Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep581 | Hot topics (including COVID-19) | ECE2020

Oral antioxidants improve sperm motility, sperm concentration and reduce oxidative stress in males with oligoasthenozoospermia

Zhaku Vegim , Beadini Sheqibe , Beadini Nexhbedin , Xhaferi Vjosa , Milenkovic Tatjana

Male infertility is a worldwide healthcare issue, which has driven developed countries to take the necessary steps in detecting and treating the problem. While transition countries such as North Macedonia and most of the surrounding states belonging to the Western Balkans, usually blame the female partner for infertility, thus male factor is underestimated. The term ‘milieu intérieur’ means also a perfect equilibrium between reactive oxygen species (ROS) and a...

ea0081p225 | Thyroid | ECE2022

Comparison in lipid parameters before and after L-thyroxine treatment in subclinical hypothyroidism according to the presence of thyroid peroxidase antibodies

Velkoska Nakova Valentina , Krstevska Brankica , Cheshlaroska Markushoska Katerina , Jovanovska Mishevska Sasha , Milenkovic Tatjana

Objective: Subclinical hypothyroidism (ScH) is a common condition and may be associated with dyslipidemia. We investigated the effect of levothyroxine therapy (L-T4) on lipid parameters in patients with a mild form of subclinical hypothyroidism according to the presence of thyroid peroxidase antibodies (anti-TPO antibodies). Material and methods: Fifty-seven patients with newly diagnosed ScH (TSH levels between upper reference value and 10 mIU/l with nor...

ea0090ep890 | Pituitary and Neuroendocrinology | ECE2023

Case report of a patient with paraganglioma diagnosed after surgery

Cheshlaroska Markushoska Katerina , Milenkovic Tatjana , Cheshlaroska Hristina , Bilaloglu Jovanoska Belma , Tafa Arta

Introduction: Paraganglioma is a tumour derived from extra-adrenal chromaffin cells of the sympathetic paravertebral ganglia of the thorax, abdomen and pelvis. About 36 % to 60 % of the paragangliomas are functional secreting norepinephrine and normetanephrine, which cause hypertension. Non-functional paragangliomas can produce Chromogranin A. Paragangliomas also arise from the parasympathetic ganglia located along the glossopharyngeal and vagal nerves in the neck and at the b...

ea0070ep518 | Thyroid | ECE2020

Management of subclinical hyperthyroidism presented by several cases

Velkoska Nakova Valentina , Krstevska Brankica , Pemovska Gordana , Ahmeti Irfan , Milenkovic Tatjana

Subclinical hyperthyroidism (ScHyper) is a condition with suppressed TSH, and normal free T3 and free T4 hormones, affecting 10% of the population. There are two subgroups of patients, the first group with TSH lower than 0.1 U/l, and the second group with mildly suppressed TSH between 0.1 and the lower assay reference limit. The patients from the first group should be treated, but there is no evidence for therapy for the second group of patients.We prese...

ea0099p384 | Thyroid | ECE2024

Echocardiographic differences between the mild form of subclinical hypothyroidism and healthy subjects

Velkoska Nakova Valentina , Krstevska Brankica , Srbinovska Kostovska Elizabeta , Georgievska Ismail Ljubica , Volkanovska Ilijevska Cvetanka , Milenkovic Tatjana

Background: Treatment of subclinical hypothyroidism (ScH) when TSH is between the upper reference value and 7mU/L, especially in patients younger than 65 years is controversial.Objectives: To compare the risk factors for atherosclerosis and echocardiographic parameters in patients with ScH1 (4, 2≤TSH≤7mU/L) to euthyroid subjects and patients with ScH2 (TSH>7mU/L).Material and Methods: Prospectively 54 consecutive pa...

ea0070aep737 | Pituitary and Neuroendocrinology | ECE2020

Body composition and bone mineral density in 107 patients with childhood onset growth hormone deficiency (CO-GHD) at the time of transition from pediatric to adulthood endocrine care

Doknic Mirjana , Stojanovic Marko , Milenkovic Tatjana , Zdravkovic Vera , Maja Jesic , Todorovic Sladjana , Katarina Mitrovic , Vukovic Rade , Miljic Dragana , Pekic Djurdjevic Sandra , Soldatovic Ivan , MilanPetako

Transition from childhood to adulthood is a vulnerable period in all adolescents and particularly inCO-GHD patients. Low bone mineral density (BMD) and body composition alterations are frequently reported in young adults with CO-GHD, but relevant large monocentric studies are lacking.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study conducted from 2005–2019, 107 CO-GHD patients were analyzed (17–26 yea...

