Diabetes, Obesity, Metabolism and Nutrition | 0070 | ECE2020 | 22nd European Congress of Endocrinology

Heterogeneity of diabetes mellitus (DM) determines difficulties in the diabetes type verification and further treatment. With this regard, in 2019 WHO published a new classification of DM with categories: “hybrid types of diabetes” and “unclassified diabetes” intended for use in clinical practice.Aim: To investigate the heterogeneity and clinical features of DM in young adult patients with an unspecified type of diabetes.<p cl...

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ea0070aep244 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Hemoglobin glycation index is associated with incident chronic kidney disease in subjects with impaired glucose metabolism: A 10-year longitudinal cohort study

Kim Wonjin , Huh JiHye

Objectives: We investigated associations between hemoglobin glycation index (HGI) and incident chronic kidney disease (CKD) in treatment naïve subjects with prediabetes or diabetes.Methods: A prospective cohort study was conducted in 2,187 subjects with prediabetes or diabetes. The HGI was calculated as the measured HbA1c minuspredicted HbA1c, which was calculated from the linear relationship between HbA1c and fastingplasma glucose levels. Incident ...

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ea0070aep245 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Assessment of arrhythmia risk due to hypoglycemia with continuous glucose monitoring device and 24-hour holter monitoring

Sahin Mustafa , Keskin Caglar , Cinel Murat , Bahceci Begum , Corapcioglu Demet

Previous studies have shown increased hypoglycemia-associated cardiac arrhythmia and mortality in patients with type 2 diabetes and cardiovascular disease.In this study, we aimed to evaluate the response of gastrointestinal hormones and glucoregulatory hormones to the oral glucose tolerance test in patients who were diagnosed with reactive hypoglycemia and to evaluate the risk of arrhythmia with long-holter ECG measurements in patients with a diagnosis o...

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ea0070aep246 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Insights from whole exome sequencing in a Maltese cohort with gestational diabetes

Paul Pace Nikolai , Vella Barbara , Craus Johann , Abou-Hussein Samir , Caruana Ruth , Felice Alex , Savona-Ventura Charles , Vassallo Josanne

Background: Gestational diabetes (GDM) can be driven by mutations or rare variants in various genes associated with monogenic or atypical forms of diabetes. The reported frequency of monogenic defects of beta cell function in GDM varies extensively, in part due to differences in ethnicity, patient ascertainment criteria and techniques used for genetic analysis. The objective was to evaluate the frequency and molecular spectrum of mutations in a curated list of genes associated...

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ea0070aep247 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Features of sarcopenia and body composition measured with bioimpedance in patients with diabetes mellitus type 2

Onuchina Yulia , Gurieva Irina

Aim: To investigate the association between presence of sarcopenia and type 2 diabetes mellitus (T2DM).Methods: The study included 76 women over 60 years old (Me72[67;77] years). Patients were examined with evaluation of muscle mass, muscle strength and muscle function. Skeletal muscle mass index (SMMI) was evaluated with bioimpedance testing. Sarcopenia was defined as a SMMI ≤6,75 kg/m2. Peripheral neuropathy was studied with calculatio...

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ea0070aep248 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evaluation of the endocrine cells ratio in the pancreas of rats with type 2 diabetes mellitus following long-term therapy with incretin mimetics and their combination with sulfonylureas drugs

Tuchina Taisiia , Skotnikova Ksenia , Vtorushina Anna , Rogoza Olga , Babenko Alina , Galagudza Mikhail

Introduction: New medicinal products that have been introduced into first-line therapy for type 2 diabetes mellitus (T2DM) include glucagon-like peptide-1 receptor agonists (GLP-1ra) and dipeptidyl peptidase-4 inhibitors (DPP-4i). These products have been shown to increase beta-cell proliferation. Some studies also demonstrated an increase in pancreatic alpha-cell proliferation. Various sulfonylureas drugs (SU) have been shown to produce different effects on apoptosis pancreat...

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ea0070aep249 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

A multi-center, randomized, double-blind, parallel, active-controlled phase III clinical trial to evaluate the efficacy and safety of controlled-release pregabalin and immediate-release pregabalin in diabetic peripheral neuropathic pain

Hyuk lee Jae , Lee Min-Kyung , Im Hur Yang

Pregabalin is a highly used drug for the effective treatment of diabetic neuropathic pain. This study compared the efficacy and safety of a controlled-release (CR) Pregabalin tablet (GLA5PR GLARS-NF1) with an immediate-release (IR) Pregabalin capsuleafter 12 week administration in patients with diabetic peripheral neuropathy. In multicenter, randomized, double- blind, active- controlled, parallel- group, phase III study, the primary outcome was to confirm that CR pregabalin wi...

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ea0070aep250 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Gestational diabetes in korea: Temporal trends in prevalence, treatment, and short-term consequences from a national health insurance claims database 2012 – 2016

Jung Chan-Hee , Mok Ji-Oh , Jung Sang-Hee

Aims: This population-based cross-sectional study aimed to investigate the recent trends in the prevalence and treatment of gestational diabetes mellitus (GDM) in a nationally representative sample of Korean patients. We also investigated trends of annual prevalence rate of pregnancy-induced hypertension (PIH) and cesarean section (C-section) in patients with GDM.Methods: We used data from the Health Insurance Review and Assessment-National Patient Sampl...

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ea0070aep251 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Twin pregnancy with gestational diabetes mellitus: Maternal and fetal outcomes

Fonseca Liliana , Santos Tiago , Vilaverde Joana , Saraiva Miguel , Pereira Teresa , Nunes Inês , Pinto Clara , Rodrigues Rosa , Pichel Fernando , Dores Jorge

Introduction: In singleton pregnancies, gestational diabetes mellitus (GDM) results in an increased risk for maternal and neonatal complications. In twin pregnancies, however, the effect of GDM on maternal and neonatal complications appears to be different in comparison to singletons. The few studies that investigated the consequences of GDM in twin pregnancies are small and present conficting evidence, with some finding no difference in perinatal outcomes between GDM and non-...

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ea0070aep252 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Immunomodulatory and anti-diabetic actions of a structurally-modified analogue of esculentin-2CHa isolated from the skin secretion of the frog, lithobates chiricahuensis (ranidae)

Ojo Opeolu , Ofosu Wendy , Abiodun Falobi Ayodele , Benjamin Falana Ayokunle , Sen Monica , Smyth Lesley

Aim: Our previousstudies have shown evidence for insulin-releasing actions of some amphibian skin peptides; including esculentin-2CHa. However, there is a need to further improve the potency of some of this peptides and to characterize their other beneficial effects. This study investigates the effect of a Leu31→Lys substitution on the insulin-releasing and immunomodulatory effects of esculentin-2CHa.Methods: BRIN-BD11 cells were incubat...

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ea0070aep253 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Congenital hyperinsulinemic hypoglycemia: A case report

Widmer Andrea , Zumsteg Urs , Szinnai Gabor , Filges Isabel , Meier Stephanie , Marie Carmen De Geyter Julie , Antwi Kwadwo , Nuoffer Jean-Marc , Wild Damian , Christ Emanuel

Introduction: Persistent endogenous hyperinsulinemic hypoglycemia in neonates (congenital hyperinsulinism; CHI) is usually due to monogenetic gene variants affecting the insulin secretion. The genetic cause is known in about 50% of patients. We present a new variant within the short-chain L-3-hydroxyacyl-CoA dehydrogenase (HADH) gene causing CHI in two cousins.Methods: The cases of two patients with CHI are presented with a follow-up of >30 ...

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ea0070aep254 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Chronic activation of adaptive immunity in type 2 diabetes

Garstka Malgorzata , Liu Shan , Ren Xu , Kong Ying , Xu Xiaoqiang , Li Xiaozhen , Jiao Yang , Huang Na , Min Xiaoyun , Ma Ning , Li Baohua , Li Ke , Xu Jing

Context: Type 2 diabetes (T2D) is associated with an increased incidence of infections and several cancers. Although low-grade inflammation and certain immune defects have been found in diabetic patients, the role of adaptive immune response remains to be fully elucidated.Objective: We aimed to explore whether patients with T2D show defects in the activation of T cells.Design: Immune cell phenotypes, T cell functional reactivity, s...

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ea0070aep255 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Thrombocyting haemostasis in children with diabetes mellitus type I

Nikolaeva Nataliia , Bolotova Nina , Averyanov Andrei , Poliakov Vadim , Dronova Elena , Nikolaeva Nadezhda

Thrombocytes play important role in pathogenesis of diabetic vascular complications.Aim: To study peculiarities of thrombocyting haemostasisin children with diabetes mellitus type 1 (T1DM).Patients and Methods: 120 children (66 boys, 54 girls) 3–17 y.o. with T1DM were examined. The duration of the disease was: less than 1 year in 29 patients (HbAc1 7.5 ± 0.4%) – group 1, from 1 to 5 years in 41 patients (HbAc1...

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ea0070aep256 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Fatty liver, irrespective of ethnicity, is associated with reduced insulin clearance and insulin resistance in obese youths

Trico Domenico , Galderisi Alfonso , Galuppo Brittany , Pierpont Bridget , Samuels Stephanie , Santoro Nicola , Caprio Sonia

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease in Western countries and identifies people at high risk to develop metabolic and cardiovascular disease. Fatty liver has been associated with reduced endogenous insulin clearance (EIC) and hepatic insulin resistance (HIRI), which are early features of type 2 diabetes. These relationships however might be differentially affected by the ethnic background, as populations of African ance...

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ea0070aep257 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Abstract unavailable...

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ea0070aep258 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Are we being too demanding with obese pregnant women with gestational diabetes?

Lima Ferreira Joana , Maria Príncipe Rosa , Sá Couto Adelina , de Estudos de Diabetes e Gravidez Portuguese Society of Diabetology Grupo

Introduction: Nutritional therapy is essential in the treatment of gestational diabetes mellitus (GDM). International recommendations suggest a target of 5–9 kg weight gain in obese women during pregnancy. However, some studies advocate a reduced weight gain (<5 kg) due to better obstetric and neonatal outcomes, compared to an adequate or excessive weight gain.Aim: To compare obstetric and neonatal outcomes of obese women with GDM wit...

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ea0070aep259 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Randomized controlled trial of different intensities of glycemic control in women with gestational diabetes

Popova Polina , Tkachuk Aleksandra , Vasukova Elena , Dronova Aleksandra , Bolotko Yana , Pustozerov Evgenii , Vasilieva Elena , Kokina Maria , Li Olga , Zazerskaya Irina , Pervunina Tatiana , Grineva Elena

Background and aims: Current glycaemic treatment targets for women with gestational diabetes (GDM) are controversial. The aim of the study was to compare the effect of different intensities of glycaemic control in pregnant women with GDM on perinatal outcomes.Materials and methods: Pregnant women in the 8th to 31st week of gestation were randomly assigned to 2 groups per target glycaemic levels: GDM1 (very tight glycaemic targets, fasting blood glucose (...

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ea0070aep260 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Weight loss through lifestyle modification or liraglutide is associated with improvement of NAFLD severity and changes in amino acid concentrations

Khoo Joan , Koo Seok-Hwee , Ching Jianhong , Soon Gaik-Hong , Kovalik Jean-Paul

Introduction: Non-alcoholic fatty liver disease (NAFLD), defined as excess fat accumulation in the liver, is increasingly prevalent due to obesity. NAFLD may lead to steatohepatitis and eventually cirrhosis. Weight loss, either through diet and exercise or medications such as the glucagon-like peptide-1 agonist liraglutide, improves transaminitis, a marker of NAFLD severity. Visceral obesity is associated with increased plasma levels of the amino acids alanine, phenylalanine, ...

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ea0070aep261 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Lack of mitochondrial medium chain acyl-coenzyme A synthetase Acsm3 in an inbred rat strain with diet-induced hypertriglyceridemia and insulin resistance

Junková Kristýna , Šeda Ondřej , Liška František , Pravenec Michal , Vcelak Josef , Mirchi Lukáš

Introduction: Metabolic syndrome (MetS), the combination of obesity, glucose metabolism impairment, dyslipidemia and high blood pressure, is becoming a worldwide burden of morbidity and mortality. Both genetic and enviromental factors are involved in its pathogenesis, with heritability of each component of MetS 25–80%.Aim: We aim to contribute to dissection of the genetic architecture of MetS using PD (polydactylous) rats, which present a unique mi...

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ea0070aep262 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evaluation of serum and salivary subfatin and asprosin hormone levels in patients with nonalcoholic steatohepatisis

Cosar Ugurcan , Ugur Kader , Fazıl Akkoç Ramazan , Yardım Meltem , Aydın Süleyman

Objective: Nonalcoholic steatohepatitis (NASH) is a metabolic disease characterized by liver steatosis. There is a correlation between liver steatosis and metabolic hormone dysregulation. Subfatin and asprosin are two important metabolic components of adipose tissue and play a role in carbohydrate metabolism, insulin resistance, and glucose regulation. Therefore, the primary aims of this study were to determine how serum and salivary subfatin and asprosin levels change simulta...

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ea0070aep263 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Capabilities of ultrasonography in diagnosis of latent post-injection lipodystrophies

Savasteeva Irina , Evdochkova Tamara , Selkina Veronika , Rusalenko Mariya

Introduction: Condition of injected skin and subcutaneous tissue is assessed by visual inspection and palpation and it has only 10–15% diagnostic value. The standard ultrasonography comparison of symmetrical skin areas is not valuable as they are usually used for injections.Objective: We examined 143 patients, aged 43.3 ± 3.9 years, with DM duration of 6.5 ± 2.8 years, receiving basal-bolus insulin therapy.Methods: ...

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ea0070aep264 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evaluation of glycemia course in patients with diabetes mellitus type

Makhlina Elena , Navmenova Yana , Savasteeva Irina

Objectives: To analyze the indicators of carbohydrate metabolism depending on the characteristics of the manifestation of hypoglycemic reactions.Materials and methods: The study daily glucose dynamics was carried out with Medtronik MINIMED Continious Glucose Monitoring System (CGMS), USA.The standard glycose profile (4–5 per day) was measured in capillary blood with the Precision PCχTM glucose meter, MediSense. To analyz...

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ea0070aep265 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Hand grip strength is correlated with peripheral neuropathy and metabolic control in patients with diabetes

Diana Reghina Aura , Maria Balea Ana , Iancu Mirela , Ilinca Laura , Diana Niculica Anca , Fica Simona

Background: Peripheral neuropathy is the most prevalent chronic complication in diabetes and increases the risk of sarcopenia in these patients. Hand grip strength (HGS) measurement is a good predictor for the presence of sarcopenia.The aim of the study was toevaluate HGS in diabetes patients with and without neuropathy and the clinical and paraclinical parameters that are correlated with HGS.Methods: We evaluated 102 diabetes pati...

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ea0070aep266 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association between gestational glycemic profile and delivery with a large for gestational age baby in pregnant women with type 1 diabetes

Inashvili Ekaterine , Asatiani Natalia , Kurashvili Ramaz , Shelestova Elena , Dundua Mzia , Kopaleishvili Ana

Background: Hyperglycemia is believed to be the underlying cause for many of the adverse fetal, neonatal, and maternal outcomes in pregnancies complicated by type 1diabetes (T1DM). In particular, the rates of a large for gestational age (LGA) neonates and macrosomia remain high and suggest that hyperglycemia may not be the only driver of fetal overgrowth for women with T1DM.Aim: Our aim was to assess the association between gestational glycemic profiles ...

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ea0070aep267 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Peculitaries of markers of renal function in patients with Diabetic Kidney Disease depending on C/T polymorphism in the DIO 1 gene

Abramova Nataliia , Pashkovska Nataliia , Marchuk Yulia , Pankiv Ivan , Piddubna Antonina , Koval Galina , Tsaryk Iryna

Introduction: Decrease in thyroid hormones (TH) levels is associated with reduced blood flow to kidneys and decreased glomerular filtration rate (GFR) along with alteration of tubular reabsorption.Deiodinase type 1 is an enzyme that is active in liver and kidneys and plays an important role in TH metabolism.The aim of the research was to study the dependence of markers of renal function on C/T polymorphism in the DIO 1 gene in pati...

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ea0070aep268 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association of the APOEgene polymorphism with diabetic nephropathy

Hasan Taner , Josifovska Slavica , Trajkovska Ivana , Doneva Daniela , Nedeska Natasha , Volkanovska Ilijevska Cvetanka

The protein isoformes that are products of the Apolipoprotein E (APOB) gene polymorphism have partially altered biological activity and that may lead to greater susceptibility of the patientsto microvascular complications including Diabetic nephropathy (DN)in patients with the Type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the association between the allele ε2, ε3, and ε4 of the APOE gene, as well as their combination, w...

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ea0070aep269 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Characterizing familial partial lipodystrophy: Baseline data of the BROADEN study

O’Dea Louis , Tami Joseph , Alexander Veronica , Watts Lynnetta , Hurh Eunju , Hubbard Brant , Schmidt Hartmut , Tiulpakov Anatoly , Mertens Ann , Garg Abhimanyu , Oral Elif

Introduction: Familial Partial Lipodystrophy (FPLD) is a rare genetic disorder characterized by marked loss of subcutaneous adipose tissue from the extremities and is associated with a variety of metabolic abnormalities. While phenotypic elements of the disorder can vary across genotypes, symptomatic presentation, disease severity, and onset can also vary among individuals with the same disease-causing variant, or even among family members. Due to this variabili...

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ea0070aep270 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

A comparison of the level of appetite, food intake, metabolic hormones, basal metabolic rate and adiposity in normal and short stature children

Kausar Nighat , Akram Maleeha , Shahid Gulbin , Ahmed Naseem Afzaal , Qayyum Mazhar , Tahir Fahim , Jahan Sarwat , Afshan Kiran , Rafi Muhammad , Raza Rizvi Syed Shakeel

The acceleration in linear growth at puberty is attributed to the combined physiological effects of both somatotropic and gonadal axes. In synergy, growth hormone (GH) and gonadal steroids (testosterone (T) and estradiol (E2)) stimulate longitudinal bone growth through direct stimulation of chondrocytes and osteoblast. Nutrition such as sufficient amount of nutrients including calcium, phosphate, sodium, potassium and iron and vitamins like vitamin D, vitamin A and vitamin C p...

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ea0070aep271 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

MODY5 with a whole deletion of HNF1B based on 17q12 microdeletion in a patient with primary amenorrhoea due to severe genitalabnormalities

Kruszyńska Aleksandra , Skórka Agata , Dębska Marzena

Introduction: Maturity-onset diabetes of the young (MODY) 5 is caused by mutations in the TCF2 (HNF1B) gene encoding the transcription factor hepatocyte nuclear factor-1. However, in 60% ofthe patients with a phenotype suggesting MODY5, no pointmutation is detected in TCF2 gene. In some of those patients genomic rearrangements may be responsible for the phenotype.MODY5 or renal and diabetes syndrome (OMIM #137920) encompasses a wide cli...

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ea0070aep272 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Difficulties in diagnosing of artificial hypoglycemia: Insulin analogues

Yukina Marina , Nuralieva Nurana , Troshina Ekaterina , Malysheva Natalia , Nikankina Larisa

Introduction: One of the manifestations of Munchausen syndrome is the deliberate injection of insulin to achieve hypoglycemia or artificial hypoglycemia. If human insulin is injected, we will always determine high level of insulin and low level of Cpeptideatthemomentofhypoglycemia. Incasesof insulin analogues injection the diagnos is maybe difficult when we use analyzers specific only to human insulin: the low level of IRI and C peptide will be determined.<p class="abstext...

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ea0070aep273 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effects of different metabolic states and surgical models on glucose metabolism and secretion of ileal L-Cell peptides: Results from the HIPER-1 study

Cagiltay Eylem , Pouwels Sjaak , Celik Alper

Objective: To compare the impact of 4 surgical procedures (mini gastric bypass [MGB], sleeve gastrectomy [SG], ileal transposition [IT], and transit bipartition [TB]) versus medical management on gut peptide secretion, beta cell function, and resolution of hyperglycaemia in type 2 diabetes (T2DM).Research design and methodsA mixed-meal tolerance test (MMTT) was administered 6–24 months after each surgical procedure (mini gast...

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ea0070aep274 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The influence of simultaneous pancreas-kidney transplantation on the evolution of diabetic foot lesions and peripheral arterial disease

Monteiro Sílvia , Pereira Catarina , Duarte Diana , Santos Tiago , Silva Filipa , Martins La Salete , Amaral Cláudia , Freitas Cláudia , Carvalho André , Martins Joana , Loureiro Luís , Carvalho Rui , Dores Jorge

Introduction: Simultaneous pancreas-kidney transplantation remains the best treatment option in type 1 diabetic patients with chronic kidney failure, providing a euglycemic state associated with an improvement on diabetic chronic complications. However, there are only a few studies addressing the potential ischemic deterioration of peripheral arterial disease, due to blood diverting from the iliac artery to the kidney graft.Aim: Evaluate diabetic foot le...

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ea0070aep275 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Female AKR1D1 knockout mice have impaired intestinal health with evidence of gut dybiosis, increased gut permeability and an increased incidence of colon cancer

Arvaniti Anastasia , Harris Shelley , Nikolaou Nikolaos , Potter Tom , Cox Roger , Odermatt Alex , Tomlinson Jeremy , Gathercole Laura

Metabolic syndrome (MS) is an important etiologic risk factor for the development and progression of certain cancers, including colorectal. Bile acids (BA) are potent antimicrobials that support gastrointestinal health and the dysregulation of BA homeostasis is thought to contribute to gut dysbiosis and drive endotoxemia. Furthermore, an increase in the cytotoxicity ofintestinal BA species can directly damage enterocytes and promote carcinogenesis. We have previously shown tha...

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ea0070aep276 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Metabolic and cardiovascular consequences of Ramadan fasting in type 2 diabetic patients

Boukhayatia Fatma , Oueslati Ibtissem , Cheikh Meriem , Hammami Bassem , Kardi Asma , Yazidi Meriem , Feki Moncef , Romdhane Neila Ben , Chihaoui Melika

Introduction: Ramadan fasting stands for abstaining from eating, drinking, smoking and oral medication use from predawn to sunset during one month. The duration of the fast from 10 to 19 hours, lifestyle changes and sleep disturbances can affect the glycemic control in diabetic patients with a high risk of hypoglycemia and hyperglycemia. However, fasting has been shown to improve insulin sensitivity and reduce oxidative stress, inflammation and the risk of atherosclerosis....

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ea0070aep277 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association and predictive ability of maternal body composition parameters in early pregnancy to identify gestational diabetes mellitus

Cremona Alexandra , O’Gorman Clodagh , Ismail Khadijah , Hayes Kevin , Donnelly Alan , Hamilton Jill , Cotter Amanda

Background: Accurate early risk prediction for gestational diabetes mellitus (GDM) would target intervention and prevention in women at the highest risk. We evaluated maternal risk factors and parameters of body composition to develop a prediction model for GDM in early gestation.Methods: A prospective observational study was undertaken. Pregnant women aged between 18–50 y of age with gestational age between 10–16 weeks were included in ...

