Endocrine Abstracts

Contents

• ESE Young Endocrinologists and Scientists (EYES) 2023
• • Oral Communications
  • Oral communication 1: Adrenal Diseases
  • • Generation and characterization of CYP21A2-I173N MICE: A humanized mutant animal model for 21-hydroxylase deficiency

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    • Morbidity in patients with chronic adrenal insufficiency - cardiovascular risk factors and hospitalization rate compared to population based controls

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    • Preoperative 1 mg dexamethasone suppression test predicts hypothalamus-pituitary-adrenal axis recovery: A one-year retrospective study of adrenal incidentalomas undergoing unilateral adrenalectomy

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    • Constitutional duplication of PRKACA gene is a cause of isolated primary pigmented nodular adrenocortical disease (PPNAD): Results of its systematic search in bilateral nodular adrenal disease

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    • Enhanced inflammation and steroidogenesis sensitize adrenal cells to ferroptosis

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    • Outcome of surgical versus conservative management in patients with mild autonomous cortisol secretion

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    • Clinical prediction model for primary aldosteronism subtyping and special focus on adrenal volumetric assessment: A pilot study

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    • FKBP5 methylation in adrenal insufficiency: Looking at a new tool for assessing the quality of glucocorticoid replacement?

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  • Oral communication 2: Neuroendocrinology
  • • Effect of protein supplementation on plasma sodium levels in the syndrome of inappropriate antidiuresis - a monocentric open-label proof-of-concept study - the treasure study

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    • Effects of glucagon-like peptide-1 receptor agonists on copeptin in healthy volunteers and patients with primary polydipsia

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    • Soluble alpha klotho, a new biomarker of growth hormone action

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    • Psychopathological characteristics in patients with arginine vasopressin deficiency (central diabetes insipidus) and primary polydipsia

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    • Hypogonadotropic hypogonadism in a patient with Allgrove syndrome: A case report

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    • Comparison of metyrapone, osilodrostat and ketoconazole in the short-term therapy of endogenous Cushing's syndrome: Preliminary results of the Mosketeer study

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  • Oral communication 3: Adrenal Tumors and Neuroendocrine Tumors
  • • Targeting the ferroptosis-macrophage crosstalk in adrenocortical carcinoma

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    • Bone fragility in well-differentiated gastroenteropancreatic-neuroendocrine tumors: Results from a retrospective two-centered study

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    • Preclinical and clinical evidence of progesterone/megestrol acetate activity in metastatic adrenocortical carcinoma

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    • Towards an understanding of the microenvironment of ACC: Impact of steroid hormones and driver pathways

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    • FGF/FGFR signaling in adrenocortical tumorigenesis: Novel potential therapeutic targets in adrenocortical carcinoma

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    • ROR-1 specific CAR-T cells with CRISPR/CAS9 mediated glucocorticoid receptor-knockout exert potent antitumor efficacy in advanced adrenocortical carcinoma

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    • Identification of adrenocortical masses malignancy through radiomics: A pilot study

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  • Oral communication 4: Pituitary and Neuroendocrinology
  • • Comparative evaluation of diagnostic performance of the most commonly used screening tests for pathological hypercortisolism: A single centre analysis

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    • Different molecular forms of pituitary adenomas, explaining behavior and prognosis. A new concept

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    • Transcriptome in paraffin samples for the diagnosis and prognosis of pituitary neuroendocrine tumors (PITNETS)

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    • The genetic background of acromegaly in a tertiary referral centre in Krakow, Poland

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    • Whole blood transcriptomic signature of Cushing's syndrome

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    • The role of the GH receptor polymorphisms as a prognostic factor of vertebral fractures in acromegalic patients resistant to first-generation SSAs and treated with Pegvisomant or Pasireotide Lar

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    • Hepatic Steatosis Index as a non-invasive marker for liver steatosis in patients with endogenous Cushing Syndrome, ERCUSYN Krakow database

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    • Folliculo-stellate cells in nonfunctioning pituitary neuroendocrine tumors

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  • Oral communication 5: Reproductive Endocrinology
  • • Quantification of 27 sex hormones, precursors and metabolites thereof in human plasma by a mass spectrometry-based method combining direct detection and specific hydrolysis of glucuronide conjugates

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    • Luteinizing hormone/choriogonadotropin receptor (LHCGR)/G protein-coupled estrogen receptor (GPER) heteromers impact on reproductive signals

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    • Follicle stimulating hormone in male idiopathic infertility: How to predict its efficacy?

