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Endocrine Abstracts (2020) 70 AEP378 | DOI: 10.1530/endoabs.70.AEP378

1Centro Hospitalar e Universitário de S. João, Department of Endocrinology, Diabetes and Metabolism, Porto, Portugal; 2Centro Hospitalar e Universitário de S. João, Centro de Responsabilidade Integrado de Obesidade, Porto, Portugal

Introduction: Despite the abundance of data addressing the influence of patient’s age on surgery-related complications, its impact on several cardiovascular risk factors following bariatric surgery has been overlooked.

Methods: Retrospective unicentric study of 1728 obese patients who underwent bariatric surgery between January/2010 and June/2015. Patients were divided in three groups, according to their age at surgery: <40 (n = 751), 40 to 59 (n = 879), and ≥60 years old (n = 98). Parameters with cardiometabolic impact, such as body anthropometric measures, lipid profile, and glycemic status, before and 24 months after surgery, were compared between these groups. A multiple linear regression was performed, adjusting differences between groups for sex, surgery type, and body mass index (BMI) variation.

Results: The group <40 years old presented more weight loss (–35.4 ± 9.0 kg, P < 0.001), greater BMI reduction (–15.8 ± 6.1 kg/m2, P <0.001), and larger changes in waist (–34 ± 13.8 cm, P < 0.001) and hip circumferences (–28.7 ± 11.9 cm, P < 0.05).The group of ≥60 years old presented the heaviest reduction in fasting glucose (–23.3 ± 11.0 mg/dl, P < 0.001) and A1c (–0.7 ± 1.0%, P < 0.001), and also had a tendency to have the biggest changes in systolic blood pressure (–14.7 ± 18.7 mmHg; P = 0.071).

Conclusion: Patients with ≥60 years old benefit the most from bariatric surgery regarding parameters with cardiometabolic impact, presenting heavier reductions in fasting glucose as well as A1c, and a tendency towards a higher decrease in systolic blood pressure. No clinically-significant differences in lipid profile were observed between groups.

Volume 70

22nd European Congress of Endocrinology

05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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