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ea0070aep278 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Glucose metabolism and lipid profile in centenarians: What can they predict?

Matchekhina Lubov , Eruslanova Ksenia , Dudinskaya Ekaterina , Tkacheva Olga

Aim of the study: To assess the most important metabolic factors in centenarians and their impact on mortality and prognosisMaterials and methods: Itwasalongitudinalstudy, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and MOCA scores. We also analyzed levels of HbA1c, cholesterol, LDL, H...

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ea0070aep279 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association of FT3 levels and FT3/FT4 ratio in the first trimester with the risk of developing gestational diabetes

Isabel Álvarez Schettini María , Ruiz Ochoa David , Alberto Vázquez Salvi Luis , Higinio Ortega Sánchez Carlos , Alio Lavín Gómez Bernardo , Montalbán Carrasco Coral

Introduction: Gestational diabetes (GD) is one of the most common complications of pregnancy. Thyroid hormones play an important role in carbohydrate homeostasis, however, their influence on the risk of developing gestational diabetes has shown contradictory results.Objective: To explore whether variations in thyroid function parameters, within the thresholds of normality, can be associated with the risk of developing GD.Material a...

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ea0070aep280 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Protein Kinase Cα attenuates neuronal insulin signalling and worsen neuronal insulin-resistance

Mishra Devanshi , Sankar Dey Chinmoy

PKCα has been implicated in different neuronal functions like, apoptosis, synaptic plasticity, and memory formation. PKCα has been linked to control insulin signalling in peripheral tissues as a feedback regulator. However, the exact mechanism how this kinase regulates insulin signalling in neuron is not yet understood completely. Therefore the objective of the present study was to understand the mechanism of action of PKCα on neuronal insulin signalling cascade...

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ea0070aep281 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The MAFA gene mutation responsible for familial insulinomatosis and diabetes impairs insulin secretion and results in downregulation of critical cell cycle regulators

Iacovazzo Donato , Thong Lim Chung , Quezado Rosana , Drummond Juliana , Antonio de Sousa Barros Fernando , Cuenco Joyceline , Brändle Michael , Walker Emily , Guo Min , Collier David , Khan Faraz , Wang Jun , Tan Tricia , Ellard Sian , Stein Roland , Korbonits Marta

The islet-enriched transcription factor MAFA regulates the expression of genes critical to beta cell function and insulin secretion. We previously described anovel MAFA mutation (c.191C > T, p.S64F) causing familial insulinomatosis and diabetes mellitus, with male carriers more often developing diabetes and females more prone to insulinomatosis. The exact molecular mechanisms underlying these phenotypes are unclear. In this study, we assessed glucose metabolism an...

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ea0070aep282 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Residual fasting C-peptide secretion and its association with glycemic control in type 1 diabetes

Lopes Sara , Barbosa Mariana , Barros Inês , Sá Juliana , Joana Santos Maria , Margarida Monteiro Ana , Fernandes Vera , Matos Catarina , Lopes Pereira Maria , Marques Olinda , Alves Marta

Background: Residual C-peptide (CP) secretion has been associated with better glycemic control in patients with type 1 diabetes (T1D).Aim: To evaluate how residual fasting CP (fCP) secretion impacts glycemic control in T1D and to identify possible confounding factors.Methods: A retrospective analysis of adult patients with T1D followed in our department that had their fCP and glucose levels obtained on the same blood sample during ...

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ea0070aep283 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Identification of a diagnostic and prognostic miRNA signature in women with gestational diabetes mellitus

Sanchez-Lechuga Begoña , Pfeiffer Shonna , Halang Luise , Prehn Jochen HM , Campos-Caro Antonio , Byrne Maria M , López-Tinoco Cristina

Gestational Diabetes Mellitus (GDM) is characterized by insulin resistance accompanied byreduced beta-cell compensation to increased insulin demand, typically observed in the secondand third trimester and associated with adverse pregnancy outcomes. There is a need for abiomarker that can accurately diagnose GDM, predict onset and accurately monitor status, reducing foetal-maternal morbidity and mortality risks. To this end, circulating microRNAs(miRNAs) present themselves as p...

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ea0070aep284 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Inflammasome components and food addiction behaviors in morbid obesity and bariatric surgery: Novel promising targets for a chronic disease

Herrero-Aguayo Vicente , Sáez-Martínez Prudencio , Luis López-Cánovas Juan , Jesús Montero-Hidalgo Antonio , Membrives Antonio , David Gahete Manuel , José Molina-Puerta María , Pastor Castaño Justo , Ángeles Gálvez-Moreno María , Miguel Luque Raúl , Dulcinea Herrera-Martínez Aura

Obesity is a chronic metabolic disease associated with important metabolic and inflammatory comorbidities, which can be reversed or improved after bariatric-surgery (BS). However, some underlying mechanisms, independent of weight-loss, are still unknown. In this context, dysregulations in the inflammasome, a multiproteic complex that promotes cytokine maturation and induces cellular pyroptosis, has been associated to the development/stage of some cancer-types and obesity. Howe...

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ea0070aep285 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Secretion of bile acids in different techniques of bariatric surgery

Jiménez Inés , Ortega Isabel , Larrad Angelica , Barabash Ana , Bordiu Elena , Sánchez-Pernaute Andrés , Pérez-Ferre Natalia , Marcuello Clara , Matía Pilar , Torres Antonio J , Angeles Cuadrado Maria , Calle-Pascual Alfonso L , Rubio Miguel A

Background: Bariatric surgery (BS) has proven to be an effective and sustainable long-term treatment in the remission of metabolic disorders. Bile acids (BAs) are involved in the improvement of metabolic comorbidities by acting on the distal ileum (releasing GLP1, PYY and FGF19) and on the microbiota. Our aim is to verify whether the formation of ABs depends on the type of bariatric surgery.Subjects and Methods: 21 patients (81% women) underwent bariatri...

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ea0070aep286 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Liraglutide and PYY_3–36 combination therapy partially achieves the metabolic benefits of Roux-en-Y gastric bypass surgery in diet-induced obese rats

Dischinger Ulrich , Hasinger Julia , Königsrainer Malina , Corteville Carolin , Otto Cristoph , Fassnacht Martin , Hankir Mohamed , Seyfried Florian

Background: Circulating levels of the appetite-suppressing and glucoregulatory gut hormones glucagon-like peptide 1 (GLP-1) and peptide tyrosine tyrosine 3–36 (PYY3–36) are markedly increased after Roux-en-Y gastric bypass surgery (RYGB), which may contribute to some of its profound metabolic benefits in morbidly obese individuals.Objectives: To directly compare the metabolic effects of chronic systemic administration of the clinic...

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ea0070aep287 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The day-to-day variability of insulin sensitivity measured during ogtt in young adult males

Kauffmann Adriana , Carvalho Davide

There are a wide range of tests to measure insulin sensitivity. Alternative techniques for estimating insulin sensitivity include measurements made during the oral glucose tolerance test (OGTT). We aimed to describe the weekly intraindividual daily variability of measures of insulin sensitivity indexes (HOMA-IR, QUICKI, Matsuda’s insulin sensitivity index (ISIM), Insulinogenic Index, Early C Peptide, Stumvoll’s Insulin Sensitivity Index (ISIS), OGIS_120)...

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ea0070aep288 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association between the circadian rhythm and the inhibitory effect of glucocorticoids on browning of adipocytes

Congiusta Noemi , Gesmundo Iacopo , Negri Mariarosaria , Pagliaro Pasquale , Pivonello Rosario , Penna Claudia , Ghigo Ezio , Granata Riccarda

White adipose tissue (WAT) stores excess energy as triglycerides, while brown adipose tissue (BAT) dissipates energy through heat, acting as a defense against cold and obesity and as a positive regulator of metabolic functions. The thermogenic function of BAT is mainly regulated by the mitochondrial uncoupling protein 1 (UCP1) in brown adipocytes. Moreover, it has been shown that chronic exposure to glucocorticoids (GC) or synthetic GC receptor (GR) agonists inhibits the activ...

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ea0070aep289 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association of nutritional support with in-hospital mortality in malnourished medical inpatients – a population-based cohort study

Kutz Alexander , Nina Kaegi-Braun , Marlena Mueller , Beat Mueller , Philipp Schuetz

Background: Malnutrition has been associated with increased adverse clinical outcomes and affects a considerable proportion of hospitalized medical patients. While recent evidence from clinical trials revealed a survival benefit from nutritional support, data from a large real-world population is still missing.Methods: In this population-based cohort study, using a Swiss administrative claims database from January 2012 to December 2017, we created a medi...

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ea0070aep290 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Magnesium supplementation and higher magnesium levels in T2DM patients are associated with better glycemic control and higher rates of total and partial remission post-bariatric surgery

Silva Maria , Mendonça Fernando , João Fonseca Maria , João Ferreira Maria , Salazar Daniela , Pedro Jorge , Guerreiro Vanessa , Sergio Neves João , Lau Eva , Belo Sandra , Varela Ana , Freitas Paula , Carvalho Davide

Introduction: Magnesium (Mg) is an essential mineral for human health. Chronic Mg2+ deficiency and low Mg2+ dietary intake have been associated with increased risk of T2DM. Despite the increased risk of T2DM associated with Mg2+ deficiency; T2DM is often accompanied by hypomagnesemia, especially in patients with poorly controlled glycemic profiles.Bariatric surgery remains the most effective long-term therapy for the management of patients wi...

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ea0070aep291 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Nesfatin-1, an appetite-suppressing and anti-obesogenic neuropeptide, is decreased in the human brainstem of obese subjects.

Psilopanagioti Aristea , Makrygianni Maria , Nikou Sofia , Logotheti Souzana , Chartoumpekis Dionysios , Papadaki Helen

Background/Aims: Food intake is orchestrated by complex neuronal networksresiding in the forebrain, hypothalamus, and brainstem, via orexigenic and anorexigenic neuropeptides. Nesfatin-1, the amino-terminal fragment of nucleobindin 2, is a potent anorexigenic and anti-obesogenic neuropeptide, with widespread central distribution in rodents. In obese humans, our research group has recently reported reduced nesfatin-1 protein expression in the lateral hypothalamic area, a brain ...

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ea0070aep292 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Digital evaluation of ketosis and other diabetes emergencies (DEKODE) algorithm: Automated auditing system for diabetic ketoacidosis (DKA) management

Johnson Agnes , Thomas Lucretia , Melson Eka , Singh Chandan Joht , Ghosh Sandip , Narendran Parth , Kempegowda Punith

Background: Effective management of diabetic ketoacidosis (DKA) improves clinical outcomes. Regular auditing and performance feedback are key to achieving sustained and significant improvement in the management of DKA. One of the major limitations for maximal impact of an audit is the delay from initiation to results as the latter may not be applicable to the then current practice. In order to overcome this, we created an automated auditing system called Digital Evaluation of ...

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ea0070aep293 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Type 2 diabetes did not show significant risk effect on cerebral aneurysm in Koreans: A single center, cross-sectional study

Sung Choi Hoon , Taek Kim Jin , Won Yoon Ji

Backgrounds: Cerebral aneurysms are a common disease that affects 1–5% of general populations, with an annual rupture risk of 0–1%. Smoking, high blood pressure, diabetes and aging have been considered as risk factors for cerebral aneurysms, but there were few epidemic studies. In this study, we evaluated the risk effect of diabetes on cerebral aneurysm in Korean population.Methods: We used data from participants who underwent brain MRA and l...

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ea0070aep294 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Fibroblast growth factor 21 (FGF21) in hyper- and hypothyroidism, association with metabolic disturbances

Szczepańska Ewa , Gietka-Czernel Małgorzata , Glinicki Piotr , Jastrzębska Helena , Słowińska-Srzednicka Jadwiga , Kapuścińska Renata , Zgliczyński Stefan , Zgliczyński Wojciech

Background: FGF21 is a critical metabolic regulator with beneficial effects on lipid and glucose metabolism. FGF21 is produced primarily by the liver and stimulates fatty acids oxidation, which prevents hepatic triglycerides accumulation and nonalcoholic fatty liver disease (NALFD). FGF21also increases insulin sensitivity and glucose uptake in adipose tissue. Paradoxically FGF21 is elevated in insulin resistance states e.g. NALFD, obesity and type 2 diabetes. It is not determi...

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ea0070aep295 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Excess risk of thyroid cancer in individuals with type 1 diabetes compared to those without diabetes in Finland; nationwide study

Mäkimattila Sari , Harjutsalo Valma , Forsblom Carol , Groop Per-Henrik

The prevalence and possible excess risk of thyroid cancer in T1D compared to individuals without T1D is poorly known. Therefore, the aim of this study was to assess excess risk of thyroid cancer in adults with long-term T1D compared to sex- and age-matched control individuals.Study included 4758 individuals with T1D from the Finnish Diabetic Nephropathy (FinnDiane) Study. For each individual, three nondiabetic control individuals who were matched for sex...

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ea0070aep296 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Pulse wave velocity and circulating Retinol binding protein 4: A cross sectional association in early postmenopausal women

Armeni Eleni , Nigdelis Meletios P , Chondrou Asimina , Anagnostis Panagiotis , Augoulea Areti , Rizos Dimitrios , Kaparos George , Alexandrou Andreas , Goulis Dimitrios G , Patras Raphael , Aivalioti Evmorfia , Stamatelopoulos Kimon , Lambrinoudaki Irene

Introduction: Recent evidence recognized the value of Retinol-Binding Protein (RBP4), as potential biomarker of cardiovascular and cerebrovascular pathology. The possible association between RBP4 and functional vascular disease remains unexplored, while recent data in postmenopausal populations suggested lack of association between RBP4 and subclinical atherosclerosis. We evaluated the possible link between RBP4 and menopause-specific cardiovascular risk factors, in a sample o...

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ea0070aep297 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Metabolic syndrome severity score for predicting cardiovascular events: A nationwide population-based study from Korea

Hye Huh Ji , Kim Wonjin , Goo Kang Jun , Jin Lee Seong , Ihm Sung-Hee

Background and aims: Recently, a metabolic syndrome severity score (MS score) using a dataset of the Korea National Health and Nutrition Examination Surveys has been developed. We aimed to determine whether the newly developed score is a significant predictor of cardiovascular (CV) events among the Korean population.Methods: From the Korean National Health Insurance System, 2,541,364 (aged 40–59 years) subjects with no history of CV events (ischemi...

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ea0070aep298 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

High prevalence of cognitive dysfunction and vitamin B12 deficiency in patients with type 2 diabetes over 50 years

Weinert Letícia , Romani Fabiana , Coelho Machado Eduardo

Introduction: Hyperglycemia is a common disorder in elderly patients. Diabetes management in this population requires evaluation of medical, pharmacological and functional domains. Screening for diabetes chronic complications should include, in addition to traditional micro- and macrovascular disease, search for cognitive impairment and vitamin B12 deficiency.Objective: To evaluate the prevalence of cognitive impairment, depression, and associated clinic...

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ea0070aep299 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Prevalance of undiagnosed dementia in young diabetic population in central india

Saboo Bharat

Dementia is increasing day by day as longevity is increasing. There is a underlying need to evaluate Dementiaamongst Diabetics as they are more prone for dementia, By identifying early and preventing the incidence or advance of microangiopathy we can play an important role in maintaining quality of life and reducing mortality in patients with diabetes mellitus. Type 2 diabetes is a robust cause of cognitive impairment and decline in even in younger adults.<p class="abstext...

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ea0070aep300 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Features of phenotypes of diabetic kidney disease depending on the type of underlying disease

Tsaryk Iryna , Pashkovska Nataliia , Koval Galina , Abramova Nataliia , Marchuk Yulia , Piddubna Antonina , Pankiv Ivan

Introduction: Chronic kidney disease (CKD) is one of the leading causes ofdisability and mortality in patients with diabetes mellitus. Existence of specific phenotypes of diabetic kidney disease (DKD) is established nowadays. The prevalence of the classic albuminuric phenotype has decreased by 24% over the past decade (NHANES).The purpose of our work was to investigate the phenotypic features of DKD depending on the type of diabetes.<p class="abstext...

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ea0070aep301 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Maturity- onset diabetes of the young type 6 (MODY6): A case report of two relatives (mother and daughter) with undescribed heterozygous variant of mutation in NeuroD1 gene

Kalugina Valentina

A 37-year-old Caucasian female, pharmacist, referred to Diabetological center in February 2017. The main complaint was frequent urination.Medical history: She was diagnosed with T2DM at the age of 32 year. She was taking Metformin 850 mg twice daily. Her plasma glucose was 7.8 mmol/l at fasting; 10.8 mmol/l postprandial.Family history: Her father has elevated glucose levels also (up to 8 mmol/l before meal). Her moth...

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ea0070aep302 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Challengesrelated to prevention and management of diabetes mellitus inprimary healthcare settings

Kvanchakhadze Rusudan , Mebonia Nana , Shelestova Elena , Maghradze Tamar , Kurashvili Ramaz

Introduction: Over 94% of total mortality in Georgia is attributable to non-communicable diseases (NCDs). Alhought various NCDs guidelines and protocols have been developed and approved in Georgia, their implementation at the primary healthcare (PHC) level has not been successful. The AIM of the study was to assess PHCs approaches to prevention and management of diabetes.Methods: General practitioners (GPs), family and village doctors were involved in a ...

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ea0070aep303 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

An assessment into the insulin secretion during visceral leishmaniasis

Sinha Sukrat

Objective: Visceral Leishmaniasis is a macrophage associated disorder. About 5 percent of the patients may develop insulin dependent diabetes mellitus. It appears to have a direct action on pancreatic beta cells, resulting in initial insulin release followed by impaired insulin secretion. Within this context we looked into alternate therapies of treatment.Methods: In this study, we investigated whether alteration in the CD2 mediated coordination of an im...

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ea0070aep304 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Diagnostic accuracy of fatty liver index in type 1 diabetes mellitus patients

Mertens Jonathan , Eveline Dirinck , Jonas Weyler , Luisa Vonghia , Sven Francque , Christophe De Block

Introduction: Nonalcoholic fatty liver disease (NAFLD) affects ±55% of subjects with type 2 diabetes and contributes to cardiovascular mortality. NAFLD data in type 1 diabetes (T1DM) are scarce. Biopsy is the diagnostic reference but is not suited for routine screening. Ultrasound (US) is validated to diagnose steatosis as first-line imaging but is restricted to trained operators. The Fatty Liver Index (FLI) is a score to predict fatty liver based on triglycerides, Body M...

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ea0070aep305 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

CTRP-1 levels are related to insulin resistance in gestational diabetes mellitus

Deischinger Carola , Kautzky-Willer Alexandra , Leitner Karoline , Baumgartner-Parzer Sabina , Harreiter Juergen

Introduction: CTRP-1 belongs to the adipose tissue-derived C1qTNF superfamily of proteins involved in e.g. glucose metabolism regulation. Recent studies have shown significant differences in CTRP-1 levels between type 2 diabetics and controls. We aim at investigating a possible link between gestational diabetes mellitus (GDM) and CTRP-1 as there is little data on CTRP-1 and its possible functions in pregnancy.Patients and Methods: In 167 women (93 with n...

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ea0070aep306 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

New-onset diabetes mellitus after liver transplantation in the patients with acute liver failure: Is there any effect of pretransplant hypoglycemia?

Topaloğlu Ömercan , Cengiz Muhammet , Cengiz Ayșe , Evren Bahri , Yoloğlu Saim , Yılmaz Sezai , Şahin İbrahim

Introduction: The frequency of new-onset diabetes after transplant (NODAT) is 5–30% in liver transplant recipients. We aimed to analyze the frequency and predictors of NODAT in the patients undergoing liver transplantation (LTx) due to acute liver failure(ALF), and to investigate whether pretransplant hypoglycemia had any effect on NODAT.Materials and methods: Adult patients undergoing LTx due to ALF were analyzed retrospectively. The patients with...

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ea0070aep307 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Perception regarding marriage of diabetics in central indian population

Saboo Bharat

Background: Marriage is an integral part of Indian society. In spite of the large number of people with diabetes mellitus (DM) in India, India is not a diabetes-friendly society. The society suffers from lots of myths regarding diabetes and insulin use. This survey highlights perceptions of general population with regards to marriage, associated diabetes distress, and suggests potential solutions. If no one is ready to accept diabetics as a bride or groom for their children an...

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ea0070aep308 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effect of maternal obesity and degree of glucose intolerance on neonatal hypoglycaemia and birth weight: A retrospective observational cohort study in women with gestational diabetes mellitus

Cremona Alexandra , Saunders Jean , Cotter Amanda , Hamilton Jill , Donnelly Alan , O’Gorman Clodagh

Introduction: Gestational diabetes mellitus (GDM) is an increasing problem worldwide. Post-natal-hypoglycaemia and excess-foetal-growth are known important metabolic complications of neonates born to women with diabetes. This retrospective-cohort-study aims to determine the influence of obesity and glucose-intolerance on neonatal-hypoglycaemia and birth-weight over the 90th percentile (LGA).Methods: Data were abstracted from 303 patient medical records f...

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ea0070aep309 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Untargeted plasma metabolomics identifies broad metabolic perturbations in glycogen storage disease type I

Tamara Mathis , Martin Poms , Matthias Gautschi , Barbara Plecko , Matthias Baumgartner , Hochuli Michel

Background/Introduction: The primary metabolic defect in glycogen storage disease type I (GSDI) results in fasting hypoglycemia and typical secondary metabolic abnormalities (e.g. hypertriglyceridemia, hyperlactatemia, hyperuricemia). The aim of this study was to broadly assess further perturbations of the metabolic network in GSDI by using untargeted plasma metabolomics.Methods: Plasma samples of 14 adult GSDI patients (11 GSDIa, 3 GSDIb. Mean age 26.4&...

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ea0070aep310 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Characterization of muscle function, lifestyle and motivational indices in obese women

Marocco Chiara , Cella Vittoria , Innocenti Lorenzo , Bimonte Viviana , Pietro Emerenziani Gian , Mocini Edoardo , Ferretti Elisabetta , Lenzi Andrea , Bonavolontà Vincenzo , Fornari Rachele , Maria Donini Lorenzo , Baldari Carlo , Bertollo Maurizio , Guidetti Laura , Migliaccio Silvia

Introduction: Obesity is a chronic metabolic condition characterized by an excess of adipose tissue leading to an increased risk of developingdiseases such as diabetes mellitus and cardiovascular pathologies. Unbalanced nutrition and sedentary lifestyle are among the main influencing factors leading to a reduction in muscle mass, strength and functionality, predisposing obese subjects to sarcopenia and functional disability. Moreover, recent studies suggest the possible presen...

