Endocrine Abstracts

IntroductionParagangliomas (PGL) of the urinary bladder are an extremely rare entity. During pregnancy, PGL can carry higher risk of foetal and maternal mortality, which can be significantly reduced when the diagnosis is made antepartum and adequate multidisciplinary management and surveillance is started. However, despite clinical stability, delivery complications rates are still higher than in the general obstetric population.Cas...

IntroductionNon-classical congenital adrenal hyperplasia (NC-CAH) is a chronic disease characterized by excessive androgen production. Affected children may have their quality of life negatively affected by the awareness of a medical condition, symptoms of hyperandrogenism and the burden of daily medication administration. Pediatric Quality of Life Inventory 4.0 (PedsQL) is a validated tool to assess health-related QoL (HRQoL).Meth...

Background: Neuroendocrine neoplasms (NENs) are rare group of tumors with a different clinical course, prognosis and location. Radioligand therapy (RLT) is currently registered in gastroenteropancreatic (GEP) G1-G2 NENs. Tumors with an unknown point of origin, diagnosed outside the gastrointestinal tract and pancreas, or with Ki-67 >20%, do not qualify in many countries to standard RLT.Materials and Methods: 48 patients with progressive NENs of unkno...

Neuroendocrine tumors (NETs) represent a heterogeneous group of malignancies with increasing incidence worldwide, due in part to enhanced awareness and diagnosis improvements. Surgery is often effective for local disease, whereas disseminated or metastatic disease require pharmacological treatment, which is not always successful. Pancreatic (Pan-NETs) and pulmonary (Lung-NETs) neuroendocrine tumors frequently express somatostatin receptors (SSTs), providing the target for trea...

Background: The optimal management of paediatric craniopharyngiomas has been debated for years. Radical surgery aimed at complete resection (CR) was the approach for several decades, with higher reported rates of tumour control compared with incomplete resection (IR). The shift towards conservative surgery with adjuvant radiotherapy (DXT), aimed at reducing post-operative morbidities, especially hypothalamic and visual, has not been systematically studied.<p class="abstext...

Introduction: Monitoring of hormonal control represents a key part in the management of congenital adrenal hyperplasia (CAH). It remains suboptimal and relies on frequent blood tests, which are traumatising in children and young persons (CYP). Recent evidence suggests a crucial role of adrenal-derived 11-oxygenatedC19 androgens in the pathogenesis of CAH. Therefore, we aimed to establish a non-invasive test for monitoring of adrenal-specific androgens in CAH.<p class="abst...

Bariatric surgery for obesity remains the most effective method to achieve weight loss and improvements in mortality. However, as the number of procedures increases to match the rising burden of obesity, unusual metabolic complications are now coming to the fore. One example of this is postprandial hypoglycaemia (PPH). The incidence of PPH has been reported as <1% although this problem is underreported. A correct diagnosis is essential as the condition can be extremely dis...

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an unfavorable prognosis. Despite the poor prognosis in the majority of patients, no improvements in treatment strategies have been achieved. Therefore, the discovery of new prognostic biomarkers is of enormous interest. Sterol-O-acyl transferase 1 (SOAT1) is involved in cholesterol esterification and lipid droplet formation. Recently, it was demonstrated that SOAT1 inhibition leads to impaired steroidogenesis ...

Introduction: Despite the abundance of data addressing the influence of patient’s age on surgery-related complications, its impact on several cardiovascular risk factors following bariatric surgery has been overlooked.Methods: Retrospective unicentric study of 1728 obese patients who underwent bariatric surgery between January/2010 and June/2015. Patients were divided in three groups, according to their age at surgery: <40 (n = 751...

Introduction: Chronic diseases such as type 1 diabetes can be associated with psychiatric disorders. Previous data suggest a high prevalence of depression, anxiety, disordered eating and diabetes distress among patients with diabetes. Mental health problems could interfere with treatment adherence, glucose control and chronic complications.Objective: We aim to evaluate the prevalence of psychiatric disorders, drug abuse, and treatment adherence in patien...