Endocrine Abstracts

Objectives: Leptin is an adipokine responsible for controlling appetite and fat accumulation. The role of leptin in pathophysiology of obesity and diabetes mellitus is an area of active investigation.The aim was to study leptin levels in diabetic and nondiabetic patients with increased body mass index (BMI).Methods: A sample of 246 patients with type 2 diabetic mellitus and 86 age and BMI-matched controls were examined. The mean age of the participants w...

Objectives: Adiponectin is an adipokine that play an important role in glucose metabolism and energy homeostasis. The aim of our study was to evaluate adiponectin levels in type 2 diabetes mellitus patients compared with healthy controls.Methods: A sample of 246 patients with type 2 diabetic mellitus and 86 age and BMI-matched controls were included. The mean duration of diabetes was 9.54 (5–13) years. The mean glucose level was 8.14 (5.56–9.9)...

Background and aims: There is compelling evidence that the decline in appendicular muscle mass is a poor prognostic factor for the development of chronic complications of diabetes. In addition to chronic hyperglycemia, reduction of muscle component may be determined by metabolic disorders. Therefore, the aim of study was to assess the possible links between serum myostatin, IGF-1 and a reduction in muscle mass in type 1 diabetes mellitus (T1DM).Materials...

Background: There is convincing evidence that the increasing of visceral fat is a risk factor for vascular disease. Type 1 diabetes mellitus (T1DM) is characterized by the development of micro-, and later, and macrovascular complications. The aim of the study was to examine features of body composition fat distribution parameters in T1DM patients.Materials and methods: 96 patients with T1DM (59 women and 37 men) (mean age: 32.52±10.71 years, duratio...

Osteoporosis is a common skeletal disease characterized by low bone mass and microarchitectural deterioration with increased susceptibility to fracture. Osteoporosis has a complex etiology and is considered to be a multifactorial polygenic disease. There are more than 150 genes associated with bone mineral density. Our aim was to investigate the frequency of occurrence of vitamin D receptor (VDR) – (FokI, BsmI, ApaI, TaqI) – single nucleotide polymorphisms (SNPs) in ...

Objective: Diabetes mellitus represent a demanding set of biopsychosocial challenges(depression, anxiety disorders, eating disorders) for patients and their families regardless of the age of disease onset. Disordered eating behaviors and eating disorders(ED) represent a spectrum of symptoms that may include restricted caloric intake, distorted body image, binge eating and/or purging behaviors such as excessive exercise, vomiting, and the use of laxatives to lose weight. The pr...

Aims: The clinical and radiological observation of patients with diabetic osteoarthropathy (DOAP) was carried out with the aim of determining the most significant factors in type 1 and type 2 diabetes mellitus (DM) patients.Methods and materials: Anamnesis, clinical and radiological data were analsed in 28 DOAP patients. The patients were divided into two groups according to the type of diabetes: group 1 included 14 patients with type 1 DM (mean age 37.8...

Status of carbohydrate metabolism in patients with hypercalcaemia and the influence of hypercalcemia on the risk of type 2 diabetes continue to be studied.Objective: To study the prevalence of type 2 diabetes in patients with hypercalcemia and in patients without hypercalcemia.Materials and methods: Continuous survey of 1000 people, average age 54.68±16.96 (727 women, 273 men) from 18 to 96 years. Examination: total calcium, t...

Status of carbohydrate metabolism in patients with primary hyperparathyroidism (PGPT) has been studied extensively in recent years, but the results of studies on the impact of long-term elevated levels of parathyroid hormone and hypercalcemia on the risk of type 2 diabetes continues to be in the discussion.Objective: To study is to examine the prevalence of type 2 diabetes in patients with manifested and asymptomatic PGPT.Materials...

Background: It is known that the prevalence of skin diseases in patients with type 2 diabetes (T2D) is increased including psoriasis. Patients with T2D and psoriasis have an increased risk of psoriasis exacerbations. The study of the psoriasis manifestation features in patients with T2D can help to reduce the number of exacerbations, their severity and duration.Aims: To study the influence of T2D on the psoriasis manifestation and exacerbation. Materials...