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ea0070aep311 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Study of the effect of sibutramine on central mechanisms of regulation of eating behavior in patients with obesity by means of fMRI. Preliminary results

Logvinova Oksana , Kuznetsova Polina , Tsvetkova Evdokiia , Kremneva Elena , Troshina Ekaterina , Romantsova Tatiana , Tanashyan Marine , Kornilova Anastasia , Kolpakova Evgenia

Introduction: Patient’s nutrition is generally considered to be the main cause of the accumulation of excess body weight. However, this accumulation can be mitigated by treatment involving drugs with a central mechanism of action. By using functional Magnetic Resonance Imaging (fMRI) we can meliorate our understanding of the organization of neuronal networks responsible for eating behavior, and see how they respond to the mechanisms of action of sibutramine in the treatm...

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ea0070aep312 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Combination of baseline body weight with active plasma ghrelin level could predict early response with liraglutide 3.0 mg in patients with obesity

Logvinova Oksana , Troshina Ekaterina

Introduction: Liraglutide 3.0 mg could be effective option for obesity management. It is known that patients who have ≥5% weight loss in 16 weeks (‘early responders’ (ERs)) will have ≥10% weight loss in 56 weeks [1]. Predictors of this early response (ER) in 16 weeks are unknown.Methods: 22 obese patients (30% men; median age 40.0 [33.0; 48.5]) were recruited. The exclusion criteria were diabetes, psychotic disorders, obesity due ...

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ea0070aep313 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Omega-3 PUFA and probiotics as a single formulation for insulin resistance and obesity: Evidence from animals to randomized clinical studies

Kobyliak Nazarii , Falalyeyeva Tetyana , Mykhalchyshyn Galyna , Savchuk Olexiy , Kyriienko Dmytro , Ostapchenko Lyudmyla , Komisarenko Iuliia

Background: Probiotics and omega-3 polyunsaturated fatty acids supplementation (PUFA) have beneficial effect on obesity related disorders in animal models. We have previously shown, on rats with monosodium glutamate-induced obesity, that in take of the combination based on live probiotics and omega-3 PUFA is accompanied by the preventive effect concerning experimental obesity development, lead toinsulin resistance (IR) improvement and more obvious decrease of he paticsteatosis...

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ea0070aep314 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Antibodies to insulin receptor in the diagnosis of non-diabetic hypoglycemia

Yukina Marina , Nuralieva Nurana , Troshina Ekaterina , Malysheva Natalia , Nikankina Larisa

Introduction: One of the autoimmunenon-diabetic hypoglycemia (NDH) causes isthe antibodies to insulinreceptor (AB-rIRI) formation and/orinsulin resistance type B (TBIR).Objectives: To determine the prevalence of increased AB-rIRI level in patients with suspected NDH of different genesis and in healthy individuals; to determine significance of AB-rIRI investigation in NDH diagnosis.Methods: In a prospective study we determined AB-rI...

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ea0070aep315 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Time to glycemic control – an observational study of 3 different operations

Celik Alper , Pouwels Sjaak , Can Karaca Fatih , Cagiltay Eylem , Ugale Surendra , Etikan Ilker , Büyükbozkırlı Deniz , Emre Kilic Yunus

Background: Medical treatment fails to provide adequate control for many obese patients with type 2 diabetes mellitus (T2DM). A comparative observational study of bariatric procedures was performed to investigate the time at which patients achieve glycemic control within the first 30 postoperative days following sleeve gastrectomy (SG), mini-gastric bypass (MGB), and diverted sleeve gastrectomy with ileal transposition (DSIT).Methods: Included patients h...

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ea0070aep316 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Appropriateness of the 6 mm insulin needle length comparing the glycemic control in overweight-obese and normal weight patients with type 2 diabetes – four years observational study

Gonsalves Bensley

Introduction: The length of the insulin needle in last three decades has reduced from 16 mm to 4 mm. The BMI of 10 kg/m2 difference accounts for a 4 mm difference in subcutaneous tissue thickness. We compared the glycemic control in patients switched from 4 mm needle to 6 mm needle in the Normal Weight (NW) patients (BMI < 25 kg/m2) with the Obese and Overweight (OOW) patients (BMI ≥ 25 kg/m2)</...

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ea0070aep317 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Pancreas-kidney transplantation improves quality of life in type 1 diabetes patients

Dolores Alcántara-Laguna María , Durán-Martínez Manuel , Calleja-Lozano Rafael , Manuel Sánchez-Hidalgo Juan , Ángeles Gálvez-Moreno María

Introduction: Diabetes is increasing its prevalence as an enhancement of treatment options arises and mortality declines. Pancreas transplantation has been postulated as one of them, specifically indicated for cases with end-stage renal failure where kidney transplantation is required besides. It has been analysed whether there is a clinical benefit in terms of quality of life (QoL) in patients undergoing pancreas-kidney transplantation (PKT) compared to dyalisis population or...

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ea0070aep318 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Glycemic control in patients with acute myocardial infarction in an intensive care unit

Isachkina Volha , I Danilova Larissa

Background: Dysglycemia is independently associated with increased risk of death in critically ill adults. The aim of this study was to analyze the differences in glycemic control between the diabetic and non- diabetic patients underwent acute myocardial infarction (AMI).Materials and methods: Retrospective descriptive study of patients with acute myocardial infarction (AMI) admitted to the intensive care unit (ICU) from January to June 2016, including b...

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ea0070aep319 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Vitamin D supplementation and glucose metabolism parameters in pre-diabetic women

Andreeva Alena , Karonova Tatiana

Objective: To assess glucose metabolism (GM) parameters before and after vitamin D treatment in pre-diabetic women.Material and Methods: In the study were included fifty eight women with prediabetes (impaired fasting glucose (IFG) or impaired glucose tolerance (IGT)) aged from 40 to 55 with signed informed consent. The study didn’t include women with diseases affecting the vitamin D metabolism, as well as women receiving regular vitamin D supplemen...

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ea0070aep320 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Euglycemic DKA after initiating an SGLT-2 Inhibitor and the P90X diet

Berquist John , Kaplan Jason , Young Tessa

Introduction: We present a case of a patient with type two diabetes mellitus (T2DM) who started empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor and the P90X diet and presented with euglycemic DKA seven days later.Case Presentation: A male in his 5th decade of life with a history of T2DM presented for a routine office appointment and had a measured hemoglobin A1C of 9.3. His home diabetes regimen consisted of metformin and sitagliptan. D...

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ea0070aep321 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Severe insulin resistance with cirrhosis: A case report

Durmaz Himmet , Evranos Ogmen Berna , Ahmadova Konul , Kucukcongar Yavas Aynur , Keskin Caglar , Dirikoc Ahmet , Cakir Bekir

Background: Alstrom syndrome is a rare autosomal recessive genetic disorder characterised by vision loss, hearing loss, childhood obesity, insulin resistance and hyperinsulinemia, type 2 diabetes, hypertriglyceridemia, cardiomyopathy, and progressive pulmonary, hepatic, and renal dysfunction. Hyperinsulinemia develops early, and pancreatic islets show beta-cell proliferation, thus suggesting that both insulin resistance and increased insulin secretion might contribute to gluco...

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ea0070aep322 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Switching from liraglutide to dulaglutide, is it worth it?: Outcomes at 24 weeks follow-up

Cayón-Blanco Manuel , García-Figueras-Mateos Carolina

Introduction: Once-daily liraglutide and once-weekly dulaglutide, both glucagón-like peptide-1 receptor agonists, improve glycemic control and reduce weight in patients with type 2 diabetes mellitus (T2DM) with a similar efficacy according to head-to-head trial AWARD-6. Nevertheless, there is a lack of evidence in a real-world setting. The focus of our study is to assess changes in glycemic control and weight resulting from switching from liraglutide to dulaglutide in pat...

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ea0070aep323 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The impact of new technologies on metabolic control in children with type 1 diabetes mellitus during early and middle childhood

Bojoga Irina , Gabriela Duta Simona , Ruxandra Calapod Ioana , Cima Luminita , Ioacara Sorin , Fica Simona

Background: Using new technologies, such as glucose sensors and insulin pumps, may help patients with type 1 diabetes mellitus achieve better glycemic control and quality of life. With the occasion of implementing the National Program for free distribution of continuous glucose monitoring systems (CGMS) starting with January 2019, children aged under 13 years were investigated in order to assess the association between previous use of CGMS and insulin pumps and the metabolic c...

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ea0070aep324 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Long-term efficacy and safety of flash glucose monitoring system: 30-month real-life experience

Rodia Cosimo , Falcetta Pierpaolo , Bertolotto Alessandra , Bianchi Cristina , Del Prato Stefano , Aragona Michele

The use of FreeStyle Libre (FSL) or Flash Glucose Monitoring (FGM) system becomes increasingly popular among people with diabetes, especially type 1 diabetes (T1DM) and several randomized and controlled study have shown how its use is associated with less and shorter hypoglycemic events without deterioration of HbA1c. Nevertheless, there are not yet consistent and lasting data reporting the impact of FGM in people with diabetes in real-life conditions. In this study we evaluat...

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ea0070aep325 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evaluation of the effects of phone support programme for patients with type 2 diabetes in treatment with insulin glargine 300 u/ml (T-coah)

Lara-Barea Almudena , Mateo-Gavira Isabel , Sánchez-Toscano Esteban , Medina-Rivero Daniel , Aguilar-Diosdado Manuel

Introduction: T-Coach program is a phone support platform for patients with type 2 diabetes (T2D) treated with insulin glargine 300 U/ml in order to adjust basal insulin dose, reinforce diabetes education and encourage patients to get their goals through regular phone calls. The aim of the study was to evaluate T-Coach program effectiveness in metabolic control and level of satisfaction in patients with T2D.Methods: We conducted a retrospe...

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ea0070aep326 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Inappropriately elevated serum C-peptide after dosing may interfere with PK and/or PD measurements of study insulin in a euglycemic clamp

Liu Hui , Yu Hongling , Sun Lisi , Qiao Jingtao , Li Jiaqi , Tan Huiwen , Yu Yerong

Objective: To examine the relationship between C-peptide levels and endogenous insulin secretion and to understand the effects of elevated C-peptide after dosing on evaluating study insulin and its analogs’ PK/PD values in euglycemic clamps.Method: The study included 33 healthy male volunteers who underwent an 8-h euglycemic clamp with a subcutaneous injection of insulin aspart (0.2 U/kg). Blood glucose (BG), C-peptide, human insulin, and insu...

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ea0070aep327 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Metabolic effects of semaglutide after the first months of treatment: A new GLP-1-RA revolution?

Jiménez Sara , Pla Begoña , M Ramos-Leví Ana , Carraro Raffaele , Lahera Marcos , Hernando Iñigo , Alfonso Arranz J , Marazuela Mónica

Background: Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1-RA) whose role as a second-line treatment for patients with type 2 diabetes (T2D) has significantly increased. It has demonstrated cardiovascular safety and superiority in terms of glycaemic control and weight loss, compared to other GLP-1-RAs. The most common side effects are mild gastrointestinal, but it may also cause renal failure secondary to dehydration and an increased risk of diabetic retinopa...

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ea0070aep328 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The icone study’: Multicenter evaluation of the impact of contour next one and contour diabetes app on self-management and adherence in insulin-treated patients with diabetes type 1 or 2

Fernandez-Garcia Diego , Aguilera Hurtado Eva , Arranz Martin Alfonso , Gonzalez Aguilera Beatriz , Gonzalez Jauregui Blanca , Luis Menendez Torre Edelmiro , Reyes Garcia Rebeca , Soto Gonzalez Alfonso , Tejera Perez Cristina , Fernandez-Tresguerres Beatriz , Petruschke Thorsten

Objectives: The primary objective was to determine if the use of Contour Next One (CNO) with Contour Diabetes app (APP) was associated with improved self-management using the Summary of Diabetes Self-Care Activities questionnaire (SDSCA). A secondary objective was to establish if CNO and APP together had impact on adherence to self-monitoring blood glucose (BG), indicated by frequency of BG readings and hypoglycemic events. Other secondary objectives were to observe a possible...

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ea0070aep329 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Experience of using insulin therapy with the closed loop method among patients with type 1 diabetes mellitus in Russia

Volkova Anna R , Chernaya Maria , Vlasova Ksenia A

The aim: To evaluate the efficiency and safety of using closed loop systems in patients with type 1 DM living in Russia.Results: 88 respondents (or those legal representatives) with type 1 DM in insulin therapy by closed loop systems, members of Russian-speaking community, were included to the study. 90% of respondents living in Russia. All respondents using do-it-yourself artificial pancreas systems (DIYAPS): Loop (19.3%), Open APS (30.7%) and Andr...

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ea0070aep330 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Use of statins and cognitive performance in elderly type 2 diabetic patients

Fagotto Valentina , Colussi GianLuca , Da Porto Andrea , Cavarape Alessandro , Alberto Sechi Leonardo

Background: Type 2 diabetes (T2D) is known as risk factor for mild cognitive impairment (MCI), which can lead to confirmed dementia. T2D patients often take statins for cardiovascular prevention but, nowadays, it is not clear if these drugs could also prevent cognitive impairment.Objective: We aimed to evaluate the association between statins in primary or secondary cardiovascular prevention and cognitive performance in old T2D patients referring to our ...

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ea0070aep331 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Clinical and metabolic benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) therapy in diabetic patients with psychiatric comorbidities

Concepción Terroba-Larumbe María , Crespo-Soto Cristina , Palacio-Mures Jose Maria , Gonzalez-Sagrado Manuel , Conde-Vicente Rosa , Ventosa-Viña Marta , Peña-Lozano Silvia , Portela-Martin Ainara , Fernandez-Nuñez Marta , Calleja-Barnada Mar , Cuellar-Olmedo Luis

Introduction: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) therapyhas proven effective in type 2 diabetes but there is little data on its effect in patients with psychiatric comorbidity, who usually present worse metabolic and clinical control. The aim of this study was to evaluate if there are differences in the effect of this therapy in relation to the presence of these pathologies.Methods: 225 patients included in a therapy protocol with SGLT2i,...

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ea0070aep332 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Immune checkpoint inhibitors (ICIs) and ‘Fulminant Diabetes’: Two emblematic cases

Sgro’ Daniele , Giannarelli Rosa , Aragona Michele , Viola Nicola , Cosentino Giada , Brancatella Alessandro , Latrofa Francesco , Del Prato Stefano , Santini Ferruccio , Marcocci Claudio , Lupi Isabella

Context: Programmed cell death protein 1/programmed cell death protein ligand 1 (PD-1/PD-L1) are key regulators in T-cell activation and tolerance. Nivolumab (PD-1 inhibitor) and Atezolizumab (PD-L1 inhibitor) are monoclonal antibodies approved for the treatment of several types of advanced cancers. Immune checkpoint inhibition caused by these drugs can result in immune-related adverse events (irAEs) New-onset diabetes mellitus has been reported in fewer than 1% of patients an...

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ea0070aep333 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Vitamin B12 levels and its association with glycaemic control and pregnancy outcomes in women with gestational diabetes

Pappa Dimitra , Navrozidou Parthena , Barmpa Eleftheria , Gkorezi Ntabela Irontianta , Daponte Alexander , Bargiota Alexandra

Introduction: Data on Vitamin B12 deficiency and its relationship with Gestational Diabetes Mellitus (GDM) andpregnancy outcomes are limited. The aim of the present study is to determine, in pregnant women with GDM, the association between Vitamin B12 levels and glycemic control, as well as with pregnancy outcomes.Methods: We studied 44 women with GDM, mean age 31.9 ± 5.8 years old, at the second trimester and at labor and measured weight, height, b...

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ea0070aep334 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Abstract unavailable...

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ea0070aep335 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Study on lipid compositions of the skeletal and liver tissues in animals with the induced alimentary obesity and insulin resistance

Irgasheva Sanobarkhon , Ishanhodjaev Tokhir , Ibragimova Elvira , Saatov Talat

Obesity is thought to be a main risk factor of insulin resistance and diabetes mellitus. Study on concentrations of lipids in the tissues of animals with experimental model of obesity resulting in insulin resistance remains currently central. The work was initiated to study the spectrum of lipids and their concentrations in the tissues of experimental animals with the induced alimentary obesity.Alimentary obesity with concurrent insulin resistance was in...

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ea0070aep336 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Studying the care and social pathway of young adults with endocrine and metabolic diseases during transition: The ‘Transend’ cohort

Le Roux Enora , Menesguen Florence , Tejedor Isabelle , Halbron Marine , Popelier Marc , Faucher Pauline , Poitou Christine , Polak Michel , Touraine Philippe

Context: The transition period between pediatric and adult medicine is associated with poor patient outcomes and an important number of patients lost to follow up. Intervention exist but the few published randomized trials do not allow to study long-term patient outcomes nor intervention sustainability in time. Objective. Describe the cohort of patients in adult care who benefit from a new transition program based on case management approach, its activity and follow-up outcome...

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ea0070aep337 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The complexity of associations between type 2 diabetes mellitus and comorbidities in multimorbid population in Lithuania

Švaikevičienė Kristina , Puronaitė Roma , Visockienė Žydrūnė , Kasiulevičius Vytautas

Introduction: Diabetes is one of the most common chronic diseases in multimorbid population and one of the most frequently detected conditions in multimorbid disease clusters. Approximately 40% of diabetic patients have three or more coexisting chronic conditions.Aim: To assess the frequency (percentage) of chronic conditions co-occurring with diabetes in multimorbid Lithuanian population.Methods: Database fromthe Lithuanian Nation...

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ea0070aep338 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Lipoprotein (a) in patient with type 2 diabetes mellitus and healthy subjects

Deerochanawong Chaicharn , Dansirikul Rungtip , Konthong Pattraporn

Backgroud: Increased lipoprotein (a) {Lp(a)} concentrations are associated with cardiovascular disease. Whether type 2 diabetes increase the level of Lp(a) still controversial. We studied the level of Lp(a) in health and type 2 diabetes Thai subjects and studied the relationship between Lp(a) and metabolic factors in both groupsMethods: The study included 180 normal glucose tolerance healthy subjects that have age and sex matched with 180 type 2 diabetes...

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ea0070aep339 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Correlation between BMI and cognitive performance in type 2 diabetic patients

Fagotto Valentina , Colussi GianLuca , Da Porto Andrea , Cavarape Alessandro , Alberto Sechi Leonardo

Background: The association between diabetes (DM) and cognitive impairment is already well established. DM affects multiple superior domains, in primis working memory and executive functions and damages nervous system in both morphological and functional ways. The Montreal Cognitive Assessment(MoCA) is a neuropsychological test defined as the best tool evaluating mild cognitive impairment (MCI) in DM.Objective: Our study aimed to invest...

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ea0070aep340 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Prevalence and prognosis impact of diabetes in cirrhotic patients

Samir Bradai , Akkari Imen , Soumaya Mrabet , Jazia Elhem Ben

Introduction: The prevalence of diabetes increases during cirrhosis resulting from a significant alteration in carbohydrate metabolism modifying the management of diabetes and worsening the liver prognosis. The aim of this work is to determine the prevalence of diabetes during cirrhosis, and to assess its prognostic impact on the disease.Material and method: this is a study collecting all cirrhotics followed in the gastroenterology department over a peri...

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ea0070aep341 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Anti-Lipogenic effects of cabergoline: A molecular study on white adipocytes

Negri Mariarosaria , Pivonello Claudia , Amatrudo Feliciana , Gentile Annalisa , Montò Tatiana , Patalano Roberta , Simeoli Chiara , Ferrigno Rosario , Simona Auriemma Renata , Colao Annamaria , Pivonello Rosario

Obesity is caused by an imbalance between dietary energy intake and expenditure. The expression of dopamine receptors (DRs) in human adipocytes has been already demonstrated. Moreover, the effects of cabergoline, a dopamine agonist, on body weight and glucose homeostasis in obese subjects without hyperprolactinemia has already been reported. The current study investigates the effects of cabergoline on lipid accumulation and on adipogenic factors expression to better define the...

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ea0070aep342 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Modification of standard thresholds improves performance of noninvasive scores of liver fibrosis in patients undergoing bariatric surgery

Meneses Diego , Cos Blanco Ana , Corripio Ramón , Méndez Carmen , Olveira Martín Antonio , Romero Míriam , Vicent David , Herranz Lucrecia

Background: In bariatric surgery (BS) patients, nonalcoholic fatty liver disease and fibrosis are present in up to 90% and 24%, respectively. Several fibrosis risk scores have been developed and have been validated in cohorts different from morbid obesity (MO). We aimed to determine whether established liver fibrosis scores were accurate in predicting fibrosis in MO subjects.Material and Methods: Cross-sectional analysis in a cohort of MO patients underg...

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ea0070aep343 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effects of bariatric surgery on heart rhythm disorders: A systematic review and meta-analysis

Sanches Elijah , Pouwels Sjaak

Background: Obesity is associated with cardiac structural changes, repolarization abnormalities and rhythm disorders. The aim of this systematic review is to provide an overview of the literature on obesity, cardiac arrhythmias, obesity associated ECG abnormalities and the effects of bariatric and metabolic surgery.Methods: A systematic search on the effects of obesity and bariatric surgery on cardiac arrhythmias and associated ECG abnormalities was cond...

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ea0070aep344 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Physical activity is associated with lower arterial stiffness after the menopause: The effect of BMI

Armeni Eleni , Paschou Stavroula , Karagkouni Iliana , Augoulea Areti , Georgiopoulos George , Rizos Dimitrios , Kaparos George , Panoulis Konstantinos , Apostolakis Michael , Tsoltos Nikolaos , Stamatelopoulos Kimon , Lambrinoudaki Irene

Introduction: Metabolic syndrome and cardiovascular disease (CVD) are well-known long-term implications of the menopausal transition. Lifestyle practices like exercise could potentially act protective with regards to future cardiovascular risk at midlife. We aimed to assess the impact of physical activity on the development of subclinical CVD in postmenopausal women, adjusting for the effect of underlying obesity.Methods: This cross-sectional study from ...

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ea0070aep345 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Role of an automated screening tool in familial hypercholesterolemia

Jokiniitty Antti , Metso Saara , Saarela Tanja , Eskola Markku

Familial hypercholesterolemia (FH) remains underdiagnosed in general population. Screening programs in unselected individuals have shown modest results in identifying patients with FH. Incidence of FH is higher in young patients with coronary artery disease (CAD), especially when associated with high LDL-cholesterol levels. Targeted screening in this population could add value to FH-index patient identification. We have established an IT-based automated screening tool to enhan...

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ea0070aep346 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Sodium taurocholate cotransporting polypeptide (NTCP) is a new and promising target for treatment of hypercholesterolemia: A proof of concept from a randomized double-blind placebo-controlled phase I trial

Zhu Zhenzhen , Fan Cuili , Zhu Shanwei , Wang Lizhen , Cai Fei , Gao Xian , Zhang Li , Tang Xiaolu , Liu Hongli , Wei Zhenman

Bile acids (BAs) are synthesized by converting cholesterol in hepatocytes and recycling it via enterohepatic circulation. Most BAs are reabsorbed into hepatocytes, where they inhibit their own synthesis by activating FXR pathway. NTCP is a major transporter of BAs via absorption from portal blood into hepatocytes. Hepalatide is a 47aa synthetic peptide that specifically binds NTCP resulting in BA spillover of hepatocytes into the systemic circulation. In this way, BA synthesis...

