Searchable abstracts of presentations at key conferences in endocrinology

ea0090p74 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Assessment of insulin-releasing and glucose-lowering actions of aqueous extracts of Pterocarpus mildbraedii cellular and diet-induced mice models of type 2 diabetes

Ojo Opeolu , Benjamin Falana Ayokunle , Abiodun Falobi Ayodele , Kaur Heer Simren , Adie Mojisola , Nneka Edeani Joy , Anyanwu Gabriel , Ejike Uju

Aim: The use of commonly consumed vegetables, such as Pterocarpus mildbraedii, in the treatment of metabolic conditions is consistent with the food-as-medicine strategy. To characterise its pharmacological actions, this study assessed insulin-releasing and glucose lowering effects of effects of P. mildbraedii in models of type 2 diabetes.Methods: Clonal pancreatic cells, BRIN-BD11, were treated P. mildbraedii extracts...

ea0099p482 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

The conjugation of tigerinin-1r with modified gastric inhibitory polypeptide enhanced its cellular uptake and metabolic actions

Ojo Opeolu , Abiodun Falobi Ayodele , Nneka Edeani Joy , Amy Ofosu Wendy , Smyth Lesley , Corcoran Olivia , Dunmore Simon

Aim: Previous reports indicate therapeutic potentials of tigerinin-1R, isolated from the skin secretions of Hoplobatrachus rugulosus, as an antidiabetic agent. Despite the report of its insulin-releasing effects, the peptide’s mechanism of actions is poorly understood. This study investigates the impact of conjugation of tigerinin-1R with (dAla2)-GIP on the cellular uptake and anti-diabetic actions of the peptide.Method: Amphipathicity, net...