endocrinology 

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