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ea0070aep347 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Prevalence andassociated factors with sensitive neuropathy in a population of patients with diabetes

Jemai Chaima , El Frigui Sinène

Introduction: Sensitive neuropathy is a degenerative complication of diabetes, precipitated by chronic glycemic imbalance. It is estimated that it is present in 50% of diabetics, and that it requires treatment in 10 to 20% of cases.This study aimedto assess the prevalence of sensitive neuropathy and to identify the factors associated with it in a population of patients with diabetes.Patients and Methods: This is a descriptive and a...

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ea0070aep348 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Assessment of renal insufficiency in the absence of albuminuria in patients with type 2 diabetes mellitus

Demirtaș Ezgi , Belgin Efe Fatma , Toygar Kalkan Ahmet , Nur Kebapçı Medine , Yorulmaz Göknur , Akalın Aysen

Introduction: Diabetic nephropathy is a clinical syndrome characterized by overt proteinuria and decreased renal function in the course of diabetes mellitus. The earliest symptom is the presence of albuminuria, but a decrease in glomerular filtration rate(GFR) has been observed in patients without albuminuria. In our study, it was aimed to investigate the presence and prevalence of nonalbuminuric diabetic kidney disease observed in patients with type 2 diabetes, and to determi...

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ea0070aep349 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Rhinosinusal mucormycosis: A devastating infection in diabetes Mellitus

Masmoudi Mohamed , Hasnaoui Mehdi , El Omri Malika , Lahmar Rihab , Mighri Khalifa , Driss Nabil

Introduction: Mucormycosis is an unusual but serious fungal infection that most commonly affects people with diabetes mellitus. Treatment shoud be initiated urgently and associates antifungal treatment, surgical resection and control of risk factors. This infection is associated with high morbidity and mortality rates.Case reports: We report three cases of rhinosinusal mucormycosis occuring occurring in one female and two males. The medium age of the pat...

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ea0070aep350 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

PHIGNA-DM2 study: Fatty liver and nonalcoholic steatohepatitis prevalence in type 2 diabetes in an andalusian cohort

Jesús Martínez Ortega Antonio , Remon Pablo , Deniz Garcia Alejandro , Ampuero Javier , Romero-Gomez Manuel , Pablo Garcia-Luna Pedro , Soto-Moreno Alfonso

Introduction: Non-alcoholic fatty liver disease (NAFLD) is an underdiagnosed complication in Type 2 Diabetes (T2D). This condition can evolve into steatohepatitis (NASH) and more severe entities such as liver cirrhosis and hepatic failure, being currently the first cause for liver transplantation in our environment. In Andalusian T2D patients, the exact prevalence is still unknown. Our aim is to assess the prevalence of NAFLD/NASH in a cohort of these patients.<p class="ab...

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ea0070aep351 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evaluation of clinical factors predictive of diabetes remission after bariatric surgery

Lara-Barea Almudena , Mateo-Gavira Isabel , Sánchez-Toscano Esteban , Medina Rivero Daniel , Aguilar Diosdado Manuel

Introduction: Bariatric surgery is an effective treatment in order to achieve an important weight loss and improvement of metabolic comorbidities. This study aimed to assess the clinical factors that can influenced on evolution of type 2 diabetes (T2D) and obesity patients after bariatric surgery.Methods: We conducted a cohort study with a sample of patients with type 2 diabetes and class II obesity or above who underwent bariatric surgery at Hospital Un...

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ea0070aep352 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The relationship between cardiovascular autonomic neuropathy and markers of oxidative stress in patients with type 2 diabetes mellitus

Stepura Olena , Gonchar Olga , Mankovsky Borys

Introduction: Cardiovascular autonomic neuropathy (CAN) is a significant risk factor for cardiovascular morbidity, mortality in patients with diabetes mellitus (DM). On the other hand, oxidative stress is one of the important factor of pathogenesis of diabetic complications. However, an association between CAN, cardiovascular autonomic reflex tests (CARTs), heart rate variability (HRV) and markers of oxidative stress in patients with DM was not fully investigated.<p class=...

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ea0070aep353 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Relationship between pregnancy induced hypertension in women with gestational diabetes mellitus and proinflamatory cytokines

Lara-Barea Almudena , Sánchez-Lechuga Begoña , Vidal-Suárez Alvaro , Campos-Caro Antonio , Aguilar-Diosdado Manuel , López-Tinoco Cristina

Justification and objectives: Gestational Diabetes Mellitus (GDM) is associated with an increased risk of Pregnancy-Induced Hypertension (PIH). Previous studies suggest a relationship between inflammatory markers and the development of PIH and obstetric and perinatal complications. The aim of the study was to establish the relationship between pro and anti-inflammatory cytokines and the development of PIH and the impact on obstetric and perinatal outcomes.<p clas...

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ea0070aep354 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The pattern of nerve involvement in type 1 diabetic patients with subclinical peripheral neuropathy

Mashkova Maryia , Shishko Alena , Bylodid Irina , Semushina Alena , Korshova Natalia

The concept of a subclinical form of diabetic peripheral neuropathy (DPN) is well established. Although there has been considerable research of peripheral neuropathy in type 1 diabetes, still there is controversy regarding the pattern of nerve involvement in diabetic neuropathy. Detection of the pattern of nerve involvement can help to establish a protocol for screening of DPN in its subclinical stage.Aim: The aim of this study was to describe the patter...

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ea0070aep355 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Nursing networking for insulin pump therapy

Minic Sanja , Medenica Sanja , Muzurovic Emir , Kavaric Sreten , Djogo Aleksandar , Krnjevic Djordjije , Boskovic Olivera , Vujosevic Snezana

Objective: Diabetes mellitus is among the most common of chronic disorders with increasing prevalence worldwide, affecting 50 000 citizens in Montenegro. The insulin pump is a medical device that works on the principle of continuous insulin injection, and is used in the control of diabetes in insulin dependent patients. The objective of this study was to highlight the role of nurse in education of the patients, implantation of insulin pump and nursing networking for insulin pu...

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ea0070aep356 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effect of lipid metabolism of mothers with type 1 diabetes and obesity on clinical and laboratory parameters of their newborns

Prylutskaya Veranika , Solntsava Anzhalika , Goncharik Antonina , Pavlovets Marya , Kurlovich Ivan

Background and objective: According to recent studies, adipose tissue produces important biological factors (adipokines include leptin, adiponectin, etc.) for hormonal, lipid and glucose metabolism, insulin resistance, endothelial dysfunction and atherosclerosis development. The study of this factors and it’s correlation with maternal lipid metabolism and neonatal anthropometric characteristics would be of great interest.This study aims to analyze ...

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ea0070aep357 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Different steroidogenesis in patients with alzheimer’s disease and Type 2 diabetes mellitus

Vankova Marketa , Hill Martin , Vcelak Josef , Vejrazkova Daniela , Bendlova Bela

Alzheimer’s disease (AD) is a neurodegenerative diseasethat is manifested by a progressive loss of cognitive and behavioral function. In previous studies, we have constructed a predictive model for the classification of AD patients based on levels of circulating steroids and their polar conjugates.Both AD and Type 2 diabetes mellitus(T2DM) are well known to affect the levels of some steroid hormones, however, in the opposite direction, and in a gen...

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ea0070aep358 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The trio of severe hypertriglyceridemia, acute pancreatitis and diabetic ketoacidosisin a young subject not known before with diabetes. A case report

Kermaj Marjeta , Fureraj Thanas , Hoxha Violeta , Poshi Klodiana , Ylli Dorina , Haxhiraj Adela , Elezi Edlira , Muco Ermira , Kapia Mariola , Guni Mirjeta , Ylli Agron

Introduction: The trio of severe hypertriglyceridemia, acute pancreatitis and diabetic ketoacidosis (DKA) is a rare occurrence. Previous cases have presented DKA as the initial factor, contributing to subsequent hypertriglyceridemia and pancreatitis. Moderate hypertriglyceridemia is commonly observed in DKA but severe hypertriglyceridemia is very rarely reported.Case report: We report a case, male 29 years old, diagnosed with hypertriglyceridemia 3 years...

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ea0070aep359 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Case of type 1 diabetes development after programmed cell death-1 inhibitor immunotherapy

Kyung Kim Mi , Seok Park Jae , Hee Cho Nan

Programmed cell death-1 (PD-1) receptor inhibitor is an immune check point blockade for anticancer treatment and is currently used for various malignancies such as melanoma, non-small cell lung cancer, and so on. However, an immune check point blockade is associated with a risk for immune related adverse events. Among these events, Type 1 diabetes is rare. We present a case of a 52-year-old man, with no previously diabetic history, who developed diabetic ketoacidosis (DKA) aft...

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ea0070aep360 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Arare case of caucasian patient with insulin autoimmune syndrome induced by a-lipoic acid

Glikofridi Spyridoula , Papanastasiou Labrini , Markou Athina , Andrianesis Vasileios , Gravvanis Christos , Kounadi Theodora

Introduction: Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia caused by insulin autoantibodies (IA) in the absence of exogenous insulin administration. The occurrence of IAS may be influenced by a genetic predisposition determined by HLA class II. IAS is frequently reported in Japanese and Koreans due to their genetic predisposition (HLA-DRB1*0406) rather than in the Caucasians. Some drugs containing sulfhydryl compounds are known to initiate the...

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ea0070aep361 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Autoimmune causes of hypoglycemia

Baraia-Etxaburu Marta , Álvarez Pilar , Vela Amaia , Monroy Jorge , Sáez de la Maleta Ruth , María Delgado Ana , Grau Gema , Rodríguez Amaia , Ruiz Enrique , Rica Itxaso

Background: Identifying the etiology of hypoglycemia in a non-diabetic patient is a significant challenge. Hyperinsulinemic hypoglycemia can lead to pancreatectomy in patients with no evident organic disease. Insulin autoimmune syndrome (IAS) or Hirata diseaseand Type B insulin resistance syndrome are the two typesof autoimmune hypoglycemia, with a low worldwide prevalence.Objective: We report two real-lifecases that illustrate each of them.<p class=...

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ea0070aep362 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Cardiovascular manifestation of alkaptonuria

Shah Preet , Hingolikar Ankita

Case History: A 64-year-old gentleman presented with progressive exertional breathlessness since 1 year. He had started noticing pigmentation in the eyes 2 years back, and gave a history of passing black coloured urine since childhood. He had never consulted a medical professional for the same. Examination revealed hyperpigmentation of both ears and conjunctivae, and an ejection systolic murmur (Grade V) at the aortic area, which radiated to both his carotids. A sample of his ...

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ea0070aep363 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The quantitative relationship between Autonomous cortisol secretion, Dysglycemia and the Metabolic syndrome

Bleier Jonathan , Shlomai Gadi , Fishman Boris , Dotan Zohar , Rosenzweig Barak , Tirosh Amir

Objective: Autonomous cortisol secretion (ACS) is the most common endocrine abnormality in the evaluation of adrenal incidentalomas. The categorization of ACS is derived from a 1 mg dexamethasone suppression test (DST). Impaired DST is associated with several metabolic derangements. In this study we assess the correlation between post-DST cortisol level, analyzed as a continuous parameter, and indices of glycemic metabolism.Study design: We prospectively...

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ea0070aep364 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

In vitro and in vivo insulinotropic actions of magainin-AM1 on pancreatic beta cells and high fat fed mice

Abiodun Falobi Ayodele , Benjamin Falana Ayokunle , Abdel-Wahab Yasser HA , Flatt Peter R , Ojo Opeolu

Aim: Insulin-releasing effects and potential anti-diabetic actions of peptides isolated from the skin secretion of the African clawed frog, Xenopus amieti has been reported. However, peptides such as magainin-AM1 has not been previously studied for its ability to stimulate insulin secretion or promote glucose uptake. This study investigated insulin releasing effects as well as possible underlying mechanisms.Methods: Acute and chronic actions of ...

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ea0070aep365 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The acute effects of short-term insulin therapy on the secretory ability of beta cells in patients with diabetes mellitus type 2, after the secondary failure of the oral therapy

Grbic Aleksandra , Malesevic Gabrijela , Soldat-Stankovic Valentina , Caric Bojana , Popovic-Pejcic Snjezana

Introduction: Secondary failure (SF) to treatment with oral therapy is defined as the absence of a favorable reaction to the oral therapy which was effective in the previous course of the treatment. The aim of the work was to investigate the acute effects of the short-term insulin therapy on the secretory ability of endocrine pancreatic beta cells and the insulin resistance. Materials and Methods: 98 patients with diabetes mellitus type 2 (DM T2) and confirmed the SF to the or...

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ea0070aep366 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Clinical pharmacology of insulin aspart: Hyperinsulinemic euglycemic clamp study of the biosimilar product

Dorotenko Artem , Makarenko Igor , Mosikyan Anna , Magruk Maksim , Drai Roman

Introduction: Rapid-acting insulins is widely used in the treatment of either type 1 diabetes mellitus, or type 2 diabetes mellitus. A mealtime injection of rapid-acting insulin, such as insulin aspart, allow the diabetic patients to control the levels of post-prandial glucose. The clinical development plan of the insulin biosimilarsusually contains pharmacology studies to evaluate pharmacokinetics (PK), pharmacodynamics (PD) and clinical safety of the investigational products...

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ea0070aep367 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Does short term intensive insulin therapy in newly diagnosed type 2 diabetes mellitus delay eventual insulin dependence?

Patil Madhuri , Gunasekaran Uma

In patients with type 2 diabetes mellitus (T2DM), dysfunction of β-cellsstarts years before the diagnosis of T2DM and rapidly worsens after overt hyperglycemia. Use of short-term intensive insulin therapy (STIIT) at the time of diagnosis of overt hyperglycemia has shown clinical recovery of β-cells for up to 2 years. A systematic literature review of studies looking for the effect of STIIT, used within two years of diagnosis of T2DM, on the duration from relapse of h...

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ea0070aep368 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Nurse education in diabetes and endocrinology – important part of the improvement of care provided to people with diabetes and other endocrine disorders

Saxvadze Marina , Kurashvili Ramaz , Tsutskiridze Liana , Shelestova Elena

Background and aims: Diabetes (DM) is a huge global health emergency of the 21st century. Around 463 million adults haveDM. Every 2-nd adult with DM is undiagnosed. Over 374 million people have impaired glucose tolerance, their risk of developing DM is very high. According to Diabetes Atlas-2019 DM national prevalence for Georgia is 7.1%. Increasing prevalence of DM/other endocrine disorders, specific health needs ofthese populations, increasing load on healthca...

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ea0070aep369 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Insulin regulated aminopeptidase (IRAP) inhibition affects glucose metabolism in obese pre-diabetic Zucker rats

Krskova Katarina , Balazova Lucia , Dobrocsyova Viktoria , Balogova Erika , Suski Maciej , Olszanecki Rafal , Zorad Stefan

Skeletal muscle and adipose tissue has been identified as an endocrine organ and their metabolism exerts an impact on whole-body metabolism. Endocrine functions attributed to adipokines and myokines are involved in body weight regulation and insulin sensitivity. Obesity is associated with dys-regulation of adipose tissue and skeletal muscle metabolism and is accompanied with insulin resistance. Our study investigates the effect of insulin regulated aminopeptidase (IRAP) inhibi...

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ea0070aep370 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Relationship of blood dopamine and leptin with anthropometric data in childhood obesity

Viazava Liudmila , Solntsva Anzhalika , Zaytseva Elena

Background: Some of neurohormonal peptides, such as dopamine and leptin, get involved in modulationof food ingestion, eating behaviorand obesity.Study aim was to detect associations blood dopamine, leptin and anthropometric indexes to predict the probability of obesity in children.Material and Methods: 223 children (11–17.9 y.; II – V Tanner stages) with BMI ≥2 SDS and BMI = ± 1 SDS (normal weight (N...

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ea0070aep371 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The influence of obesity on changes in adipokines during the menstrual cycle

Šrámková Monika , Kolátorová Lucie , Včelák Josef , Lischkova Olga , Stárka Luboslav , Dušková Michaela

The purpose of the menstrual cycle is to prepare the egg for fertilization and implantation. The changes and functions of the basic steroid hormones during the menstrual cycle are well known. However, changes to other hormones occur during the menstrual cycle as well, including those influencing the intake of food. These changes have been described inconsistently in the literature, especially considering differences in overweight and obese women. The aim of this study was to d...

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ea0070aep372 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The effect of SNP (rs174537) in FADS1 gene on fatty acid composition in serum lipids

Metelcová Tereza , Vaňková Markéta , Zamrazilová Hana , Hovhannisyan Milena , Tvrzická Eva , Staňková Barbora , Hill Martin , Včelák Josef , Kunešová Marie

Background: Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body (Sergeant et al., 2012). Single nucleotide polymorphism (SNP) in FADS1 gene and percentage of polyunsaturated fatty acids inserum lipids was associated (Klingel et al., 2018). Genetically predisposition to higher plasma arachidonic and stearic acid levels were associated with incidence oflarge-artery stroke and venous thromboembolism...

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ea0070aep373 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The educational training to the Mediterranean diet-like pattern is followed by improvement in cardiometabolic parameters and ecology of the microbiome in children with obesity: Preliminary results of the GOOD DAY trial

Ricotti Roberta , Archero Francesca , Landoni Valentina , Mancioppi Valentina , Caputo Marina , Bellone Simonetta , Solito Arianna , Novello Giorgia , Gamalero Elisa , Mignone Flavio , Cavaletto Maria , Agosti Emanuela , Bona Elisa , Prodam Flavia

Introduction: In the pediatric population the progression of obesity-related diseases can be delayed or prevented through changes in lifestyle, including the promotion of a Mediterranean-like dietary (MD) pattern.Objective: We aimed to assess the efficacy of an educational training to MD based on gamification with respect to a conventional weight-loss treatment in obese pediatric subjects on weight decreased and cardiometabolic risk factors (GOOD-DAY Tri...

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ea0070aep374 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Liraglutide downregulates the expression of miRNA-424 in patients with obesity

Dimitriadis Georgios K , Dimitri Federica , Bate Danielle , Leca Bianca , Davasgaium Allan , Tripathi Gyanendra , Miras Alexander D , Rubino Francesco , Christian Mark , Randeva Harpal S

Aims: Liraglutide 3 mg once daily is an approved, prescription injectable Glucagon Like Peptide-1 receptor agonist that, when used with a low-calorie diet and increased physical activity, can reduce excess weight in patients with obesity. MiRNAs are small non-coding single stranded RNAs that regulate gene expression post-transcriptionally by inhibiting their mRNA target translation into proteins. MiRNAs can be secreted in the blood stream and affect the molecular pathways...

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ea0070aep375 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Predictors of metabolic disease in normal weight postmenopausal women: A cross-sectional study

Armeni Eleni , Paschou Stavroula A , Augoulea Areti , Rizos Dimitrios , Kaparos George , Palaiologou Anastasia , Soureti Anastasia , Karagouni Iliana , Apostolakis Michael , Lambrinoudaki Irene

Introduction: The aim of this study was to evaluate predictors of metabolic disease in normal weight postmenopausal women.Patients and Methods: This cross-sectional study included 457 non-obese postmenopausal women, recruited from the Menopause Clinic of Aretaieio Hospital, National and Kapodistrian University of Athens. The diagnostic criteria of the International Diabetes Federation for the definition of Metabolic Syndrome were used, in order to classi...

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ea0070aep376 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Phase angle (PA) and body composition changes in obese patients with associated comorbidities (by AACE criteria) through a very low calorie diet (VLCD) program

Maria Cornejo Pareja Isabel , Ma Vegas-Aguilar Isabel , Fernández-Medina Beatriz , Tinahones Francisco J , García-Almeida Jose Manuel

Introduction: Obesity is defined as a chronic disease by AACE/ACE. Includes presence/severity of complications. VLCD diets induce relevant weight loss by improving these complications. PA is a bioelectric measure of the cell mass and it is marker a global prognostic factor of cellular functionalism.Methods: Case-control retrospective study of severe obesity in a weight loss program comparing intensive intervention (41 cases, VLCD 800 kcal/d, 1g protein/k...

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ea0070aep377 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The additive effect of obesity in the incidence of neurocognitive disorders in offspring of women with gestational diabetes

Simó Andreu , Perea Veronica , Valverde Maite , Quirós Carmen , Orois Aida , García-Pascual Luis , Barahona MªJosé

Aim: Gestational diabetes (GDM) has been associated with an increased risk ofneurocognitive outcomes in offspring such as attention deficit/hyperactive disorders (ADHD) and autism spectrum disorders (ASD). However GDM-related comorbidities (obesity or excessive weight gain –EWG-) in this setting have been scarcely studied. So, the aim of our study was to estimate the risk of ADHD and ASD in this population.Material and Methods: Cohort study. Single...

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ea0070aep378 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Bariatric surgery impact on cardiovascular risk factors: Is age a factor to consider?

Mendonça Fernando , Silva Maria , João Ferreira Maria , Salazar Daniela , Guerreiro Vanessa , Pedro Jorge , Sergio Neves Joao , Viana Sara , Belo Sandra , Varela Ana , Freitas Paula , Carvalho Davide

Introduction: Despite the abundance of data addressing the influence of patient’s age on surgery-related complications, its impact on several cardiovascular risk factors following bariatric surgery has been overlooked.Methods: Retrospective unicentric study of 1728 obese patients who underwent bariatric surgery between January/2010 and June/2015. Patients were divided in three groups, according to their age at surgery: <40 (n = 751...

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ea0070aep379 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

TGFβ1 downregulates hepatic SHBG production by decreasing HNF-4α levels via SMAD and STAT3 pathways

Brianso-LLort Laura , Fuertes-Rioja Lidia , Hernandez Cristina , Simo Rafael , Martinez David

Low plasmasex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represents a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We are interested in studying the molecular mechanisms by which plasma SHBG levels are reduced in fatty liver disease. In this regard, we have previously shown that fat accumulation in the liver reduces SHBG production by reducing hepatic nuclear fac...

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ea0070aep380 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Cryptogenic cirrhosis and metabolic syndrome: What relationship?

bradai Samir , Akkari Imen , Soumaya Mrabet , Jazia Elhem Ben

Introduction: Cryptogenic cirrhosis is cirrhosis that remains of unknown etiology after an exhaustive investigation. The relationship of cryptogenic cirrhosis with metabolic syndrome is strongly suggested. The aim of this work was to study the clinical-progressive profile of cryptogenetic cirrhosis and to determine the frequency of the metabolic syndrome.Patients and Methods: This is a study collecting all cirrhotic patients over a period of 4 years in o...

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ea0070aep381 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association of osteoprotegerin and metabolic status in children with obesity

Mikhno Hanna , Solntsava Anzhalika , Dashkevich Helena

Objective: Determination of changes in metabolic status and osteoprotegerin concentrations in obese children.Methods: We examined 221 children in the University Hospital (Minsk) from 2017 to 2019 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of osteoprotegerin (OPG), insulin were determined. In the biochemical blood test, the parameters of uric acid, insulin were evaluated. All children were di...

