Endocrine Abstracts

Background: Subacute thyroiditis (SAT) is typically a self-limiting condition, with patients usually returning to normal thyroid function after healing. However, very rarely, Graves’ disease (GD) may develop following SAT. Case presentation: A 50-year-old female patient presented to an outside internal medicine outpatient clinic with anterior neck pain, fatigue, and subclinical fever symptoms. Her medical history included a diagnosis of psoriatic ar...

Background: Primary hyperparathyroidism (PHPT) is associated with various musculoskeletal complaints. It is difficult to evaluate muscle strength as it is hard to extract objective data due to lack of definite methods for measurement.Objective: To assess the differences between PHPT patients and healthy controls regarding maximum foot force and plantar pressure distribution by using platform pressure measuring system [Footscan (RSscan)].<p class="abs...

Background: ChatGPT, an advanced language model, employs sophisticated deep learning techniques to generate human-like responses. It stands as one of the most extensive publicly accessible language models. Despite the longstanding application of Artificial Intelligence (AI) in diverse domains, its application in healthcare raises concerns about the reliability of information. It is equally important to assess whether the provided information is supported by dependable referenc...

Background: Proton-density fat fraction (PDFF), derived from chemical shift encoding-based water-fat magnetic resonance imaging, has emerged as an important surrogate method for calculation of fat composition in a number of tissues including liver, vertebrae and muscles. This study aims to determine whether fat composition of these tissues, as well as visceral and subcutaneous adiposity differ between women with PCOS and healthy controls.Methods: 17 lean...

Background: Immune function and responses are tightly regulated by the circadian clock system and hypothalamic-pituitary-adrenal (HPA) axis. Accumulating evidence supports that there is a strong mutual relationship between these two regulatory systems at multiple levels. Recent publications suggest that the clock system may also regulate glucocorticoid release from adrenal glands by altering the sensitivity of the adrenal cortex to adrenocorticotropic hormone (ACTH).<p cla...

Background: Circadian rhythmicity is generated by a set of genes including Period3. Changes in the expression of Period3 and other clock genes have been linked with regulation of the immune system. Period3 polymorphisms have been associated with circadian disruption and so immune system dysregulation and altered secretion of several cytokines, which can lead to inflammatory and autoimmune disorders.Aim: To investigate the influence of a polymorphism in P...

Background: Endocrine-related adverse effects of immune check-point inhibitors (ICIs) have been identified in growing number of cancer patients.Case presentation: A 49-year-old male with laryngeal cancer applied to ouroutpatient clinic with weakness, loss of appetite, weight loss, nausea and vomiting for the last three weeks. He was diagnosed with T3N1M0 laryngeal squamous cell cancer seven months before this admission and was given concurrent cisplatin ...

Introduction: Pregnancy occurs relatively rare women with acromegaly. However, in recent years, pregnancy has become more likely to occur in acromegalic women possibly due to improvements in acromegaly treatment, and advanced assisted reproduction techniques.Methods: In this case series, we retrospectively analyzed 11 pregnancies of 8 acromegalic women followed in the university hospital in a time range between 2009–2019. Data were obtained from pa...

Background: The effects of gender-affirming hormonal therapy (GAHT) on body composition in transgender people assigned female at birth (AFAB) have been an area of interest. However, the impact of GAHT on muscle strength remains inadequately studied. We aimed to evaluate early alterations in muscle strength following GAHT in transgender people AFAB by isokinetic dynamometry, the gold standard for assessment of strength.Subjects and Methods: A total of 20 ...

Background: Adult beta-thalassemia patients experience various endocrine complications associated with iron deposition. However, data regarding adrenal insufficiency (AI) are limited.Subjects and Methods: A total of 104 beta-thalassemia patients examined between 2015 and 2024 in our outpatient clinic had at least one measurement of morning serum ACTH and cortisol levels. At the time of presentation, two male patients had already been diagnosed with prima...