ea0056p748 | Neuroendocrinology | ECE2018

Metabolic status, body composition and bone mineral density in 85 patients with childhood onset growth hormone deficiency (COGHD) in transition period

Doknic Mirjana , Milenkovic Tatjana , Zdravkovic Vera , Jesic Maja , Todorovic Sladjana , Mitrovic Katarina , Vukovic Rade , Miljic Dragana , Pekic Sandra , Soldatovic Ivan , Stojanovic Marko , Petakov Milan

Transition from childhood to adulthood is particularly important in patients with COGHD mainly because of the associated metabolic abnormalities, inadequate body composition and decreased bone mineral density (BMD). There is a lack of large monocentric studies related to this issue.Design: Monocentric, observational, retrospective cross-sectional study.Patients: We collected 85 COGHD patients (58 males, aged 17–26 years) trans...

ea0099p347 | Pituitary and Neuroendocrinology | ECE2024

Safety profile of growth hormone replacement (GHr) in GH deficient patients during transition period treated for intracranial tumors and malignancy in childhood- Single center expirence

Doknic Mirjana , Curcic Mihajlo , Stojanovic Marko , Milenkovic Tatjana , Zdravkovic Vera , Jesic Maja , Todorović Slađana , Milicevic Mihailo , Stanimirovic Aleksandar , Scepanovic Vuk , Mitrović Katarina , Vukovic Rade , Miljic Dragana , Pekic Djurdjevic Sandra , Cekic Ivana , Jevtic Ivan , Manojlovic Gacic Emilija , Grujicic Danica , Petakov Milan , Soldatovic Ivan

Introduction: Considering the mitogenic potential of GH and IGF1, the safety profile of growth hormone therapy since the beginning of its use has been debated. From that point of view, adolescents in transition to adulthood who were treated in childhood for endocranial tumors or malignancies require special caution.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study spanning 18 years, we analyzed 251 childhood onset...

ea0078p1 | Adrenal | BSPED2021

Analysis of therapy monitoring in the International Congenital Adrenal Hyperplasia Registry

Lawrence Neil , Bacila Irina , Dawson Jeremy , Bryce Jillian , van den Akker Erica , Sartori Sanchez Bachega Tania Aparecida , Baronio Federico , Birkebaek Niels Holtum , Bonfig Walter , Claahsen Hedi , Correa Costa Eduardo , Devries Liat , Elsedfy Heba , Guven Ayla , Hannema Sabine , Iotova Violeta , van der Kamp Hetty J , Clemente Leon Maria , Lichiardopol Corina Raducanu , Milenkovic Tatjana , Neumann Uta , Nordenstrom Ana , Poyrazoglu Sukran , Probst-Scheidegger Ursina , De Sanctis Luisa , Thankamony Ajay , Vieites Ana , Yavas Zehra , Ahmed Faisal , Krone Nils

Background: Congenital Adrenal Hyperplasia (CAH) requires exogenous steroid replacement and can be monitored with 17-OH Progesterone and Androstenedione. We reviewed real world data to evaluate these markers in relation to hydrocortisone dose in patients treated in 21 centres throughout 14 countries.Method: Retrospective cohort study using pseudonymised data from patients with 21α-Hydroxylase Deficiency recorded in the International Congenital Adren...

ea0066oc1.1 | Oral Communications 1 | BSPED2019

Exploring trends in the glucocorticoid and mineralocorticoid treatment of congenital adrenal hyperplasia by analysing data from the I-CAH registry

Bacila Irina-Alexandra , Blankenstein Oliver , Neumann Uta , Grinten Heidi L Claahsen-van der , Krone Ruth , Bachega Tania SS , Miranda Mirela C , Mendonca Berenice , Birkebaek Niels H , Cools Martine , Milenkovic Tatjana , Bonfig Walter , Tomlinson Jeremy W , Elsedfy Heba , Balsamo Antonio , Ortolano Rita , Hannema Sabine , Higham Claire , Atapattu Navoda , Lichiardopol Corina , Guran Tulay , Abali Zehra , Mohnike Klaus , Finken Martijn JJ , Vieites Ana , Darendeliler Feyza , Guven Ayla , Korbonits Marta , Vries Liat de , Costa Eduardo , Einaudi Silvia , Kamp Hetty van der , Iotova Violeta , Ross Richard , Ahmed S Faisal , Krone Nils

Introduction: There is no unified approach in clinical practice regarding the medical management of congenital adrenal hyperplasia (CAH), despite existent international guidance. We aimed to explore geographical and temporal variations in the treatment with glucocorticoids and mineralocorticoids of patients with CAH.Methods: We collected data recorded by 33 centres from 16 countries in the I-CAH Registry. We analysed patient visits between 1982 and 2018,...