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ea0070aep382 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Different effects of 5α-dihydrotestosterone treatment on hepatic and visceral adipose tissue inflammation in animal model of polycystic ovary syndrome

Vojnovic Milutinovic Danijela , Velickovic Natasa , Nikolic Marina , Djordjevic Ana , Brkljacic Jelena , Teofilovic Ana , Bursac Biljana , Jelaca Sanja , Macut Djuro

Polycystic ovary syndrome (PCOS) is a complex reproductive disorder that is usually associated with metabolic disturbances such as obesity, dyslipidemia and insulin resistance. In this study, female rats treated with nonaromatizable 5α dihydrotestosterone (DHT) were used as an animal model of PCOS. The aim of this study was to assess the presence of inflammation in liver and visceral adipose tissue (VAT), which accompanies metabolic disturbances in animal model of PCOS. F...

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ea0070aep383 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association of AdipoQ gene & its expression in adipose tissue with post prandial hypertriglyceridemia and glucose intolerance

SV Madhu , Mishra Brijesh , Banerjee Basudev , Mohd Aslam , Agrawal Vivek

Background: AdipoQ gene is located at the 3rd chromosome and encodes foradiponectin which is involved in fat metabolism and insulin sensitivity and plays a protective role in diabetes and atherogenesis. AdipoQgene variants have been reported to be associated with hypertriglyceridemia and risk of diabetes in different studies. We aimed to study whether polymorphism of rs2241766 polymorphic form of AdipoQ gene & its expression in adipose tissue is associated with post prandi...

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ea0070aep384 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evaluation of macrovascular complications with Ankle-Brachial index in Type 2 diabetes

Gülçiçek Gamze , Mert Meral , Akyol Berk

Aim: In our study; we aimed to evaluate the relationship between Ankle-brachial index (ABI) values and diabetes duration, and macrovascular complications in patients with DM with demographic data, anthropometric measurements, as well as clinical and laboratory data.Materials and methods: Our study is a cross-sectional study of 226 randomly selected DM patients who were admitted to the diabetes outpatient clinic of our hospital between April 2019 and Octo...

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ea0070aep385 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Maternally inherited diabetes and deafness presenting as diabetic ketoacidosis

Shaikh Sheeba , Jude Edward

Background: A 29 year old female presented to the Emergency department with headache, vomiting and loose stools for 24 hours. She was not known to have diabetes. She had a background of bilateral sensorineural deafness for 6 years and resolved Gillian Barre syndrome 8 years prior. She has a family history of deafness and diabetes mellitus in her maternal grandmother and mother; and diabetes in her maternal aunty and two maternal uncles diagnosed with prediabetes. She has a par...

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ea0070aep386 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association of depressive symptoms and diabetes-related distress with glycemic control, self-care activities and quality of life in diabetic patients

Grgurevic Mladen , Kljajic Kristina , Gulin Tonko , Rahelic Dario

Background: Depressive symptoms (DS) and diabetes-related distress (DD) are common comorbidities in diabetic patients adversely affecting diabetes self-management and patients’ well-being.Aim: To examine associations between DS and DD with glycaemic control, quality of life and diabetes self-management.Materials and methods: Depressive symptoms, DD, quality of life, diabetes self-management and metabolic indicators were asses...

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ea0070aep387 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Albuminuria and carotid intima-media thickness as surrogate markers of atherosclerosis in asymptomatic patients with type 2 diabetes

Malesevic Gabrijela , Popovic Pejicic Snjezana , Grbic Aleksandra , Caric Bojana , Risovic Ivona , Soldat Stankovic Valentina

Introduction: Clinical assessment of atherosclerotic complications in type 2 diabetes mellitus (DM) was diverted to the detection of subclinical form of atherosclerosis using the non-invasive diagnostic methods. Surrogate markers of subclinical atherosclerosis are carotid intima-media thickness (IMT) and albuminuria. The aim of this study was to analyze a relationship between the presence of albuminuria and carotid IMT in patients with type 2 DM and silent ischemia.<p clas...

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ea0070aep388 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Exacerbations of psoriasis in patients with type 2 diabetes

Brutskaya-Stempkovskaya Elena , Sushynski Vadzim , Shishko Elena , Sikorskaya Tatsiana , Plotnikova Anastasia

Psoriasis patients have an increased risk of cardiovascular disease, stroke, hypertension, and type 2 diabetes (T2D). External factors (infections, stress, trauma, endocrine diseases) can trigger psoriasis. Skin diseases in patients with T2D are increased, hyperglycemia leads to damage to vascular intima. Itching of the skin leads to disruption of the repair and regeneration.Objective: To study the influence of T2D on the exacerbations of psoriasis.<...

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ea0070aep389 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Disordered eating behaviour in type 2 diabetic patients receiving oral hypoglycemic drugs

Lobashova Veranika , Shepelkevich Alla , Dydyshko Yulia

Objective: Patients with type 2 diabetes mellitus (DM) are expected to follow numerous dietary recommendations which can be difficult to adhere and that can cause changes in their eating behavior. Few studies have examined prevalence rates eating disorders in adults with type 2 DM despite the fact that DM is highly correlated with overweight and obesity. The aim of the study was to assess the prevalence of disordered eating behavior in type 2 diabetes mellitus patients receive...

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ea0070aep390 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Insulin need and determinants of insulin usage in diabetes mellitus during pregnancy

Taskiran Bengur , Baris Cansu Guven

Aim: We aimed determinants of insulin usage in pregnant women with impaired carbohydrate metabolism (ICM).Methods: We collected 164 pregnant women in any trimester who were referred to endocrinology unit due to suspicion of ICM by obstetricians. Diagnostic laboratory criteria were as follows: fasting glucose ≥126 mg/dl in first trimester; 1 hour 50 g challenge test glucose ≥180 mg/dl; any value exceeding threshold during OGTT (...

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ea0070aep391 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Arginine metabolism and gut microbiota changes in pediatric patients with type 1 diabetes

Aghajanova Elena , Melkonyan Arthur , Alchujyan Nina , Gayane Bayburdyan , Hovhannisyan Margarita , Navasardyan Lusine , Markosyan Renata , Kalantaryan Lusine , Issa Vrej , Arakelyan Lusine , Gevorgyan Zara

Introduction: Incidence of type 1 diabetes mellitus (T1DM) is rising steadily around the globe, including Armenia. It is one of the most common autoimmune and metabolic disorders in pediatric population, resulting from autoimmune destruction of pancreatic β-cells leading to insulin deficiency. Gut microbiota (GM) is reportedly involved in the pathogenesis of T1DM likely by influencing the immune response with the help of arginine-metabolizing enzymes. Arginase i...

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ea0070aep392 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Freestyle libre flash glucose monitoring system in pregnant woman affected by type 1 diabetes: Our experience

Bautista Recio Carmen , Gomez Perea Ana , Domínguez López Marta , González Romero Stella , Colomo Rodriguez Natalia , Vallejo Mora Rosario , Soledad Ruiz de Adana Navas Maria , Olveira Fuster Gabriel

Objective: Prospective observational study in a group of pregnant patients affected by type 1 diabetes (T1DM), that are monitored by the Endocrinology and Pregnancy Unit.Material and Methods: Weevaluated 12 pregnant patients with T1DM in which a FreeStyle Libre Flash Glucose Monitoring Systemwas installed, in addition to their capillary glucose self-control (SMBG), over the past year 2019. Time above range (TAR), time in range (TIR) and time below range ...

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ea0070aep393 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

2-hr vs 1-hr glucose tolerance testing for pre-DM diagnosis, among HIV-infected patients

Guerreiro Vanessa , Cristina Santos Ana , Serrão Rosário , Sarmento António , Carvalho Davide , Freitas Paula

Introduction: Plasma glucose concentration at 1h(1hPG) during an oral glucose tolerance test(OGTT) may be a better predictor of future diabetes mellitus(DM) than 2-h post load glucose concentration(2hPG). HIV-infected individuals may have differential risk of DM compared to the general population, and the optimal diagnosis algorithm for DM in HIV-infected persons remain unclear. We evaluated the agreement of the methods 1 hPG vs 2 hPG) for the diagnosis of pre-D...

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ea0070aep394 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Thiamine-responsive megaloblastic anemia syndrome with dysrhythmia

El Ebrashy Ibrahim , El Haddad Hemmat , Moustafa Heba , Galal Mai , Salam Randa , Magdi Mohamed

Introduction: Thiamine responsive megaloblastic anemia syndrome(TRMA), is an autosomal recessive disorder due to mutation of gene (SLC19A2) encoding thiamine transporter protein TRMA ischaracterized by a triad of anemia, diabetes mellitus, and sensorineural deafness.Case report: A 15 year old girl admitted to the ERwith diabetic ketoacidosis. She was diagnosed as neonatal diabetesat the age of 16 months and wasput on insulin therapy. Her parents arehealt...

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ea0070aep395 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Betamethasone administration in pregnant women with pre-existing diabetes mellitus

Kakoulidis Ioannis , Ilias Ioannis , Linardi Anastasia , Michou Aikaterini , Milionis Charalampos , Venaki Evangelia , Koukkou Eftychia

Introduction: Betamethasone (BM) is widely used in pregnancy. Its diabetogenic potential is known, and in combination with placental insulin resistance in pregnancy, leads to a transient increase in glycemia. Our aim was to study the changes in glycemia in women with singleton pregnancies and pre-existing diabetes mellitus, under insulin therapy, after administration of BM for obstetric causes.Materials and methods: We closely monitored and assessed the ...

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ea0070aep396 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Falling insulin requirements in women with pregestational diabetes

Carmi Adi , Wiener Yifat , Hovav Tali Shapiro , Koren Shlomit , Koren Ronit

Background: Previous studies evaluating the association between falling insulin requirements (FIR) during late pregnancy and adverse maternal and neonatal outcomes yielded controversial results.Methods: We conducted a retrospective cohort analysis of data collected from women delivering at Shamir Medical Center (a referral university-affiliated facility in central Israel), between 2008–2018. The percent of FIR was calculated by dividing the remaind...

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ea0070aep397 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Exposure to phenolic compounds (Bisphenol A and Methyl Paraben) in pregnancy and its relationship with gestational diabetes mellitus, insulin homeostasis and pancreatic beta cell function

Serrano Joaquin , Picó-Alfonso Antonio , Fernández Mariana F , Pedro Arrebola Juan , Alfayate-Guerra Rocio , Teresa López Maria , Moreno-Perez Oscar

Objectives: The effect of exposure to endocrine disruptors (exogenous chemical compounds that interfere with hormonal homeostasis), such as Bisphenol A (BPA) and Methyl Paraben (MPB), on gestational diabetes mellitus (GDM) has only been investigated in a small number of studies, with inconclusive results. Our objective was to investigate the association between concentrations of BPA and MPB in urine and the presence of DMG, insulin sensitivity and function of beta cells in a c...

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ea0070aep398 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The prophylactic effects of metoprolol, diltiazem and pilocarpine on hypoglycemia-induced prolongation of QT interval

Cagiltay Eylem , Pouwels Sjaak

Background: Insulin-induced hypoglycemia has been demonstrated to prolong the corrected QT (QTc) interval. Prolongation of QTc interval, especially in diabetic patients using insulin, can cause fatal ventricular arrhythmias. The aim of this study was to evaluate the effects of metoprolol, diltiazem and pilocarpine on hypoglycemia-induced QTc prolongation.Methods: Thirty rats were randomly distributed into the following five groups: Group 1 (1 ml/kg salin...

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ea0070aep399 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Serum vaspin level in patients with diabetes mellitus type 2 as a predictive index of atherosclerosis

Pylov Daniel , Smirnov Ivan , Zhuravlyova Larysa

Background: It has been proved that the adipose tissue is an active endocrine organ. It secretes a large number of adipokineswhich are involved in and affect regulation of metabolic process and can influence pathogenesis of atherosclerosis. Vaspin-new representative of adipokineswhich is secreted by adipose tissue and have an insulin-sensitizing properties. Vaspin engagement into atherosclerotic process poorly investigated.Aim: To establish the value of ...

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ea0070aep400 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Systematic screening reveals large number of undiagnosed and untreated cardiovascular risk factors in adults with prader-willi syndrome

Pellikaan Karlijn , Rosenberg Anna , Davidse Kirsten , Jan Van der Lely Aart , De Graaff Laura

Introduction: Prader-Willi syndrome (PWS) is a complex hypothalamic disorder, combining hypotonia, intellectual disability (ID), pituitary hormone deficiencies and hyperphagia. In PWS, up to 3% of patients die every year. In half of the patients, the cause of death is obesity related and / or of cardiovascular origin. Obesity is caused by hyperphagia combined with a low energy expenditure. Untreated hormone deficiencies like hypogonadism and hypothyroidism can cause low muscle...

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ea0070aep401 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The severity of insulin resistance in hypertensive patients depending on triglyceride-glucose index

Nesen Andriy , Zlatkina Vira , Chernyshov Volodymir , Shkapo Volodymir , Starchenko Tatyana

Objective: To establish the association of triglyceride-glucose index (TyG) index with metabolic parameters of cardiovascular risk (CVR) in patients with arterial hypertension (AH). We examined 255 patients – 123 women and 132 men aged 45–55 years with AH stage II grade 2which were divided on TyG index into two groups: gr.1 –TyG index < 4.81 units (n = 134) and TyG index > 4.82 units (n = 121) – gr.2.<p class="abste...

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ea0070aep402 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Fish oil and metformin combination to target dyslipidemia in women with polycystic ovarian syndrome

Weaver Olivia , Ghosh Mahua , Maximova Katerina , Proctor Spencer , Vine Donna

Background: Woman with Polycystic Ovarian Syndrome (PCOS) are at risk of developingmetabolic syndrome (MetS), insulin resistance, dyslipidemia, Type 2 Diabetes and Cardiovascular Disease. Atherogenic dyslipidemia occurs in > 70% of women with PCOS which includes high fasting plasma TG, LDL-C, non-HDL-C or ApoB, and low HDL-C. In addition to diet and lifestyle as the first-line intervention, metformin is commonly prescribed for impaired glucose sensitivity. However, metform...

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ea0070aep403 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Epicardial fat accumulation and coronary artery calcification in non-alcoholic fatty liver disease

Perdomo Carolina M , Casajús Ana Ezponda , García Goñi Marta , Zapata Cardenas Juana K , Beloqui Ruiz Óscar , Fruhbeck Gema , Bastarrika Alemañ Gorka , Escalada Javier

Patients with non-alcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular disease, particularly patients with liver fibrosis. Studies have shown a relationship between epicardial fat/coronary calcium and myocardial ischemia.Aim: Quantify epicardial fat and coronary calcium assessed by computed tomography (CT) in patients with NAFLD. Additionally, determine whether patients with hepatic fibrosis quantitatively assessed by liver el...

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ea0070aep404 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effects of azilsartan vs telmisartan on insulin resistance and metabolic biomarkers in patients of essential hypertension associated with type 2 diabetes mellitus: An open-label, randomized clinical trial

Meher Bikash

Background: Based on various preclinical studies, it is anticipated that azilsartan, an angiotensin II receptor blocker, will increase insulin sensitivity in addition to its antihypertensive effect. The present study was undertaken to evaluate the effect of azilsartan compared to telmisartan on insulin sensitivity in patients of hypertension coexisted with type 2 diabetes mellitus.Methods: This study was a prospective, randomized, active controlled, open...

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ea0070aep405 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Aldo-keto reductase (AKR) 1C1 – a potential driver of cell cycle progression in hepatocellular carcinoma

da Conceição Ismael , Nikolaou Nikolaos , Arvaniti Anastasia , Gathercole Laura , Hodson Leanne , Tomlinson Jeremy

The health burden associated with non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, continues to escalate. Not only is NAFLD associated with significant liver-specific and cardiovascular morbidity and mortality, but patients are at risk of the development of hepatocellular carcinoma (HCC); a malignancy where the incidence continues to rise and there are very limited therapeutic strategies.Aldo-keto reductase ...

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ea0070aep406 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Connection of glucose control with the 25-OH vitamin D status in type 1 diabetic young patients

Navasardyan Lusine , Ghubatyan Anna , Markosyan Renata , Aghajanova Yelena

Background and aims: A growing number of studies show the impact of vitamin D deficiency on chronic diseases, such as obesity, type 2 diabetes, cardiovascular disorders etc. Recently the lower limit of vitamin D sufficiency, appeared to be safe and sufficient for skeletal health in the healthy general population, was documented as 20 ng/ml (50 nmol/l). The aim of current work is to evaluate whether the 25-OH vitamin D status is associated with the glucose control in type ...

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ea0070aep407 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Microangiopathy and cardiovascular risk in type 2 diabetic population

Kalthoum Mehdi , Ben Nacef Ibtissem , Rojbi Imen , Adel Meriem , Mechirgui Nadia , Khiari Karima

Introduction: Type 2 diabetes is a springboard to metabolic and cardiovascular complications. The objective of our work was to investigate the different cardiovascular risk factors in diabetic type 2 population, and study relation between the level of cardiovascular risk and the occurrence of degenerative complications.Patients and Methods: Retrospective study including 149 patients with type 2 diabetes consultant at the Department of Endocrinology at th...

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ea0070aep408 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Prolonged QT interval during diabetic ketoacidosis: A case series

Rania Ghariani , Yosra Chrif , Derbal Samar , Laamouri Rihab , Dahmene Fatma Ben , Maya Abdallah

Introduction: Prolonged QT syndrome is defined as exceeding of the QT interval on the elecrocardiography (ECG) (> 450 ms in men and > 460 ms in women). It is either congenital or secondary to medication, electrolyte disturbances, heart disease. However, prolonged QT due to diabetic ketoacidosis (DKA) was rarely described. In this study, we tested the hypothesis that QTc prolongation occurs during DKA and returns to normal with resolution of ketosis.<p class="abstex...

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ea0070aep409 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Factors associated with good knowledge of foot health in a population of patients with diabetes

Jemai Chaima , El Frigui Sinène

Aims: To assess the knowledge of diabetic patients on the health of their feetand to identify the associated factors with good knowledge, while providing podiatric advice.Methodology: It was a descriptive and analytical transversal prospective studyabout 100 diabetic patients (44 men, 56 women; age range 29–87 years). They had an evaluation of their knowledge on the diabetic foot, using a pre-established questionnaire as well as a metabolic evaluat...

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ea0070aep410 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Foot self-care practices of Diabetic patients in Tunisia

Sghir Mouna , Elarem Soumaya , Haj Salah Aymen , Haddada Ikram , Allaya Wafa , Kessomtini Wassia

Introduction: Diabetic foot is a major health problem for people with diabetes mellitus. It can cause serious complications leading to lower extremity amputations. Furthermore, foot self-care practice is one of the most important self-management behaviors to prevent the ocurrence of diabetic foot ulcers.The aim of this study was to identify foot self-care practices among diabetic patients in a Tunisian population.Methods: A cross-s...

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ea0070aep411 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Particularities of the evolution of type 1 diabetes in 102 Tunisian adolescents

Sonda Sellami , Olfa Berriche , Aicha Hechaichi , Belhadj Maha

Introduction: One of the most common chronic diseases in adolescents is type 1 diabetes (T1D).This period of growth is characterized by hormonal fluctuations and psychological changes which are risk factors for diabetes imbalance.Aims: Describe the clinical, paraclinical and therapeutic profile in adolescents with type 1 diabetes in TunisiaMethods: Cross-sectional study conducted atthe Institute of Nutrition ...

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ea0070aep412 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Relationship between chronic pancreatitis and non-alcoholic fatty liver disease in patients with type 2 DM

Rakhmonova Gulzor , Abdullaeva Aziza , Maksutova Nigora , Aykhodjaeva Mokhira , Shamansurova Zulaykho

Background: People with type 2 Diabetes Mellitus (DM2) more predisposed to Non-Alcoholic Fatty Liver Disease (NAFLD). Accompanied chronic pancreatitis impaired glycemic control by affecting gastrointestinal absorption, also by affecting of pancreatic insulin secretion. We study the frequency of NAFLD in DM2 patients with accompanied chronic pancreatitis.Material and Methods: In 44 people with DM2 blood glucose, HbA1c, Cholesterol, triglycerides, LDLP, HD...

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ea0070aep413 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Fungal necrotizing external otitis in diabetic patients

Masmoudi Mohamed , Hasnaoui Mehdi , El Omri Malika , Thabet Wadii , Mighri Khalifa , Driss Nabil

Introduction: Fungal necrotizing otitis externa is a serious and potentially life-threatening condition that is challenging to manage. Diabetic patients are susceptible to develop this severe infection. The diagnosis is often delayed and its frequency has increased over the last few years.Material and Methods: we reported 8 cases of fungal necrotizing external otitis in diabetic patients treated in the ENT department of Tahar Sfar Hospital in Tunisia fro...

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ea0070aep414 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Non-alcoholic fatty liver disease and type 2 diabetes mellitus: Diagnostic methods

Haydarova Feruza , Sadikova Dildora

Actuality: Type 2 diabetes mellitus patients have a higher risk of developing severe liver disease compared with non-diabetes patients. According to the data, among patients with type 2 diabetes, the incidence of cardiovascular, cerebrovascular and peripheral vascular diseases, as well as nephropathy and retinopathy, is significantly higher in the case of concomitant NAFLD. The fact of liver damage in T2DM is beyond doubt. The liver plays a key role in all metabolic processes ...

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ea0070aep415 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association between diabetic peripheral neuropathy (DPN) and hypertiglyceridemia in patients with type 2 diabetes in georgia

Maghradze Tamar , Shelestova Elena , Moistsrapishvili Maka , Kurashvili Ramaz

Background: Diabetic neuropathy is a widespread chronic diabetes complication. This heterogeneous group of conditions affects different parts of nervous system and presents with diverse clinical manifestations. Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes (T2DM), it may cause foot ulcer, gangrene or amputation. The risk of developing DPNincreases with age, diabetes duration and poor glycemia control. About 60% to 70% of all T2DM people will ...

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ea0070aep416 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Hypoglycaemia during ramadan in patients with diabetes from Tunisia

Lajili Olfa , Ounaissa Kamilia , Rachdi Rim , Souissi Nessrine , Zemni Zeineb , Amrouche Chiraz

Introduction: Fasting during Ramadan is an obligatory practice for adultMuslims. Although exemptions exist in certain conditions, including diabetes, the majority ofdiabetic patients fast despite this concession with the risk of complications mainly hypoglycemic accidents.The aim of this study is to establish the relationship between hypoglycemic accidents and drug treatment, therapeutic education, clinical and biological characteristics oftunisian diabe...

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ea0070aep417 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Clinical and metabolic impact of ramadan fasting in tunisian patients with diabetes

Lajili Olfa , Ounaissa Kamilia , Rachdi Rim , Ali Khaoula Ben , Amrouche Chiraz

Introduction: Ramadan fasting is one of the sacred rites in Islam. Diabetes patients are spared this obligation. However, mostof them insists on fasting.The aim of this study is to assess the clinical and metabolic impact of Ramadan fasting in Tunisia patients with diabetes during Ramadan 2019.Materials and methods: Prospective descriptivestudy carried out during Ramadan 2019 including 86 diabetic patients followed at the Nati...

