ECE2020 Audio ePoster Presentations Pituitary and Neuroendocrinology (217 abstracts)
Body composition and bone mineral density in 107 patients with childhood onset growth hormone deficiency (CO-GHD) at the time of transition from pediatric to adulthood endocrine care
Mirjana Doknic 1,2 , Marko Stojanovic 1,2 , Tatjana Milenkovic 3 , Vera Zdravkovic 2,4 , Jesic Maja 2,4 , Sladjana Todorovic 3 , Mitrovic Katarina 3 , Rade Vukovic 2,3 , Dragana Miljic 1,2 , Sandra Pekic Djurdjevic 1,2 , Ivan Soldatovic 2,5 & MilanPetakov 1,2
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Department of Neuroendocrinology, Belgrade, Serbia; 2University of Belgrade, Medical Faculty, Belgrade, Serbia; 3Mother and Child Health Care Institute of Serbia’Dr Vukan Cupic’, Department of Endocrinology, Belgrade, Serbia; 4University Children’s Clinic Tirsova, Department of Endocrinology, Belgrade, Serbia; 5Institute of Medical Statistics and Informatics, Belgrade, Serbia
Transition from childhood to adulthood is a vulnerable period in all adolescents and particularly inCO-GHD patients. Low bone mineral density (BMD) and body composition alterations are frequently reported in young adults with CO-GHD, but relevant large monocentric studies are lacking.
Patients and Methods: In a monocentric, observational, retrospective cross-sectional study conducted from 2005–2019, 107 CO-GHD patients were analyzed (17–26 years old, 80 males) at the time of transfer from pediatric to adult endocrine care. Median age at transfer was 19.6 ± 2.2 years. Subjects withcongenital and idiopathic GHD (CON) were compared with age-, sex- and BMI-matched patients with hypothalamic/pituitary tumor history (TUM). Body composition (% fat, fat mass – FM and lean body mass – LBM) and BMD in lumbar spine (LS) and femoral neck (FN) – (BMD g/cm2, Z score) were analyzed by DXA.
Results: Congenital and idiopathic causes of GHD were more frequent than hypothalamic/pituitary tumoral causes (74.8% vs 25.2%).All patients received GH replacement during childhood for average duration of 5.4 ± 1.4 yrs. GH replacement was discontinued prior to transfer for 2.7 ± 0.9 yrs. Recovery of GH/IGF-I axis was confirmed by retesting in 15.5%. Percentage of fat was significantly higher in TUM vs CON (30.1 vs 34.0 kg; P < 0.05) and LBM was significantly higher in CON (46.2 vs 40.1 kg; P < 0.05). BMD (g/cm2) and Zsc in LS and FN were lower in TUM (> P 0.05) while FM was higher in TUM (P > 0.05).
Conclusion: Patients with CO-GHD caused by hypothalamic/pituitary tumors demonstrated worse body composition and lower BMD at the time of childhood to adulthood transition compared to matched transition patients with congenital CO-GHD
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more