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    • Variants in the neurodevelopmental gene bone morphogenic protein/retinoic acid inducible neural-specific 2 (BRINP2) are associated with severe delayed puberty

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    • Testosterone serum levels in idiopathic male infertility: An epidemiological insight with pathophysiological and clinical consequences

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    • Alteration of adrenal and sex steroid profiles in pregnant women with preeclampsia

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    • Evolution of cardiovascular risk markers in polycystic ovary syndrome: Results from a long-term monocentric cohort study

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    • Regulation of the postnatal activity of the HPG axis in male Callithrix jacchus - A project description

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    • Body composition in association with serum anti-Mullerian hormone (AMH) levels in adult males implies hemodilution effects

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  • Oral communication 6: Thyroid Diseases and Tumors
  • • Loss of thyroid receptor beta (THRB) results in circadian rewiring of the transcriptome and lipidome in livers of adult male mice

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    • Thyroid hormone (TH) action in acute and chronic ischemic heart disease

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    • Clinical features of synchronous medullary and papillary thyroid carcinomas presenting as collision tumor

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    • Hyperthyroidism in 2 forms: The Marine-Lenhart syndrome

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  • Oral communication 7: Diabetes, Obesity and Metabolism
  • • Statin use and perimenopausal BMI determine the risk of incident diabetes mellitus in the postmenopause: Results of Palladia study

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    • Insulin secretion defect in children and adolescents with obesity: Clinical and molecular genetic characterisation

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    • Influence of diabesity in the visceral adipose tissue miRNA expression profile

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    • Glycaemic and inflammatory profile changes in patients with hybrid closed loop systems

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    • Amino acids and biogenic amines circadian fluctuation in health and in hypercortisolism states

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    • Abstract unavailable

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    • Effects of chronic pancreatitis in beta-cell function and incretin secretion

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  • Oral communication 8: Interdisciplinary Endocrinology and Environment, Society and Governance
  • • Bisphenols in adrenocortical cell culture

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    • Identifying and characterizing novel HSP90 inhibitors with senolytic activity in a hormone-induced breast cancer-senescence model

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    • Factors determining number of top performances in short, middle, and long-distance running in women - impact of doping, antidoping and testosterone limitations

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    • Metabolic and growth outcome of two-years growth hormone treatment in children born small for gestational age (SGA): A retrospective study

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  • Oral communication 9: Calcium and Bone
  • • Bone metabolism in mice requires canonical TRA action

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    • Pregnancy-related osteoporosis - difficulties regarding diagnosis and treatment

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    • Parameters of calcium and phosphate homeostasis in patients with predialysis CKD in response to 150 000 IU cholecalciferol treatment

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    • Challenging diagnosis and management of tumor induced osteomalacia - A story of alternating bad news and good news

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• Poster Presentations
• • Guided Poster Tour 1: Adrenal and Neuroendocrine tumors
  • • Proposition of an histopathological classification of bilateral macronodular adrenal disease (BMAD) and its correlation with ARMC5 and KDM1A mutations

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    • Assessment of the hypothalamus-pituitary-adrenal axis in patients following adrenalectomy

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    • MEN 2 syndrome heterogeneity in a cohort of Romanian patients

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    • Decrease in anticortisolic drug osilodrostat plasma exposure in patients treated with mitotane for an adrenocortical carcinoma

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    • An overview of adrenal vein sampling for primary aldosteronism in Croatia (2016-2023)

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    • New possible pathogenic variants involved in pheochromocytomas and paragangliomas

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    • Identification and characterization of biologically active small molecules against primary aldosteronism driver mutations

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    • Remission rate of primary aldosteronism after unilateral adrenalectomy

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    • A rare case of bilateral micronodular adrenal cortical disease

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    • The fibroblast growth factor-23/Klotho axis in patients with acromegaly

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  • Guided Poster Tour 2: Miscellaneous
  • • Postpartum osteoporosis: A case report

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    • Severe osteoporosis in a 21-year-old female with primary hyperparathyroidism and multiple additional risk factors

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    • Analysis of membrane fluidity in patients with vascular diabetic foot

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    • Assessment of knowledge and awareness of disease in patients with diabetes

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    • Metformin effect on retinal epithelial cells under different concentrations of glucose

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    • If not soon, at least not late (two cases report of Lada)

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    • Alcohol induced ketoacidosis with hyperglycaemia: A case report

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    • Adrenal gland metastasis of endometrial cancer: A case report

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    • Two cases of anticoagulation-induced pituitary macroadenoma apoplexy

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    • Venous thromboembolism in Cushing syndrome - A call for standardized anticoagulation regimen in hypercortisolism

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    • Association of the elevated level of prenatal testosterone, maternal stress and vitamin D3 deficiency during pregnancy with the development of ADHD like symptoms in toddlers

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    • Post-covid precipitates cardiovascular risk in women - premenstrual syndrome worsening, weight gain, and mental health disturbances

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