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ea0070aep418 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Cognitive impairment in patients with type 2 diabetes is associated with increased level of circulating Granzyme B

Pashkovska Nataliia , Koval Galina , Pashkovska Olga , Abramova Nataliia , Marchuk Yulia , Pankiv Ivan , Piddubna Antonina

Introduction: Diabetes mellitus is known as a factor of cognitive impairment. The risk of dementia in patients with type 2 diabetes mellitus (T2DM) increases almost twice. The results of epidemiological, visualization and autopsy studies showed the presence of both cerebrovascular and neurodegenerative mechanisms of brain lesions. Cell death of key substrates – neurons and endothelial cells lays in the basis of the formation of cerebral disorders. Granzyme B (GrB) is a s...

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ea0070aep419 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Clinical evidence of the cost effectiveness of bariatric surgery in management of type 2 diabetes mellitus and obesity to prevent associated co-morbidity

Bashir Mahamud , Patel Shrini , Jugnarain Davina , Mlawa Gideon

Introduction: Diabetes is a chronic condition which has become a major public health concern approaching epidemic proportions globally. Effective diabetes management often presents many challenges. Clinicians and patients often become overwhelmed by the need to address co-morbid chronic conditions in addition to patients’ diabetes-specific treatment goals. It is widely accepted that bariatric surgery can help improve health in a range of metabolic diseases, including T2D...

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ea0070aep420 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Pecularities of bile homeostasis in patients with chronic cholecystitis combinedwith diabetes mellitus type 2

Marchuk Yulia , Pashkovska Nataliia , Abramova Nataliia , Koval Galina , Piddubna Antonina , Pankiv Ivan , Tsaryk Iryna

Introduction: In order to improve the early diagnostics of cholelithiasis in patients with chronic acalculous cholecystitis combined with diabetes mellitus type 2 (DM), individual parameters are usually not sufficient. Therefore, we decided to establish and analyze the correlation between the serum and biochemical parameters of bile to evaluate biochemical connections in a system of lipid homeostasis by comorbid pathology. The aim of our study was to determine the peculiaritie...

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ea0070aep421 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Pecularities of antithyroid autoimmunity indicators in patients with diabetes mellitus type 2 depending on leptin level and impact of selenium-containing medicines intake on their titers

Abramova Nataliia , Pashkovska Nataliia

During the last three decades the number of patients with diabetes mellitus (DM) type 2 have increased, which is associated with an increase in the prevalence of obesity among the world’s population. DM type 2 and obesity are closely linked with the production of leptin by adipose tissue. Diseases of the thyroid gland (TG) as well as type 2 DM are the most common endocrine pathologies. Many studies have found an increase of antithyroid antibodies titers against the backg...

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ea0070aep422 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The associations between adipocytokines and future vascular complications in type 2 diabetes

Mok Ji-Oh , Jung Chan-Hee , Kang Sung-Koo

Aims/Introduction: It is thought that adipocytokines contribute to the increased riskof vascular complications in type 2 diabetes (T2DM). However, some data indicate that adipocytokines may protect against cardiovascular disease. The net effects of adipocytokines on vascular pathology are complex and not completely understood. Although previous our cross-sectional studies showed that adipocytokines such as adiponectin, leptin, and TNF-alfa were associated with vascular complic...

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ea0070aep423 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Serum osteoprotegerin level in relation to ankle brachial index among type 2 diabetic patients with subclinical hypothyroidism

Shoaeeb Ghada , Atef Marwa , Hafez Yasser , Ezzat Sherif , Elahwal Loai

Background: Osteoprotegerin (OPG) acts as an important regulatory molecule in vascular disease. The presence of diabetes mellitus greatly increases the risk of peripheral artery disease, Also both subclinical and overt hypothyroidism have been clearly linked with dyslipidemia, which is a known risk factor for peripheral arterial disease.Aim: We aimed to evaluate the relation between serum osteoprotegerin and peripheral artery disease among type 2 diabeti...

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ea0070aep424 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The role of peripheral serotonin in obese wistar rats studied by using of LP533401

Bogomilov Ivaylo , Mihneva Vesela , Boyadjieva Nadka , Nikolov Rumen , Daskalova Ivona

Background and aims: Although 95% of serotonin is produced in the periphery, its functions have been ignored until now. Recently it became clear that theserotonin system in the periphery regulates multiple physiological aspects independently of the brain-derived serotonin. In particular, peripheral serotonin playsa pivotal function in the regulation of glucose and lipid homeostasis by acting on different organs and cell types. Serotonin produced in pancreatic b- cellspromotes ...

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ea0070aep425 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Determining the nutrition, sleep quality and body composition conditions of working shift workers in furniture production

Mantar Ferhan , Dilan Kanmıș Hande

Approximately 20 percent of the world’s working population is working shifts. The shift working system that affects such a large population often causes circadian rhythm disturbances. These disorders adversely affect nutritional habits and quality, sleep patterns and quality, and body composition. The risk of chronic diseases, especially obesity and diabetes, increases due to the direct and indirect effects of disruption in the circadian rhythm. The aim of this study is ...

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ea0070aep426 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effects of bariatric surgery in patients with craniopharyngioma

Dischinger Ulrich , Kötzner Laura , Koschker Ann-Cathrin , Haas Christina , Herrmann Martin , Fassnacht Martin , Seyfried Florian

Effects of Bariatric Surgery in Patients with CraniopharyngiomaObjectives: The prime objective of this study is the identification of the limiting factors of metabolic surgeries on weight reduction in patients with craniopharyngioma (CP) and consecutive hypothalamic obesity (HO).Patients: As of now, 37 patients were included, of which5 patients presented with HO and earlier bariatric surgery (mean BMI 50.44 kg/m2), ...

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ea0070aep427 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Relationship between blastocystis sp. parasitization and metabolic syndrome in an obese spanish population

Caudet-Esteban. Jana , Cifre Martinez Susana , Trelis Villanueva María , Camara-Gómez Rosa , Palasí Rosana , Merino Torres Juan Francisco

Introduction: Blastocystissp. (BS) is the most common intestinal parasite that is isolated in human fecal samples. Its pathogenic role is still questioned. While some consider it a beneficial component of the human intestinal microbiota, some evidence relates it with dysbiosis and development of metabolic syndrome (MS). Its presence has been inversely correlated with BMI.Objective: The objective of this study is two-fold: determining the prevale...

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ea0070aep428 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Adiponectin and omentin-1 concentrations in patients with systemic sclerosis

Bik Wojciech , Dopytalska Klaudia , Kalisz Małgorzata , Litwinuk Anna , Baranowska-Bik Agnieszka , Walecka-Herniczek Irena

Adipokines belong to a group of proteins involved in the pathogenesis and progression of immune/inflammatory diseases. It is an open question whether and how adipokines contribute to these diseases. Adiponectin might be a key regulator of the immune system, playing a role in the progression of inflammatory disorders. Omentin has been recognized as an anti-inflammatory adipokine with influence on immune response regulation and inflammation, Systemic sclerosis (SSc) is a chronic...

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ea0070aep429 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The management of nonalcoholic fatty liver disease with a choline containing antioxidant compound

Athanassiou Panagiotis , Athanassiou Lambros , Kotrotsios Anastasios , Gatsiou Marina , Tsakiridis Pavlos , Devetzi Eirini , Mavroudi Maria , Kaiafa Georgia , Savopoulos Christos , Kostoglou-Athanassiou Ifigenia

Nonalcoholic fatty liver disease has an increased worldwide prevalence due to obesity and the use of various drugs affecting the liver. The pathogenesis of nonalcoholic fatty liver disease is presently not completely defined. In addition, there is a paucity of agents for its treatment. Choline deficiency has been shown to induce nonalcoholic liver disease. Systemic autoimmune rheumatic diseases require chronic systemic treatment with various agents, which may affect liver func...

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ea0070aep430 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Muscle endocrinology and its relation with liver disease

Miguel Peteiro Miranda Carlos , Jorge Ortez Toro José , Sanz Martín Borja , Román Gimeno Sergio , Urdaniz Borque Rosana , Antonio Gimeno Orna José , Julia Ocón Bretón María

Background: Evidence suggests that muscle mass depletion is associated with poor clinical outcomes in clinical population. However, the significance of sarcopenia in the liver transplantation (LT) population remains unclear. The purpose of this study is to investigate the prevalence and the impact of sarcopenia and sarcopenic obesity in cirrhosis patients awaiting LT.Methods: We retrospectively analyzed patients who underwent LT at our center between Jan...

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ea0070aep431 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Differential miRNA expression profile in adipose and muscle tissue of obese individuals with T2DM

Morales Sánchez Paula , Rodríguez Rodero Sandra , Sanz Lourdes , Turienzo Estrella , Luis Rodicio Miravalles José , Amoza País Sonia , Moreno Gijón Maria , Sanz Navarro Sandra , Ares Blanco Jessica , Menéndez Torre Edelmiro , Delgado Álvarez Elias

Aim: Obesity represents a risk factor for the development of type 2 diabetes mellitus (T2DM). Although, this seems to reflect common environmental and genetic factors underlying both pathologies, the link between these conditions is not so clear. A diverse group of elements, including miRNAs, has been implicated in the development of these two metabolic diseases. miRNAs are involved in complex regulatory networks of gene expression. This suggests that alterations in ...

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ea0070aep432 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Do early gestation maternal body composition parameters identify neonates born large for gestational age?

Cremona Alexandra , Cotter Amanda , Ismail Khadijah , Hayes Kevin , Donnelly Alan , Hamilton Jill , O’Gorman Clodagh

Background: Globally, birth-weights are increasing progressively. Birth-weights large for gestational age (LGA) defined as ≥90th centile are linked to increased delivery complications, and adiposity in the neonate. This has been linked to glucose intolerance and CVD later in life. Oversupply of nutrients in utero contribute to excess foetal growth, and maternal obesity may contribute to this rise. The aim of this study is to examine the relationship between para...

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ea0070aep433 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Associations between FSH levels and indices of total and regional obesity in women after menopause

Armeni Eleni , Paschou Stavroula A. , Augoulea Areti , Stergiotis Stefanos , Chatzivasiliou Panagiota , Rizos Dimitrios , Kaparos George , Panoulis Konstantinos , Palaiologou Anastasia , Lambrinoudaki Irene

Introduction: Recent evidence reports a controversial extra-gonadal role of follicle stimulating hormone (FSH). Conflicting data support that the association between FSH and obesity might be maintained by a direct or even indirect effect to the adipose tissue. The aim of this study was to evaluate the associations between FSH concentrations and various obesity indices in women after menopause.Patients and Methods: This cross-sectional study included 420 ...

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ea0070aep434 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Thyroid stimulating hormone, insulin resistance and leptin in patients with obesity after bariatric surgery

Volkova Anna R. , Semikova Galina , Fishman Michael

Background: The function of the thyroid gland effects on obesity and comorbidities. It has been proven for bariatric surgery to be the most effective in obesity treatment.Aim: To evaluate the dynamics of body weight, thyroid status, leptin and insulin resistance in obese patients after bariatric surgery.Materials and methods: 78 obese patients were observed after bariatric surgery (sleeve gastrectomy – 46, gastric bypass &#82...

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ea0070aep435 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Fructose-induced alterations of hepatic lipid metabolism are modulated by chronic stress in male rats

Velickovic Natasa , Vojnovic Milutinovic Danijela , Brkljacic Jelena , Teofilovic Ana , Bursac Biljana , Nikolic Marina , Gligororovska Ljupka , Kovacevic Sanja , Djordjevic Ana , Preitner Frédéric , Tappy Luc , Matic Gordana

Overconsumption of fructoseenriched beverages and everyday stress are both involved in the pathogenesis of metabolic disorders through their effects on hepatic lipid metabolism. The aim of this study was to investigate whether highfructose diet and chronic stress synergistically perturbs lipid metabolism in rat liver. Therefore, we analyzed the effects of 9-week 20% liquid fructose diet and 4-week chronic unpredictable stress, separately and in combination, on dyslipidemia, VL...

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ea0070aep436 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Autoimmune polyglandular syndrome type ii presenting as an endocrine emergency

Ichiche Malika , Laura Iconaru , Rafik Karmali

Introduction: Autoimmune polyglandular syndrome (APS) is a group of polyendocrinopathies characterizedby multiple glands insufficiencies associated with other autoimmune diseases resulting from immune mediated destruction. We describe a patient with type 2 APS presenting first with diabetes type 1 followed later by adrenal insufficiency and Hashimoto disease.Case report: A 23-year-old male, known with diabetes type 1, presented with a very low blood pres...

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ea0070aep437 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Hepatic steatosis indices as a predictors of vitamin D3 deficiency in patients with non-alcoholic fatty liver disease and type 2 diabetes

Mahmoud Udwan , Kobyliak Nazarii , Kyriienko Dmytro , Komisarenko Iuliia

Background: Recently, vitamin D3 deficiency is considered one of the factors associated with the development of non-alcoholic fatty liver disease (NAFLD). The aim was to evaluate steatosis indices and metabolic parameters in NAFLD depending on D3 status.Materials and methods: According to the recommendations of the European Society of Endocrinology, all patients were divided into 3 groups: group 1 – with an optimal level of vitamin D3 (30 ng/m...

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ea0070aep438 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Clinical differences between patients with new-onset diabetes and those without it in a cohort of individuals with pancreatic cancer

Silva Vaca Carlos , Males David , Martin Gonzalez Alba , García Elena , Martínez Guillermo , León Miguel

Background: Pancreatic Cancer (PC) is uncommon; however, it is one of the most deadly cancer types of all. New-onset diabetes (NOD) is associated with a higher risk of pancreatic cancer than general population, particularly if late-onset. An association between new-onset diabetes and increased mortality in patients with pancreatic cancer has been suggested but clinical relevant differences between those individuals with new-onset diabetes and those without are not well establi...

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ea0070aep439 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

HbA1c in the diagnosis of dysglycemia

Belkacem Samira , Mourad Semrouni

Introduction: Type 2 diabetes is a painless and silent pathology, often overlooked, 30% to 50% underdiagnosed. Its prevalence is constantly increasing. It affects 3 new cases every 10 seconds and more than 6 million per year.Aim of the work: Compare the HbA1c test to the carbohydrate status established by the HGPO on a sample of an unknown Algerian population with diabetes but at high risk. And try to establish HbA1c thresholds by appreciating the validi...

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ea0070aep440 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Diabetic ketoacidosis with hypertriglyceridemia-induced acute pancreatitis as first presentation of diabetes mellitus associated with risperidone treatment, a case report

Elamin Yasir , Al-Rubaish Fatima

The triad of hypertriglyceridemia-induced acute pancreatitis with concurrent diabetic ketoacidosis (DKA) is rare in previously undiagnosed diabetic patients. Drug-induced diabetesis one of the main adverse effects of Risperidone, a second generation (atypical) class of antipsychotic used in the treatment of schizophrenia and bipolar disorder, however, Risperidone-induced diabetic ketoacidosis is rare. We are reporting a case of diabetic ketoacidosis associated with hypertrigly...

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ea0070aep441 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Does the association between patterns of fruit and vegetables and metabolic syndrome incidence vary according to lifestyle factors and socioeconomic status?

mirmiran Parvin , Bakhshi Bahar , Hossainpour Somayeh , Azizi Fereidoun

Background: The aim of this study was to investigate the association between the identified patterns of fruits and vegetables and metabolic syndrome incidence, and to investigate whether lifestyle factors (weight change and smoking) and socioeconomic status (education and occupation status) modify the effect of the patterns on metabolic syndrome risk.Methods: We prospectively studied 1915 participants of the Tehran Lipid and Glucose study aged 19–7...

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ea0070aep442 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Diabetes mellitus and glucose-6-phosphate dehydrogenase deficiency: About a case report

Hadj Ali Zohra , Htira Yosra , Khalaf Rahma , Yamoun Rihab , Abadlia Salma , Zemni Zeineb , Mami Faika Ben

Introduction: The glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in humans. In red blood cells, the pentose phosphate pathway is the only source of nicotinamide adenine dinucleotide (NADPH), and defense mechanisms against oxidative damage are highly dependent on G6PD activity. The occurrence of acute haemolysis in patient with G6PD deficiency and diabetes has been reported and ascribed to various mechanisms. Her we report a case of pat...

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ea0070aep443 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Results of survey of patients trained in the outpatient diabetes school

Taukin Ina , Shyshko Volha , Yurenya Alena , Lazovtseva Volha , Mokhort Tatjana , Bilodid Iryna

Background: Constant feedback is required for optimal performance, allowing for flexible planning of outpatient diabetes schools.Aim: To study patient satisfaction with the results of education in the outpatient school for type 1 diabetes (s.d.).Materials and methods: 96 patients with type 1 diabetes (T1D) were included. The survey contained 5 questions: Have patients previously been trained at the s.d.? Which sou...

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ea0070aep444 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Factors associated with being underweight among diabetic outpatient in Cotonou

Lionel Medenou P , Hélene Bihan , Adebayo Alassani , Sopio Tatulashvilli , Baudry Camille

Introduction: Under-nutrition is a greater risk factor for low productivity andpoor health as diabetes1. In Benin 11.9% of males and 9.5% of females were underweight2 and 5.3% of the population have diabetes3. There is no data available on underweight among diabetic in Benin.The aim of this study is to determine the prevalence of underweight among diabetic and the associated factors.Method: It was a...

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ea0070aep445 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Prevalence of dyslipidemia in elderly diabetics

Mizouri Ramla , Zahra Hajer , Naceur Khadija Ben , Temessek Aroua , Mami Faika Ben

Introduction: Diabetes in the elderly is often accompanied by other comorbidities, particularly dyslipidemia, which considerably increases the cardiovascular risk in these patients.The aim of our work was to determine the lipid profile in elderly diabetic subjects.Methods: This was a descriptive and analytical study carried out on 100 elderly type 2 diabetics hospitalized in our department for unbalanced diabetes. Each patient unde...

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ea0070aep446 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Real-time continuous glucose monitoring impact on the metabolic control over the summer in children with type 1 diabetes

Gabriela Duta Simona , Bojoga Irina , Ruxandra Calapod Ioana , Marin Alexandra , Malinici Elisabeta , Ioacara Sorin , Fica Simona

Background: Type 1 diabetes is a chronic disease requiring constant management and a disciplined lifestyle, especially in children. Real-time continuous glucose monitoring system (RT-CGMS) can be a useful tool in maintaining good glycemic control. In our medical centre, beginning with January 2019, a National Program for free distribution of RT-CGMS has been set in motion. The results from one of our previous studies indicated a significant increase in glycosylated haemoglobin...

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ea0070aep447 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The impact of real-time continuous glucose monitoring on metabolic control in children with type 1 diabetes

Ioana Ruxandra Calapod , Bojoga Irina , Gabriela Duta Simona , Stancu Ana-Maria , Arhire Amalia , Ioacara Sorin , Fica Simona

Background: Real-Time Continuous Glucose Monitoring Systems (RT-CGMS) represent a minimally invasive method for frequent glucose monitoring, allowing a better glycemic control for patients with type 1 diabetes. With the occasion of implementing the National Program for free access to RT-CGMS, we assessed the 6 months impact of RT-CGMS on the metabolic control, evaluated by glycated haemoglobin (HbA1c).Methods: In this unicentric, prospective cohort study...

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ea0070aep448 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Phospholipid metabolism in patients with type I and 2 diabetes mellitus

Artykbaeva Gulnora , Saatov Talat

The onset of diabetes mellitus caused by insulin deficiency and insulin resistance is simultaneous with the onset of disorders in lipid and carbohydrate metabolism. Phospholipids are subjected to major alterations in the lipid structures. The data on composition of phospholipids in diabetes mellitus are discordant. The work was initiated to study concentrations of phospholipids in blood of patients with type 1 and type 2 diabetes mellitus. 24 patients with type 1 DM (T1DM) and...

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ea0070aep449 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

High prevalence of psychiatric disorders and its association with worse glycemic control in patients with type 1 diabetes

Fritzen Thiago M , Rodrigues Ticiana C , de Boer Saskia C , Denk Isabele B , Succolotti Deuschle João Alberto , Conte Isabel , Picolo Menegolla Maurício , Weinert Letícia

Introduction: Chronic diseases such as type 1 diabetes can be associated with psychiatric disorders. Previous data suggest a high prevalence of depression, anxiety, disordered eating and diabetes distress among patients with diabetes. Mental health problems could interfere with treatment adherence, glucose control and chronic complications.Objective: We aim to evaluate the prevalence of psychiatric disorders, drug abuse, and treatment adherence in patien...

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ea0070aep450 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Congenital anomaly of the kidney and urinary tract and mody 5 due to 17Q12 deletion syndrome; a case report

Siolos Athanasios , Merkoviti Maria , Georgiou Ioannis , Siomou Ekaterini , Tigas Stelios

Hepatocyte nuclear factor 1B (HNF1B) defects (mutations or deletion) are associated with amultisystem disorder, including urinary tract abnormalities and diabetes (MODY 5, maturity-onset diabetes of the young type 5). We present the case of a patient with congenital anomalies of the kidney and urinary tract in the context of 17q12 deletion syndrome who several years later, presented with MODY 5. A 20-year-old male presented at the outpatient Endocrine Clinic with new-...

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ea0070aep451 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Sleep quality of diabetic patients with metabolic syndrome, is therea difference?

Karataș Savaș , Isiklar Aysun

Objective: Poor sleep quality is a prevalent health problem among patients with diabetes. Metabolic syndrome (MetS) is common in type 2 diabetic patients, and associated with morbidity and mortality. We aimed to investigate sleep quality among type 2 diabetes patients according to their metabolic syndrome status.Participants: This was an analysis of data collected from 189 adult type 2 diabetic patients.Methods: The patients were d...

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ea0070aep452 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Retinol-binding protein in the diagnosis nafld and type 2 diabetes

Larissa Zvenigorodskaya , Mikhail Shinkin , Tamara Nilova , Alexander Petrakov , Galina Varvanina

Retinol binding protein (RBP) is an adipokine, related to insulin resistance (IR). Excess free fat acid reduces the binding of insulin by hepatocyte receptors and leads to hyperinsulinemia. RBP transport protein synthesized in hepatocytes and adipocytes. The level of RBP increases in patients with obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). It is positively correlated with the degree of severity of the inflammatory process and fibrosis. The RBP regulates t...

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ea0070aep453 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Prevalence of disordered eating behaviour in type 2 diabetic patients receiving insulin

Lobashova Veranika , Shepelkevich Alla

Objective: Diabetes mellitus represent a demanding set of biopsychosocial challenges(depression, anxiety disorders, eating disorders) for patients and their families regardless of the age of disease onset. Disordered eating behaviors and eating disorders(ED) represent a spectrum of symptoms that may include restricted caloric intake, distorted body image, binge eating and/or purging behaviors such as excessive exercise, vomiting, and the use of laxatives to lose weight. The pr...

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ea0070aep454 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Constructing a model for the differential diagnosis MODY diabetes and type 2 diabetes

Ovsyannikova Alla , Rymar Oksana , Shakhtshneider Elena , Voevoda Mikhail

Most young patients with hyperglycemia are diagnosed with type 1 diabetes mellitus and type 2 diabetes mellitus (T2DM) but up to 10% of all cases of the disease occur in MODY diabetes. Diagnosis of the correct type of diabetes mellitus (DM) leads to the appointment of pathogenetic effective therapy, adequate management of pregnancy and the prevention of specific complications. The aim of the study was to create a model for the differential diagnosis of T2DM and MODY.<p cla...

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ea0070aep455 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Acidosis is not a sine qua non for DKA

Sarıbeyliler Göktuğ , Kapar Caner , Yılmaz Ayșenur , Alibeyoğlu Alpay , İdiz Cemile , Mutlu Ümmü , Nasifova Vefa , Telci Caklili Ozge , Merve Çelik Ayșe , Çakmak Ramazan , Gül Nurdan , Karșıdağ Kubilay , Dinççağ Nevin

Although Diabetic ketoalkalosis (DKAlk) has beendescribed as a mixed acid-base disorder over half a century ago, there is unawareness among physicians. Here, we present two cases to emphasize DKAlk which is more common than it’s thought.Case-1: A thirty-year-old female patient with type-1 diabetes and ten weeks of pregnancy presented with several weeks of vomiting. She also reported that she had hyperthyroidism for 2 weeks and that she used propylt...

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ea0070aep456 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effect of dietary intake of branched chain amino acids on type 2 diabetic patients

Hamdy Nehal , Salam Randa , sayed Hammad El , Abd el shafy Samah

Background: BCAAs up regulate glucose transporters and activate insulin secretion has been widely demonstrated. However, several researchers have suggested that excessive intake of amino acids could lead to inhibition ofinsulin signalling. BCAAs may induce insulin resistance throughm TOR activation insulin resistance may be linked with high intake of BCAAs, Controversiesremain on whether an increase in plasma BCAA levels is a cause or consequence of insulin resistance.<p c...

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ea0070aep457 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Real-life clinical experience with GLP1 analogs and SGLT2 inhibitors in the treatment of diabetes type 2 and obesity

Pérez-Rodríguez José , Calderón-Vicente Dulce , González-López Javier , Martín-Iglesias David , Alramadan Mubarak

Objectives: SGLT2 inhibitors and GLP1 analogs are the treatment of choice after metformin in patients with type 2 diabetes (DM2) and overweight-obesity (OB). The aim of this study is to analyze the effectiveness and safety of these treatments alone or in combination.Methodology: This is a retrospective observational study in the usual clinical practice. We analyzed the effects of SGLT2 inhibitors and GLP1 analogs treatments in patients with DM2 and OB wh...

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ea0070aep458 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Glucose scan behaviour in people with type 1 diabetes using flash glucose monitoring in a real-world setting

Hochfellner Daniel , Ziko Haris , Elsayed Hesham , Cigler Monika , Knoll Lisa , Pöttler Tina , Aberer Felix , Mader Julia

Introduction: Flash glucose monitoring (FGM) enables people with diabetes to regularly track their glucose levels without performing capillary finger-stick measurements (SMBG). Clinical studies have shown improvement in glycemic control, reduction of hypoglycemia, improvement in comfort and quality of life in people with type 1 diabetes (T1D) using this technology. In contrast to continuous glucose monitoring, FGM requires the performance of a scan to obtain the current glucos...

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ea0070aep459 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Mediterranean diet as a novel adjuvant treatment for type 1 diabetes

Kyriacou Alexis , Kyriacou Angelos , Evans Josie MM

Introduction: The importance of good glycaemic control in Type 1 diabetes (T1D), including its association with reduced cardiovascular disease, is well established. Current education programs focus on carbohydrate counting and its matching to the insulin dose. We set out to investigate the association between Mediterranean diet (MD) and the glycaemic control in patients with T1D.Study design: This was a cross-sectional study that was a collaboration betw...

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ea0070aep460 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Impact of interval walking training on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes mellitus

Sokolovska Jelizaveta , Krilatiha Ksenija , Ostrovska Karina , Pahirko Leonora , Varblane Gunita , Cirulnieks Austris , Klavina Aija , Selavo Leo

Background: Physical activity is the first-line treatment in type 2 diabetes. Interval walking training has demonstrated good tolerability and more pronounced positive effects on physical fitness and metabolism in type 2 diabetes, compared to continuous walking. However, the effects of interval walking on vascular health markers, such as albuminuria, has not been extensively studied. Type 2 diabetes is associated with derangements in leptin/adiponectin axis, which might predis...

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ea0070aep461 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The effect of empagliflozin treatment on biomarkers of fibrosis in patients with type 2 diabetes and a very high risk of cardiovascular events

Lebedev Denis , Babenko Alina

Objective: To evaluate the alterations of fibrosis biomarkers during empagliflozin treatment in patients with type 2 diabetes mellitus (T2DM) and a very high risk of cardiovascular events.Materials and methods: Twenty-six patients with type 2 diabetes mellitus received 10 mg of empagliflozin within 24 weeks. Inclusion criteria: women and men aged 18 to 70 years with T2DM, glycated hemoglobin (HbA1c) 7.0–11.0%, stable hypoglycemic therapy at least 1...

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ea0070aep462 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effects of semaglutide on glycemic control and body composition in patients with type 2 diabetes mellitus and obesity in a real life setting in spain

luiza luca Bogdana , Miguel Sierra Poyatos Roberto , Cardenas Jersy , Sanchez Gomez Nancy , Jesus Silva Rodriguez Maria , Modroño Mostoles Naiara , Montoya Alvarez Teresa , Sanchez Lopez Raquel , Cruces Vega Eva , Estrella Alicia , Barrio Pilar , Sanchez Lechuga Begoña , Gonzalo Montesinos Irene , Jose De la Cruz Fernandez Maria , Perez Alvarez Enrique , Vazquez Martinez Clotilde

Introduction: Semaglutide is a GLP1 receptor agonist (GLP1RA) recently approved in Spain for the treatment of Type 2 Diabetes (T2D) and the National Health Service finances it for patients with T2D and body mass index (BMI) > 30 with a poor metabolic control with metformin.Objectives: Evaluate the effects of Semaglutide on glycemic control and body composition in patients with T2D (PwT2D) and obesity after 6 months of use in a real life setting.<...

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ea0070aep463 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Study on hypoglycemic effect of polyphenolic compounds isolated from the Euphorbia L. plants growing in uzbekistan

Saatov Talat , Mustafakulov Mukhammadjon , Ishanhodjaev Tokhir , Ibragimova Elvira

Members of the Euphorbia L. genus have been used both in both traditional and alternative medicine for treatment of a wide range of disorders since time immemorial. Due to a wide spectrum of compounds of phoyphenolic nature, they are known to show anti-oxidant, anti-inflammatory, antimicrobial, fungicidal and antileukemic effects. The work was initiated to study a hypoglycemic effect of polyphenolic compounds isolated from two types of the Euphorbia L. genus. Polyphen...

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ea0070aep464 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The effectiveness of glucagon-like peptide 1 receptor agonist and prebiotic on short-chain fatty acids and carbohydrate metabolism in patients with carbohydrate metabolism violation

Egshatyan Lilit , Khachaturian Nane , Silvestrova Svetlana , Mkrtumyan Ashot

Background: Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material. SCFAs play an important role in health and disease. They may reduce the risk of inflammatory diseases, type 2 diabetes, obesity, heart disease and other conditions.Aims: to examine the effectivenessof glucagon-like peptide (GLP)-1 receptor agonist and prebiotic treatment on SCFAs, carbohydrate metabolism in pa...

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ea0070aep465 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Adherence with lipid treatment guidelines in Swiss patients with diabetes mellitus – results from the SwissDiab study

Singeisen Hélène , Renstroem Frida , Braendle Michael , Bilz Stefan

Introduction: The major cause of death and disability in patients with diabetes mellitus is atherosclerotic cardiovascular disease (ASCVD). Therefore, treatment guidelines specify strict target lipid levels for these patients. The aim of this study is to evaluate the adherence of diabetes mellitus type 1 and 2 patients (DM1 and DM2, respectively) with respect to the European and Swiss lipid treatment guidelines (ESC/EAS and AGLA, respectively).Methods: T...

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ea0070aep466 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effectiveness of PCSK9 inhibitors in familial hypercholesterolemia in asturias, spain

González Martínez Silvia , Rodriguez Escobedo Raul , Luis Fernández Morera Juan , José López Alba Alfonso , Antonio Álvarez Tamargo José , José Lamela Piteira Carlos , Villazón González Francisco

Introduction: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of LDL cholesterol (LDL-C) from birth. Treatment with statins and ezetimibe achieves in most cases large reductions in LDL-C. In those patients in whom the reduction in LDL-C is insufficient or who have intolerance to such treatments, the appearance of PCSK9 inhibitors has been an effective and safe alternative to achieve the LDL-C objectives.Materials and...

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ea0070aep467 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Outcomes of long pouch roux-en Y gastric bypass (LPRYGB): 4-years experience in primary and revision cases

Ribeiro Rui , Pouwels Sjaak , Parmar Chetan

Background: One of the most important complications of the One Anastomosis Gastric Bypass (OAGB) is enterobilioacid reflux (EBAR). We report the concept of the Long Pouch Roux-en Y Gastric Bypass (LPRYGB) meaning a Roux-en-Y with a long pouch and a 100 cm alimentary limb to avoid EBAR, with a long biliopancreatic limb to increase metabolic effects.Methods: A total of 300 LPRYGB cases in a four-year period, with a 90% follow up rate, were analyzed. Anthro...

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ea0070aep468 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The relationship between estradiol and obesity in men

Pospisilova Hana , Stárka Luboslav , Hill Martin , Dušková Michaela

Introduction: Obesity increases the incidence of hypogonadism in men, and hypogonadism in turn plays a role in obesity. One of the first mechanisms proposed to explain this was a hypothesis based on the principle that obese men have higher estrogen levels, and that increased estrogens provide feedback to the hypothalamic-pituitary-testicular axis, reducing the secretion of gonadotropins and leading to a decrease of overall testosterone levels. This concept has since been quest...

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ea0070aep469 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Role of biochemical indices in the pathogenesis of metabolic syndrome

Smirnova Olga , Kasparov Eduard , Moskalenko Olga

The defeat of the metabolic syndrome (MS) of young people with the development of severe vascular and diabetic complications determines the relevance of its study for the purpose of early diagnosis. Changes in blood at the preclinical stage of MS are reversible, while the main pathogenetic factors of MS are insulin resistance and dyslipidemia. The aim of the study was to assess the role of biochemical parameters in the pathogenesis of MS.Materials and me...

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ea0070aep470 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Sleeve gastrectomy with loop duodenal switch (Fixed common channel) – Modification of single anastomosis duodenoileal bypass with sleeve for diabesity: An Institutional experience

Vennapusa Amar , Bhargav Panchangam Ramakanth

Introduction: Biliopancreatic diversion with duodenal switch (BPD DS) is the most effective metabolic surgery, but accounts for < 1% of metabolic surgeries performed Worldwide due to its technical complexity and severe malabsorption. Its loop modification, single anastomosis duodenoileal bypass with sleeve (SADI S) with 200–250 cm common channel, reduces malabsorption to some extent. But a 250 cm common channel appears to be shorter for Indian patients. &#8...

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ea0070aep471 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Circulating steroid hormones and BMI in men

Mazurina Natalya , Ershova Ekaterina , Komshilova Ksenya , Galieva Marina , Seniushkina Evgeniya , Ioutsi Vitaly , Troshina Ekaterina

Introduction: Previous studies reported significant associations of steroid hormones with anthropometric parameters including body-mass-index (BMI) and waist circumference, as well as with some metabolic parameters such as triglycerides.Methods: 48 reproductive age males (age 18–49) were included in the study (27 obese individuals, 12 persons with excess body weight, 9 normal weight controls). We have examined the association between circulating st...

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ea0070aep472 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

AKR1D1 regulates androgen availability in vitro by generating metabolites that are unable to activate the androgen receptor

Gangitano Elena , Storbeck Karl , Nikolaou Nikolaos , Tomlinson Jeremy

Introduction: AKR1D1 is a 5β-reductase that sits at the interface of steroid hormone metabolism and primary bile acid biosynthesis. 5β-reduced androgens are widely believed to be inactive, but to our knowledge there are currently no data that have directly tested their ability to activate the androgen receptor (AR). We therefore wanted to test the ability of AKR1D1 to regulate androgen availability in vitro and to determine if 5β-reduced androgens are a...

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ea0070aep473 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Refeeding syndrome – an unexpected clinical case

Puga Francisca , Baptista Patrícia , França Margarida , Araújo Correia João

Refeeding syndrome can be defined as the potentially fatal shift in fluids and electrolytes that may occur after the reintroduction of feeding after a period of starvation or fasting in malnourished patients. The hallmark characteristic of refeeding syndrome is hypophosphatemia. However, the syndrome is complex and may also feature abnormal sodium and fluid balance, changes in glucose, protein and fat metabolism, hypokalemia, hypomagnesemia and thiamine deficiency. The underly...

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ea0070aep474 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Clinical analysis of three families caused by mitochondrial DNA mutation A3243G

Yang Luyang , Yang Jing , Liu Yunfeng , Yin Jinhua

Maternally inherited diabetes and deafness (MIDD) is a rare form of diabetes caused by a mitochondrial DNA mutation. The condition is maternally inherited as mitochondrial DNA is practically only derived from oocytes. Patients typically have progressive insulinopenia, sensorineural hearing loss and maculardystrophy. We reported here 3 mitochondrial diabetes (two females and one male) and their families. Both of the 3 patients had diabetes, progressive loss of motor skills and ...

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ea0070aep475 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Descriptive analysis of body composition and phase angle (PA) in achondroplastic patients: Case-control study

Mª Vegas-Aguilar Isabel , Maria Cornejo Pareja Isabel , Leiva Gea Antonio , Tinahones Francisco J , Manuel García-Almeida Jose

Introduction: Data on body composition in patients with achondroplasia are scarce. The Phase Angle (PA) is a bioelectric measurement of our body cells. The PA is considered to be a global prognostic factor that gives information about cellular function in relation to body composition.Objectives: To describe body composition parameters PA, standardized PA (sPA), resistance (Rz), reactance (Xc), body cell mass (BCM), total body water (TBW), fat mass (FM), ...

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ea0070aep476 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

A comparative analysis of the impact of the filipino plate method ‘Pinggang Pinoy’ vs standard nutrition education on food group proportions and 2-hour postprandial blood sugar levels of filipino diabetes patients

Montevirgen Richultz , Kristine Lopez Lizette , Bea Mendoza Kristine

Objectives: To assess whether nutrition education via the Filipino Plate Method ‘Pinggang Pinoy’ will be effective in developing better meal planning skills and 2-Hour Post Prandial Blood Sugar levels (2h-PPBS), comparable to standard nutrition education as recommended by the ADA.Research design and method: The Filipino Plate Method ‘Pinggang Pinoy’ is a simple tool for nutrition advise and would only take approximately 15 minutes...

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ea0070aep477 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Comparison of basal metabolism rate assessment in athletes using indirect calorimetry, bioimpedance, and wearable monitors

Fernandes Oliveira-Filho Antonio , Nunes Adriana , Cavalcanti Cruz Wesley , Carla Silva Lima Erika , Cosmo Rocha Lucas , Candeia Gurjao Edmar , Eduardo Silva Barbosa Paulo

Wearable physical activity monitors are growing in popularity as they provide the opportunity for self-monitoring, real time data collection and data sharing for cardiovascular and sports medicine. However, there are discussions about the accuracy of their energy expenditure estimate. This study examined and compared basal metabolic rate through indirect calorimetry and through wrist-worn devices and bioimpedance. The group consisted of 30 healthy male individuals, professiona...

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ea0070aep478 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effectiveness of the low-calorie diet and exercise as an adjunct to the orlistat for the sustained change in metabolic parameters in young patients with type 2 diabetes with obesity

Chittawar Sachin , Mohnani Laxmi

Introduction: Obesity is a multifactorial disease which poses a serious public health problem, with an alarming epidemic character. The increase in bodyweight is associated with an increased risk of excessive fatrelated metabolic diseases including diabetesMethods: We conducted an observational study to evaluate the clinical effects of orlistat in obese patients (BMI ≥ 30 kg/m2), adhering to low calorific diet limited to 1000–...

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ea0070aep479 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The effect of demographic factors on obesity in children (COSI project 2019), preliminary results

Taxová Braunerová Radka , Kalousková Pavla , Metelcová Tereza , Procházka Bohuslav , Malechová Anežka , Vignerová Jana , Pařízková Jana , Hill Martin , Zamrazilová Hana , Kunešová Marie

Introduction: Demographic factors such as place of residence, urbanization grade and family background are considered to be associated with overweight and obesity in children. Our study investigates differences in obesity prevalence and related characteristics in children from urban, semi-urban, and rural areas, and in children from complete and incomplete families. The study is part of the fifth round of World Health Organization Europe’s Childhood Obesity Surveillance ...

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ea0070aep480 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Investigating the role of olfactory receptors in endometrial cancer cells

Shibel Rand

Laron syndrome (LS) is a rare autosomal recessive genetic disorder caused by growth hormone receptor (GH-R) gene mutations, leading to congenital insulin-like growth factor-1 (IGF1) deficiency and dwarfism. Epidemiological studies have shown that there are no LS patients that suffer from cancer, which means they are protected from cancer development. While the mechanisms associated with cancer protection in LS are unknown, cancer protection might involve the insulin (INS) and ...

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ea0070aep481 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Nesidioblastosis a rare cause of hipoglycemia in adults

Elena Lopez Alaminos Maria , Gonzalez Fernandez Mikel , Almendra Alvarado Rosas Karol , Serrano Urzaiz Leticia , de Diego Garcia Patricia , Trincado Pablo , Acha Perez Javier

Introduction: Noninsulinoma pancreatogenous hypoglycemia syndrome (NIPHS) is an entity with low prevalence (4%), more frequent in neonates and infants and with a male preponderance, characterized by endogenous hyper insulinemic hypoglycemia, not caused by an insulinoma. Pancreatic histology usually reveals diffuse nesidioblastosis.Case report: A 21-years-old man without a remarkable personal or family history was referred describing a 15 kg weight g...

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ea0070aep482 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Adherence to treatment in 102 tunisian adolescents with type 1 diabetes

Sonda Sellami , Olfa Berriche , Nadra Bendag , Smida Amal , Henda Jamoussi

Background: Type 1 diabetes mellitus is the most common chronic illness in childhood. His treatment involves a multifaceted regimen that includes daily blood glucose monitoring, insulin injections, a dietary plan, and regular exercise. Patients, especially during adolescence, do not fully adhere to the diabetes treatment and, as a result, they appear to be at risk for serious medical complications, including hyperglycemic episodes, Ketoacidosis and microvascular complications ...

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ea0070aep483 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evolution of lipidic parameters in a population of patients with type 2 diabetes after switching on insulin analogs

Jemai Chaima , Chaari Cyrine , Ben Mami Feika

Introduction: The advent of insulin analogs has significantly reduced the undesirable effects of human insulin, particularly hypoglycemia. Beneficial effects on the lipid balance have also been described. The aimof our study was to describe the evolution of the lipidic parameters after the switch on insulin analogs.Patients and Methods: This is a longitudinal retrospective study about 61 patients with type 2 diabetes, switched to insulin analogs since at...

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ea0070aep484 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Flash glucose monitoring system: Impact on glycaemic control and body mass index in type 1 diabetes mellitus

Sá Juliana , Lopes Sara , Barbosa Mariana , Ferreira Barros Inês , Margarida Monteiro Ana , Fernandes Vera , Matos Catarina , Alves Marta , Lopes Pereira Maria , Marques Olinda , Joana Santos Maria

Background: The use of Flash Glucose Monitoring (FGM) for the management of type 1 diabetes mellitus (T1D) is rapidly increasing.Aims: To assess the longitudinal evolution of glycated haemoglobin (HbA1c) and body mass index (BMI) with the use of FGM in patients with T1D; to determine predictive factors of benefit with the use of this technology.Materials and methods: Retrospective study of T1D patients, using FGM ≥6 months an...

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ea0070aep485 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effect of ramadan’s fastingon the glycemic balance of a diabetic population with an HbA1C before the fast greater than 10%

Jemai Chaima , Mami Feika Ben

Introduction: International recommendations prohibit fasting of the month of Ramadan in patients with diabetes, particularly unbalanced ones.The aim of our study was to describe the evolution of the glycemic balance in unbalanced diabetics with an HbA1C before the fasting greater than 10%.Patients and Methods: This is a descriptive evaluative study carried out on 25 patients with type 2 and with an HbA1C before fasting greater than...

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ea0070aep486 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Glycemic variability in type 1 diabetes

Santos Tiago , Inácio Isabel , Soares Bruno , Vilaverde Joana , Teixeira Sofia , Cardoso Helena

Introduction: Glycemic variability (GV) is emerging as a measure of glycemic control in type 1 diabetic patients (T1DM) given that it provides an integrated picture of postprandial hyperglycemia and hypoglycemic episodes and is associated with diabetic complications and mortality. However, little is known about the best way to address this problem in clinical practice.Aim: To characterize GV in T1DM patients followed in our center and to identify clinica...

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ea0070aep487 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Efficacy and safety of switching from a dipeptidyl peptidase-4 inhibitor to a glucagon-like peptide-1 receptor agonist: A real-world experience

García-Figueras-Mateos Carolina , Cayón-Blanco Manuel

Introduction: Glucagon-like peptide-1 agonists (GLP1a) and dipeptidyl peptidase-4 inhibitors (DPP4i) are both incretin-based therapies for type 2 diabetes (T2DM) but with distinct efficacy according to glycemic and weight control and side effect profiles. There is scarce information about changes observed after switching from a DPP4i to a GLP1a in patients with T2DM on a complex treatment regimen and routine clinical practice conditions. To assess these changes, we carried out...

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ea0070aep488 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evaluation of the results obtained with flash continuous glucose monitoring in patients with type 1 diabetes after a structured training program

Pla Peris Begoña , Ramos Leví Ana M , Lahera Vargas Marcos , Carraro Casieri Raffaele , Aguirre Moreno Nerea , Knott Torcal Carolina , Marazuela Mónica , Arranz Martín Alfonso

Introduction: Funding of continuous glucose monitoring (CGM) has been established by Madrid Health Service for adults with type1 Diabetes Mellitus (DM) who meet specific criteria. This has brought to lightthe need foran increasedinvestment in care time. In our Division, a structured training program has been established, consisting of 2 training sessions (TS); the first one based on basic contents to initiateFlash-CGM, and the second one, more intensive and targeted, focused o...

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ea0070aep489 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The association of vitamin B12 deficiency with metformin uses

Puca Entela , Bitri Sonila , Dyrmishi Blertina , Lumi Ema , Daka Albana , Puca Edmond

Introduction: Metformin is the first line treatment of type 2 diabetes, but now has been reported to cause a decrease in level of Vitamin B12.The aim of the study is to describe the prevalence of vitamin B12 deficiency in adults with type 2 Diabetes Mellitus who were in treatment with metformin compared in those without diabetes.Material and Methods: Total number of patients were 130 between 16–84 years old. Mean age 54.2 &#1...

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ea0070aep490 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Clinical and safety profile of empagliflozin in nepalese type 2 diabetes patients

Joshi Ansumali , Yonzon Priyadarshini , Thapa Luna , Karki Ritika

Background: The only available SGLT2 inhibitor in Nepal till date is empagliflozin. Empaglilozin has shown to be cardioprotective and renoprotective in randomized trials. It has shown to reduce some weight. There is a lack of data of SGLT2 inhibitors in Nepalese Type 2 diabetes patients.Aim: The aim of our study is to determine the effects of empagliflozin in glycemic control in terms of HbA1C reduction, weight, improvement in eGFR and side effect profil...

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ea0070aep491 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The efficacy of dulaglutide in the treatment of patients with type 2 diabetes and NAFLD in real clinical practice

Nechaeva Olga , Dreval Alexander , Bogomolov Pavel , Bueverov Alexey , Liusina Ekaterina

Background: Dulaglutide has been approved as a hypoglycemic agent for the treatment of patients with T2DM. A positive effect on carbohydrate metabolism and body weight was shown in RCT.It was found that GLP-1 agonists may prevent the progression of NAFLD directly affecting lipid metabolism and inflammation.Aim: To assess the effect of dulaglutide on carbohydrate and hepatic metabolism in patients with T2DM and NAFLD in real clinica...

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ea0070aep492 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association of B12 levels with metformin use in type 2 diabetes patients

Pankiv Ivan

Background: Metformin is the most widely used oral antihyperglycaemic drug, but it may lower B12 status, which could have important clinical implications.Aim: To study serum Vitamin B12 levels in patients with type 2 diabetes mellitus who were receiving metformin and compared them to those never treated with metformin.Materials and methods: A total of 60 patients with type 2 DM (group 1, n = 35, r...

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ea0070aep493 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Insulin usage and injection practices in a largeIndian cohort: An audit

Baruah Manash

Objective: Despite an increase ininsulin utilization in India over the past 10 years, wide variation exists in injection practices and usage across the Indian geography. This cross-sectional study was designed to audit various aspects of insulin usage, tolerability and efficacy of insulin regimens, degree of variability in injection techniques and its causes, interactions, and associations with glucose control and other outcomes.Methods: Data for th...

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ea0070aep494 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Vitamin D, osteoprotegerin and metabolic status in children with obesity

Mikhno Hanna , Solntsava Anzhalika , Dashkevich Helena

Objective: Determination of changes in metabolic status and vitamin D, osteoprotegerin concentrations in obese children.Methods: We examined 221 children in the University Hospital (Minsk) from 2017 to 2019 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of vitamin D, osteoprotegerin (OPG), insulin were determined. In the biochemical blood test, the parameters of uric acid, glucose were evaluated...

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ea0070aep495 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Is body mass indexbefore the fast of the month of ramadan associated with the evolution of lipid parameters in diabetic women?

Jemai Chaima , Mami Feika Ben

Aim: The objective of our study is to describe the evolution of the parameters of the lipid balance after fasting in a population of diabetic women, and to determine if the BMI before the fast is associated with the variation of these parameters.Materials and methods: This is a prospective evaluative study conducted on 44 female patients with type 2 diabetes who have received prior education and therapeutic adjustment adapted according to the recommendat...

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ea0070aep496 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Interrelationship between fasting evaluation of insulin sensitivity, body composition, physical activity and total energy expenditure in obese males

Kauffmann Adriana , Carvalho Davide

The prevalence of obesity markedly increased in the last 2 decades. This have asserted researchers’ attention to the role of adipose tissue throughout the pathophysiology process of a number of diseases. Fatness, namely abdominal fat, is a risk for insulin resistance, type 2 diabetes mellitus (T2DM), and cardiovascular disease. Physical activity is recommended as one of treatment options for individuals with T2DM. This study aimed to determine the relationship between in...

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ea0070aep497 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The effectiveness of complex treatment of obesity on theknee osteoarthritisand the dynamics of cytokines, depending on the degree of weight loss

Strebkova Ekaterina , Alekseeva Ludmila

Objective: Assess the effectiveness of complex treatment of obesity with the use of orlistat (intestinal lipase inhibitor) on the knee OA (KOA) and the dynamics of cytokines (CRP, IL-6, TNF-α) depending on the degree of weight loss.Methods: 50 female patients (45–65 y.o.) with Kellgren-Lawrence stage II-III KOA and obesity (BMI > 30 kg/m²). Patients in Group 1 (n = 25) took 120 mg of orlistat 3 times a day in co...

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ea0070aep498 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evolution of comorbidities associated with obesity one year after bariatric surgery, our hospital experience

de Carlos Joaquin , Anda Emma , Zugasti Ana , Petrina Estrella , Marí Amelia , Rendón Henry , Botella Sonsoles

Bariatric surgery (BS) improves quality of life and health due to the beneficial effect on the metabolism at multiple levels. Specifically, its effectiveness in weight loss and the attenuation or resolution of comorbidities associated with obesity, means lower morbidity and mortality compared to other types of interventions. The objective is to analyze the evolution of obesity-related diseases after twelve months of follow-up.Methods: Retrospective study...

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ea0070aep499 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Obesogens and obesity pandemic

Heshmati Hassan

Introduction: Obesity is a worldwide pandemic associated with increased morbidity/mortality and high cost for the society. The prevalence of obesity has doubled in more than 70 countries (including developing countries) since 1980. The number of adult subjects with obesity is around 700 million worldwide. The current pandemic in obesity cannot be explained solely by alterations in food intake and/or decrease in exercise. Obesity pandemic coincides with the marked increase of t...

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ea0070aep500 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Comparative effectiveness of three methods for body composition assessment in the verification of manifestations of sarcopenia in obese patients

Vasileva Valeriia , Marchenkova Larisa , Sergeev Valeriy

Aim of the study was to compare the effectiveness of three methods of body composition assessment such as bioimpedans analysis (BIA), air-replacement bodyplatismography (BodPod) and Dual X-ray absorptiometry Total body program (DXA Total Body) in the verification of reducing of skeletal muscle mass as sign of sarcopenic obesity in obese patients.Material and Methods: The study group included 95 patients aged 21–69 y.o. (average age 53.9 ± 11.0...

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ea0070aep501 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Combination of topiramate and empagliflozin is considered a good option for treatment of obesity

Younis Mahmoud

Objectives: The aim was to show if the combination of topiramate and empagliflozin have the greatest weight decreasing effect in comparison to each drug alone and to control.Design: Observational cohort prospective study 6-month trial.Materials and methods: Observational cohort prospective study with the following of 200 obese patients who were in 4 parallel groups. Had been monitored in a private clinic, each group 50 patient...

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ea0070aep502 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Different short-term responses of image dissatisfaction and distortion to sleeve gastrectomy

Naliato Erika

Introduction: Bariatric surgery is one of the most important treatment modalities for obesity. Studies suggested that obese subjects have distorted body image perception. Dissatisfaction with body shape is one of the leading reasons for treatment referral.Aim: To prospectively study body image perception and its relationship with body composition in patients treated with bariatric surgery.Methods: Nineteen patients were evaluated b...

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ea0070aep503 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Impact of isoflavone intervention on microbiota, predicted metagenome and metabolic profile in polycystic ovary syndrome

Haudum Christoph , Lindheim Lisa , Ascani Angelo , Trummer Christian , Münzker Julia , Horvath Angela , Obermayer-Pietsch Barbara

Objective: Polycystic ovary syndrome (PCOS) affects 5–20% of women of reproductive age worldwide and is associated with disorders of glucose metabolism. Hormone and metabolic signalling may be influenced by phytoestrogens, such as isoflavones. Their endocrine effects may modify symptom penetrance in PCOS.We investigated, whether women with PCOS and healthy controls differ in their capacity to metabolize dietary isoflavones and whether this capacity...

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ea0070aep504 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Genetic variability in antioxodative and inflammatory pathways modifies the risk for PCOS and influences metabolic profile of the syndrome

Herman Rok , Jensterle Mojca , Janez Andrej , Goricar Katja , Dolzan Vita

Background: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder of multifactorial etiopathology likely to involve the interactions between genetics and lifestyle. Chronic inflammation and oxidative stress (OS) may participate in the pathophysiology of the syndrome. The question of the extent to which OS and inflammation are causally related to the development of the syndrome and metabolic complications remains unanswered. Furthermore, the role of NLR...

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ea0070aep505 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Challenging hypoglycaemia management in a patient with metastatic insulinoma

Giannopoulou Angeliki , Surya Ashutosh , Nidumolu Ravi , Witczak Justyna , Kumar Nagappan , Rees Aled

Background: Metastatic insulinomas are very rare (fewer than 1:100000) and therefore may pose a therapeutic challenge as there are no case controlled studies comparing the efficacy of various therapeutic approaches avialable. The Ki 67 index from the histology of the primary tumour is an established prognostic marker for metastatic disease with tumours showing low Ki 67(<3%) being defined as low risk of early recurrence.Case Presentation: A 60 year o...

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ea0070aep506 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Does the pilgrimage increase the podiatry risk in diabetic patients?

Ameni Salah , Hasni Yosra , Amara Safa , Kamoun Zomorda , Mrad Saoussen , Abdelkarim Asma Ben , Chadli Molka , Saad Ghada , Kacem Maha , Maaroufi Amel , Ach Koussay

Background: The number of diabetic pilgrims could exceed 220000/year. Among the complications that can be observed in these patients, foot lesions are very common. We are therefore interested in this study in the assessment of podiatric risk among diabetic pilgrims.Material and Methods: A Cross-sectional study covered 43 diabetic patients from the city of Sousse, intending to perform the pilgrimage during 2019. The evaluation was made before and after pi...

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ea0070aep507 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Diabetic foot: An important, yet underestimated complication in albanian healthcare

Celo Eni , Hasho Sokol , Toti Florian

Diabetic foot is a main complication of Diabetes Mellitus that affects 15–25% of diabetes patients at least once in their lifetime. This complication has severe consequences at patient’s life quality and a high cost not only for the patient but also for the society. However, this complication is still underestimated in Albania.Aim of study: Our main objective is to summarize the causes and pathogenic mechanisms leading to diabetic foot, and t...

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ea0070aep508 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Diabet foot unit of the marqués de valdecilla university hospital: A data-analytic look of a multidisciplinary team

Higinio Ortega Sánchez Carlos , Isabel Álvarez Schettini María , Margarita Castillo Ledesma Nathalia , Manuel Mora Barrios Joan , Pérez Álvarez Enrique , Montalbán Carrasco Coral

Objective: We will analyze various characteristics of the patients who attend the HUMV Diabetic Foot Unit for a week. The variables studied are sex, age, type of diabetes, years of evolution, type of current treatment, last glycosylated hemoglobin, presence of other cardiovascular risk factors and existence of previous ulcerations and amputationsMaterial and Methods: We worked with Microsoft Excel to coollect the data and perform the statistical study.</...

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ea0070aep509 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Lower urinary tract symptoms in patients with metabolic syndrome and life quality impact: Preliminary results

Sghir Mouna , Elarem Soumaya , Salah Aymen Haj , Haddada Ikram , Baha Zantour , Wassia Kessomtini

Introduction: Recent epidemiological surveys have demonstrated a significant association between MS and lower urinary tract symptoms (LUTS). The aims of this study were to determine LUTS in patients with metabolic syndrome (MS) and to evaluate their impacts in patients’ life quality.Patients and Methods: A cross-sectional study was conducted on patients with metabolic syndrome MS diagnosed according to the criteria of the US National Cholesterol Ed...

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ea0070aep510 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Fungal necrotizing otitis externa in diabetic patients: Clinical features and diagnostic difficulties

Abir Meherzi , Kdissa Amal , Khalifa Mouna , Ghamam Monia , Bellakhdhar Mouna , Wassim Kermani , Mohamed Abdelkefi

Objectives: To describe and analysis theimpact of diabetes on clinical presentation andthe difficulties we could affront within the management of this entity.Materials and methods: A retrospective study conducted between 2006 and 2019 based on 24 patients managed at our Otolaryngology Head and Neck Surgery Department.Results: 24 poorly controlled diabetic patients were enrolled in this study: 15 men and 9 women, with a mean age of ...

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ea0070aep511 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

HNF1A MODY revealed by recurrent hypoglycemia

Belaid Rym , Sebaa Rabah Ben , Alfred Penfornis

Introduction: Hepatocyte nuclear factor 1A MODY (HNF1A-MODY) is the most common form of Maturity-onset diabetes of the young (MODY) diagnosed in adults. It is caused by heterozygous mutations in the HNF1A gene and is associated with progressive β-cell failure and increasing hyperglycemia due to reduced insulin secretion. HNF1A-MODY is characterized by a large phenotypic variability. We herein report the case of a 40-year-old diabetic woman who was identified as h...

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ea0070aep512 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Development of diabetic complications in patients with type 2 diabetes mellitus and impaired circadian rhythms

Garieva Mayya , Kosyan Anyuta

The study involved 37 people with type 2 diabetes who received oral hypoglycemic medications, aged 35–65 years. The first group included 22 people with a daily work schedule, and the second group included 15 people with a night work schedule of more than 5 years as a model of patients with impaired circadian rhythm. Comparative analysis of descriptive data shows the predominance of creatinine levels (P < 0.05) and, accordingly, a decrease in GFR (P ...

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ea0070aep513 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Anemia is associated risk factor of chronic kidney disease in diabetes type 2 patients

Vasilkova Volha , Mokhort Tatsiana , Korotaeva Ludmila , Shestovets Oksana , Yarets Yulia , Borovets Yana , Vasuhina Irina

Introduction: Diabetes is the leading cause of chronic kidney disease (CKD) and is associated with excessive cardiovascular morbidity and mortality. On the other hand, anemia is common among those with diabetes and CKD and greatly contributes to patient outcomes.Aim: The aim of this study was to investigate the prevalence and associated risk factors of CKD among the patients with diabetes type 2 (DT2).Methods: We examined at baseli...

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ea0070aep514 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Lipid metabolism in patients with diabetic nephropathy

Muminova Sitorakhon , Ismailov Said

Introduction: Diabetes is the most common endocrine disease in the world. Persistent hyperlipidemia in type 2 diabetes is accompanied by damage to various organs, on the basis of which generalized changes in the microvasculature lie. In patients with diabetes mellitus with chronic kidney disease, dyslipidemia can be aggravated with hyperglycemia and insulin resistance. Control of dyslipidemia is an important therapeutic goal, since normalization of lipid metabolism and glycemi...

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ea0070aep515 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Increased ultra sensitive CRP: Abiomarker of microvascular risk in men with type 2 diabetes

Lajili Olfa , Tmessk Aroua , Rayhane Soltane Mariem , Ali Khaoula Ben , Safi Eya , Madhbouh Mariem , Htira Yosra , Mami Feika Ben

Introduction: RaisedCRP is observed in obesity, metabolic syndrome and type 2 diabetes in the absence of any inflammatory or infectious disease. Indeed, it may constitute a mark of cardiovascular risk and macro and micro-vascular complications. The objective of our study is to assess the association between raised ultra-sensitive CRP and macro-vascular and micro-vascular complications in a group ofpatients with type 2 diabetes (T2DM).Materials and method...

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ea0070aep516 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evaluation of anxiety frequency in school-aged children with diabetes mellitus type 1 depending on carbohydrate metabolism compensation

Navmenova Yana , Makhlina Elena , Rusalenko Maria

To study anxiety frequency in school-aged children with diabetes mellitus type 1 (DM type 1) depending on carbohydrate metabolism compensation.Materials and methods: 96 patients with DM type 1 aged 13.9 ± 1.97 years. Diabetes duration is 1.72 ± 22.33 Year. We determined glycated hemoglobin (НbA1). The level of HbA1 of 7.5% or more indicated the decompensation of carbohydrate metabolism. Evaluation of the anxiety level was carried out usin...

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ea0070aep517 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Prevalence of peripheral and cardiac autonomic neuropathy in hypertensive pre-diabetic georgian patients by Sudoscan

Kopaleishvili Ana , Kurashvili Ramaz , Akhobadze Tinatin , Asatiani Natalia , Shelestova Elena

Background: Sudomotor function is used to assessperipheral autonomic system. Electrochemical Skin Conductancemeasurement using electrochemical reaction betweenchloride ions in sweat and stainless steel plate electrodes is a simple, non-invasive and quick method. Several factors, including age, sex, BMI, glycemic status influence sweat function.Aim: Our aim was to determineprevalence of peripheral (DPN) and cardiac autonomic neuropathy (CAN) in hypertensi...

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ea0070aep518 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Hyperuricemia as independent cardiovascular risk factors in T2D

Nelaj Ergita , Gjata Margarita , Kecaj Irida , Gjermeni Ilir , Tase Mihal

Background: Uric acid is an inflammatory factor and may have a role in endothelial dysfunction and act as a mediator of diabetic nephropathy. Hyperuricemia is a risk factor for cardiovascular events and renal insufficiency in diabetic patients. The aim of this study was to evaluate the relationships between serum uric acid concentration and level of urinary albumin excretion as well as markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus.<p clas...

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ea0070aep519 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Neurological disorder in a patient with decompensated T2DM

Maria Fernandez-Trujillo-Comenge Paula , Hernández Lázaro Alba , Kuzior Agnieszka , Esteban Nivelo-Rivadeneira Manuel , Delia Santana-Suarez Ana , Javier Martinez-Martin Francisco

Introduction/aim: Neurological symptoms are rarely related to decompensated type 2 diabetes mellitus. However, thanks to complementary tests, we can identify this association more easily.Material and method: Review of the patient’s clinical record and the relevant literature.Results: A 76-year old man complained in the last year of a progressive, involuntary and disabling movement disorder consisting in hemichorea of the left...

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ea0070aep520 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Short and long-term glycemic variability associated with severe hypoglycemia and retinopathy in type 1 diabetes mellitus

Sanz Martín Borja , Roman Gimeno Sergio , Miguel Peteiro Miranda Carlos , Jorge Ortez Toro Jose , Agudo Ana , Urdaniz Rosana , Antonio Gimeno Orna José

Introduction: Severe hypoglycemia and retinopathy are two of the main complications of diabetes mellitus (DM). Traditionally, glycosylated hemoglobin (or A1C) has been used as the gold standard measurement of glycemic control; however, there is a significant percentage of complications riskassociated with the evolution of diabetes that is not fully explained by this single marker. Short and long-term glycemic variability has been postulated as one of the main variables that co...

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ea0070aep521 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Baseline characteristics of a cohort of type 1 diabetes patients on continuous subcutaneous insulin infusion therapy. Evaluation of glycemic variability parameters and complications.

Lecumberri Pascual Edurne , Bengoa Rojano Nuria , Fernandez Argüeso Maria , Lia Nattero Chavez Maria

Introduction: Glycemic variability (GV) has been associated, regardless to A1C levels, to chronic complications of diabetes mellitus (DM).Objective: To describe baseline characteristics, GV parameters, and microvascular complications rates in a selected simple of type 1 diabetes patients (T1DM) on continuous subcutaneous insulin infusion (CSII).Methods: We performed a retrospective observational study with 130 T1DM patientson (CSII...

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ea0070aep522 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The role of tau-protein in the diagnosis of cognitive impairment in diabetes

Matveeva Mariia , Samoilova Julia , Zhukova Natalie

Diabetes mellitus (DM) is a metabolic disease, which is accompanied by systemic damage to organs, including the central nervous system. Clinically, these changes are associated with cognitive impairment, the pathogenesis of which is also largely heterogeneous.Objective: To evaluate the role of tau-protein in the diagnosis of cognitive impairment in patients with type 1 and type 2 diabetes.Materials and methods: The study was tested...

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ea0070aep523 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Diabetic muscle infarction: A life changing diagnosis with poor long term prognosis

Manjunath Pramod , Siddique Rana , Rajagopal Vivek , Tauni Rahat

A 64 year old Caucasian man with long standing type 1 diabetes and complications of retinopathy, neuropathy and nephropathy was referred with suspected deep venous thrombosis (DVT) in the left lower limb. He had a week’s history of worsening pain and swelling in the medial left thigh and struggled to weight bear on that leg. He felt unwell a day before admission and was found to have hyperosmolar hyperglycaemic state with ketosis on admission. Ultrasound Doppler was nega...

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ea0070aep524 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The connection between dopamine activated AVP release regulation and sugar substitutes

Sepp Krisztian , Hausinger Péter , Molnár Zsolt , Radács Marianna , László Anna , Serester Andrea , László Márta , Csikós Andrea , Valkusz Zsuzsanna , Gálfi Márta

The human homeostasis is determined by psycho-neuro-endocrine-immuno processes. This biological balance-system depends on their communication of direct environment (eg. nutrition, respiration, etc. as in the metabolism). The basic of human communication-way with environment are defined by nutrition. This contains various agents: eg. proteins, lipids, sugars, vitamins, ions, etc. When the elements of nutrition is substituted, the markers of homeostatic processes and regulations...

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ea0070aep525 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Hyponatraemia in hospital care

Ó Murchú Oisín , Durkan Maeve

Introduction: Hyponatraemia (serum sodium <136 mmol/l) is associated with significant morbidity and mortality. International guidelines suggest a clear algorithm for investigation, inclusive of measurements of paired urine sodium and osmolality, thyroid function tests and a morning cortisol. The aim of this study was to prospectively investigate the assessment, management and clinical outcomes associated with hyponatraemia on hospital admission.Metho...

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ea0070aep526 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Triglyceride and glucose (TyG) index is an effective biomarker to identify severe acute pancreatitis

Lee Kyongjoo

Background: To predict severe acute pancreatitis (AP) at early stage is important to reduce morbidity and mortality. We aimed to investigate the association between the triglyceride and glucose index (TyG index) and the prognosis of acute pancreatitis.Methods: The TyG index was calculated as the ln[fasting triglycerides (mg/dl) × fasting plasma glucose (mg/dl)]/2. Patients were then categorized into low TyG index group (<5) and high TyG index gr...

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ea0070aep527 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Hormonal function of muscles in acromegaly in relation to metabolic disorders

Mizera Łukasz , Grzegrzółka Jędrzej , Halupczok-Żyła Jowita , Jędrzejuk Diana , Kolackov Katarzyna , Bolanowski Marek , Daroszewski Jacek

Skeletal muscle constitutes the largest endocrine organ in human body through capability of secreting myokines, which biological activity plays a key role in energy homeostasis. Among the myokines irisin (Ir) is of particular interest, considering it’s broad spectrum of protective influence on obesity and metabolic diseases development, determining therapeutical potential of this molecule. Latest studies indicate close interrelations between Ir and myostatin (Mstn), myok...

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